LOCUS       NM_020761               6838 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens regulatory associated protein of MTOR complex 1
            (RPTOR), transcript variant 1, mRNA.
ACCESSION   NM_020761 XM_927205 XM_941271
VERSION     NM_020761.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6838)
  AUTHORS   Aljaibeji,H., Heydarpour,M., Stanton,A.M., Williams,J.S.,
            Pojoga,L.H., Romero,J.R. and Williams,G.H.
  TITLE     Role of Raptor Gene Variants in Hypertension: Influence on Blood
            Pressure Independent of Salt Intake in White Population
  JOURNAL   Hypertension 81 (5), 1167-1177 (2024)
   PUBMED   38497230
  REMARK    GeneRIF: Role of Raptor Gene Variants in Hypertension: Influence on
            Blood Pressure Independent of Salt Intake in White Population.
REFERENCE   2  (bases 1 to 6838)
  AUTHORS   Wu,K., Yu,X., Wang,Y., Li,X., An,Y., Zhao,Z. and Ma,L.
  TITLE     MALAT1 DEREPRESSES MIR-433-3P-MEDIATED RPTOR SUPPRESSION TO IMPAIR
            AUTOPHAGY AND DRIVE PYROPTOSIS IN ENDOTOXEMIA
  JOURNAL   Shock 61 (3), 477-489 (2024)
   PUBMED   38010109
  REMARK    GeneRIF: MALAT1 DEREPRESSES MIR-433-3P-MEDIATED RPTOR SUPPRESSION
            TO IMPAIR AUTOPHAGY AND DRIVE PYROPTOSIS IN ENDOTOXEMIA.
REFERENCE   3  (bases 1 to 6838)
  AUTHORS   Liu,Y., Zhu,Y., Chen,H., Zhou,J., Niu,P. and Shi,D.
  TITLE     Raptor mediates the selective inhibitory effect of cardamonin on
            RRAGC-mutant B cell lymphoma
  JOURNAL   BMC Complement Med Ther 23 (1), 336 (2023)
   PUBMED   37749558
  REMARK    GeneRIF: Raptor mediates the selective inhibitory effect of
            cardamonin on RRAGC-mutant B cell lymphoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6838)
  AUTHORS   Xu,C., Pan,X., Wang,D., Guan,Y., Yang,W., Chen,X. and Liu,Y.
  TITLE     O-GlcNAcylation of Raptor transduces glucose signals to mTORC1
  JOURNAL   Mol Cell 83 (16), 3027-3040 (2023)
   PUBMED   37541260
REFERENCE   5  (bases 1 to 6838)
  AUTHORS   He,J., Liu,S., Guo,X., Zhang,F., Fan,Y., Wu,L., Takiff,H.E. and
            Zhao,Y.
  TITLE     Association of PI3K/AKT/mTOR pathway autophagy-related gene
            polymorphisms with pulmonary tuberculosis susceptibility in a
            Chinese population
  JOURNAL   Rev Soc Bras Med Trop 56, e01042023 (2023)
   PUBMED   37493735
  REMARK    GeneRIF: Association of PI3K/AKT/mTOR pathway autophagy-related
            gene polymorphisms with pulmonary tuberculosis susceptibility in a
            Chinese population.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6838)
  AUTHORS   Sun,C., Southard,C. and Di Rienzo,A.
  TITLE     Characterization of a novel splicing variant in the RAPTOR gene
  JOURNAL   Mutat Res 662 (1-2), 88-92 (2009)
   PUBMED   19388141
REFERENCE   7  (bases 1 to 6838)
  AUTHORS   Nojima,H., Tokunaga,C., Eguchi,S., Oshiro,N., Hidayat,S.,
            Yoshino,K., Hara,K., Tanaka,N., Avruch,J. and Yonezawa,K.
  TITLE     The mammalian target of rapamycin (mTOR) partner, raptor, binds the
            mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR
            signaling (TOS) motif
  JOURNAL   J Biol Chem 278 (18), 15461-15464 (2003)
   PUBMED   12604610
  REMARK    GeneRIF: raptor binds to p70S6k and 4E-BP1 through their respective
            TOS (conserved TOR signaling) motifs.
