LOCUS       NM_058192               2048 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens RNA pseudouridine synthase domain containing 1
            (RPUSD1), transcript variant 1, mRNA.
ACCESSION   NM_058192
VERSION     NM_058192.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2048)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2048)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   3  (bases 1 to 2048)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG686882.1, BM763460.1, BC011783.2 and CB529100.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_058192.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.237804.1,
                                           SRR1163658.337473.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154125
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000007264.7/ ENSP00000007264.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BG686882.1         3-13
            12-133              BM763460.1         1-122
            134-2040            BC011783.2         1-1907
            2041-2048           CB529100.1         18-25               c
FEATURES             Location/Qualifiers
     source          1..2048
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2048
                     /gene="RPUSD1"
                     /gene_synonym="C16orf40; RLUCL"
                     /note="RNA pseudouridine synthase domain containing 1"
                     /db_xref="GeneID:113000"
                     /db_xref="HGNC:HGNC:14173"
     exon            1..126
                     /gene="RPUSD1"
                     /gene_synonym="C16orf40; RLUCL"
                     /inference="alignment:Splign:2.1.0"
     exon            127..315
                     /gene="RPUSD1"
                     /gene_synonym="C16orf40; RLUCL"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1072
                     /gene="RPUSD1"
                     /gene_synonym="C16orf40; RLUCL"
                     /note="isoform 1 is encoded by transcript variant 1; RNA
                     pseudouridylate synthase domain-containing protein 1;
                     ribosomal large subunit pseudouridine synthase C-like
                     protein; RNA pseudouridylate synthase domain containing 1"
                     /codon_start=1
                     /product="RNA pseudouridylate synthase domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_478072.1"
                     /db_xref="CCDS:CCDS10426.1"
                     /db_xref="GeneID:113000"
                     /db_xref="HGNC:HGNC:14173"
                     /translation="MEPGSVENLSIVYRSRDFLVVNKHWDVRIDSKAWRETLTLQKQL
                     RYRFPELADPDTCYGFRFCHQLDFSTSGALCVALNKAAAGSAYRCFKERRVTKAYLAL
                     LRGHIQESRVTISHAIGRNSTEGRAHTMCIEGSQGCENPKPSLTDLVVLEHGLYAGDP
                     VSKVLLKPLTGRTHQLRVHCSALGHPVVGDLTYGEVSGREDRPFRMMLHAFYLRIPTD
                     TECVEVCTPDPFLPSLDACWSPHTLLQSLDQLVQALRATPDPDPEDRGPRPGSPSALL
                     PGPGRPPPPPTKPPETEAQRGPCLQWLSEWTLEPDS"
     exon            316..439
                     /gene="RPUSD1"
                     /gene_synonym="C16orf40; RLUCL"
                     /inference="alignment:Splign:2.1.0"
     exon            440..542
                     /gene="RPUSD1"
                     /gene_synonym="C16orf40; RLUCL"
                     /inference="alignment:Splign:2.1.0"
     exon            543..644
                     /gene="RPUSD1"
                     /gene_synonym="C16orf40; RLUCL"
                     /inference="alignment:Splign:2.1.0"
     exon            645..2048
                     /gene="RPUSD1"
                     /gene_synonym="C16orf40; RLUCL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2020..2025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPUSD1"
                     /gene_synonym="C16orf40; RLUCL"
                     /note="hexamer: AATAAA"
     polyA_site      2048
                     /gene="RPUSD1"
                     /gene_synonym="C16orf40; RLUCL"
                     /note="major polyA site"
ORIGIN      
        1 gcggaagcgc tgccaggcgt ccggagcgga gcttccaggg tctctgggtc gccagcgcgc
       61 gggcgcgcgg ctggagccgg cgccgggcac ggcatcgggg gcctggactg cacggcccgg
      121 cagcaggccg gccatggagc caggcagcgt ggagaacctg tccatcgtgt accggagccg
      181 cgacttcctg gtggtcaaca agcactggga cgttcgcatt gacagcaagg cgtggcggga
      241 gactctgacc ctgcagaagc agctgcggta ccgctttccc gagctggccg accctgacac
      301 ctgctacggg ttcaggttct gccaccagct ggatttctcc accagcgggg cgctgtgcgt
      361 ggccctaaac aaggcagccg ccggcagcgc gtacaggtgc ttcaaggagc ggcgcgtgac
      421 caaggcttac ctggcattgc tgcgggggca catccaggag agccgggtaa ccatcagcca
      481 tgccattggc aggaacagca cggagggccg ggcccacacc atgtgcatcg agggctcgca
      541 gggttgtgag aacccaaagc caagcctcac agatctcgtg gttctggaac acgggctgta
      601 cgcaggcgat cctgtctcca aagtgctgct gaagccgctc acgggccgga cacaccagct
      661 gcgcgtgcac tgcagtgccc tgggccaccc cgtggtgggc gacctgacct acggagaagt
      721 ctcgggccgg gaggaccggc cgttcagaat gatgctgcac gctttctacc tgcgcatccc
      781 cacggacacc gagtgtgtgg aggtctgcac gcctgacccc ttcctgccct ccctggatgc
      841 ctgctggagc ccccacacac tgctgcagtc gctggaccag ctcgtgcagg ccttacgggc
      901 cacccccgac cctgaccccg aggatagggg ccccaggcca ggcagcccct ccgcactcct
      961 gcctgggccc ggccggcctc ctccaccccc aaccaagccc cctgagactg aggcacagcg
     1021 gggcccctgc ctgcagtggc tgtcggagtg gacgctggaa ccggacagct gagagccgtg
     1081 gggctggggc agggggtgtc agctgcacag cgggactcta gggagatggg cgagcgagcg
     1141 tctgctcact ggctctgggg cctcgaggtg ccaggcagca tcaggcccac tgggttgccc
     1201 cggccaggcc tgcgaggaag ggctgaggtg gggccggcag ggggcgccag gcagccgtga
     1261 tcacaggtga cgaccgcacc gcggccgtgg gactgatgcg ggatcccgag ggccttcctg
     1321 cccacatgcc ccgggagaaa ccgaggcccc tccctcctcc tggaacagct tccggctctc
     1381 aagcgtcacc ccaggggcgt cagttttacg gactcaaggt cacctcagga agaggcaggg
     1441 ccaggttttg ggataggctt tgcctccagg atgggctgct cctgggcctg gtgagctact
     1501 gcccccaacc taccctctag aggggctggg aagggccgtt ctgggctcac ctggcctggg
     1561 agacccatct ggtccctgcg tcctctgccc ctcactgctc tgtgcagatc ctgtcgccct
     1621 cagctgcctc ctcccgagac ctaatggtcc ctgctgggct cgagtctgca ggcccggctg
     1681 cgtgtgcctt ggcctcactg taccagtggt tccctctctg cccggattct gagctcagtg
     1741 tggtgtttgg tgcacagggg ttggtcaggg gccatggcca aggccctgcc acgcacgccc
     1801 atccctcaga tccactgtga gcaccaacct gctgcagtct cttgggcccc tgctggcagc
     1861 tctgccacgt caccgcctgc ctggctccca cacagccatg cattgtcact ctgcctccgg
     1921 gaccccagct tgggagctgt gggtctgcca ggtcccacct cctctgtccc ccatgccaca
     1981 acctgggctc ctggctacag cagggctcca gggactccaa ataaatgttc agtgactggc
     2041 tccaagga
//
