LOCUS       NM_001365613            5049 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ribosome binding protein 1 (RRBP1), transcript variant
            3, mRNA.
ACCESSION   NM_001365613
VERSION     NM_001365613.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5049)
  AUTHORS   Chiu,C.H., Hsuan,C.F., Lin,S.H., Hung,Y.J., Hwu,C.M., Hee,S.W.,
            Lin,S.W., Fong,S.W., Hsieh,P.C., Yang,W.S., Lin,W.C., Lee,H.L.,
            Hsieh,M.L., Li,W.Y., Lin,J.W., Hsu,C.N., Wu,V.C., Chuang,G.T.,
            Chang,Y.C. and Chuang,L.M.
  TITLE     ER ribosomal-binding protein 1 regulates blood pressure and
            potassium homeostasis by modulating intracellular renin trafficking
  JOURNAL   J Biomed Sci 30 (1), 13 (2023)
   PUBMED   36803854
  REMARK    GeneRIF: ER ribosomal-binding protein 1 regulates blood pressure
            and potassium homeostasis by modulating intracellular renin
            trafficking.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5049)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5049)
  AUTHORS   Luo,H.L., Liu,H.Y., Chang,Y.L., Sung,M.T., Chen,P.Y., Su,Y.L.,
            Huang,C.C. and Peng,J.M.
  TITLE     Hypomethylated RRBP1 Potentiates Tumor Malignancy and
            Chemoresistance in Upper Tract Urothelial Carcinoma
  JOURNAL   Int J Mol Sci 22 (16), 8761 (2021)
   PUBMED   34445467
  REMARK    GeneRIF: Hypomethylated RRBP1 Potentiates Tumor Malignancy and
            Chemoresistance in Upper Tract Urothelial Carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5049)
  AUTHORS   Shriwas,O., Arya,R., Mohanty,S., Mohapatra,P., Kumar,S., Rath,R.,
            Kaushik,S.R., Pahwa,F., Murmu,K.C., Majumdar,S.K.D., Muduly,D.K.,
            Dixit,A., Prasad,P., Nanda,R.K. and Dash,R.
  TITLE     RRBP1 rewires cisplatin resistance in oral squamous cell carcinoma
            by regulating Hippo pathway
  JOURNAL   Br J Cancer 124 (12), 2004-2016 (2021)
   PUBMED   33762722
  REMARK    GeneRIF: RRBP1 rewires cisplatin resistance in oral squamous cell
            carcinoma by regulating Hippo pathway.
            Erratum:[Br J Cancer. 2021 Jun;124(12):2039. doi:
            10.1038/s41416-021-01414-w.. PMID: 33963301]
REFERENCE   5  (bases 1 to 5049)
  AUTHORS   Zhu,J., Zhao,R., Xu,W., Ma,J., Ning,X., Ma,R. and Meng,F.
  TITLE     Correlation between reticulum ribosome-binding protein 1 (RRBP1)
            overexpression and prognosis in cervical squamous cell carcinoma
  JOURNAL   Biosci Trends 14 (4), 279-284 (2020)
   PUBMED   32536673
  REMARK    GeneRIF: Correlation between reticulum ribosome-binding protein 1
            (RRBP1) overexpression and prognosis in cervical squamous cell
            carcinoma.
REFERENCE   6  (bases 1 to 5049)
  AUTHORS   Foster,L.J., Zeemann,P.A., Li,C., Mann,M., Jensen,O.N. and
            Kassem,M.
  TITLE     Differential expression profiling of membrane proteins by
            quantitative proteomics in a human mesenchymal stem cell line
            undergoing osteoblast differentiation
  JOURNAL   Stem Cells 23 (9), 1367-1377 (2005)
   PUBMED   16210410
REFERENCE   7  (bases 1 to 5049)
  AUTHORS   Diefenbach,R.J., Diefenbach,E., Douglas,M.W. and Cunningham,A.L.
  TITLE     The ribosome receptor, p180, interacts with kinesin heavy chain,
            KIF5B
  JOURNAL   Biochem Biophys Res Commun 319 (3), 987-992 (2004)
   PUBMED   15184079
  REMARK    GeneRIF: Results identify the ribosome receptor, p180, as a binding
            partner of the kinesin heavy chain isoform KIF5B.
