LOCUS       NM_001177314            2038 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens RAS related 2 (RRAS2), transcript variant 3, mRNA.
ACCESSION   NM_001177314
VERSION     NM_001177314.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2038)
  AUTHORS   Cifuentes,C., Oeste,C.L., Fernandez-Pisonero,I., Hortal,A.M.,
            Garcia-Macias,C., Hochart,J., Rubira,R., Horndler,L., Horndler,C.,
            Bustelo,X.R. and Alarcon,B.
  TITLE     Unmutated RRAS2 emerges as a key oncogene in post-partum-associated
            triple negative breast cancer
  JOURNAL   Mol Cancer 23 (1), 142 (2024)
   PUBMED   38987766
  REMARK    GeneRIF: Unmutated RRAS2 emerges as a key oncogene in
            post-partum-associated triple negative breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2038)
  AUTHORS   Zeng,L., Wang,J., Zhu,H., Huang,Y., Deng,Y., Wei,P., Nie,J.,
            Tang,B., Chen,A. and Zhu,S.
  TITLE     The RRAS2 pathogenic variant (c.67G>T; p. Gly23Cys) produces Noonan
            syndrome with embryonal rhabdomyosarcoma
  JOURNAL   Mol Genet Genomic Med 12 (1), e2313 (2024)
   PUBMED   37942564
  REMARK    GeneRIF: The RRAS2 pathogenic variant (c.67G>T; p. Gly23Cys)
            produces Noonan syndrome with embryonal rhabdomyosarcoma.
REFERENCE   3  (bases 1 to 2038)
  AUTHORS   Sun,C., Mahapatra,K.D., Elton,J., Li,C., Fernando,W.,
            Lohcharoenkal,W., Lapins,J., Homey,B., Sonkoly,E. and Pivarcsi,A.
  TITLE     MicroRNA-23b Plays a Tumor-Suppressive Role in Cutaneous Squamous
            Cell Carcinoma and Targets Ras-Related Protein RRAS2
  JOURNAL   J Invest Dermatol 143 (12), 2386-2396 (2023)
   PUBMED   37423552
  REMARK    GeneRIF: MicroRNA-23b Plays a Tumor-Suppressive Role in Cutaneous
            Squamous Cell Carcinoma and Targets Ras-Related Protein RRAS2.
REFERENCE   4  (bases 1 to 2038)
  AUTHORS   Lacuna,M., Hortal,A.M., Cifuentes,C., Gonzalo,T., Alcoceba,M.,
            Bastos,M., Bustelo,X.R., Gonzalez,M. and Alarcon,B.
  TITLE     Characterization of Three Somatic Mutations in the 3'UTR of RRAS2
            and Their Inverse Correlation with Lymphocytosis in Chronic
            Lymphocytic Leukemia
  JOURNAL   Cells 12 (23), 2687 (2023)
   PUBMED   38067115
  REMARK    GeneRIF: Characterization of Three Somatic Mutations in the 3'UTR
            of RRAS2 and Their Inverse Correlation with Lymphocytosis in
            Chronic Lymphocytic Leukemia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2038)
  AUTHORS   Ehrhardt,G.R., Leslie,K.B., Lee,F., Wieler,J.S. and Schrader,J.W.
  TITLE     M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of
            a constitutively active mutant results in factor-independent growth
            of an interleukin-3-dependent cell line
  JOURNAL   Blood 94 (7), 2433-2444 (1999)
   PUBMED   10498616
REFERENCE   6  (bases 1 to 2038)
  AUTHORS   Linnemann,T., Geyer,M., Jaitner,B.K., Block,C., Kalbitzer,H.R.,
            Wittinghofer,A. and Herrmann,C.
  TITLE     Thermodynamic and kinetic characterization of the interaction
            between the Ras binding domain of AF6 and members of the Ras
            subfamily
  JOURNAL   J Biol Chem 274 (19), 13556-13562 (1999)
   PUBMED   10224125
REFERENCE   7  (bases 1 to 2038)
  AUTHORS   Rosario,M., Paterson,H.F. and Marshall,C.J.
  TITLE     Activation of the Raf/MAP kinase cascade by the Ras-related protein
            TC21 is required for the TC21-mediated transformation of NIH 3T3
            cells
  JOURNAL   EMBO J 18 (5), 1270-1279 (1999)
   PUBMED   10064593
REFERENCE   8  (bases 1 to 2038)
  AUTHORS   Chan,A.M., Miki,T., Meyers,K.A. and Aaronson,S.A.
  TITLE     A human oncogene of the RAS superfamily unmasked by expression cDNA
            cloning
  JOURNAL   Proc Natl Acad Sci U S A 91 (16), 7558-7562 (1994)
   PUBMED   8052619
REFERENCE   9  (bases 1 to 2038)
  AUTHORS   Roberts,A.E.
  TITLE     Noonan Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301303
REFERENCE   10 (bases 1 to 2038)
  AUTHORS   Drivas,G.T., Shih,A., Coutavas,E., Rush,M.G. and D'Eustachio,P.
  TITLE     Characterization of four novel ras-like genes expressed in a human
            teratocarcinoma cell line
  JOURNAL   Mol Cell Biol 10 (4), 1793-1798 (1990)
   PUBMED   2108320
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK300103.1, BQ023701.1,
            AA873016.1 and BQ020351.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001177314.1.
            
            Summary: This gene encodes a member of the R-Ras subfamily of
            Ras-like small GTPases. The encoded protein associates with the
            plasma membrane and may function as a signal transducer. This
            protein may play an important role in activating signal
            transduction pathways that control cell proliferation. Mutations in
            this gene are associated with the growth of certain tumors.
            Pseudogenes of this gene are found on chromosomes 1 and 2.