REFERENCE   8  (bases 1 to 6838)
  AUTHORS   Loewith,R., Jacinto,E., Wullschleger,S., Lorberg,A., Crespo,J.L.,
            Bonenfant,D., Oppliger,W., Jenoe,P. and Hall,M.N.
  TITLE     Two TOR complexes, only one of which is rapamycin sensitive, have
            distinct roles in cell growth control
  JOURNAL   Mol Cell 10 (3), 457-468 (2002)
   PUBMED   12408816
REFERENCE   9  (bases 1 to 6838)
  AUTHORS   Hara,K., Maruki,Y., Long,X., Yoshino,K., Oshiro,N., Hidayat,S.,
            Tokunaga,C., Avruch,J. and Yonezawa,K.
  TITLE     Raptor, a binding partner of target of rapamycin (TOR), mediates
            TOR action
  JOURNAL   Cell 110 (2), 177-189 (2002)
   PUBMED   12150926
  REMARK    GeneRIF: raptor is an essential scaffold for the mTOR-catalyzed
            phosphorylation of 4EBP1 and mediates TOR action in vivo.
REFERENCE   10 (bases 1 to 6838)
  AUTHORS   Kim,D.H., Sarbassov,D.D., Ali,S.M., King,J.E., Latek,R.R.,
            Erdjument-Bromage,H., Tempst,P. and Sabatini,D.M.
  TITLE     mTOR interacts with raptor to form a nutrient-sensitive complex
            that signals to the cell growth machinery
  JOURNAL   Cell 110 (2), 163-175 (2002)
   PUBMED   12150925
  REMARK    GeneRIF: Raptor is a missing component of the mTOR pathway that
            through its association with mTOR regulates cell size in response
            to nutrient levels
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AI821182.1, AY090663.1,
            AK055912.1, AB082951.1, BC033258.1 and BC073898.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_020761.2.
            
            Summary: This gene encodes a component of a signaling pathway that
            regulates cell growth in response to nutrient and insulin levels.
            The encoded protein forms a stoichiometric complex with the mTOR
            kinase, and also associates with eukaryotic initiation factor
            4E-binding protein-1 and ribosomal protein S6 kinase. The protein
            positively regulates the downstream effector ribosomal protein S6
            kinase, and negatively regulates the mTOR kinase. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY090663.1, SRR1660803.158119.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306801.8/ ENSP00000307272.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               AI821182.1         15-481              c
            468-2309            AY090663.1         38-1879
            2310-2559           AK055912.1         2169-2418
            2560-3908           AB082951.1         1768-3116
            3909-4400           BC033258.1         137-628
            4401-4800           AB082951.1         3609-4008
            4801-6838           BC073898.1         395-2432
FEATURES             Location/Qualifiers
     source          1..6838
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..6838
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /note="regulatory associated protein of MTOR complex 1"
                     /db_xref="GeneID:57521"
                     /db_xref="HGNC:HGNC:30287"
                     /db_xref="MIM:607130"
     exon            1..954
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             793..4800
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /note="isoform 1 is encoded by transcript variant 1; p150
