LOCUS       NM_001102669            2209 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens RAS related 2 (RRAS2), transcript variant 2, mRNA.
ACCESSION   NM_001102669
VERSION     NM_001102669.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2209)
  AUTHORS   Cifuentes,C., Oeste,C.L., Fernandez-Pisonero,I., Hortal,A.M.,
            Garcia-Macias,C., Hochart,J., Rubira,R., Horndler,L., Horndler,C.,
            Bustelo,X.R. and Alarcon,B.
  TITLE     Unmutated RRAS2 emerges as a key oncogene in post-partum-associated
            triple negative breast cancer
  JOURNAL   Mol Cancer 23 (1), 142 (2024)
   PUBMED   38987766
  REMARK    GeneRIF: Unmutated RRAS2 emerges as a key oncogene in
            post-partum-associated triple negative breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2209)
  AUTHORS   Zeng,L., Wang,J., Zhu,H., Huang,Y., Deng,Y., Wei,P., Nie,J.,
            Tang,B., Chen,A. and Zhu,S.
  TITLE     The RRAS2 pathogenic variant (c.67G>T; p. Gly23Cys) produces Noonan
            syndrome with embryonal rhabdomyosarcoma
  JOURNAL   Mol Genet Genomic Med 12 (1), e2313 (2024)
   PUBMED   37942564
  REMARK    GeneRIF: The RRAS2 pathogenic variant (c.67G>T; p. Gly23Cys)
            produces Noonan syndrome with embryonal rhabdomyosarcoma.
REFERENCE   3  (bases 1 to 2209)
  AUTHORS   Sun,C., Mahapatra,K.D., Elton,J., Li,C., Fernando,W.,
            Lohcharoenkal,W., Lapins,J., Homey,B., Sonkoly,E. and Pivarcsi,A.
  TITLE     MicroRNA-23b Plays a Tumor-Suppressive Role in Cutaneous Squamous
            Cell Carcinoma and Targets Ras-Related Protein RRAS2
  JOURNAL   J Invest Dermatol 143 (12), 2386-2396 (2023)
   PUBMED   37423552
  REMARK    GeneRIF: MicroRNA-23b Plays a Tumor-Suppressive Role in Cutaneous
            Squamous Cell Carcinoma and Targets Ras-Related Protein RRAS2.
REFERENCE   4  (bases 1 to 2209)
  AUTHORS   Lacuna,M., Hortal,A.M., Cifuentes,C., Gonzalo,T., Alcoceba,M.,
            Bastos,M., Bustelo,X.R., Gonzalez,M. and Alarcon,B.
  TITLE     Characterization of Three Somatic Mutations in the 3'UTR of RRAS2
            and Their Inverse Correlation with Lymphocytosis in Chronic
            Lymphocytic Leukemia
  JOURNAL   Cells 12 (23), 2687 (2023)
   PUBMED   38067115
  REMARK    GeneRIF: Characterization of Three Somatic Mutations in the 3'UTR
            of RRAS2 and Their Inverse Correlation with Lymphocytosis in
            Chronic Lymphocytic Leukemia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2209)
  AUTHORS   Ehrhardt,G.R., Leslie,K.B., Lee,F., Wieler,J.S. and Schrader,J.W.
  TITLE     M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of
            a constitutively active mutant results in factor-independent growth
            of an interleukin-3-dependent cell line
  JOURNAL   Blood 94 (7), 2433-2444 (1999)
   PUBMED   10498616
REFERENCE   6  (bases 1 to 2209)
  AUTHORS   Linnemann,T., Geyer,M., Jaitner,B.K., Block,C., Kalbitzer,H.R.,
            Wittinghofer,A. and Herrmann,C.
  TITLE     Thermodynamic and kinetic characterization of the interaction
            between the Ras binding domain of AF6 and members of the Ras
            subfamily
  JOURNAL   J Biol Chem 274 (19), 13556-13562 (1999)
   PUBMED   10224125
REFERENCE   7  (bases 1 to 2209)
  AUTHORS   Rosario,M., Paterson,H.F. and Marshall,C.J.
