LOCUS       NM_001003699            8625 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens ras responsive element binding protein 1 (RREB1),
            transcript variant 1, mRNA.
ACCESSION   NM_001003699
VERSION     NM_001003699.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8625)
  AUTHORS   Zhang,Z., Liu,B., Mei,L., Chen,R., Zhou,H. and Li,Z.
  TITLE     RREB1 could act as an immunological and prognostic biomarker: From
            comprehensive analysis to osteosarcoma validation
  JOURNAL   Int Immunopharmacol 143 (Pt 1), 113312 (2024)
   PUBMED   39405927
  REMARK    GeneRIF: RREB1 could act as an immunological and prognostic
            biomarker: From comprehensive analysis to osteosarcoma validation.
REFERENCE   2  (bases 1 to 8625)
  AUTHORS   Xu,J., Sivakumar,C., Ryan,C.W. and Rao,R.C.
  TITLE     A novel interaction between RNA m6A methyltransferase METTL3 and
            RREB1
  JOURNAL   Biochem Biophys Res Commun 733, 150668 (2024)
   PUBMED   39278095
  REMARK    GeneRIF: A novel interaction between RNA m[6]A methyltransferase
            METTL3 and RREB1.
REFERENCE   3  (bases 1 to 8625)
  AUTHORS   Dong,Q., Qiu,H., Piao,C., Li,Z. and Cui,X.
  TITLE     LncRNA SNHG4 promotes prostate cancer cell survival and resistance
            to enzalutamide through a let-7a/RREB1 positive feedback loop and a
            ceRNA network
  JOURNAL   J Exp Clin Cancer Res 42 (1), 209 (2023)
   PUBMED   37596700
  REMARK    GeneRIF: LncRNA SNHG4 promotes prostate cancer cell survival and
            resistance to enzalutamide through a let-7a/RREB1 positive feedback
            loop and a ceRNA network.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8625)
  AUTHORS   Mattis,K.K., Krentz,N.A.J., Metzendorf,C., Abaitua,F.,
            Spigelman,A.F., Sun,H., Ikle,J.M., Thaman,S., Rottner,A.K.,
            Bautista,A., Mazzaferro,E., Perez-Alcantara,M., Manning Fox,J.E.,
            Torres,J.M., Wesolowska-Andersen,A., Yu,G.Z., Mahajan,A.,
            Larsson,A., MacDonald,P.E., Davies,B., den Hoed,M. and Gloyn,A.L.
  TITLE     Loss of RREB1 in pancreatic beta cells reduces cellular insulin
            content and affects endocrine cell gene expression
  JOURNAL   Diabetologia 66 (4), 674-694 (2023)
   PUBMED   36633628
  REMARK    GeneRIF: Loss of RREB1 in pancreatic beta cells reduces cellular
            insulin content and affects endocrine cell gene expression.
REFERENCE   5  (bases 1 to 8625)
  AUTHORS   Li,H., Jiang,Y., Hu,J., Xu,J., Chen,L., Zhang,G., Zhao,J., Zong,S.,
            Guo,Z., Li,X., Zhao,X. and Jing,Z.
  TITLE     The U2AF65/circNCAPG/RREB1 feedback loop promotes malignant
            phenotypes of glioma stem cells through activating the TGF-beta
            pathway
  JOURNAL   Cell Death Dis 14 (1), 23 (2023)
   PUBMED   36635261
  REMARK    GeneRIF: The U2AF65/circNCAPG/RREB1 feedback loop promotes
            malignant phenotypes of glioma stem cells through activating the
            TGF-beta pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8625)
  AUTHORS   Ray,S.K., Nishitani,J., Petry,M.W., Fessing,M.Y. and Leiter,A.B.
  TITLE     Novel transcriptional potentiation of BETA2/NeuroD on the secretin
            gene promoter by the DNA-binding protein Finb/RREB-1
  JOURNAL   Mol Cell Biol 23 (1), 259-271 (2003)
   PUBMED   12482979
REFERENCE   7  (bases 1 to 8625)
  AUTHORS   Zhang,L., Zhao,J. and Edenberg,H.J.
