LOCUS       NM_006064               2051 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Ras related GTP binding B (RRAGB), transcript variant
            RAGBs, mRNA.
ACCESSION   NM_006064
VERSION     NM_006064.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2051)
  AUTHORS   Li,X., Wang,J., Lin,W., Yuan,Q., Lu,Y., Wang,H., Chen,Y., Chen,L.,
            Dai,P., Long,H. and Li,X.
  TITLE     circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits
            the progression of colorectal cancer by antagonizing the
            HIF1A-RRAGB-mTORC1 positive feedback loop
  JOURNAL   Mol Cancer 21 (1), 135 (2022)
   PUBMED   35739524
  REMARK    GeneRIF: circEXOC6B interacting with RRAGB, an mTORC1 activator,
            inhibits the progression of colorectal cancer by antagonizing the
            HIF1A-RRAGB-mTORC1 positive feedback loop.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2051)
  AUTHORS   Xiao,J., Liu,Q., Wu,W., Yuan,Y., Zhou,J., Shi,J. and Zhou,S.
  TITLE     Elevated Ras related GTP binding B (RRAGB) expression predicts poor
            overall survival and constructs a prognostic nomogram for colon
            adenocarcinoma
  JOURNAL   Bioengineered 12 (1), 4620-4632 (2021)
   PUBMED   34320917
  REMARK    GeneRIF: Elevated Ras related GTP binding B (RRAGB) expression
            predicts poor overall survival and constructs a prognostic nomogram
            for colon adenocarcinoma.
REFERENCE   3  (bases 1 to 2051)
  AUTHORS   Shi,Y., Xu,S., Ngoi,N.Y.L., Hui,Y. and Ye,Z.
  TITLE     Rag GTPases suppress PRL-3 degradation and predict poor clinical
            diagnosis of cancer patients with low PRL-3 mRNA expression
  JOURNAL   Biochem Biophys Res Commun 576, 108-116 (2021)
   PUBMED   34482023
  REMARK    GeneRIF: Rag GTPases suppress PRL-3 degradation and predict poor
            clinical diagnosis of cancer patients with low PRL-3 mRNA
            expression.
REFERENCE   4  (bases 1 to 2051)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2051)
  AUTHORS   Shibutani,S., Okazaki,H. and Iwata,H.
  TITLE     Dynamin-dependent amino acid endocytosis activates mechanistic
            target of rapamycin complex 1 (mTORC1)
  JOURNAL   J Biol Chem 292 (44), 18052-18061 (2017)
   PUBMED   28808055
  REMARK    GeneRIF: Data suggest DNM2/RRAGB- (or DNM2/RRAGC-)dependent
            endocytosis of extracellular amino acids (AAs) plays critical role
            in mTORC1 transport/activation; recruitment of mTORC1 from
            cytoplasm to lysosome is suppressed by DNM2 inhibition; AA
            deprivation appears to be main cause of mTORC1 inactivation via
            DNM2 inhibition. (RHEB = Ras homolog enriched in brain; DNM2 =
            dynamin II; RRAG = Ras-related GTP binding protein)
REFERENCE   6  (bases 1 to 2051)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   7  (bases 1 to 2051)
  AUTHORS   Tomarev,S.I., Wistow,G., Raymond,V., Dubois,S. and Malyukova,I.
  TITLE     Gene expression profile of the human trabecular meshwork: NEIBank
            sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 44 (6), 2588-2596 (2003)
   PUBMED   12766061
REFERENCE   8  (bases 1 to 2051)
  AUTHORS   Sekiguchi,T., Hirose,E., Nakashima,N., Ii,M. and Nishimoto,T.
  TITLE     Novel G proteins, Rag C and Rag D, interact with GTP-binding
            proteins, Rag A and Rag B
  JOURNAL   J Biol Chem 276 (10), 7246-7257 (2001)
   PUBMED   11073942
REFERENCE   9  (bases 1 to 2051)
  AUTHORS   Hirose,E., Nakashima,N., Sekiguchi,T. and Nishimoto,T.
