LOCUS       NM_006570               1599 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens Ras related GTP binding A (RRAGA), mRNA.
ACCESSION   NM_006570
VERSION     NM_006570.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1599)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1599)
  AUTHORS   Zhang,L., Yu,J., Zheng,M., Zhen,H., Xie,Q., Zhang,C., Zhou,Z. and
            Jin,G.
  TITLE     RAGA prevents tumor immune evasion of LUAD by promoting CD47
            lysosome degradation
  JOURNAL   Commun Biol 6 (1), 211 (2023)
   PUBMED   36823443
  REMARK    GeneRIF: RAGA prevents tumor immune evasion of LUAD by promoting
            CD47 lysosome degradation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1599)
  AUTHORS   Cui,Z., Napolitano,G., de Araujo,M.E.G., Esposito,A.,
            Monfregola,J., Huber,L.A., Ballabio,A. and Hurley,J.H.
  TITLE     Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex
  JOURNAL   Nature 614 (7948), 572-579 (2023)
   PUBMED   36697823
  REMARK    GeneRIF: Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator
            megacomplex.
REFERENCE   4  (bases 1 to 1599)
  AUTHORS   Jansen,R.M., Peruzzo,R., Fromm,S.A., Yokom,A.L., Zoncu,R. and
            Hurley,J.H.
  TITLE     Structural basis for FLCN RagC GAP activation in MiT-TFE
            substrate-selective mTORC1 regulation
  JOURNAL   Sci Adv 8 (37), eadd2926 (2022)
   PUBMED   36103527
REFERENCE   5  (bases 1 to 1599)
  AUTHORS   Egri,S.B. and Shen,K.
  TITLE     An interdomain hydrogen bond in the Rag GTPases maintains stable
            mTORC1 signaling in sensing amino acids
  JOURNAL   J Biol Chem 297 (1), 100861 (2021)
   PUBMED   34116056
  REMARK    GeneRIF: An interdomain hydrogen bond in the Rag GTPases maintains
            stable mTORC1 signaling in sensing amino acids.
REFERENCE   6  (bases 1 to 1599)
  AUTHORS   Sekiguchi,T., Todaka,Y., Wang,Y., Hirose,E., Nakashima,N. and
            Nishimoto,T.
  TITLE     A novel human nucleolar protein, Nop132, binds to the G proteins,
            RRAG A/C/D
  JOURNAL   J Biol Chem 279 (9), 8343-8350 (2004)
   PUBMED   14660641
REFERENCE   7  (bases 1 to 1599)
  AUTHORS   Sekiguchi,T., Hirose,E., Nakashima,N., Ii,M. and Nishimoto,T.
  TITLE     Novel G proteins, Rag C and Rag D, interact with GTP-binding
            proteins, Rag A and Rag B
  JOURNAL   J Biol Chem 276 (10), 7246-7257 (2001)
   PUBMED   11073942
REFERENCE   8  (bases 1 to 1599)
  AUTHORS   Hirose,E., Nakashima,N., Sekiguchi,T. and Nishimoto,T.
  TITLE     RagA is a functional homologue of S. cerevisiae Gtr1p involved in
            the Ran/Gsp1-GTPase pathway
  JOURNAL   J Cell Sci 111 (Pt 1), 11-21 (1998)
   PUBMED   9394008
REFERENCE   9  (bases 1 to 1599)
  AUTHORS   Li,Y., Kang,J. and Horwitz,M.S.
  TITLE     Interaction of an adenovirus 14.7-kilodalton protein inhibitor of
            tumor necrosis factor alpha cytolysis with a new member of the
            GTPase superfamily of signal transducers
  JOURNAL   J Virol 71 (2), 1576-1582 (1997)
   PUBMED   8995684
REFERENCE   10 (bases 1 to 1599)
  AUTHORS   Schurmann,A., Brauers,A., Massmann,S., Becker,W. and Joost,H.G.
  TITLE     Cloning of a novel family of mammalian GTP-binding proteins (RagA,
            RagBs, RagB1) with remote similarity to the Ras-related GTPases
  JOURNAL   J Biol Chem 270 (48), 28982-28988 (1995)
   PUBMED   7499430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC009990.2 and BX346838.2.