  TITLE     Activation of the Raf/MAP kinase cascade by the Ras-related protein
            TC21 is required for the TC21-mediated transformation of NIH 3T3
            cells
  JOURNAL   EMBO J 18 (5), 1270-1279 (1999)
   PUBMED   10064593
REFERENCE   8  (bases 1 to 2209)
  AUTHORS   Chan,A.M., Miki,T., Meyers,K.A. and Aaronson,S.A.
  TITLE     A human oncogene of the RAS superfamily unmasked by expression cDNA
            cloning
  JOURNAL   Proc Natl Acad Sci U S A 91 (16), 7558-7562 (1994)
   PUBMED   8052619
REFERENCE   9  (bases 1 to 2209)
  AUTHORS   Roberts,A.E.
  TITLE     Noonan Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301303
REFERENCE   10 (bases 1 to 2209)
  AUTHORS   Drivas,G.T., Shih,A., Coutavas,E., Rush,M.G. and D'Eustachio,P.
  TITLE     Characterization of four novel ras-like genes expressed in a human
            teratocarcinoma cell line
  JOURNAL   Mol Cell Biol 10 (4), 1793-1798 (1990)
   PUBMED   2108320
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG428983.1, AK309683.1,
            AC011084.17, BQ023701.1, AA873016.1 and BQ020351.1.
            
            On Apr 3, 2010 this sequence version replaced NM_001102669.1.
            
            Summary: This gene encodes a member of the R-Ras subfamily of
            Ras-like small GTPases. The encoded protein associates with the
            plasma membrane and may function as a signal transducer. This
            protein may play an important role in activating signal
            transduction pathways that control cell proliferation. Mutations in
            this gene are associated with the growth of certain tumors.
            Pseudogenes of this gene are found on chromosomes 1 and 2.
            Alternate splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region, compared to variant 1. The resulting isoform (b) is
            shorter at the N-terminus compared to isoform a. Both variants 2
            and 4 encode the same isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.346033.1, AK309683.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BG428983.1         2-43
            43-611              AK309683.1         1-569
            612-612             AC011084.17        61336-61336         c
            613-1012            AK309683.1         571-970
            1013-1365           BQ023701.1         13-365              c
            1366-1777           AA873016.1         1-412               c
            1778-2209           BQ020351.1         1-432               c
FEATURES             Location/Qualifiers
     source          1..2209
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.2"
     gene            1..2209
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /note="RAS related 2"
                     /db_xref="GeneID:22800"
                     /db_xref="HGNC:HGNC:17271"
                     /db_xref="MIM:600098"
     exon            1..271
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /inference="alignment:Splign:2.1.0"
     exon            272..359
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /inference="alignment:Splign:2.1.0"
     exon            360..462
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..778
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /EC_number="3.6.5.2"
                     /note="isoform b is encoded by transcript variant 2;
                     ras-like protein TC21; teratocarcinoma oncogene; related
                     RAS viral (r-ras) oncogene homolog 2"
                     /codon_start=1
                     /product="ras-related protein R-Ras2 isoform b"
                     /protein_id="NP_001096139.1"
                     /db_xref="CCDS:CCDS44544.1"
                     /db_xref="GeneID:22800"
                     /db_xref="HGNC:HGNC:17271"
                     /db_xref="MIM:600098"
