LOCUS       NM_001011                732 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ribosomal protein S7 (RPS7), mRNA.
ACCESSION   NM_001011
VERSION     NM_001011.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 732)
  AUTHORS   Zhou,Y.J., Yang,M.L., He,X., Gu,H.Y., Ren,J.H., Cheng,S.T., Fu,Z.,
            Zhang,Z.Z. and Chen,J.
  TITLE     RNA-binding protein RPS7 promotes hepatocellular carcinoma
            progression via LOXL2-dependent activation of ITGB1/FAK/SRC
            signaling
  JOURNAL   J Exp Clin Cancer Res 43 (1), 45 (2024)
   PUBMED   38326908
  REMARK    GeneRIF: RNA-binding protein RPS7 promotes hepatocellular carcinoma
            progression via LOXL2-dependent activation of ITGB1/FAK/SRC
            signaling.
            Erratum:[J Exp Clin Cancer Res. 2024 Mar 14;43(1):80. doi:
            10.1186/s13046-024-02999-9.. PMID: 38481346]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 732)
  AUTHORS   Skorodumova,L.O., Davydenko,K.A., Filatova,A.Y., Skoblov,M.Y.,
            Kulemin,N.A., Khadzhieva,M.B., Zakharova,E.S., Gordeeva,V.D.,
            Smetanina,N.S., Fedyushkina,I.V., Anastasevich,L.A. and Larin,S.S.
  TITLE     Splice-site variant in the RPS7 5'-UTR leads to a decrease in the
            mRNA level and development of Diamond-Blackfan anemia
  JOURNAL   Clin Genet 103 (1), 93-96 (2023)
   PUBMED   36057918
  REMARK    GeneRIF: Splice-site variant in the RPS7 5'-UTR leads to a decrease
            in the mRNA level and development of Diamond-Blackfan anemia.
REFERENCE   3  (bases 1 to 732)
  AUTHORS   Kubickova,A., Maceckova,Z., Vojta,P., Ondra,M., Volejnikova,J.,
            Koralkova,P., Jungova,A., Jahoda,O., Mojzikova,R., Hadacova,I.,
            Cermak,J., Horvathova,M., Pospisilova,D. and Hajduch,M.
  TITLE     Missense mutation in RPS7 causes Diamond-Blackfan anemia via
            alteration of erythrocyte metabolism, protein translation and
            induction of ribosomal stress
  JOURNAL   Blood Cells Mol Dis 97, 102690 (2022)
   PUBMED   35871033
  REMARK    GeneRIF: Missense mutation in RPS7 causes Diamond-Blackfan anemia
            via alteration of erythrocyte metabolism, protein translation and
            induction of ribosomal stress.
REFERENCE   4  (bases 1 to 732)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   5  (bases 1 to 732)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 732)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   7  (bases 1 to 732)
  AUTHORS   Annilo,T., Laan,M., Stahl,J. and Metspalu,A.
  TITLE     The human ribosomal protein S7-encoding gene: isolation, structure
            and localization in 2p25
  JOURNAL   Gene 165 (2), 297-302 (1995)
   PUBMED   8522193
REFERENCE   8  (bases 1 to 732)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   9  (bases 1 to 732)
  AUTHORS   Mundus,D.A., Bulygin,K.N., Yamkovoy,V.I., Malygin,A.A.,
            Repkova,M.N., Vratskikh,L.V., Venijaminova,A.G., Vladimirov,S.N.
            and Karpova,G.G.
  TITLE     Structural arrangement of the codon-anticodon interaction area in
            human placenta ribosomes. Affinity labelling of the 40S subunits by
            derivatives of oligoribonucleotides containing the AUG codon
  JOURNAL   Biochim Biophys Acta 1173 (3), 273-282 (1993)
   PUBMED   8318536
REFERENCE   10 (bases 1 to 732)
  AUTHORS   Sieff,C.
  TITLE     Diamond-Blackfan Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BU963807.1, BC002866.2 and BF312642.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 11, 2018 this sequence version replaced NM_001011.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S7E family of ribosomal proteins. It is located in the
            cytoplasm. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK125944.1, SRR5189655.161158.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000645674.2/ ENSP00000496757.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BU963807.1         4-50
            48-731              BC002866.2         1-684
            732-732             BF312642.1         646-646
FEATURES             Location/Qualifiers
     source          1..732
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.3"
     gene            1..732
                     /gene="RPS7"
                     /gene_synonym="DBA8; eS7; S7"
                     /note="ribosomal protein S7"
                     /db_xref="GeneID:6201"
                     /db_xref="HGNC:HGNC:10440"
                     /db_xref="MIM:603658"
     exon            1..91
                     /gene="RPS7"
                     /gene_synonym="DBA8; eS7; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            92..184
                     /gene="RPS7"
                     /gene_synonym="DBA8; eS7; S7"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..694
                     /gene="RPS7"
                     /gene_synonym="DBA8; eS7; S7"
                     /EC_number="3.6.5.3"
                     /note="40S ribosomal protein S7"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS7"
                     /protein_id="NP_001002.1"
                     /db_xref="CCDS:CCDS1648.1"
                     /db_xref="GeneID:6201"
                     /db_xref="HGNC:HGNC:10440"
                     /db_xref="MIM:603658"
                     /translation="MFSSSAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELN
                     ITAAKEIEVGGGRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILP
                     KPTRKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDK
                     AQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQL"
     exon            185..256
                     /gene="RPS7"
                     /gene_synonym="DBA8; eS7; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            257..400
                     /gene="RPS7"
                     /gene_synonym="DBA8; eS7; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            401..465
                     /gene="RPS7"
                     /gene_synonym="DBA8; eS7; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            466..616
                     /gene="RPS7"
                     /gene_synonym="DBA8; eS7; S7"
                     /inference="alignment:Splign:2.1.0"
     exon            617..732
                     /gene="RPS7"
                     /gene_synonym="DBA8; eS7; S7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      708..713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS7"
                     /gene_synonym="DBA8; eS7; S7"
                     /note="hexamer: AATAAA"
     polyA_site      732
                     /gene="RPS7"
                     /gene_synonym="DBA8; eS7; S7"
                     /note="major polyA site"
ORIGIN      
        1 ctcgcgctgt ttccgcctct tgccttcgga cgccggattt tgacgtgctc tcgcgagatt
       61 tgggtctctt cctaagccgg cgctcggcaa gttctcccag gagaaagcca tgttcagttc
      121 gagcgccaag atcgtgaagc ccaatggcga gaagccggac gagttcgagt ccggcatctc
      181 ccaggctctt ctggagctgg agatgaactc ggacctcaag gctcagctca gggagctgaa
      241 tattacggca gctaaggaaa ttgaagttgg tggtggtcgg aaagctatca taatctttgt
      301 tcccgttcct caactgaaat ctttccagaa aatccaagtc cggctagtac gcgaattgga
      361 gaaaaagttc agtgggaagc atgtcgtctt tatcgctcag aggagaattc tgcctaagcc
      421 aactcgaaaa agccgtacaa aaaataagca aaagcgtccc aggagccgta ctctgacagc
      481 tgtgcacgat gccatccttg aggacttggt cttcccaagc gaaattgtgg gcaagagaat
      541 ccgcgtcaaa ctagatggca gccggctcat aaaggttcat ttggacaaag cacagcagaa
      601 caatgtggaa cacaaggttg aaactttttc tggtgtctat aagaagctca cgggcaagga
      661 tgttaatttt gaattcccag agtttcaatt gtaaacaaaa atgactaaat aaaaagtata
      721 tattcacagt ac
//