                     target of rapamycin (TOR)-scaffold protein containing
                     WD-repeats; raptor"
                     /codon_start=1
                     /product="regulatory-associated protein of mTOR isoform 1"
                     /protein_id="NP_065812.1"
                     /db_xref="CCDS:CCDS11773.1"
                     /db_xref="GeneID:57521"
                     /db_xref="HGNC:HGNC:30287"
                     /db_xref="MIM:607130"
                     /translation="MESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKS
                     LAQSWRMKDRMKTVSVALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETI
                     GANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTV
                     NGEVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELE
                     VAAINPNHPLAQMPLPPSMKNCIQLAACEATELLPMIPDLPADLFTSCLTTPIKIALR
                     WFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQ
                     KLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQ
                     LPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPPEQLPIVLQVLLSQVHRLRAL
                     DLLGRFLDLGPWAVSLALSVGIFPYVLKLLQSSARELRPLLVFIWAKILAVDSSCQAD
                     LVKDNGHKYFLSVLADPYMPAEHRTMTAFILAVIVNSYHTGQEACLQGNLIAICLEQL
                     NDPHPLLRQWVAICLGRIWQNFDSARWCGVRDSAHEKLYSLLSDPIPEVRCAAVFALG
                     TFVGNSAERTDHSTTIDHNVAMMLAQLVSDGSPMVRKELVVALSHLVVQYESNFCTVA
                     LQFIEEEKNYALPSPATTEGGSLTPVRDSPCTPRLRSVSSYGNIRAVATARSLNKSLQ
                     NLSLTEESGGAVAFSPGNLSTSSSASSTLGSPENEEHILSFETIDKMRRASSYSSLNS
                     LIGVSFNSVYTQIWRVLLHLAADPYPEVSDVAMKVLNSIAYKATVNARPQRVLDTSSL
                     TQSAPASPTNKGVHIHQAGGSPPASSTSSSSLTNDVAKQPVSRDLPSGRPGTTGPAGA
                     QYTPHSHQFPRTRKMFDKGPEQTADDADDAAGHKSFISATVQTGFCDWSARYFAQPVM
                     KIPEEHDLESQIRKEREWRFLRNSRVRRQAQQVIQKGITRLDDQIFLNRNPGVPSVVK
                     FHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMEYLNGQDCSLLLTAT
                     DDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLMSSGDVRI
                     VRIWDTDREMKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRV
                     MTYREHTAWVVKASLQKRPDGHIVSVSVNGDVRIFDPRMPESVNVLQIVKGLTALDIH
                     PQADLIACGSVNQFTAIYNSSGELINNIKYYDGFMGQRVGAISCLAFHPHWPHLAVGS
                     NDYYISVYSVEKRVR"
     exon            955..1057
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1140
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1299
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1446
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1622
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1682
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1783
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1928
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2004
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2106
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2190
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2301
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2376
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2442
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2634
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2775
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2893