  TITLE     RagA is a functional homologue of S. cerevisiae Gtr1p involved in
            the Ran/Gsp1-GTPase pathway
  JOURNAL   J Cell Sci 111 (Pt 1), 11-21 (1998)
   PUBMED   9394008
REFERENCE   10 (bases 1 to 2051)
  AUTHORS   Schurmann,A., Brauers,A., Massmann,S., Becker,W. and Joost,H.G.
  TITLE     Cloning of a novel family of mammalian GTP-binding proteins (RagA,
            RagBs, RagB1) with remote similarity to the Ras-related GTPases
  JOURNAL   J Biol Chem 270 (48), 28982-28988 (1995)
   PUBMED   7499430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB252202.1 and BC034726.1.
            
            On Jun 2, 2019 this sequence version replaced NM_006064.4.
            
            Summary: Ras-homologous GTPases constitute a large family of signal
            transducers that alternate between an activated, GTP-binding state
            and an inactivated, GDP-binding state. These proteins represent
            cellular switches that are operated by GTP-exchange factors and
            factors that stimulate their intrinsic GTPase activity. All GTPases
            of the Ras superfamily have in common the presence of six conserved
            motifs involved in GTP/GDP binding, three of which are
            phosphate-/magnesium-binding sites (PM1-PM3) and three of which are
            guanine nucleotide-binding sites (G1-G3). Transcript variants
            encoding distinct isoforms have been identified. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2, also known as RAGBs) lacks an
            alternate in-frame exon in the coding region, compared to variant
            1, resulting in a shorter isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034726.1, SRR7410570.689939.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374941.9/ ENSP00000364077.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               DB252202.1         29-160
            133-2051            BC034726.1         136-2054
FEATURES             Location/Qualifiers
     source          1..2051
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.21"
     gene            1..2051
                     /gene="RRAGB"
                     /gene_synonym="bA465E19.1; RAGB"
                     /note="Ras related GTP binding B"
                     /db_xref="GeneID:10325"
                     /db_xref="HGNC:HGNC:19901"
                     /db_xref="MIM:300725"
     exon            1..671
                     /gene="RRAGB"
                     /gene_synonym="bA465E19.1; RAGB"
                     /inference="alignment:Splign:2.1.0"
     CDS             580..1620
                     /gene="RRAGB"
                     /gene_synonym="bA465E19.1; RAGB"
                     /note="short isoform is encoded by transcript variant
                     RAGBs; GTP-binding protein ragB; ras-related GTP-binding
                     protein B; rag B"
                     /codon_start=1
                     /product="ras-related GTP-binding protein B short isoform"
                     /protein_id="NP_006055.3"
                     /db_xref="CCDS:CCDS14371.1"
                     /db_xref="GeneID:10325"
                     /db_xref="HGNC:HGNC:19901"
                     /db_xref="MIM:300725"
                     /translation="MEESDSEKTTEKENLGPRMDPPLGEPEGSLGWVLPNTAMKKKVL
                     LMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTF
                     MENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVH
                     KMDLVQEDQRDLIFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQ
                     QLEMNLRNFAEIIEADEVLLFERATFLVISHYQCKEQRDAHRFEKISNIIKQFKLSCS
                     KLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLE
                     RVDGPKQCLLMR"
     exon            672..705
                     /gene="RRAGB"
                     /gene_synonym="bA465E19.1; RAGB"
                     /inference="alignment:Splign:2.1.0"
     exon            706..805
                     /gene="RRAGB"
                     /gene_synonym="bA465E19.1; RAGB"
