LOCUS       NM_001013                713 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens ribosomal protein S9 (RPS9), transcript variant 1,
            mRNA.
ACCESSION   NM_001013
VERSION     NM_001013.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 713)
  AUTHORS   Huang,Y., Peng,M., Qin,H., Li,Y., Pei,L., Liu,X. and Zhao,X.
  TITLE     LAPTM4B promotes AML progression through regulating RPS9/STAT3 axis
  JOURNAL   Cell Signal 106, 110623 (2023)
   PUBMED   36758682
  REMARK    GeneRIF: LAPTM4B promotes AML progression through regulating
            RPS9/STAT3 axis.
REFERENCE   2  (bases 1 to 713)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 713)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 713)
  AUTHORS   Yang,W., Qian,Y., Gao,K., Zheng,W., Wu,G., He,Q., Chen,Q., Song,Y.,
            Wang,L., Wang,Y., Gu,P., Chen,B. and Zhai,R.
  TITLE     LncRNA BRCAT54 inhibits the tumorigenesis of non-small cell lung
            cancer by binding to RPS9 to transcriptionally regulate JAK-STAT
            and calcium pathway genes
  JOURNAL   Carcinogenesis 42 (1), 80-92 (2021)
   PUBMED   32459848
  REMARK    GeneRIF: LncRNA BRCAT54 inhibits the tumorigenesis of non-small
            cell lung cancer by binding to RPS9 to transcriptionally regulate
            JAK-STAT and calcium pathway genes.
REFERENCE   5  (bases 1 to 713)
  AUTHORS   Song,K.P., Shu,P., Ma,J.L., Wang,B. and Chen,B.
  TITLE     [Ribosomal Protein S9 Expression in Multiple Myeloma and Its Effect
            on Cell Biological Function]
  JOURNAL   Zhongguo Yi Xue Ke Xue Yuan Xue Bao 41 (2), 175-182 (2019)
   PUBMED   31060671
  REMARK    GeneRIF: Inhibition of RPS9 can promote apoptosis, cell cycle
            arrest, and proliferation of myeloma cells. RPS9 can affect the
            activation of NF-kappaB pathway and cell apoptosis through SENP1
REFERENCE   6  (bases 1 to 713)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   7  (bases 1 to 713)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   8  (bases 1 to 713)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   9  (bases 1 to 713)
  AUTHORS   Frigerio,J.M., Dagorn,J.C. and Iovanna,J.L.
  TITLE     Cloning, sequencing and expression of the L5, L21, L27a, L28, S5,
            S9, S10 and S29 human ribosomal protein mRNAs
  JOURNAL   Biochim Biophys Acta 1262 (1), 64-68 (1995)
   PUBMED   7772601
REFERENCE   10 (bases 1 to 713)
  AUTHORS   Mundus,D.A., Bulygin,K.N., Yamkovoy,V.I., Malygin,A.A.,
            Repkova,M.N., Vratskikh,L.V., Venijaminova,A.G., Vladimirov,S.N.
            and Karpova,G.G.
  TITLE     Structural arrangement of the codon-anticodon interaction area in
            human placenta ribosomes. Affinity labelling of the 40S subunits by
            derivatives of oligoribonucleotides containing the AUG codon
  JOURNAL   Biochim Biophys Acta 1173 (3), 273-282 (1993)
   PUBMED   8318536
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AB055775.1, U14971.1 and BC007410.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001013.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S4P family of ribosomal proteins. It is located in the
            cytoplasm. Variable expression of this gene in colorectal cancers
            compared to adjacent normal tissues has been observed, although no
            correlation between the level of expression and the severity of the
            disease has been found. As is typical for genes encoding ribosomal
            proteins, multiple processed pseudogenes derived from this gene are
            dispersed through the genome. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), as well as variants 2, 3, and
            4, encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.184569.1,
                                           SRR5189652.94038.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302907.9/ ENSP00000302896.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AB055775.1         1-62
            63-304              U14971.1           42-283
            305-713             BC007410.2         287-695
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..713
                     /gene="RPS9"
                     /gene_synonym="S9; uS4"
                     /note="ribosomal protein S9"
                     /db_xref="GeneID:6203"
                     /db_xref="HGNC:HGNC:10442"
                     /db_xref="MIM:603631"
     exon            1..31
                     /gene="RPS9"
                     /gene_synonym="S9; uS4"
                     /inference="alignment:Splign:2.1.0"
     exon            32..153
                     /gene="RPS9"
                     /gene_synonym="S9; uS4"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..641
                     /gene="RPS9"
                     /gene_synonym="S9; uS4"
                     /note="isoform a is encoded by transcript variant 1; 40S
                     ribosomal protein S9; small ribosomal subunit protein uS4"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS4 isoform a"
                     /protein_id="NP_001004.2"
                     /db_xref="CCDS:CCDS12884.1"
                     /db_xref="GeneID:6203"
                     /db_xref="HGNC:HGNC:10442"
                     /db_xref="MIM:603631"
                     /translation="MPVARSWVCRKTYVTPRRPFEKSRLDQELKLIGEYGLRNKREVW
                     RVKFTLAKIRKAARELLTLDEKDPRRLFEGNALLRRLVRIGVLDEGKMKLDYILGLKI
                     EDFLERRLQTQVFKLGLAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFS
                     LRSPYGGGRPGRVKRKNAKKGQGGAGAGDDEEED"
     exon            154..276
                     /gene="RPS9"
                     /gene_synonym="S9; uS4"
                     /inference="alignment:Splign:2.1.0"
     exon            277..463
                     /gene="RPS9"
                     /gene_synonym="S9; uS4"
                     /inference="alignment:Splign:2.1.0"
     exon            464..713
                     /gene="RPS9"
                     /gene_synonym="S9; uS4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      689..694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS9"
                     /gene_synonym="S9; uS4"
                     /note="hexamer: AATAAA"
     polyA_site      713
                     /gene="RPS9"
                     /gene_synonym="S9; uS4"
                     /note="major polyA site"
ORIGIN      
        1 ctctttctca gtgaccgggt ggtttgctta ggcgcagacg gggaagcgga gccaacatgc
       61 cagtggcccg gagctgggtt tgtcgcaaaa cttatgtgac cccgcggaga cccttcgaga
      121 aatctcgtct cgaccaagag ctgaagctga tcggcgagta tgggctccgg aacaaacgtg
      181 aggtctggag ggtcaaattt accctggcca agatccgcaa ggccgcccgg gaactgctga
      241 cgcttgatga gaaggaccca cggcgtctgt tcgaaggcaa cgccctgctg cggcggctgg
      301 tccgcattgg ggtgctggat gagggcaaga tgaagctgga ttacatcctg ggcctgaaga
      361 tagaggattt cttagagaga cgcctgcaga cccaggtctt caagctgggc ttggccaagt
      421 ccatccacca cgctcgcgtg ctgatccgcc agcgccatat cagggtccgc aagcaggtgg
      481 tgaacatccc gtccttcatt gtccgcctgg attcccagaa gcacatcgac ttctctctgc
      541 gctctcccta cgggggtggc cgcccgggcc gcgtgaagag gaagaatgcc aagaagggcc
      601 agggtggggc tggggctgga gacgacgagg aggaggatta agtccacctg tccctcctgg
      661 gctgctggat tgtctcgttt tcctgccaaa taaacaggat cagcgcttta caa
//