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..3034
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3193
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3194..3312
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..3416
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..3600
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3601..3711
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3712..3817
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3818..3932
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            3933..4057
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            4058..4162
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            4163..4269
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            4270..4397
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            4398..4484
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            4485..4601
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            4602..4731
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     exon            4732..6838
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6820..6825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /note="hexamer: AGTAAA"
     polyA_site      6838
                     /gene="RPTOR"
                     /gene_synonym="KOG1; Mip1"
                     /note="major polyA site"
ORIGIN      
        1 gtcctggcaa tatggcgtcc tccttgatgg gctgatgaga tgagtttcac tgtagctcca
       61 aaccagaggg caaagctccc atgacccaat aagcccacat tgtccctttc ctccgtggtt
      121 ccgtgtcgcc cgtttctcag gactcgttct caggcaggag agagcctcgg ggctgaaggc
      181 caggaccagc caggccgcgc ggacctgagg ttgaggaacc gggtgcaggc gagcacgatg
      241 ggccggtcgt ggctctggtt gcagcagctc agacgagtgc gggacccgca gggctgagag
      301 tggctggagg agacccaggg ccctttgaac ccgatccctt ggccggagac ctcagcccag
      361 tcggcccagt gggcgaaccg gcaccaagag cggcctgcct gtcttcggaa ctgctgaggc
      421 ggtggaggcc gagagcaggg tcatcgtgag gcctgaagtc tcttacgctt ttggcagctc
      481 ccctcgcagc ccctctggaa acgtacagcc tcaggagcag ccagtggctt gggacctggg
      541 gtggtgtgtg tctgcggagc ttcttgggct gccccatttc ctagcggccc ccacctcccc
      601 acttcccgct cagagttaga gataaggatc tcagactttt gcctgagtaa gggtctccgc
      661 actctttatc catttggttt tcgatttccc gtttttgttt cttatttcac caattctggt
      721 acacgctagt ttttaaggct ggaggttctc gagcgcttgc tgccaaggac tcccccaccc
      781 cctcccccac tgatggagtc cgaaatgctg caatcgcctc ttctgggcct gggggaggaa
      841 gatgaggctg atcttacaga ctggaaccta cctttggctt ttatgaaaaa gaggcactgt
      901 gagaaaattg aaggctccaa atccttagct cagagctgga ggatgaagga tcggatgaag
      961 acagtcagtg ttgccttagt tttgtgcctg aatgttggtg tggaccctcc cgatgtggtg
     1021 aagaccacgc cctgtgcacg cttggaatgc tggatcgatc ctctgtcgat gggtcctcag
     1081 aaagctctgg aaaccatcgg tgcaaattta cagaagcagt acgagaactg gcagccaagg
     1141 gcccggtaca agcagagcct tgacccaact gtggatgaag tcaagaagct ctgcacgtcc
     1201 ttacgtcgca acgccaagga ggagcgagtc ctctttcact acaatggcca cggggtgccc
     1261 cggcccacag tcaacgggga ggtctgggtc ttcaacaaga actacacgca gtacatccct
     1321 ctgtccatat atgacctgca gacgtggatg ggcagcccgt cgatcttcgt ctacgactgc
     1381 tccaatgctg gcttgatcgt caagtccttc aagcagttcg cactacagcg ggagcaggag
     1441 ctggaggtag ctgcaatcaa cccaaatcac cctcttgctc agatgccttt gcctccgtcg
     1501 atgaaaaact gcatccagct ggcagcctgc gaggccaccg agctgctgcc catgatcccc