                     /inference="alignment:Splign:2.1.0"
     exon            806..872
                     /gene="RRAGB"
                     /gene_synonym="bA465E19.1; RAGB"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1095
                     /gene="RRAGB"
                     /gene_synonym="bA465E19.1; RAGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1191
                     /gene="RRAGB"
                     /gene_synonym="bA465E19.1; RAGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1314
                     /gene="RRAGB"
                     /gene_synonym="bA465E19.1; RAGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1406
                     /gene="RRAGB"
                     /gene_synonym="bA465E19.1; RAGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1522
                     /gene="RRAGB"
                     /gene_synonym="bA465E19.1; RAGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..2051
                     /gene="RRAGB"
                     /gene_synonym="bA465E19.1; RAGB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2030..2035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRAGB"
                     /gene_synonym="bA465E19.1; RAGB"
                     /note="hexamer: AATAAA"
     polyA_site      2051
                     /gene="RRAGB"
                     /gene_synonym="bA465E19.1; RAGB"
                     /note="major polyA site"
ORIGIN      
        1 agatgcccac gtgatcctgg cctgcagttg ggtggctgcg gtgagatacc tgggttcctg
       61 aagggcgggt ggttaggtcg taactactgc ccccgccggc tgactctccg agcggccggg
      121 ctcggaagcc acgagccagc tgaggcgttc tccgcttagt gcctacggca tgggtcagct
      181 ctttctgcca cctccgcctt cgcggtcctc acctctttgc gggtgaagtt acctttgggt
      241 ttccagacct tgggggcctg aggcccaaac tcgggacgaa cccctaaccc acctctcttt
      301 tcctgtcatt ctccaactct tactttgtac cacggaatca cttggcctta aagctagcca
      361 gctcggccgt gccttgaggc caggttcgag agataaaggt aaccgtgggg aaagcggccc
      421 cccagtggac aaaggcggag gcaagaatag agcaggcctg agggccatag gcgatgagaa
      481 taggcagttg aggggtgaaa aagaaaacaa acaaacaaca acaacaaacc ctgaagagta
      541 ctgaagattt agaagggact ggaaaggact tgttgcgcaa tggaagaatc tgactctgag
      601 aaaacgacgg agaaagaaaa tctggggccg agaatggatc caccactagg ggaaccggaa
      661 ggatcgcttg ggtgggtgct accaaataca gccatgaaga aaaaggtgct gttgatgggt
      721 aaaagtgggt ctggtaagac cagcatgagg tctattatct ttgcaaatta tattgccaga
      781 gacacacgtc gccttggcgc aacaattgat gtagaacatt ctcatgttcg atttctggga
      841 aacctggtat tgaacctgtg ggattgtggt gggcaagaca ccttcatgga aaattatttc
      901 actagccaac gggacaacat cttccgaaat gtggaggttc tgatttatgt ctttgatgtg
      961 gagagccgcg aactggaaaa ggacatgcac tattaccaat catgcctgga ggccattctg
     1021 cagaattctc cagatgccaa aatattttgc ttggtacaca aaatggatct ggtacaggag
     1081 gatcaacggg acctgatttt taaagagcga gaagaagatt tgaggcgttt gtctcgccca
     1141 ttggaatgtt cttgtttccg aacatctatc tgggatgaaa ccctctataa ggcttggtcc
     1201 agcatagttt atcagctgat tcccaatgtt cagcagctgg aaatgaacct aaggaatttt
     1261 gctgaaatta tcgaagctga tgaagtactt ctttttgaga gagctacttt tctggtaatt
     1321 tctcactatc agtgtaaaga gcagcgtgat gcccatagat ttgagaaaat aagcaacatt
     1381 attaagcagt tcaagctgag ctgcagcaag ctggctgcct ctttccagag tatggaagtc
     1441 aggaactcta acttcgctgc tttcattgac atctttacat ccaacactta tgtgatggtt
     1501 gtgatgtctg atccgtccat tccttctgca gctactctga tcaacatccg caatgccagg
     1561 aaacactttg aaaagctgga aagagtggat ggaccaaagc agtgtcttct catgcgctaa
     1621 acattgatga atattgtttc acacaaaaat taaaagtttc ctaattaatg ttgtattcat
     1681 atatgtaggc tctgaaatgt tgtgatgctt attgcttctg tatttcttct ctactcccta
     1741 gtcttaatgt ttaaccttga atgctattaa cttaaatagc cattgaggag ttagaagatg
     1801 aattgttcat gaagtcggtg ttacataaaa gtaggtgata tgtaagtttt ctgataacaa
     1861 ggttctaata gtgtttaaat gtactggtaa cctggttcca atagttgtgt ttgcccaagc
     1921 ctttctcggc atcatcttgt attccttatc agatagtaag taacctgtaa gtttggagta
     1981 ttactgtttt ctcagcatgc attaaaaata ttccttaact tcaattgtaa ataaactttt
     2041 ggtgttaggg a
//
