LOCUS       NM_006270                986 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens RAS related (RRAS), mRNA.
ACCESSION   NM_006270
VERSION     NM_006270.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 986)
  AUTHORS   Chen,G., Pei,Y., Ye,Q., Xie,Z., Gyawali,L. and Liang,X.
  TITLE     NEDD4L-mediated RASGRP2 suppresses high-glucose and oxLDL-induced
            vascular endothelial cell dysfunctions by activating Rap1 and R-Ras
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119844 (2024)
   PUBMED   39260747
  REMARK    GeneRIF: NEDD4L-mediated RASGRP2 suppresses high-glucose and
            oxLDL-induced vascular endothelial cell dysfunctions by activating
            Rap1 and R-Ras.
REFERENCE   2  (bases 1 to 986)
  AUTHORS   Talajic,A., Dominko,K., Loncaric,M., Ambriovic-Ristov,A. and
            Cetkovic,H.
  TITLE     The ancestral type of the R-RAS protein has oncogenic potential
  JOURNAL   Cell Mol Biol Lett 29 (1), 27 (2024)
   PUBMED   38383288
  REMARK    GeneRIF: The ancestral type of the R-RAS protein has oncogenic
            potential.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 986)
  AUTHORS   Chen,J.X., Chen,D.M., Wang,D., Xiao,Y., Zhu,S. and Xu,X.L.
  TITLE     METTL3/YTHDF2 m6A axis promotes the malignant progression of
            bladder cancer by epigenetically suppressing RRAS
  JOURNAL   Oncol Rep 49 (5) (2023)
   PUBMED   36960869
  REMARK    GeneRIF: METTL3/YTHDF2 m6A axis promotes the malignant progression
            of bladder cancer by epigenetically suppressing RRAS.
REFERENCE   4  (bases 1 to 986)
  AUTHORS   Adamopoulos,P.G., Tsiakanikas,P., Boti,M.A. and Scorilas,A.
  TITLE     Targeted Long-Read Sequencing Decodes the Transcriptional Atlas of
            the Founding RAS Gene Family Members
  JOURNAL   Int J Mol Sci 22 (24), 13298 (2021)
   PUBMED   34948093
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 986)
  AUTHORS   Weber,S.M., Brossier,N.M., Prechtl,A., Barnes,S., Wilson,L.S.,
            Brosius,S.N., Longo,J.F. and Carroll,S.L.
  TITLE     R-Ras subfamily proteins elicit distinct physiologic effects and
            phosphoproteome alterations in neurofibromin-null MPNST cells
  JOURNAL   Cell Commun Signal 19 (1), 95 (2021)
   PUBMED   34530870
  REMARK    GeneRIF: R-Ras subfamily proteins elicit distinct physiologic
            effects and phosphoproteome alterations in neurofibromin-null MPNST
            cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 986)
  AUTHORS   Carboni,J.M., Yan,N., Cox,A.D., Bustelo,X., Graham,S.M.,
            Lynch,M.J., Weinmann,R., Seizinger,B.R., Der,C.J., Barbacid,M. et
            al.
  TITLE     Farnesyltransferase inhibitors are inhibitors of Ras but not
            R-Ras2/TC21, transformation
  JOURNAL   Oncogene 10 (10), 1905-1913 (1995)
   PUBMED   7761092
REFERENCE   7  (bases 1 to 986)
  AUTHORS   Spaargaren,M. and Bischoff,J.R.
  TITLE     Identification of the guanine nucleotide dissociation stimulator
            for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and
            Rap
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 12609-12613 (1994)
   PUBMED   7809086
REFERENCE   8  (bases 1 to 986)
  AUTHORS   Fernandez-Sarabia,M.J. and Bischoff,J.R.
  TITLE     Bcl-2 associates with the ras-related protein R-ras p23
  JOURNAL   Nature 366 (6452), 274-275 (1993)
   PUBMED   8232588
REFERENCE   9  (bases 1 to 986)
  AUTHORS   Roberts,A.E.
  TITLE     Noonan Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301303
REFERENCE   10 (bases 1 to 986)
  AUTHORS   Lowe,D.G., Capon,D.J., Delwart,E., Sakaguchi,A.Y., Naylor,S.L. and
            Goeddel,D.V.
  TITLE     Structure of the human and murine R-ras genes, novel genes closely
            related to ras proto-oncogenes
  JOURNAL   Cell 48 (1), 137-146 (1987)
   PUBMED   3098437
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC016318.1 and BC016286.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006270.4.