  TITLE     A human Raf-responsive zinc-finger protein that binds to divergent
            sequences
  JOURNAL   Nucleic Acids Res 27 (14), 2947-2956 (1999)
   PUBMED   10390538
REFERENCE   8  (bases 1 to 8625)
  AUTHORS   Thiagalingam,A., Lengauer,C., Baylin,S.B. and Nelkin,B.D.
  TITLE     RREB1, a ras responsive element binding protein, maps to human
            chromosome 6p25
  JOURNAL   Genomics 45 (3), 630-632 (1997)
   PUBMED   9367691
REFERENCE   9  (bases 1 to 8625)
  AUTHORS   Fujimoto-Nishiyama,A., Ishii,S., Matsuda,S., Inoue,J. and
            Yamamoto,T.
  TITLE     A novel zinc finger protein, Finb, is a transcriptional activator
            and localized in nuclear bodies
  JOURNAL   Gene 195 (2), 267-275 (1997)
   PUBMED   9305772
REFERENCE   10 (bases 1 to 8625)
  AUTHORS   Thiagalingam,A., De Bustros,A., Borges,M., Jasti,R., Compton,D.,
            Diamond,L., Mabry,M., Ball,D.W., Baylin,S.B. and Nelkin,B.D.
  TITLE     RREB-1, a novel zinc finger protein, is involved in the
            differentiation response to Ras in human medullary thyroid
            carcinomas
  JOURNAL   Mol Cell Biol 16 (10), 5335-5345 (1996)
   PUBMED   8816445
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI818966.1, AB019254.1,
            AL355336.15, AL589644.6 and AL139095.15.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001003699.3.
            
            Summary: The protein encoded by this gene is a zinc finger
            transcription factor that binds to RAS-responsive elements (RREs)
            of gene promoters. It has been shown that the calcitonin gene
            promoter contains an RRE and that the encoded protein binds there
            and increases expression of calcitonin, which may be involved in
            Ras/Raf-mediated cell differentiation. Multiple transcript variants
            encoding several different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB019254.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379938.7/ ENSP00000369270.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                BI818966.1         155-251
            98-966              AB019254.1         29-897
            967-967             AL355336.15        163860-163860
            968-1397            AB019254.1         899-1328
            1398-1398           AL589644.6         11872-11872
            1399-2731           AB019254.1         1330-2662
            2732-2732           AL589644.6         13206-13206
            2733-4948           AB019254.1         2664-4879
            4949-4949           AL139095.15        7680-7680
            4950-5747           AB019254.1         4881-5678
            5748-8625           AL139095.15        9768-12645
FEATURES             Location/Qualifiers
     source          1..8625
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p24.3"
     gene            1..8625
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /note="ras responsive element binding protein 1"
                     /db_xref="GeneID:6239"
                     /db_xref="HGNC:HGNC:10449"
                     /db_xref="MIM:602209"
