LOCUS       NM_002295               1140 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ribosomal protein SA (RPSA), transcript variant 1,
            mRNA.
ACCESSION   NM_002295 NM_001012321
VERSION     NM_002295.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1140)
  AUTHORS   Kurdoglu,M., Kurdoglu,Z., Kucukaydin,Z., Erten,R., Bulut,G. and
            Ozen,S.
  TITLE     Laminin receptor 1 expression in premalignant and malignant
            squamous lesions of the cervix
  JOURNAL   Biotech Histochem 99 (3), 174-181 (2024)
   PUBMED   38736402
  REMARK    GeneRIF: Laminin receptor 1 expression in premalignant and
            malignant squamous lesions of the cervix.
REFERENCE   2  (bases 1 to 1140)
  AUTHORS   Yagita,K., Sadashima,S., Koyama,S., Noguchi,H., Hamasaki,H.,
            Sasagasako,N. and Honda,H.
  TITLE     Ribosomal protein SA is a common component of neuronal intranuclear
            inclusions in polyglutamine diseases and Marinesco bodies
  JOURNAL   Neuropathology 44 (1), 31-40 (2024)
   PUBMED   37340992
  REMARK    GeneRIF: Ribosomal protein SA is a common component of neuronal
            intranuclear inclusions in polyglutamine diseases and Marinesco
            bodies.
REFERENCE   3  (bases 1 to 1140)
  AUTHORS   Jiang,Y., Sun,S., Quan,Y., Wang,X., You,Y., Zhang,X., Zhang,Y.,
            Liu,Y., Wang,B., Xu,H. and Cao,X.
  TITLE     Nuclear RPSA senses viral nucleic acids to promote the innate
            inflammatory response
  JOURNAL   Nat Commun 14 (1), 8455 (2023)
   PUBMED   38114488
  REMARK    Erratum:[Nat Commun. 2024 Jan 29;15(1):855. doi:
            10.1038/s41467-024-45275-2.. PMID: 38287017]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1140)
  AUTHORS   Hu,D., Wang,Y., Li,A., Li,Q., Wu,C., Shereen,M.A., Huang,S., Wu,K.,
            Zhu,Y., Wang,W. and Wu,J.
  TITLE     LAMR1 restricts Zika virus infection by attenuating the envelope
            protein ubiquitination
  JOURNAL   Virulence 12 (1), 1795-1807 (2021)
   PUBMED   34282707
  REMARK    GeneRIF: LAMR1 restricts Zika virus infection by attenuating the
            envelope protein ubiquitination.
REFERENCE   5  (bases 1 to 1140)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1140)
  AUTHORS   Satoh,K., Narumi,K., Sakai,T., Abe,T., Kikuchi,T., Matsushima,K.,
            Sindoh,S. and Motomiya,M.
  TITLE     Cloning of 67-kDa laminin receptor cDNA and gene expression in
            normal and malignant cell lines of the human lung
  JOURNAL   Cancer Lett 62 (3), 199-203 (1992)
   PUBMED   1534510
REFERENCE   7  (bases 1 to 1140)
  AUTHORS   Van den Ouweland,A.M., Van Duijnhoven,H.L., Deichmann,K.A., Van
            Groningen,J.J., de Leij,L. and Van de Ven,W.J.
  TITLE     Characteristics of a multicopy gene family predominantly consisting
            of processed pseudogenes
  JOURNAL   Nucleic Acids Res 17 (10), 3829-3843 (1989)
   PUBMED   2543954
REFERENCE   8  (bases 1 to 1140)
  AUTHORS   Gehlsen,K.R., Dillner,L., Engvall,E. and Ruoslahti,E.
  TITLE     The human laminin receptor is a member of the integrin family of
            cell adhesion receptors
  JOURNAL   Science 241 (4870), 1228-1229 (1988)
   PUBMED   2970671
  REMARK    Erratum:[J Cell Biol 1989 Jun;108(6):following 2546]
REFERENCE   9  (bases 1 to 1140)
  AUTHORS   Yow,H.K., Wong,J.M., Chen,H.S., Lee,C.G., Davis,S., Steele,G.D. Jr.
            and Chen,L.B.