            
            On May 17, 2019 this sequence version replaced NM_006570.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR3476690.413698.1,
                                        SRR1660803.162941.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380527.3/ ENSP00000369899.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1557              BC009990.2         24-1580
            1558-1599           BX346838.2         80-121
FEATURES             Location/Qualifiers
     source          1..1599
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p22.1"
     gene            1..1599
                     /gene="RRAGA"
                     /gene_synonym="FIP-1; FIP1; RAGA"
                     /note="Ras related GTP binding A"
                     /db_xref="GeneID:10670"
                     /db_xref="HGNC:HGNC:16963"
                     /db_xref="MIM:612194"
     exon            1..1599
                     /gene="RRAGA"
                     /gene_synonym="FIP-1; FIP1; RAGA"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1175
                     /gene="RRAGA"
                     /gene_synonym="FIP-1; FIP1; RAGA"
                     /note="adenovirus E3-14.7K interacting protein 1; rag A;
                     adenovirus E3 14.7 kDa-interacting protein 1"
                     /codon_start=1
                     /product="ras-related GTP-binding protein A"
                     /protein_id="NP_006561.1"
                     /db_xref="CCDS:CCDS6488.1"
                     /db_xref="GeneID:10670"
                     /db_xref="HGNC:HGNC:16963"
                     /db_xref="MIM:612194"
                     /translation="MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATID
                     VEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKD
                     MHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECACF
                     RTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQ
                     CKEQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVM
                     SDPSIPSAATLINIRNARKHFEKLERVDGPKHSLLMR"
     regulatory      1536..1541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRAGA"
                     /gene_synonym="FIP-1; FIP1; RAGA"
                     /note="hexamer: ATTAAA"
     polyA_site      1557
                     /gene="RRAGA"
                     /gene_synonym="FIP-1; FIP1; RAGA"
                     /note="major polyA site"
     regulatory      1576..1581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RRAGA"
                     /gene_synonym="FIP-1; FIP1; RAGA"
                     /note="hexamer: AATAAA"
     polyA_site      1599
                     /gene="RRAGA"
                     /gene_synonym="FIP-1; FIP1; RAGA"
                     /note="major polyA site"
ORIGIN      
        1 gtatctcccg agccgttgcc actgacagcc gcgggcgctc ccatctgagt aagagccagc
       61 ccgtccgcgg cctctccagc cccgggttcg cgctctcgac tctcctgcct gcccagctgc
      121 gcggcggagc ggagcgaggc gcggcctgcg agtccccggc agcccccgac ccctccctcg
      181 gcgctgcgtg taggccgcgc cctcaggccc agtccgcggt gccccggcgg gtgatgccaa
      241 atacagccat gaagaaaaag gtgctgctga tggggaagag cgggtcgggg aagaccagca
      301 tgaggtcgat aatcttcgcc aattacattg ctcgcgacac ccggcgcctg ggggccacca
      361 ttgacgtgga acactcccac gtccgattcc tagggaacct ggtgctgaac ctgtgggact
      421 gtggcggtca ggacaccttc atggaaaatt acttcaccag ccagcgagac aatatcttcc
      481 gtaacgtgga agttttgatt tacgtgtttg acgtggagag ccgcgaactg gaaaaggaca
      541 tgcattatta ccagtcgtgt ctggaggcca tcctccagaa ctctcctgac gccaaaatct
      601 tctgcctggt gcacaaaatg gatctggttc aggaggatca gcgtgacctg atttttaaag
      661 agcgagagga agacctgagg cgtctgtctc gcccgctgga gtgtgcttgt tttcgaacgt
      721 ccatctggga tgagacgctc tacaaagcct ggtccagcat cgtctaccag ctgattccca
      781 acgttcagca gctggagatg aacctcagga attttgccca aatcattgag gccgatgaag
      841 ttctgctgtt cgaaagagct acattcttgg ttatttccca ctaccagtgc aaagagcagc
      901 gcgacgtcca ccggtttgag aagatcagca acatcatcaa acagttcaag ctgagctgca
      961 gtaaattggc cgcttccttc cagagcatgg aagttaggaa ttccaacttc gctgctttca
     1021 tcgacatctt cacctcaaat acgtacgtga tggtggtcat gtcagatccg tcgatccctt
     1081 ctgcggccac tctgatcaac attcgcaatg cccggaaaca ctttgagaag ctggagagag
     1141 tggatggccc caagcacagt ctccttatgc gttgaatatt gccaaatgct ctttctgaaa
     1201 atgctgaatt gccttttttg tttgcatcct ttatttttaa tattcataat gtcgtgtgct
     1261 taaaagtggg ctttgaagtg tgtgctgctt actcctttca tctttctccc cgcttcccca
     1321 gtctttaaac attggacgct atttactcag ctacccagta gagcttgaag ctgacctttc
     1381 tgagaagttg gtatggtgta acactaaagt aggtggttcg tgtgtgttct cattacctgg
     1441 ttatgataga tatgcacatc aaagccttta ccagtatctt cctgtattcc gtatcagatt
     1501 gcaaagacgg aatgttacta ttttatcagc aaggtattaa aatgcattta taaattcttc
     1561 ttggcttcat tcatgaataa acgtgttagc aatttaaaa
//