     exon            1..100
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /inference="alignment:Splign:2.1.0"
     exon            101..219
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /inference="alignment:Splign:2.1.0"
     exon            220..342
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /inference="alignment:Splign:2.1.0"
     exon            343..555
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..5613
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hindsight homolog; finger protein in nuclear bodies;
                     DNA-binding protein; raf-responsive zinc finger protein
                     LZ321; zinc finger motif enhancer-binding protein 1"
                     /codon_start=1
                     /product="ras-responsive element-binding protein 1 isoform
                     1"
                     /protein_id="NP_001003699.1"
                     /db_xref="CCDS:CCDS34335.1"
                     /db_xref="GeneID:6239"
                     /db_xref="HGNC:HGNC:10449"
                     /db_xref="MIM:602209"
                     /translation="MTSSSPAGLEGSDLSSINTMMSAVMSVGKVTENGGSPQGIKSPS
                     KPPGPNRIGRRNQETKEEKSSYNCPLCEKICTTQHQLTMHIRQHNTDTGGADHSCSIC
                     GKSLSSASSLDRHMLVHSGERPYKCTVCGQSFTTNGNMHRHMKIHEKDPNSATATAPP
                     SPLKRRRLSSKRKLSHDAESEREDPAPAKKMVEDGQSGDLEKKADEVFHCPVCFKEFV
                     CKYGLETHMETHSDNPLRCDICCVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPS
                     IPAGFHDLGFTDFSCRKFPRISQAWCETNLRRCISEQHRFVCDTCDKAFPMLCSLALH
                     KQTHVAADQGQEKPQATPLPGDALDQKGFLALLGLQHTKDVRPAPAEEPLPDDNQAIQ
                     LQTLKCQLPQDPGCTNLLSLSPFEAASLGGSLTVLPATKDSIKHLSLQPFQKGFIIQP
                     DSSIVVKPISGESAIELADIQQILKMAASAPPQISLPPFSKAPAAPLQAIFKHMPPLK
                     PKPLVTPRTVVATSTPPPLINAQQASPGCISPSLPPPPLKLLKGSVEAASNAHLLQSK
                     SGTQPHAATRLSLQQPRAELPGQPEMKTQLEQDSIIEALLPLSMEAKIKQEITEGELK
                     AFMTAPGGKKTPAMRKVLYPCRFCNQVFAFSGVLRAHVRSHLGISPYQCNICDYIAAD
                     KAALIRHLRTHSGERPYICKICHYPFTVKANCERHLRKKHLKATRKDIEKNIEYVSSS
                     AAELVDAFCAPDTVCRLCGEDLKHYRALRIHMRTHCGRGLGGGHKGRKPFECKECSAA
                     FAAKRNCIHHILKQHLHVPEQDIESYVLAADGLGPAEAPAAEASGRGEDSGCAALGDC
                     KPLTAFLEPQNGFLHRGPTQPPPPHVSIKLEPASSFAVDFNEPLDFSQKGLALVQVKQ
                     ENISFLSPSSLVPYDCSMEPIDLSIPKNFRKGDKDLATPSEAKKPEEEAGSSEQPSPC
                     PAPGPSLPVTLGPSGILESPMAPAPAATPEPPAQPLQGPVQLAVPIYSSALVSSPPLV
                     GSSALLSGTALLRPLRPKPPLLLPKPPVTEELPPLASIAQIISSVSSAPTLLKTKVAD
                     PGPASTGSNTTASDSLGGSVPKAATTATPAATTSPKESSEPPAPASSPEAASPTEQGP
                     AGTSKKRGRKRGMRSRPRANSGGVDLDSSGEFASIEKMLATTDTNKFSPFLQTAEDNT
                     QDEVAGAPADHHGPSDEEQGSPPEDKLLRAKRNSYTNCLQKITCPHCPRVFPWASSLQ
                     RHMLTHTGQKPFPCQKCDAFFSTKSNCERHQLRKHGVTTCSLRRNGLIPQSKESDVGS
                     HDSTDSQSDAETAAAAGEVLDLTSRDREQPSEGATELRQVAGDAPVEQATAETASPVH
                     REEHGRGESHEPEEEHGTEESTGDADGAEEDASSNQSLDLDFATKLMDFKLAEGDGEA