     1561 gacctcccgg ctgacctatt cacctcctgc ctcaccaccc ccatcaagat cgccctgcgc
     1621 tggttttgca tgcagaaatg tgtcagtctg gtgcctggcg tcacactgga tttgatagaa
     1681 aagatccctg gccgcctgaa cgacaggagg acgcccctgg gtgaactgaa ctggatcttc
     1741 acagccatca cagacaccat cgcgtggaac gtgctccccc gggatctctt ccaaaagctc
     1801 ttcagacagg acttgctggt ggctagtctg tttcgaaatt ttttattggc ggaaaggatt
     1861 atgaggtcgt ataactgcac tcccgtcagc agcccgcgtc tgccgcccac gtacatgcac
     1921 gccatgtggc aagcctggga cctggctgtt gacatctgtc tgtctcagct gccgacgatc
     1981 atcgaggaag gcactgcgtt tcggcacagc ccgttcttcg ccgagcagct gaccgcattc
     2041 caggtgtggc tcaccatggg cgtggagaac cgaaacccac ccgaacagct gcccatcgtc
     2101 ctgcaggtgc tgttaagcca agtgcaccgg ctgagagcat tggacttgct tggaagattt
     2161 ttggacctgg gtccctgggc agtgagcctg gccttgtctg tcggcatctt cccctacgtg
     2221 ctgaagctgc tccagagctc ggcccgagag ctgcggccac ttctcgtttt catctgggcc
     2281 aagatcctcg cagtggacag ctcgtgccaa gcggacctcg tgaaggacaa cggccacaag
     2341 tacttcctgt cggtcctggc ggacccctac atgccagctg aacaccggac catgacggct
     2401 ttcattctcg ccgtgatcgt caacagctat cacacggggc aggaagcctg ccttcaggga
     2461 aacctcattg ccatctgcct ggagcagctc aacgacccgc accccttgct gcgccagtgg
     2521 gtggccatct gcctcggcag gatctggcag aacttcgact cggcgaggtg gtgcggcgtg
     2581 agggacagcg ctcatgagaa gctctacagc ctcctctccg accccattcc cgaggtccgc
     2641 tgcgcagcgg tcttcgccct tggcacgttc gtgggcaact ctgcagagag gacggaccac
     2701 tccaccacca tcgaccacaa cgtggccatg atgctggccc agctggtcag cgacgggagc
     2761 cccatggtcc ggaaggagct ggtggtggct ctgagtcatc ttgtggttca gtatgaaagc
     2821 aatttctgca ccgtggccct gcagttcata gaagaggaaa agaactacgc cttgccttct
     2881 ccagcaacca cagagggagg gagtttgacc ccagtgcgag acagcccgtg cacccccaga
     2941 cttcgttctg tgagctccta tggaaacatc cgtgctgtcg ccacagccag gagcctcaac
     3001 aaatctttgc agaacctgag tttgacagag gaatctggtg gcgcggtggc gttctccccc
     3061 ggaaacctca gcaccagcag cagcgccagc agcaccctgg gcagccccga gaatgaggag
     3121 catatcctgt ccttcgagac catcgacaag atgcgccgcg ccagctccta ctcctccctc
     3181 aactccctca tcggagtttc ctttaacagt gtttacactc agatttggag agtcctgctg
     3241 cacctggctg ctgaccccta tccagaggtc tcggacgtgg ccatgaaagt actcaacagc
     3301 atcgcctaca aggccaccgt gaacgcccgg ccgcagcgcg tcctggacac ctcctccctc
     3361 acgcagtcgg cccccgccag ccccaccaac aagggcgtgc acatccacca ggcggggggc
     3421 tcccctccgg cgtccagcac cagcagctcc agcctgacca acgatgtggc caagcagccg
     3481 gtcagccgag acttgccttc tggccggccg ggcaccacag gccccgctgg ggcgcagtac
     3541 acccctcact cccaccagtt cccccggaca cggaagatgt tcgacaaggg cccagagcag
     3601 actgcggacg acgcggacga tgctgctgga cacaaaagtt tcatctccgc cacggtgcag
     3661 acggggttct gcgactggag cgcccgctat tttgcccagc ccgtcatgaa gatcccagaa
     3721 gagcacgacc tggagagtca gatccgcaag gagcgggagt ggcggttcct gcgaaacagc
     3781 cgtgtcagga ggcaggccca gcaagtcatt cagaagggca ttacgagatt ggacgaccaa
     3841 atatttctga acaggaaccc cggcgtcccc tctgtggtga aattccaccc cttcacgccg
     3901 tgcatcgccg tagccgacaa ggacagcatc tgcttttggg actgggagaa aggggagaag
     3961 ctggattatt tccacaatgg gaaccctcgg tacacgaggg tcactgccat ggagtatctg
     4021 aacggccagg actgctcgct tctgctgacg gccacagacg atggtgccat cagggtctgg
     4081 aagaattttg ctgatttgga aaagaaccca gagatggtga ccgcgtggca ggggctctcg
     4141 gacatgctgc caacgacgcg aggagctggg atggtggtgg actgggagca ggagaccggc