REFERENCE   8  (bases 1 to 5049)
  AUTHORS   Langley,R., Leung,E., Morris,C., Berg,R., McDonald,M., Weaver,A.,
            Parry,D.A., Ni,J., Su,J., Gentz,R., Spurr,N. and Krissansen,G.W.
  TITLE     Identification of multiple forms of 180-kDa ribosome receptor in
            human cells
  JOURNAL   DNA Cell Biol 17 (5), 449-460 (1998)
   PUBMED   9628588
REFERENCE   9  (bases 1 to 5049)
  AUTHORS   Basson,C.T., MacRae,C.A., Schoenberg-Fejzo,M., Morton,C.C.,
            Spinner,N.B., Genin,A., Krug,E., Seidman,J.G. and Seidman,C.E.
  TITLE     Identification, characterization, and chromosomal localization of
            the human homolog (hES) of ES/130
  JOURNAL   Genomics 35 (3), 628-631 (1996)
   PUBMED   8812507
REFERENCE   10 (bases 1 to 5049)
  AUTHORS   Savitz,A.J. and Meyer,D.I.
  TITLE     Identification of a ribosome receptor in the rough endoplasmic
            reticulum
  JOURNAL   Nature 346 (6284), 540-544 (1990)
   PUBMED   2165568
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL132765.38 and KF456852.1.
            
            On May 17, 2019 this sequence version replaced NM_001365613.1.
            
            Summary: This gene encodes a ribosome-binding protein of the
            endoplasmic reticulum (ER) membrane. Studies suggest that this gene
            plays a role in ER proliferation, secretory pathways and secretory
            cell differentiation, and mediation of ER-microtubule interactions.
            Alternative splicing has been observed and protein isoforms are
            characterized by regions of N-terminal decapeptide and C-terminal
            heptad repeats. Splicing of the tandem repeats results in
            variations in ribosome-binding affinity and secretory function. The
            full-length nature of variants which differ in repeat length has
            not been determined. Pseudogenes of this gene have been identified
            on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate
            gene in the cause of Alagille syndrome, the result of a mutation in
            a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR7346977.1241992.1, SRR1660809.158210.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377813.6/ ENSP00000367044.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AL132765.38        128384-128598       c
            216-292             AL132765.38        126355-126431       c
            293-1437            AL132765.38        105740-106884       c
            1438-1540           KF456852.1         1-103               c
            1541-2225           AL132765.38        104952-105636       c
            2226-2374           AL132765.38        89335-89483         c
            2375-2497           AL132765.38        88153-88275         c
            2498-2650           AL132765.38        82933-83085         c
            2651-2769           AL132765.38        81902-82020         c
            2770-2923           AL132765.38        79816-79969         c
            2924-3062           AL132765.38        76179-76317         c
            3063-3241           AL132765.38        73860-74038         c
            3242-3276           AL132765.38        73704-73738         c
            3277-3367           AL132765.38        71868-71958         c
            3368-3460           AL132765.38        70932-71024         c
            3461-3553           AL132765.38        68211-68303         c
            3554-3637           AL132765.38        68046-68129         c
            3638-3727           AL132765.38        67814-67903         c
            3728-3820           AL132765.38        67071-67163         c
            3821-3892           AL132765.38        66655-66726         c
            3893-3988           AL132765.38        65989-66084         c
            3989-4072           AL132765.38        64952-65035         c
            4073-4180           AL132765.38        63088-63195         c
            4181-4264           AL132765.38        62282-62365         c