                     GAGGAASQEQKLACDTCGKSFKFLGTLSRHRKAHGRQEPKDEKGDGASTAEEGPQPAP
                     EQEEKPPETPAEVVESAPGAGEAPAEKLAEETEGPSDGESAAEKRSSEKSDDDKKPKT
                     DSPKSVASKADKRKKVCSVCNKRFWSLQDLTRHMRSHTGERPYKCQTCERTFTLKHSL
                     VRHQRIHQKARHAKHHGKDSDKEERGEEDSENESTHSGNNAVSENEAELAPNASNHMA
                     VTRSRKEGLASATKDCSHREEKVTAGWPSEPGQGDLNPESPAALGQDLLEPRSKRPAH
                     PILATADGASQLVGME"
     exon            556..645
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..809
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..954
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1091
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1281
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..4192
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4193..4357
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /inference="alignment:Splign:2.1.0"
     exon            4358..5155
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /inference="alignment:Splign:2.1.0"
     exon            5156..8625
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5904..5909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /note="hexamer: AACAAA"
     polyA_site      5921
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
     regulatory      8599..8604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /note="hexamer: AATAAA"
     polyA_site      8625
                     /gene="RREB1"
                     /gene_synonym="FINB; HNT; LZ321; RREB-1; Zep-1"
                     /note="major polyA site"
ORIGIN      
        1 attccttttc cggaacaagt ttgcatctct cctcggtctc tccctgaagc ccaccggtcc
       61 ccaacgcatc atgccaggga gccaagcgtc ctgcccggcc gttgctccga ctgtgtgttc
      121 caggagtggt ggctctgagg tgtgaccctg cccacgtttg ggcccagcca ggttcagccc
      181 cccaataagg agggcagctt gataacacaa agaaaacagt gtcaacgagt actaccaaga
      241 gaagaagaca agaggtcaac acagactcat tttctactcc gtgtgaatga tagctacagc
      301 aggggaaagt ttcatagtct atcagtgggt cagaaaatgg agttttatag cagaggcttc
      361 ttagaagctt aaacccctgt cccaatgacg tcaagttcgc ccgctggctt ggaaggttca
      421 gacctatctt ccatcaacac catgatgtcg gcggtcatga gtgtagggaa ggtcacagag
      481 aatggcggga gcccccaggg gatcaagtcc ccctcgaagc ctccaggacc aaatcggatt
      541 ggcagaagga accaggaaac gaaagaggag aagtcttcct ataactgccc cctgtgtgag
      601 aagatttgca ctacccagca ccagctgacc atgcacattc gccagcacaa cacagacact
      661 ggaggagccg accactcatg cagcatctgc ggaaagtcac tgagctcggc cagctccctc
      721 gatcgccaca tgctggtgca ctctggcgag aggccttaca agtgcactgt gtgtggccag
      781 tcatttacca ccaatgggaa catgcacaga catatgaaga tccatgagaa ggaccctaac
      841 agtgccacag ccacagcccc tccatctcct ctgaaacgta ggcgattgtc ctccaagagg
      901 aaactgagtc acgatgccga gtcagagaga gaagacccag caccagctaa aaagatggta
      961 gaagacgggc agtcaggtga cttggagaag aaagctgatg aagtctttca ctgcccagta
     1021 tgtttcaagg agtttgtttg caagtatgga ctggagaccc acatggagac ccattcagat
     1081 aacccactaa gatgtgacat ttgttgtgtc acctttcgaa cacatcgagg actgctgcgt
     1141 cacaacgcgc ttgtccacaa acaacttccc agggatgcaa tgggcagacc tttcatacag
     1201 aacaaccctt caattcctgc tggcttccac gacttaggat tcacggactt ctcctgtagg