     4201 ctcctcatga gctcaggaga cgtgcggatc gtccggatct gggacacaga ccgtgagatg
     4261 aaggtgcagg acatccctac gggcgcagac agctgtgtga cgagtctgtc ctgtgattcc
     4321 caccgctcac tcatcgtggc tggcctcggt gacggctcca tccgcgtcta cgacagaagg
     4381 atggcactca gcgaatgccg cgtcatgacg taccgggagc acacagcctg ggtggtgaag
     4441 gcctccctgc agaagcgtcc cgacggccac atcgtgagtg tgagcgtcaa tggagatgtg
     4501 cgcatctttg atccccggat gcctgagtcg gtaaatgtgc ttcagatcgt gaaggggctg
     4561 acggccctgg acatccaccc ccaggcggac ctgatcgcat gtggctccgt caatcagttc
     4621 accgccatct acaacagcag cggagagctc atcaacaaca tcaagtacta cgacggcttc
     4681 atgggccagc gggtcggcgc catcagctgc ctggccttcc acccgcactg gcctcacctg
     4741 gccgtgggaa gcaacgacta ctacatctcc gtgtactcgg tggagaagcg tgtcagatag
     4801 cggcgtgacc cgggcccacc aggccacggc cgcctgctgt acatagtgaa gctgtcactc
     4861 gccggggcac ggggcgtcgg ctgctgcggc cccgcagtgt gaacgttggc tgctgcctta
     4921 gctgctgatg acggcaggag ggccctgcta ctcgcttttg tctgtcttcg ctgtcgtgtc
     4981 tggaatgtca gggaagggga gggctcgggt tgacggtggc ttcccactga gcaccagcat
     5041 ccaggtgcac ccccgcggcc acggcgcctc tgtccctctc ctgttctgtg tttctctgag
     5101 acgctgaaag gggaaacacc tcactttatt tccatgtaat cagagcatta gctgcagaaa
     5161 aaccccccga cagagccctg gcggagaggc aggcgctggg gctcctacgg gtccctgggg
     5221 cagctgtccc catcaggcca agagcgagcg agaggcgctg ccccagccag gcccaccacc
     5281 tctcacagtc agtgcacgca agcagggaca tttcctagcc agctggggga cactggaaat
     5341 tcgggaaacc aagagagagg aagaaggaga cgcccctcca actggcgggt gtgaaggaag
     5401 ccgcccaggg gtccgggctg tccttggccg ctggcagcat cactgagcag gaagcgcaca
     5461 gcccaccctc cccgcacctc caggtctctg gactccagtt ttggcccctc tcacacagag
     5521 ctgtcagcag gggccgctgt ggcggtgcac aggggaggca ggtccttggc gaggtagccc
     5581 ctgccttaat ccacggggct cctttccctc cgaagggctg ctcttcccca caggcgcggg
     5641 gacagcagcc cgacctgtgg tctccatgcc tgtgccctca cacaggtgta gcacacgcat
     5701 gtgcagatgg caccacggcc ggcacctggg ggcacacaca tgcaggcggc gtggtctccc
     5761 tgctctgtcc ccacacgttc ctcacataca ggcaagaggc actgccgggt cccggacggc
     5821 tccgggtgac accagccccg tctccagcct tgagccgccc atgctgatgc gacctcggct
     5881 gacagctggg cctgtggtgc agacaggagc tgtgtggaca gtcccgccca ggaggggccg
     5941 cagggcgtgt atgagcagtt ttgcaaacag aacacaacca caatgatggt attttgaaaa
     6001 gtgttctttc cgtgttcgtc gggaatcagg attattgaga ggtgaaggag ccaggtggct
     6061 tcattctggc ggtgagaggc ccacgaccac gggagtgaga gctggtgtgg cgaggcccgg
     6121 ctctcctgcg gtgtggctgg tggcctgccg tggccaagag catcttctgg gtggatggaa
     6181 ccctgcctgg tcacatttgg ccagagacac acctggccct cagggggctg agctggagac
     6241 tgagctgggg ctggccggga cgtgacaagg caggacagag gcggcccctc cgctgctcct
     6301 ttttggaatg cgagctccca ccagaagaag gttccggcac gaatcccatc cccacgtctg
     6361 ggccgagaaa gcagcccggg tccggaaggt gtagagagtc ccggcctcac tcagctcaca
     6421 gggcgtgcca ggcggcaaca ccagaatctt ccagaagccc agctccaccc gcacacgcag
     6481 cttcccatcc agtccttcaa ctcaattctt acccaacacg cgtttctgtt tgttttgaga
     6541 caaaatcacc acctgtcaaa aggcaggtgg ctccagaggg gtcaagaccc ccccccgccc
     6601 ccgctccacc ctggagccca cccccatggg caccgcgtgc cgcctgcacg tgggctgtct
     6661 tcacaggtct gatgtgaaaa ttcaatcacg acgttaaccg gctcgagaga gcgccggcct
     6721 agaggctcat tatctattta ttttaccaaa cgcgaattga gacggacttt gacaaaacac
     6781 gaaatggtaa tgtgaagcta agagcagaga gtgaccaaca gtaaacaaca cgcgcaga
//