                     /translation="MREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEFP
                     MILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQ
                     EQECPPSPEPTRKEKDKKGCHCVIF"
     exon            463..571
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /inference="alignment:Splign:2.1.0"
     exon            572..690
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /inference="alignment:Splign:2.1.0"
     exon            691..2195
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1346..1351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /note="hexamer: ATTAAA"
     polyA_site      1365
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /note="major polyA site"
     regulatory      2170..2175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /note="hexamer: ATTAAA"
     polyA_site      2193
                     /gene="RRAS2"
                     /gene_synonym="NS12; TC21"
                     /note="major polyA site"
ORIGIN      
        1 gggagggcgg agctggaagg gtgggaagca ccgatccacc ttattgctct ggccgaggcc
       61 agagacctcc gggagaggct gggccaccga gccgggcttt actgctccga gggtccgggc
      121 gtggggctgg agctggagcc ccgcgcgctg cttttccagc cgcctgcggc cgcgccttca
      181 ccgtcggggc gatagcggtg gcaacttggc cgcggctccg cgtggtctcc gggcttcccc
      241 gcgccgcctg agccggagct gcccgcttca atcctatttt gtaacggatt atgatccaac
      301 cattgaagat tcttacacaa agcagtgtgt gatagatgac agagcagccc ggctagatat
      361 tttggataca gcaggacaag aagagtttgg agccatgaga gaacagtata tgaggactgg
      421 cgaaggcttc ctgttggtct tttcagtcac agatagaggc agttttgaag aaatctataa
      481 gtttcaaaga cagattctca gagtaaagga tcgtgatgag ttcccaatga ttttaattgg
      541 taataaagca gatctggatc atcaaagaca ggtaacacag gaagaaggac aacagttagc
      601 acggcagctt aaggtaacat acatggaggc atcagcaaag attaggatga atgtagatca
      661 agctttccat gaacttgtcc gggttatcag gaaatttcaa gagcaggaat gtcctccttc
      721 accagaacca acacggaaag aaaaagacaa gaaaggctgc cattgtgtca ttttctagaa
      781 tcccttcagt tttagctacc aacggccagg aaaagccctc atcttctctt tctctcctca
      841 gtttacatct tgttggtacc tttctagcct tagacaaatg atcaccatgt tagccttaga
      901 cgaagaagct ggctagtcct ttctgtgaag ctaatacaat ggtcatttcc agacaaattt
      961 aaaggaaaca ctaaggctgc ttcaaagatt atctgattcc tttaaaatat atgtctatat
     1021 acacagacat gctctttttt taagtgctta cattttaata gagatgaatc agttttggaa
     1081 tctaagctgt ttgccaagct gaagctacag gttgtgaaat aatttttaac ttttggaatc
     1141 atactgccta ctgttactct aaatagaaat atagggtttt ttttaatgtg aatttttgcc
     1201 tatctttaaa catttcaatg tcagcctttg ttaaccttaa atacactgaa ttgaatctac
     1261 aaaagtgaac catctcagac ctttactgat actacaactt ttgttttctg atggccaaaa
     1321 taccaaatgc ctgttgtatt tatggattaa aaactgctta taaaaccctg tgttactact
     1381 cctactcttg gagatgataa tattctatgt ggtcaaatat ttggactcat ttaggactta
     1441 gatatttcag tgtacttgat tttttaattt aactcttttt cacagccacg ctaagggtaa
     1501 aaaggaataa tttccttctg tcttcctttt caagtatttc tgggtaaggg attcaaaaaa
     1561 ctaaaactgt ttttgtttgt aatataaaat atggaattga tctttccagg gtcagagatg
     1621 attaatgttt ttgctatata cttttataca ttattttctt atcaaactag ttaacaagta
     1681 tttttatatg tttgtaagca gatatgcttt catagcatac cttgtgtata tgtaaagata
     1741 agtatttaat tctcactgtt cacttttaac tgacaaagaa aaacaagtgg aaactacaga
     1801 aactgtggta gaacttttac ttgctggtct ggtcttggtt gtacccatct ttggccagtc
     1861 acataactac tcaagaaacc ttcccaatag agtacaacag gatgagactc tgaaatcact
     1921 ttcagtattc cctgctagat attgattgtt atttcaagta ttaagtgtaa gcttttaatg
     1981 gataattagt ataactgtgg atggcatctg attttgtttt taattctgtg gattgtgttt
     2041 aagcaattca atagtatgtt cctgattttg agatgctaag tggtattgca cagttgtcac
     2101 tttatcaagt gtgtacaaca gtcccatgaa gtttatagag catacccttg tatagcttca
     2161 ggtgctagaa ttaaaattga tctgttatca caagaaaaaa aaaaaaaaa
//
