LOCUS       NM_006583               1815 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens retinal pigment epithelium-derived rhodopsin homolog
            (RRH), mRNA.
ACCESSION   NM_006583
VERSION     NM_006583.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1815)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1815)
  AUTHORS   Nagata,T., Koyanagi,M., Lucas,R. and Terakita,A.
  TITLE     An all-trans-retinal-binding opsin peropsin as a potential
            dark-active and light-inactivated G protein-coupled receptor
  JOURNAL   Sci Rep 8 (1), 3535 (2018)
   PUBMED   29476064
  REMARK    GeneRIF: By using chimeric mutant peropsins, it was found that
            peropsin potentially generates an 'active form' that drives
            G-protein signalling in the dark by binding to all-trans-retinal,
            and that the active form photo-converts to an inactive form
            containing 11-cis-retinal.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1815)
  AUTHORS   Kalsi,G., Kuo,P.H., Aliev,F., Alexander,J., McMichael,O.,
            Patterson,D.G., Walsh,D., Zhao,Z., Schuckit,M., Nurnberger,J. Jr.,
            Edenberg,H., Kramer,J., Hesselbrock,V., Tischfield,J.A.,
            Vladimirov,V., Prescott,C.A., Dick,D.M., Kendler,K.S. and
            Riley,B.P.
  TITLE     A systematic gene-based screen of chr4q22-q32 identifies
            association of a novel susceptibility gene, DKK2, with the
            quantitative trait of alcohol dependence symptom counts
  JOURNAL   Hum Mol Genet 19 (12), 2497-2506 (2010)
   PUBMED   20332099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Hum Mol Genet. 2010 Oct 15;19(20):4121. Hesselbrock,
            Victor [added]; Tischfield, Jay A [added]]
REFERENCE   4  (bases 1 to 1815)
  AUTHORS   Luttrell,L.M.
  TITLE     Reviews in molecular biology and biotechnology: transmembrane
            signaling by G protein-coupled receptors
  JOURNAL   Mol Biotechnol 39 (3), 239-264 (2008)
   PUBMED   18240029
  REMARK    Review article
REFERENCE   5  (bases 1 to 1815)
  AUTHORS   Rivolta,C., Berson,E.L. and Dryja,T.P.
  TITLE     Mutation screening of the peropsin gene, a retinal pigment
            epithelium specific rhodopsin homolog, in patients with retinitis
            pigmentosa and allied diseases
  JOURNAL   Mol Vis 12, 1511-1515 (2006)
   PUBMED   17167409
  REMARK    GeneRIF: Peropsin gene is not a common cause of retinitis
            pigmentosa or some related retinal degenerations, at least in the
            set of patients we analyzed.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1815)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   7  (bases 1 to 1815)
  AUTHORS   Bellingham,J., Wells,D.J. and Foster,R.G.
  TITLE     In silico characterisation and chromosomal localisation of human
            RRH (peropsin)--implications for opsin evolution
  JOURNAL   BMC Genomics 4 (1), 3 (2003)
   PUBMED   12542842
REFERENCE   8  (bases 1 to 1815)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   9  (bases 1 to 1815)
  AUTHORS   Sun,H., Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Peropsin, a novel visual pigment-like protein located in the apical
            microvilli of the retinal pigment epithelium
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9893-9898 (1997)
   PUBMED   9275222
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC126283.3.
            
            On Aug 27, 2019 this sequence version replaced NM_006583.4.