     1261 aagtttcctc gcatttctca ggcctggtgc gaaacaaacc tgcggaggtg catcagcgag
     1321 caacaccgtt ttgtctgcga cacctgtgac aaggcgttcc ccatgctctg ctcactggct
     1381 ctgcacaagc agacccatgt ggcggcagac cagggtcaag aaaagccgca ggccacgccc
     1441 ctgcctggtg acgccctgga ccagaagggc ttcctggcct tgcttggcct gcagcacacc
     1501 aaagacgtca ggcctgcccc cgccgaggag cccctgccgg atgacaacca ggcaattcag
     1561 ctccagacac tcaagtgtca gctacctcag gaccccggct gcaccaacct gctgagcctg
     1621 tcacctttcg aagctgcttc cctaggcggt tctctcacag ttctccccgc gaccaaggac
     1681 agcataaagc acctgtccct gcagcccttc cagaagggct tcatcatcca gcctgacagc
     1741 agcattgtgg tcaagcccat ctctggcgag tcggccatcg agctggcaga catccagcaa
     1801 attctgaaga tggcagcctc ggctccccct cagatcagtc ttccgccctt ctccaaggcc
     1861 cctgccgccc cactgcaggc gatcttcaag cacatgcccc ctctgaagcc aaagcccctg
     1921 gtcacaccac ggacggtggt ggccacctcc acgcccccgc ctctcatcaa cgcccagcag
     1981 gcttccccgg gctgtatcag ccccagcctg ccgccaccgc ccctgaagct cctcaaaggc
     2041 tcagtggagg cggcctccaa cgcccacctg ctgcagtcca agtccgggac ccagccccac
     2101 gcggccacgc ggctctccct gcagcagccg cgggcggagc tgccgggcca gcctgagatg
     2161 aagacgcagc tggagcagga cagcatcatc gaggccctgc tgccgctgag catggaggcc
     2221 aagatcaagc aggagatcac agagggggaa ctcaaggcct tcatgacagc gcccggcggc
     2281 aagaagacgc ccgccatgcg caaggtgctc tacccctgcc gcttctgcaa ccaggtgttt
     2341 gccttctcgg gggtcttgcg tgcccacgtg cgctcccacc tgggcatctc gccataccag
     2401 tgcaacatct gcgactacat cgccgccgac aaggccgcgc tcatccgcca cctgcgcacg
     2461 cacagtgggg agcggcccta catttgcaag atctgccact accccttcac tgtcaaagcc
     2521 aactgcgagc ggcacctgcg caagaagcac ctcaaggcca cccgcaagga tatcgagaag
     2581 aacatcgagt atgtgagtag cagcgcggcc gagctggtgg acgccttctg cgccccggac
     2641 accgtgtgcc ggctgtgcgg cgaggacctc aagcactatc gtgccctgcg catccacatg
     2701 cgcacgcact gcggccgcgg cctgggcggg ggccacaagg gccgcaagcc cttcgagtgc
     2761 aaggagtgca gcgccgcgtt cgcggccaag cgcaactgca tccaccacat cctcaagcag
     2821 cacctgcacg tgcccgagca ggacatcgag agctacgtgc tggccgccga cggcctgggc
     2881 cccgcagagg cgccggccgc tgaggcgtcg gggcgcgggg aggacagtgg ctgcgctgcc
     2941 cttggtgact gcaagcccct cactgccttc ctggaacccc agaacggctt tcttcacagg
     3001 ggccccaccc agcctccacc tccccatgtc tcgatcaagt tggagcccgc cagtagcttt
     3061 gcggtggact tcaatgagcc cctggacttc tcgcagaagg gcctggccct ggtccaagtg
     3121 aagcaggaaa acatctcctt tctgagccct tcttccctgg tcccctatga ctgctccatg
     3181 gagcccatcg acctgtccat ccccaagaac ttcaggaaag gggacaagga tttggccact
     3241 cccagcgaag ccaagaagcc tgaggaggag gcggggagca gcgagcagcc ctctccctgc
     3301 ccagcacccg gcccttctct tcctgtaact ttggggccca gcggaatcct ggaaagcccc
     3361 atggcccctg ctccggcggc caccccggaa cccccagcac agcccctgca gggccctgtt
     3421 cagctggcgg tcccaatcta ctcctcagcc ctggtcagca gccctccact cgtgggcagc
     3481 tcagccctcc tgagtggcac agccttgctg cgtccactgc ggcccaagcc cccgctgctt
     3541 ttgccaaagc cccccgtgac agaagagctg cccccgctgg cctccattgc ccagatcatc
     3601 tcatctgtat cctcggcccc caccctgctg aaaaccaagg tggcggaccc agggcccgca
     3661 agcactggca gtaacaccac ggcttcagac agcttaggag gttctgtccc caaagccgcc