            Alternate splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2010].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and 5'
            coding region and initiates translation at an alternate start
            codon, compared to variant 1. The resulting isoform (b) is shorter
            and has a distinct N-terminus compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK300103.1, DC379802.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-746               AK300103.1         1-746
            747-1210            BQ023701.1         13-476              c
            1211-1622           AA873016.1         1-412               c
            1623-2038           BQ020351.1         17-432              c
FEATURES             Location/Qualifiers
     source          1..2038
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.2"
     gene            1..2038
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /note="RAS related 2"
                     /db_xref="GeneID:22800"
                     /db_xref="HGNC:HGNC:17271"
                     /db_xref="MIM:600098"
     exon            1..116
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..623
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /EC_number="3.6.5.2"
                     /note="isoform c is encoded by transcript variant 3;
                     ras-like protein TC21; teratocarcinoma oncogene; related
                     RAS viral (r-ras) oncogene homolog 2"
                     /codon_start=1
                     /product="ras-related protein R-Ras2 isoform c"
                     /protein_id="NP_001170785.1"
                     /db_xref="CCDS:CCDS53603.1"
                     /db_xref="GeneID:22800"
                     /db_xref="HGNC:HGNC:17271"
                     /db_xref="MIM:600098"
                     /translation="MSYFVTDYDPTIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMR
                     EQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEFPMILIGNKADLDHQRQV
                     TQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQEQECPPSPEPTRKEKD
                     KKGCHCVIF"
     exon            117..204
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /inference="alignment:Splign:2.1.0"
     exon            205..307
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /inference="alignment:Splign:2.1.0"
     exon            308..416
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /inference="alignment:Splign:2.1.0"
     exon            417..535
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /inference="alignment:Splign:2.1.0"
     exon            536..2038
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1191..1196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /note="hexamer: ATTAAA"
     polyA_site      1210
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /note="major polyA site"
     regulatory      2015..2020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /note="hexamer: ATTAAA"
     polyA_site      2038
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /note="major polyA site"
ORIGIN      
        1 atctcagatg catgcagctc ctgctgggcg gtttcattct ctgccagcca ttcattcaca
       61 ttaaaagcaa tggcccatta aggaaataag tggatgatgc tcctccatca cccatgtcct
      121 attttgtaac ggattatgat ccaaccattg aagattctta cacaaagcag tgtgtgatag
      181 atgacagagc agcccggcta gatattttgg atacagcagg acaagaagag tttggagcca
      241 tgagagaaca gtatatgagg actggcgaag gcttcctgtt ggtcttttca gtcacagata
      301 gaggcagttt tgaagaaatc tataagtttc aaagacagat tctcagagta aaggatcgtg
      361 atgagttccc aatgatttta attggtaata aagcagatct ggatcatcaa agacaggtaa
      421 cacaggaaga aggacaacag ttagcacggc agcttaaggt aacatacatg gaggcatcag
      481 caaagattag gatgaatgta gatcaagctt tccatgaact tgtccgggtt atcaggaaat
      541 ttcaagagca ggaatgtcct ccttcaccag aaccaacacg gaaagaaaaa gacaagaaag
      601 gctgccattg tgtcattttc tagaatccct tcagttttag ctaccaacgg ccaggaaaag
      661 ccctcatctt ctctttctct cctcagttta catcttgttg gtacctttct agccttagac
      721 aaatgatcac catgttagcc ttagacgaag aagctggcta gtcctttctg tgaagctaat
      781 acaatggtca tttccagaca aatttaaagg aaacactaag gctgcttcaa agattatctg
      841 attcctttaa aatatatgtc tatatacaca gacatgctct ttttttaagt gcttacattt
      901 taatagagat gaatcagttt tggaatctaa gctgtttgcc aagctgaagc tacaggttgt
      961 gaaataattt ttaacttttg gaatcatact gcctactgtt actctaaata gaaatatagg
     1021 gtttttttta atgtgaattt ttgcctatct ttaaacattt caatgtcagc ctttgttaac
     1081 cttaaataca ctgaattgaa tctacaaaag tgaaccatct cagaccttta ctgatactac
     1141 aacttttgtt ttctgatggc caaaatacca aatgcctgtt gtatttatgg attaaaaact
     1201 gcttataaaa ccctgtgtta ctactcctac tcttggagat gataatattc tatgtggtca
     1261 aatatttgga ctcatttagg acttagatat ttcagtgtac ttgatttttt aatttaactc
     1321 tttttcacag ccacgctaag ggtaaaaagg aataatttcc ttctgtcttc cttttcaagt
     1381 atttctgggt aagggattca aaaaactaaa actgtttttg tttgtaatat aaaatatgga
     1441 attgatcttt ccagggtcag agatgattaa tgtttttgct atatactttt atacattatt
     1501 ttcttatcaa actagttaac aagtattttt atatgtttgt aagcagatat gctttcatag
     1561 cataccttgt gtatatgtaa agataagtat ttaattctca ctgttcactt ttaactgaca
     1621 aagaaaaaca agtggaaact acagaaactg tggtagaact tttacttgct ggtctggtct
     1681 tggttgtacc catctttggc cagtcacata actactcaag aaaccttccc aatagagtac
     1741 aacaggatga gactctgaaa tcactttcag tattccctgc tagatattga ttgttatttc
     1801 aagtattaag tgtaagcttt taatggataa ttagtataac tgtggatggc atctgatttt
     1861 gtttttaatt ctgtggattg tgtttaagca attcaatagt atgttcctga ttttgagatg
     1921 ctaagtggta ttgcacagtt gtcactttat caagtgtgta caacagtccc atgaagttta
     1981 tagagcatac ccttgtatag cttcaggtgc tagaattaaa attgatctgt tatcacaa
//