            
            Summary: The protein encoded by this gene is a small GTPase
            involved in diverse processes including angiogenesis, vascular
            homeostasis and regeneration, cell adhesion, and neuronal axon
            guidance. Mutations in this gene are found in many invasive
            cancers. [provided by RefSeq, Jul 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016286.1, BC016318.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246792.4/ ENSP00000246792.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BC016318.1         5-25
            22-986              BC016286.1         1-965
FEATURES             Location/Qualifiers
     source          1..986
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..986
                     /gene="RRAS"
                     /gene_synonym="R-Ras; RRAS1"
                     /note="RAS related"
                     /db_xref="GeneID:6237"
                     /db_xref="HGNC:HGNC:10447"
                     /db_xref="MIM:165090"
     exon            1..198
                     /gene="RRAS"
                     /gene_synonym="R-Ras; RRAS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..702
                     /gene="RRAS"
                     /gene_synonym="R-Ras; RRAS1"
                     /EC_number="3.6.5.2"
                     /note="p23; oncogene RRAS; ras family small GTP binding
                     protein R-Ras; related RAS viral (r-ras) oncogene homolog"
                     /codon_start=1
                     /product="ras-related protein R-Ras"
                     /protein_id="NP_006261.1"
                     /db_xref="CCDS:CCDS12774.1"
                     /db_xref="GeneID:6237"
                     /db_xref="HGNC:HGNC:10447"
                     /db_xref="MIM:165090"
                     /translation="MSSGAASGTGRGRPRGGGPGPGDPPPSETHKLVVVGGGGVGKSA
                     LTIQFIQSYFVSDYDPTIEDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGH
                     GFLLVFAINDRQSFNEVGKLFTQILRVKDRDDFPVVLVGNKADLESQRQVPRSEASAF
                     GASHHVAYFEASAKLRLNVDEAFEQLVRAVRKYQEQELPPSPPSAPRKKGGGCPCVLL
                     "
     exon            199..286
                     /gene="RRAS"
                     /gene_synonym="R-Ras; RRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            287..389
                     /gene="RRAS"
                     /gene_synonym="R-Ras; RRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            390..498
                     /gene="RRAS"
                     /gene_synonym="R-Ras; RRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..617
                     /gene="RRAS"
                     /gene_synonym="R-Ras; RRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..986
                     /gene="RRAS"
                     /gene_synonym="R-Ras; RRAS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      964..969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRAS"
                     /gene_synonym="R-Ras; RRAS1"
                     /note="hexamer: AATAAA"
     polyA_site      986
                     /gene="RRAS"
                     /gene_synonym="R-Ras; RRAS1"
                     /note="major polyA site"
ORIGIN      
        1 ggctcccccg caggcggtag cgaaggcagc agcagcggtg gcgacatgag cagcggggcg
       61 gcgtccggga cagggcgggg gcggccccgg ggcgggggac ctgggcccgg ggaccccccg
      121 cccagcgaga cacacaagct ggtggtcgtg ggcggcggcg gcgtgggcaa gagcgcgctg
      181 accatccagt tcatccagtc ctacttcgtg tctgactacg accccactat tgaggactcc
      241 tacacgaaga tctgcagtgt ggatggcatc ccagcccggc tggacatcct ggacaccgcg
      301 ggccaggaag agttcggggc catgagagag cagtacatgc gtgctggcca cggcttcctg
      361 ctggtgttcg ccattaacga ccggcagagt ttcaacgagg tgggcaagct cttcacgcag
      421 attctgcggg tcaaggaccg cgacgacttc cccgttgtgt tggtcgggaa caaggcagat
      481 ctggagtcac agcgccaggt cccccgatca gaagcctctg ccttcggcgc ctcccaccac
      541 gtggcctact ttgaggcctc ggccaaactg cgtctcaacg tggacgaggc ttttgagcag
      601 ctggtgcggg ctgtccggaa ataccaggaa caagagctcc caccgagccc tcccagtgcc
      661 cccaggaaga agggcggggg ctgcccctgc gtcctcctgt agcccaggca agagagaagc
      721 aaccaccaca agctctcggg actagctgcc ttcgcacctt gctgtgtgac ctgaggccct
      781 cactgagcct caatttcctc atctgggtct cccaggacac atcacatacc cacccttact
      841 tcctggcctc ttctgggcta ctgccactgt gtgccttctg ccaacgcctc ctgtccccac
      901 ctaagcctgg tgggggtgag gggctccggg tcactgctgt atataactcc cctcccccag
      961 aaaaataaat gtcactgcca acgtca
//