            
            Summary: Opsins are members of the guanine nucleotide-binding
            protein (G protein)-coupled receptor superfamily. This gene belongs
            to the seven-exon subfamily of mammalian opsin genes that includes
            opsin 5 and retinal G protein coupled receptor. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF012270.1, BC128120.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317735.7/ ENSP00000314992.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC126283.3         96170-96331
            163-353             AC126283.3         101337-101527
            354-453             AC126283.3         103564-103663
            454-607             AC126283.3         104205-104358
            608-776             AC126283.3         105635-105803
            777-955             AC126283.3         110667-110845
            956-1815            AC126283.3         112281-113140
FEATURES             Location/Qualifiers
     source          1..1815
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..1815
                     /gene="RRH"
                     /note="retinal pigment epithelium-derived rhodopsin
                     homolog"
                     /db_xref="GeneID:10692"
                     /db_xref="HGNC:HGNC:10450"
                     /db_xref="MIM:605224"
     exon            1..162
                     /gene="RRH"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1070
                     /gene="RRH"
                     /note="peropsin"
                     /codon_start=1
                     /product="visual pigment-like receptor peropsin"
                     /protein_id="NP_006574.1"
                     /db_xref="CCDS:CCDS3687.1"
                     /db_xref="GeneID:10692"
                     /db_xref="HGNC:HGNC:10450"
                     /db_xref="MIM:605224"
                     /translation="MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMAGMISIISNI
                     IVLGIFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQVYA
                     GLNIFFGMASIGLLTVVAVDRYLTICLPDVGRRMTTNTYIGLILGAWINGLFWALMPI
                     IGWASYAPDPTGATCTINWRKNDRSFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKH
                     HTTSDCTESLNRDWSDQIDVTKMSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMA
                     IIAPLFAKSSTFYNPCIYVVANKKFRRAMLAMFKCQTHQTMPVTSILPMDVSQNPLAS
                     GRI"
     exon            163..353
                     /gene="RRH"
                     /inference="alignment:Splign:2.1.0"
     exon            354..453
                     /gene="RRH"
                     /inference="alignment:Splign:2.1.0"
     exon            454..607
                     /gene="RRH"
                     /inference="alignment:Splign:2.1.0"
     exon            608..776
                     /gene="RRH"
                     /inference="alignment:Splign:2.1.0"
     exon            777..955
                     /gene="RRH"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1815
                     /gene="RRH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1792..1797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRH"
                     /note="hexamer: AATAAA"
     polyA_site      1815
                     /gene="RRH"
                     /note="major polyA site"
ORIGIN      
        1 agttcataat tatcgaaggc ttattatgaa gggtgtttcg gtatcttccc tccaaaatgc
       61 taagaaataa tttaggcaac agttcagact ctaaaaatga agatggctcg gtcttttcac
      121 agactgaaca caatattgtt gcaacttact tgattatggc aggtatgata agtattatca
      181 gcaacataat agttctgggc atcttcatta agtacaagga acttcggaca cccacaaatg
      241 caattattat taacctggct gttactgata taggggtcag tagcattggc tatcccatgt
      301 ctgctgcctc agatctgtat ggaagttgga aatttggata cgcaggctgt caggtttatg
      361 ctggattgaa tatttttttt ggaatggcaa gcattggatt actcacggtc gtggctgtgg
      421 accgatacct gaccatctgc cttcctgacg tagggagaag aatgaccacc aacacttaca
      481 tcggcttgat tctgggagcc tggatcaatg gcctgttttg ggctttgatg cctatcatag
      541 ggtgggctag ttatgcccca gatcctactg gtgctacgtg taccataaac tggaggaaaa
      601 atgatagatc ttttgtgtct tacaccatga cagttattgc gataaatttt attgtgccct
      661 tgacagtgat gttttactgc tattaccatg tcacgctatc cattaaacat cacactacca
      721 gtgactgcac tgagtccctc aacagagact ggtcagatca gatagatgta acaaagatgt
      781 ctgtgatcat gatctgcatg tttctggtgg catggtcccc ttattccatc gtgtgcttat
      841 gggcttcttt tggtgaccca aagaagattc ctccccccat ggccatcata gctccactgt
      901 ttgcaaaatc ttctacattc tataacccct gcatttatgt ggttgctaat aaaaagtttc
      961 ggagggcaat gcttgccatg ttcaaatgtc agactcacca aacaatgcct gtgacaagta
     1021 ttttacccat ggatgtatct caaaacccat tggcttctgg aagaatctga aataagataa
     1081 aaggacacac tatcaaaaca ctttagtttt ttgacaatgc ttttctttta aatatgagcc
     1141 catttagatc aagtgcagac atggatcatt gtcctatgag agtgtaagct cctcaagcac
     1201 agctcgtgct tctgtttgtg cactctggct gctgtagtgt atgcttctct gtgtcctgat
     1261 atatcaactt attgctcatc tcctttgatg aattaggcat cagaggttaa ggtccccttt
     1321 ctttctccct attatggcat gcattacact gtactgatga cctttaactt gcctggctcc
     1381 tccattagaa taaaagcagt cactaattta atgttagaat aaatgaataa ttctagataa
     1441 ttactgaaat gagttgttgg atgttcccag ttagaataga aagcattttt tgaatttcaa
     1501 cattttaaca tttaaatcaa ttaacttatg ttattaaaca aaaataaatg aacattaaac
     1561 atgattgttt ctaaataaaa tgttaagtca atgcatatat attatatagc attatgaccc
     1621 ctgtgcatat tttgatgttt tctgcaattt tgagtaccat ttttctgcat atatattcca
     1681 tatatttgcc aacagagtta acttcaatca gagtggagat ttttatatgt ttgttctttg
     1741 atgtatcctt agcacatata cccaattctg tctggcatgt agtaggcact caataaatat
     1801 tttttcaatg tcaaa
//
