LOCUS       NM_001012                778 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribosomal protein S8 (RPS8), mRNA.
ACCESSION   NM_001012
VERSION     NM_001012.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 778)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 778)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 778)
  AUTHORS   Bi,N., Sun,Y., Lei,S., Zeng,Z., Zhang,Y., Sun,C. and Yu,C.
  TITLE     Identification of 40S ribosomal protein S8 as a novel biomarker for
            alcohol-associated hepatocellular carcinoma using weighted gene
            co-expression network analysis
  JOURNAL   Oncol Rep 44 (2), 611-627 (2020)
   PUBMED   32627011
  REMARK    GeneRIF: Identification of 40S ribosomal protein S8 as a novel
            biomarker for alcoholassociated hepatocellular carcinoma using
            weighted gene coexpression network analysis.
REFERENCE   4  (bases 1 to 778)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 778)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   6  (bases 1 to 778)
  AUTHORS   Nicoloso,M., Qu,L.H., Michot,B. and Bachellerie,J.P.
  TITLE     Intron-encoded, antisense small nucleolar RNAs: the
            characterization of nine novel species points to their direct role
            as guides for the 2'-O-ribose methylation of rRNAs
  JOURNAL   J Mol Biol 260 (2), 178-195 (1996)
   PUBMED   8764399
REFERENCE   7  (bases 1 to 778)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   8  (bases 1 to 778)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   9  (bases 1 to 778)
  AUTHORS   Davies,B. and Fried,M.
  TITLE     The structure of the human intron-containing S8 ribosomal protein
            gene and determination of its chromosomal location at 1p32-p34.1
  JOURNAL   Genomics 15 (1), 68-75 (1993)
   PUBMED   8432552
REFERENCE   10 (bases 1 to 778)
  AUTHORS   Pogue-Geile,K., Geiser,J.R., Shu,M., Miller,C., Wool,I.G.,
            Meisler,A.I. and Pipas,J.M.
  TITLE     Ribosomal protein genes are overexpressed in colorectal cancer:
            isolation of a cDNA clone encoding the human S3 ribosomal protein
  JOURNAL   Mol Cell Biol 11 (8), 3842-3849 (1991)
   PUBMED   1712897
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AL592166.16.
            
            On Nov 26, 2018 this sequence version replaced NM_001012.1.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S8E family of ribosomal proteins. It is located in the
            cytoplasm. Increased expression of this gene in colorectal tumors
            and colon polyps compared to matched normal colonic mucosa has been
            observed. This gene is co-transcribed with the small nucleolar RNA
            genes U38A, U38B, U39, and U40, which are located in its fourth,
            fifth, first, and second introns, respectively. As is typical for
            genes encoding ribosomal proteins, there are multiple processed
            pseudogenes of this gene dispersed through the genome. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.316090.1,
                                           SRR5189658.4207.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396651.8/ ENSP00000379888.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AL592166.16        39568-39628
            62-168              AL592166.16        40062-40168
            169-268             AL592166.16        40703-40802
            269-444             AL592166.16        41642-41817
            445-574             AL592166.16        42028-42157
            575-778             AL592166.16        42604-42807
FEATURES             Location/Qualifiers
     source          1..778
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..778
                     /gene="RPS8"
                     /gene_synonym="eS8; S8"
                     /note="ribosomal protein S8"
                     /db_xref="GeneID:6202"
                     /db_xref="HGNC:HGNC:10441"
                     /db_xref="MIM:600357"
     exon            1..61
                     /gene="RPS8"
                     /gene_synonym="eS8; S8"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..684
                     /gene="RPS8"
                     /gene_synonym="eS8; S8"
                     /note="40S ribosomal protein S8; OK/SW-cl.83"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS8"
                     /protein_id="NP_001003.1"
                     /db_xref="CCDS:CCDS513.1"
                     /db_xref="GeneID:6202"
                     /db_xref="HGNC:HGNC:10441"
                     /db_xref="MIM:600357"
                     /translation="MGISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIH
                     TVRVRGGNKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCIV
                     LIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDERKKNAKISS
                     LLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRKIKARKGK"
     exon            62..168
                     /gene="RPS8"
                     /gene_synonym="eS8; S8"
                     /inference="alignment:Splign:2.1.0"
     exon            169..268
                     /gene="RPS8"
                     /gene_synonym="eS8; S8"
                     /inference="alignment:Splign:2.1.0"
     exon            269..444
                     /gene="RPS8"
                     /gene_synonym="eS8; S8"
                     /inference="alignment:Splign:2.1.0"
     exon            445..574
                     /gene="RPS8"
                     /gene_synonym="eS8; S8"
                     /inference="alignment:Splign:2.1.0"
     exon            575..778
                     /gene="RPS8"
                     /gene_synonym="eS8; S8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      710..715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS8"
                     /gene_synonym="eS8; S8"
                     /note="hexamer: AATAAA"
     polyA_site      739
                     /gene="RPS8"
                     /gene_synonym="eS8; S8"
                     /note="major polyA site"
     regulatory      753..758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS8"
                     /gene_synonym="eS8; S8"
                     /note="hexamer: AATATA"
     polyA_site      778
                     /gene="RPS8"
                     /gene_synonym="eS8; S8"
ORIGIN      
        1 gttttacaaa ccgaaccgtg aatctttgcg gtttctcttt ccagccagcg ccgagcgatg
       61 ggcatctctc gggacaactg gcacaagcgc cgcaaaaccg ggggcaagag aaagccctac
      121 cacaagaagc ggaagtatga gttggggcgc ccagctgcca acaccaagat tggcccccgc
      181 cgcatccaca cagtccgtgt gcggggaggt aacaagaaat accgtgccct gaggttggac
      241 gtggggaatt tctcctgggg ctcagagtgt tgtactcgta aaacaaggat catcgatgtt
      301 gtctacaatg catctaataa cgagctggtt cgtaccaaga ccctggtgaa gaattgcatc
      361 gtgctcatcg acagcacacc gtaccgacag tggtacgagt cccactatgc gctgcccctg
      421 ggccgcaaga agggagccaa gctgactcct gaggaagaag agattttaaa caaaaaacga
      481 tctaaaaaaa ttcagaagaa atatgatgaa aggaaaaaga atgccaaaat cagcagtctc
      541 ctggaggagc agttccagca gggcaagctt cttgcgtgca tcgcttcaag gccgggacag
      601 tgtggccgag cagatggcta tgtgctagag ggcaaagagt tggagttcta tcttaggaaa
      661 atcaaggccc gcaaaggcaa ataaatcctt gttttgtctt cacccatgta ataaaggtgt
      721 ttattgtttt gttcccacat ttatgttgcc tgaatatatg actgttttct ctgcttta
//