     3721 accaccgcca cccccgctgc caccaccagc ccaaaagagt ctagtgagcc tcccgctcca
     3781 gccagcagcc cagaggctgc ctctcccacc gagcagggcc cagcgggcac gtcgaagaag
     3841 aggggccgga aaagggggat gaggagccga ccccgcgcca acagcggcgg ggtggacctg
     3901 gactccagcg gggagtttgc cagcatcgag aagatgctgg ccaccacaga caccaacaag
     3961 ttcagtccgt ttctgcagac agcggaggac aacactcagg atgaggtggc cggagcccct
     4021 gccgaccacc atgggcccag tgatgaagag cagggcagtc ccccagaaga caagctgctg
     4081 agggccaagc ggaactcgta caccaactgc ctgcagaaga tcacctgtcc ccactgtccc
     4141 cgggttttcc cttgggccag ctccctacag aggcacatgc tcacacacac tggtcagaaa
     4201 cccttccctt gtcaaaaatg cgatgccttc ttttctacca aatctaactg tgaacgccac
     4261 cagttgcgca aacacggagt taccacctgt tccctgagaa gaaacgggct tatcccccag
     4321 tcaaaagaga gtgatgttgg atcccatgat agcacagaca gtcagtcgga tgcggagact
     4381 gcagccgccg cgggcgaagt gctagacctc acctcacggg acagagagca gccgtcggag
     4441 ggcgccactg agctccgcca ggtcgcaggg gatgcgcctg tggagcaggc cacggcggaa
     4501 acggcctcgc cggtgcaccg ggaagagcac gggcgtgggg agagccatga gccggaggag
     4561 gagcatggca ctgaggagag cactggggac gccgacggcg cggaagagga cgcgtcgagc
     4621 aaccagagcc tggacctgga cttcgccacc aagctcatgg acttcaagct ggcggagggc
     4681 gacggcgagg caggcgccgg gggcgcggcc tcgcaggagc agaagctcgc ctgcgacacc
     4741 tgtgggaaga gcttcaagtt cctgggcacc ctgagccgcc accggaaggc gcacggccgc
     4801 caggagccca aggacgagaa gggagatggc gccagcactg cagaggaggg gccccagccc
     4861 gcccctgaac aggaggagaa gccccccgag accccggcag aggtggtgga gtcggccccg
     4921 ggtgccgggg aggccccggc ggaaaagctc gcggaggaga cggagggccc ctccgacggg
     4981 gagagcgcgg ccgagaaaag gtcctcagag aagagcgacg atgacaagaa accaaagaca
     5041 gactccccca aaagcgtggc cagcaaggca gacaagagga agaaggtctg cagcgtgtgc
     5101 aacaagcggt tctggtcgct gcaggacctg acccggcaca tgcgctccca cacaggggaa
     5161 aggccataca aatgtcagac ctgcgagcga accttcacct tgaagcacag cctggttcgc
     5221 caccagcgga tccaccagaa agccaggcat gccaaacacc acgggaagga cagcgacaag
     5281 gaagagcggg gtgaggagga cagcgagaat gagtccaccc acagcggcaa caacgccgtc
     5341 tcagagaacg aggctgagct ggctcccaat gccagcaacc acatggctgt cacccggagc
     5401 cggaaggagg gcttggccag tgccaccaag gactgcagcc acagggagga gaaggtcacg
     5461 gcagggtggc cgtctgagcc tggccagggt gaccttaacc cagagagccc ggcggccctg
     5521 gggcaggacc tgctggagcc gcgcagcaag aggcctgccc acccaatcct ggccacagct
     5581 gatggcgcct cccagctcgt ggggatggag tgacagcctc agtccccctc agcacagaca
     5641 aaagccagca gagcaaagcg tctatacttc atggggtttc ctcagtgccc tttggctgtt
     5701 gaggagtgag agagagagag agagagagag agagagagag agagagagac aagcaggagc
     5761 gtggctgctc gctcagtgcc atagccttac cgcagcctgc gcgggaggcc acagcccgtg
     5821 ccgattccag tgccttaact acttaccgga tccctccata ttatcatggg tgttgtattt
     5881 ttccaaaatg acttcttaaa caaaacaaat attataatga attgtctgga gaggacctct
     5941 tcatttgagc attagcgtta ttttgtattg gtgtgtgtga gcttgttctt gtgaatctgt
     6001 gatagcaccg tttgttctgt gagctggaaa cagaaggaaa aaacataccc ttgggtaccc
     6061 atagccaata actggaagaa aatgatgtga atttcatgta aatgaccaga ggaaagatgg
     6121 ataagatgat aatttcttaa atagacattt tccttttttc tttgtgcttc atggtggagc