            4265-4363           AL132765.38        61787-61885         c
            4364-4507           AL132765.38        61093-61236         c
            4508-5049           AL132765.38        60035-60576         c
FEATURES             Location/Qualifiers
     source          1..5049
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.1"
     gene            1..5049
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /note="ribosome binding protein 1"
                     /db_xref="GeneID:6238"
                     /db_xref="HGNC:HGNC:10448"
                     /db_xref="MIM:601418"
     exon            1..215
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            216..292
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            293..2225
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..4546
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /note="isoform 1 is encoded by transcript variant 3;
                     ES/130-related protein; ribosome receptor protein; 180 kDa
                     ribosome receptor homolog; ribosome binding protein 1
                     homolog 180kDa (dog); ribosomal receptor-binding protein
                     1; endoplasmic reticulum ribosome-binding protein 1"
                     /codon_start=1
                     /product="ribosome-binding protein 1 isoform 1"
                     /protein_id="NP_001352542.1"
                     /db_xref="CCDS:CCDS93010.1"
                     /db_xref="GeneID:6238"
                     /db_xref="HGNC:HGNC:10448"
                     /db_xref="MIM:601418"
                     /translation="MDIYDTQTLGVVVFGGFMVVSAIGIFLVSTFSMKETSYEEALAN
                     QRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKIPDHDPAPNVTVLLREPVRA
                     PAVAVAPTPVQPPIIVAPVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSI
                     QVLTSKAAILETAPKEVPMVVVPPVGAKGNTPATGTTQGKKAEGTQNQSKKAEGAPNQ
                     GRKAEGTPNQGKKTEGTPNQGKKAEGTPNQGKKAEGTPNQGKKAEGAQNQGKKVDTTP
                     NQGKKVEGAPTQGRKAEGAQNQAKKVEGAQNQGKKAEGAQNQGKKGEGAQNQGKKAEG
                     AQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKV
                     EGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQGK
                     KAEGAQNQGKKAEGAQNQGKKVEGAQNQGKKAEGAQNQGKKAEGAQNQGKKAEGAQNQ
                     GQKGEGAQNQGKKTEGAQGKKAERSPNQGKKGEGAPIQGKKADSVANQGTKVEGITNQ
                     GKKAEGSPSEGKKAEGSPNQGKKADAAANQGKKTESASVQGRNTDVAQSPEAPKQEAP
                     AKKKSGSKKKGEPGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILSEKAGIIQ
                     DTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKAKAAAG
                     EAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQLARL
                     QQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKALE
                     AKAAAFEKQVLQLQASHRESEEALQKRLDEVSRELCHTQSSHASLRADAEKAQEQQQQ
                     MAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARDA
                     QDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLREKNWKAMEA
                     LATAEQACKEKLLSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTEWLQD
                     LKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAECDQYRSILAETEGMLRDLQ
                     KSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGELESSDQVREHTSHLEAE
                     LEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQSDELALVRQQLSEMK
                     SHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQRQKLTAEFEEAQT
                     SACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQ
                     EQLAREKDTVKKLQEQLEKAEDGSSSKEGTSV"
     exon            2226..2374
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2497
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2650
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2769
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2923
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..3062