  TITLE     Increased mRNA expression of a laminin-binding protein in human
            colon carcinoma: complete sequence of a full-length cDNA encoding
            the protein
  JOURNAL   Proc Natl Acad Sci U S A 85 (17), 6394-6398 (1988)
   PUBMED   2970639
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1989 Sep;86(18):7032]
REFERENCE   10 (bases 1 to 1140)
  AUTHORS   Wewer,U.M., Liotta,L.A., Jaye,M., Ricca,G.A., Drohan,W.N.,
            Claysmith,A.P., Rao,C.N., Wirth,P., Coligan,J.E., Albrechtsen,R.,
            Mudryj,M. and Sobel,M.
  TITLE     Altered levels of laminin receptor mRNA in various human carcinoma
            cells that have different abilities to bind laminin
  JOURNAL   Proc Natl Acad Sci U S A 83 (19), 7137-7141 (1986)
   PUBMED   2429301
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BC070263.1, BC071968.1 and BM999786.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002295.5.
            
            Summary: Laminins, a family of extracellular matrix glycoproteins,
            are the major noncollagenous constituent of basement membranes.
            They have been implicated in a wide variety of biological processes
            including cell adhesion, differentiation, migration, signaling,
            neurite outgrowth and metastasis. Many of the effects of laminin
            are mediated through interactions with cell surface receptors.
            These receptors include members of the integrin family, as well as
            non-integrin laminin-binding proteins. This gene encodes a
            high-affinity, non-integrin family, laminin receptor 1. This
            receptor has been variously called 67 kD laminin receptor, 37 kD
            laminin receptor precursor (37LRP) and p40 ribosome-associated
            protein. The amino acid sequence of laminin receptor 1 is highly
            conserved through evolution, suggesting a key biological function.
            It has been observed that the level of the laminin receptor
            transcript is higher in colon carcinoma tissue and lung cancer cell
            line than their normal counterparts. Also, there is a correlation
            between the upregulation of this polypeptide in cancer cells and
            their invasive and metastatic phenotype. Multiple copies of this
            gene exist, however, most of them are pseudogenes thought to have
            arisen from retropositional events. Two alternatively spliced
            transcript variants encoding the same protein have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066941.1, CD047875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301821.11/ ENSP00000346067.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                BC070263.1         32-101
            71-1036             BC071968.1         55-1020
            1037-1140           BM999786.1         16-119              c
FEATURES             Location/Qualifiers
     source          1..1140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..1140
                     /gene="RPSA"
                     /gene_synonym="37LRP; 67LR; ICAS; LAMBR; lamR; LAMR1; LBP;
                     LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; SA; uS2"
                     /note="ribosomal protein SA"
                     /db_xref="GeneID:3921"
                     /db_xref="HGNC:HGNC:6502"
                     /db_xref="MIM:150370"
     exon            1..45
                     /gene="RPSA"
                     /gene_synonym="37LRP; 67LR; ICAS; LAMBR; lamR; LAMR1; LBP;
                     LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; SA; uS2"
                     /inference="alignment:Splign:2.1.0"
     exon            46..211
                     /gene="RPSA"
                     /gene_synonym="37LRP; 67LR; ICAS; LAMBR; lamR; LAMR1; LBP;
                     LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; SA; uS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..966
                     /gene="RPSA"
                     /gene_synonym="37LRP; 67LR; ICAS; LAMBR; lamR; LAMR1; LBP;
                     LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; SA; uS2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     laminin receptor 1 (67kD, ribosomal protein SA); 40S
                     ribosomal protein SA; 67 kDa laminin receptor; 37/67 kDa
                     laminin receptor; 37 kDa laminin receptor; laminin-binding
                     protein precursor p40; colon carcinoma laminin-binding
                     protein; multidrug resistance-associated protein MGr1-Ag;
                     small ribosomal subunit protein uS2"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS2 isoform 1"
                     /protein_id="NP_002286.2"
                     /db_xref="CCDS:CCDS2686.1"
                     /db_xref="GeneID:3921"
                     /db_xref="HGNC:HGNC:6502"
                     /db_xref="MIM:150370"