     6181 tgtcatctgg tccttggtat tacaggatgt ggttgatgaa ggtttccaat atggtttcag
     6241 gccaaaacca gggaagattc tagcttcagc ctcatgtcca tttccagtct gtcagcatta
     6301 gacatggtca ctgttcaagt ttcaagacat ccattcttaa ctatagagaa gagttactcc
     6361 cctggcgtct taacctatgg aaaacatgca cggataggat atatttgatt gcctcctctt
     6421 ccctttcagt atatgtatta ttaatattat tattattatt attattatta gttcatcagt
     6481 ttgctgttct ctgcagtgag cagaatcaaa tgggcaatat ttgtcctggg agacctgtgc
     6541 cgcacccagg tccccgtgtt aacgtgtgcc tgcggttgtg gttggcaccc tcgggtggta
     6601 gctcttctac tgtaatgaga caagcctttc ttctgtcact gcagaattta gaaggggccg
     6661 tgagcagtct tcccaagcat ggtccaggag cagctcagag agggtggagt gaggatgcat
     6721 gcatccaggg aacaggcatc aagaagccag ggccgtgcct ggagcactgc agagatgact
     6781 ttggagaaag caaagcagtg acccagtgac caggcacatt actcgtgagc gaggtattcc
     6841 cagtcttcct gctaagccta atccaagcct tacccagctg tgctactgtc atttgcaaag
     6901 caaggaaata ctactactgg taataaaact acacatgcaa gatgtcagat aagaaatagg
     6961 tttatattta ccttcctgcg atgtggggtt ggtgcttgaa gataaatgtg ctgtttctag
     7021 tttcttaaat agcccacacc cctggatgca aaaaggcagg gttattttta cccatgagca
     7081 tcctgtgcag gcaatagact tccctcactg tctccgcctg cagggaggag aatgtacccc
     7141 actgcacctg agctcctggt ccctcagcca agacctcagg ggtccccagc cagcctgctg
     7201 ctggggaccc ctgtgcttgc tgcagtgtat ggagcctctt gccttcccct ggggaggcac
     7261 ccctgtaccc cagcttcctt cccctggcct tttctggccc cagtgctcct cctttacata
     7321 gacttgttca cacagaaacg tgcacgcccc cttttctccg ccacttcacc agtttctgaa
     7381 atccaacctc ccagacttca caggaagata gatattcttg agataatgaa aagtgatatc
     7441 ttcgcatacg aaaggaaaaa aggttgaggt atatatgatt tttaactgta ttaggggtgt
     7501 atgaaccagt ttaaaaacga ggttttattt actgtagaga tgaatgcaaa tcagaaccaa
     7561 tgatcccttg gcctacttag ttaaaaccag ttcatacatc ccttagggtt tttattatta
     7621 ttattattat tattacagtt gttattgttg tttttgttgt tattattatt tggggtttct
     7681 tgtgtttttt ctttgcgact ctccacacta aacttgcaat attgtgggga gaagctgtga
     7741 ctaaactcta cgctgcggtg agatgtagca gtaatcagct cccagcgacg tgtgtagctg
     7801 gggctgccgc tcgcaataat cactattgat ttaaagcttt acttagcctt gatctgtacc
     7861 ctcgtagtca ataaggtctt gccacatttt attagtgagg tggagaaacg tattatttgt
     7921 ttgttgtttt tgcccttccc ccacccccca atattaaact gtgaaatttg tgatttgttt
     7981 aaactctggg tgaatcatag cttagtttgc atgtccagct aatttgtttc tatacatttt
     8041 gtttgattct ctttctcctt ctctcagggc ttttacaaaa aaatatatat atatggatct
     8101 tctgaaaagt tttttgaggt gcaagttttt tctctttttt tttttttttt ttttttctca
     8161 ttgattaatg gacatgatgc tgagattcaa tcactacatg aaacacctgg ctgtgaaaac
     8221 aaaacaaccc agagggctgt gttccaagca gcgctgggga agctacgtaa cagtcggatg
     8281 ccagttttgg aagattcacc atgcgttctg accctctgtt cgtctctttc ctctcctctt
     8341 tcttcaagaa ggaaattgat cctagtgatt tcagcccatg cattaaacag gaaacaataa
     8401 taaatttgta gaattcatat ttttctaaag ggaacttaaa aactgctgct acatgttatg
     8461 tacaaaactg gtttatgcca catgaacaga gaatcacaag tttggttttg gtactttttg
     8521 ttcctctttg tattcagttg tatagaactt ccaaattcag aatgagaaga aagctgttct
     8581 gtatcaaacc atttaagcaa taaatgttat attttaaaag ctgca
//