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            3063..3241
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..3276
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3367
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3460
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3553
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3637
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            3638..3727
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            3728..3820
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            3821..3892
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..3988
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            3989..4072
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            4073..4180
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            4181..4264
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            4265..4363
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            4364..4507
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     exon            4508..5049
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4610..4615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /note="hexamer: AATAAA"
     polyA_site      4629
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
     regulatory      5025..5030
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /note="hexamer: ATTAAA"
     polyA_site      5049
                     /gene="RRBP1"
                     /gene_synonym="ES/130; ES130; hES; p180; RRp"
                     /note="major polyA site"
ORIGIN      
        1 agaaagtgcc acgactccac acgcgcgcac gcagccagcg agcggccgga gcggacggca
       61 gacggggcgg gcggcgtcag ggtcgcagcg tctacagctg ctcgggggcg gtttcttggc
      121 ggaggcttgg ccggctcctc tctcccggct ccgcggcggc tgcgaaggcg gcggctcctg
      181 ccctctcgct ttccctctcg cgtctctggc tgcagaaaga agcttccggt tctgaggtcc
      241 tggaggtgcc atttccctct ctgttgaagc aaaggccggg gcagacctcc tagtgaaagg
      301 aaagcaagcc aggatggata tttacgacac tcaaaccttg ggggttgtgg tctttggagg
      361 attcatggtt gtttctgcca ttggcatctt cctggtgtcg actttctcca tgaaggaaac
      421 gtcatatgaa gaagccctag ccaaccagcg caaggagatg gcgaaaactc accaccagaa
      481 agtcgagaag aaaaagaagg agaaaacagt ggagaagaaa ggaaagacca agaaaaagga
      541 agagaaacct aatgggaaga tacctgatca tgatccagcc cccaatgtga ctgtcctcct
      601 tcgagaacca gtgcgggctc ctgctgtggc tgtggctcca accccagtgc agccccccat
      661 tatcgttgct cctgtcgcca cagttccagc catgccccag gagaagctgg cctcctcccc
      721 caaggacaaa aagaagaagg agaaaaaagt ggcaaaagtg gaaccagctg tcagctctgt
      781 agtgaattcc atccaggttc tcacttcgaa ggctgccatc ttggaaactg ctcccaagga
      841 ggtgccgatg gtggtggtgc ccccagtggg tgccaagggc aacacaccag ccactggcac
      901 tactcagggc aaaaaggcgg aggggactca gaatcaaagc aaaaaggctg aaggagcccc
      961 aaaccagggc agaaaggcag agggaacccc aaaccagggc aaaaagacag agggaacccc
     1021 aaaccaaggg aaaaaggcag agggaacccc aaaccaaggc aaaaaggcag aaggaacccc
     1081 aaaccaaggc aaaaaggcgg agggggccca gaaccagggt aaaaaggtag atacaacccc
     1141 aaaccagggg aaaaaggtgg agggggcccc aacccagggc agaaaggccg agggggctca
     1201 gaaccaggcc aaaaaggtag aaggggccca gaaccagggc aaaaaggcag agggggccca
     1261 gaatcagggc aaaaagggag agggggccca gaaccagggc aagaaggccg agggggccca
     1321 gaatcagggc aagaaggccg agggggccca gaatcagggc aagaaggccg agggggccca
     1381 gaatcagggc aagaaggccg agggggccca gaatcagggc aagaaggctg agggggctca
     1441 gaaccagggc aaaaaggccg agggggctca gaaccagggc aaaaaagtag aaggggccca
     1501 gaaccagggc aagaaggctg agggtgccca gaaccagggc aaaaaggccg agggggccca
     1561 gaatcagggc aaaaaggccg agggggccca gaaccagggc aagaaggccg agggggccca
     1621 gaaccagggc aagaaggccg agggggccca gaaccagggc aagaaggccg agggggccca
     1681 gaaccagggc aagaaggccg agggtgctca gaaccagggc aaaaaagtag aaggggccca
     1741 gaaccagggc aagaaggctg agggggccca gaaccagggc aagaaggccg agggggctca
     1801 gaaccagggc aaaaaggccg agggagccca gaaccagggc caaaaaggag agggagccca