                     /translation="MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSD
                     GIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGR
                     FTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIA
                     IPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAA
                     EKAVTKEEFQGEWTAPAPEFTATQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDW
                     SAAPTAQATEWVGATTDWS"
     exon            212..330
                     /gene="RPSA"
                     /gene_synonym="37LRP; 67LR; ICAS; LAMBR; lamR; LAMR1; LBP;
                     LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; SA; uS2"
                     /inference="alignment:Splign:2.1.0"
     exon            331..576
                     /gene="RPSA"
                     /gene_synonym="37LRP; 67LR; ICAS; LAMBR; lamR; LAMR1; LBP;
                     LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; SA; uS2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..705
                     /gene="RPSA"
                     /gene_synonym="37LRP; 67LR; ICAS; LAMBR; lamR; LAMR1; LBP;
                     LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; SA; uS2"
                     /inference="alignment:Splign:2.1.0"
     exon            706..871
                     /gene="RPSA"
                     /gene_synonym="37LRP; 67LR; ICAS; LAMBR; lamR; LAMR1; LBP;
                     LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; SA; uS2"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1140
                     /gene="RPSA"
                     /gene_synonym="37LRP; 67LR; ICAS; LAMBR; lamR; LAMR1; LBP;
                     LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; SA; uS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1016..1021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPSA"
                     /gene_synonym="37LRP; 67LR; ICAS; LAMBR; lamR; LAMR1; LBP;
                     LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; SA; uS2"
                     /note="hexamer: AATAAA"
     polyA_site      1040
                     /gene="RPSA"
                     /gene_synonym="37LRP; 67LR; ICAS; LAMBR; lamR; LAMR1; LBP;
                     LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; SA; uS2"
                     /note="major polyA site"
     regulatory      1104..1109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPSA"
                     /gene_synonym="37LRP; 67LR; ICAS; LAMBR; lamR; LAMR1; LBP;
                     LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; SA; uS2"
                     /note="hexamer: AATAAA"
     regulatory      1108..1113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPSA"
                     /gene_synonym="37LRP; 67LR; ICAS; LAMBR; lamR; LAMR1; LBP;
                     LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; SA; uS2"
                     /note="hexamer: AATACA"
     polyA_site      1121
                     /gene="RPSA"
                     /gene_synonym="37LRP; 67LR; ICAS; LAMBR; lamR; LAMR1; LBP;
                     LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; SA; uS2"
     polyA_site      1140
                     /gene="RPSA"
                     /gene_synonym="37LRP; 67LR; ICAS; LAMBR; lamR; LAMR1; LBP;
                     LBP/p40; LRP; LRP/LR; NEM/1CHD4; p40; SA; uS2"
                     /note="major polyA site"
ORIGIN      
        1 cttttccgtg ctacctgcag aggggtccat acggcgttgt tctggattcc cgtcgtaact
       61 taaagggaaa ttttcacaat gtccggagcc cttgatgtcc tgcaaatgaa ggaggaggat
      121 gtccttaagt tccttgcagc aggaacccac ttaggtggca ccaatcttga cttccagatg
      181 gaacagtaca tctataaaag gaaaagtgat ggcatctata tcataaatct caagaggacc
      241 tgggagaagc ttctgctggc agctcgtgca attgttgcca ttgaaaaccc tgctgatgtc
      301 agtgttatat cctccaggaa tactggccag agggctgtgc tgaagtttgc tgctgccact
      361 ggagccactc caattgctgg ccgcttcact cctggaacct tcactaacca gatccaggca
      421 gccttccggg agccacggct tcttgtggtt actgacccca gggctgacca ccagcctctc
      481 acggaggcat cttatgttaa cctacctacc attgcgctgt gtaacacaga ttctcctctg
      541 cgctatgtgg acattgccat cccatgcaac aacaagggag ctcactcagt gggtttgatg
      601 tggtggatgc tggctcggga agttctgcgc atgcgtggca ccatttcccg tgaacaccca
      661 tgggaggtca tgcctgatct gtacttctac agagatcctg aagagattga aaaagaagag
      721 caggctgctg ctgagaaggc agtgaccaag gaggaatttc agggtgaatg gactgctccc
      781 gctcctgagt tcactgctac tcagcctgag gttgcagact ggtctgaagg tgtacaggtg
      841 ccctctgtgc ctattcagca attccctact gaagactgga gcgctcagcc tgccacggaa
      901 gactggtctg cagctcccac tgctcaggcc actgaatggg taggagcaac cactgactgg
      961 tcttaagctg ttcttgcata ggctcttaag cagcatggaa aaatggttga tggaaaataa
     1021 acatcagttt ctaaaagttg tcttcattta gtttgctttt tactccagat cagaatacct
     1081 gggattgcat atcaaagcat aataataaat acatgtctcg acatgagttg tacttctaaa
//