     1861 gaatcagggt aaaaagacag aaggggctca gggcaaaaag gcagaaagga gtcccaacca
     1921 aggcaaaaaa ggagagggag ctcccatcca gggcaaaaag gcagattcgg ttgctaatca
     1981 gggcacaaag gtagagggta ttacaaacca ggggaaaaaa gcagaagggt cccccagtga
     2041 aggcaaaaag gcagaagggt cccccaacca aggcaaaaag gcagacgcag ctgccaatca
     2101 gggtaaaaag acagagtcag cttctgtcca gggcagaaat acagatgtgg cccagagccc
     2161 agaggcacca aagcaagagg ctcctgccaa gaagaagtct ggttcaaaga aaaaaggtga
     2221 gcctgggccc ccagatgccg acggccctct ctacctcccc tacaagacgc tggtctccac
     2281 ggttgggagc atggtgttca acgagggcga ggcccagcgg ctcatcgaga tcctgtctga
     2341 gaaggctggc atcattcagg acacctggca caaggccact cagaagggtg accctgtggc
     2401 gattctgaaa cgccagctgg aagagaagga aaaactgctg gccacagaac aggaagatgc
     2461 ggctgtcgcc aagagcaaac tgagggagct caacaaggag atggcagcag aaaaggccaa
     2521 agcagcagcc ggggaggcca aagtgaaaaa gcagctggtg gcccgggagc aggagatcac
     2581 ggctgtgcag gcacgcatgc aggccagcta ccgggagcac gtgaaggagg tgcagcagct
     2641 gcagggcaag atccggactc ttcaggagca gctggagaat ggccccaaca cgcagctggc
     2701 ccgcctgcag caggagaact ccatcctgcg ggatgccttg aaccaggcca cgagccaggt
     2761 ggagagcaag cagaacgcag agctggccaa gcttcggcag gagctcagca aggtcagcaa
     2821 agagctggtg gagaagtcag aggctgtgcg gcaagatgag cagcagcgga aagctctgga
     2881 agccaaggca gctgccttcg agaagcaggt cctgcagctg caggcgtccc acagggagag
     2941 tgaggaggcc ctgcagaagc gcctggacga ggtcagccgg gagctgtgcc acacgcagag
     3001 cagccacgcc agcctccggg cggatgccga gaaggcccag gagcaacagc agcagatggc
     3061 cgagctgcac agcaagttac agtcctccga ggcggaggtg cgcagcaaat gcgaggagct
     3121 gagtggcctc cacgggcagc tccaggaggc cagggcggag aactcccagc tcacagagag
     3181 aatccgttcc attgaggccc tgctggaggc gggccaggcg cgggatgccc aggacgtcca
     3241 ggccagccag gcggaggctg accagcagca gactcgcctc aaggagctgg agtcccaggt
     3301 gtcgggtctg gagaaggagg ccatcgagct cagggaggcc gtcgagcagc agaaagtgaa
     3361 gaacaatgac ctccgggaga agaactggaa ggccatggag gcactggcca cggccgagca
     3421 ggcctgcaag gagaagctgc tctccctgac ccaggccaag gaggaatcgg agaagcagct
     3481 ctgtctgatt gaggcgcaga ccatggaggc cctgctggct ctgctcccag aactctctgt
     3541 cttggcacaa cagaattaca ccgagtggct gcaggatctc aaagagaaag gccccacgct
     3601 gctgaagcac ccgccagctc ccgcggagcc ctcctcggac ctggcctcca agttgaggga
     3661 ggccgaggag acgcagagca cactgcaggc cgagtgtgac cagtaccgca gcatcctggc
     3721 ggagacggag ggcatgctca gagacctgca gaagagcgtg gaggaggagg agcaggtgtg
     3781 gagggccaag gtgggcgccg cagaggagga gctccagaag tcccgggtca cagtgaagca
     3841 tctcgaagag attgtagaga agctaaaagg agaacttgaa agttcggacc aggtgaggga
     3901 gcacacgtcg catttggagg cagagctgga aaagcacatg gcggccgcca gcgccgagtg
     3961 ccagaactac gccaaggagg tggcagggct gaggcaactt ctcctagaat ctcaatctca
     4021 gctcgatgcc gccaagagcg aagcccagaa acagagcgat gagcttgccc tggtcaggca
     4081 gcagttgagt gaaatgaaga gccacgtaga ggatggtgac atagctgggg ccccagcttc
     4141 ctccccagag gcgcccccag ccgagcagga ccccgttcag ctgaagacgc agctggagtg
     4201 gacagaagcc atcctggagg atgagcagac acagcggcag aagctcacgg ccgagtttga
     4261 ggaggctcag acctcggcat gtcggttaca agaagaattg gagaagctcc gcacagccgg
     4321 ccccctagag tcttcagaaa cagaggaggc ctcacagctg aaggagagac tagaaaaaga
     4381 gaagaagtta acaagtgacc tggggcgcgc cgccacgaga ctgcaggagc ttctgaagac
     4441 gacccaggag cagctggcaa gggagaagga cacggtgaag aagctgcagg aacagctgga
     4501 aaaggcagag gacggcagca gctcaaagga gggcacctct gtctgagttt cctctttgga
     4561 aaaagaagtt actgttcaac ttaccaaaat gccttacaca ttccttacaa ataaaccaac
     4621 caacctacac agcgttatcc aggcccaact tccggtagct ccgagagaag ccatgagaga
     4681 caagtctctt agagccacag aagtagacct tccagagccc cagtttgtaa atgaacctgt
     4741 gtcacatttg ataaacacta tcctgggcgc agccccgggc caccgccgag tgacgccaaa
     4801 gccctggttg actctgacag ccccgtgggt gtgtgggagg ccgggcgctc tggggtctgt
     4861 ctgtcagtgc aatcgtttag tgttttttca gtggggcggg gcgggaagcg ggtgggaccg
     4921 ggcagccagt tctcaaaggc tgtggggccg actggaggcc acagcccctc acccctagac
     4981 gttgccaacc agaactgacg tgtgacctcc tgggtgttga tgccattaaa accaacgttg
     5041 gtgcccggt
//
