LOCUS       NM_031464               5322 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ribosomal protein S6 kinase like 1 (RPS6KL1),
            transcript variant 2, mRNA.
ACCESSION   NM_031464 XM_024449718
VERSION     NM_031464.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5322)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5322)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   3  (bases 1 to 5322)
  AUTHORS   Manning,G., Whyte,D.B., Martinez,R., Hunter,T. and Sudarsanam,S.
  TITLE     The protein kinase complement of the human genome
  JOURNAL   Science 298 (5600), 1912-1934 (2002)
   PUBMED   12471243
  REMARK    GeneRIF: Identified as a pseudokinase and named RSKL2.
            Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006530.4 and AK299846.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Aug 6, 2019 this sequence version replaced
            XM_024449718.1, NM_031464.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853562.10405.1,
                                           SRR14038193.329918.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000557413.6/ ENSP00000450567.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC006530.4         73582-73662         c
            82-358              AC006530.4         72611-72887         c
            359-1207            AK299846.1         1-849
            1208-1208           AC006530.4         61715-61715         c
            1209-2289           AK299846.1         851-1931
            2290-5322           AC006530.4         54353-57385         c
FEATURES             Location/Qualifiers
     source          1..5322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..5322
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /note="ribosomal protein S6 kinase like 1"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
     exon            1..81
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /inference="alignment:Splign:2.1.0"
     exon            82..589
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /inference="alignment:Splign:2.1.0"
     exon            590..874
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             610..2259
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase-like 1 isoform 2"
                     /protein_id="NP_113652.2"
                     /db_xref="CCDS:CCDS9834.2"
                     /db_xref="GeneID:83694"
                     /db_xref="HGNC:HGNC:20222"
                     /translation="MSLVACECLPSPGLEPEPCSRARSQAHVYLEQIRNRVALGVPDM
                     TKRDYLVDAATQIRLALERDVSEDYEAAFNHYQNGVDVLLRGIHVDPNKERREAVKLK
                     ITKYLRRAEEIFNCHLQRPLSSGASPSAGFSSLRLRPIRTLSSAVEQLRGCRVVGVIE
                     KVQLVQDPATGGTFVVKSLPRCHMVSRERLTIIPHGVPYMTKLLRYFVSEDSIFLHLE
                     HVQGGTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNPHLNLLTPARLPSGHAPGQDRI
                     ALEPPRTSPNLLLAGEAPSTRPQREAEGEPTARTSTSGSSDLPKAPGGHLHLQARRAG
                     QNSDAGPPRGLTWVPEGAGPVLGGCGRGMDQSCLSADGAGRGCGRATWSVREEQVKQW
                     AAEMLVALEALHEQGVLCRDLHPGNLLLDQAGHIRLTYFGQWSEVEPQCCGEAVDNLY
                     SAPEVGGISELTEACDWWSFGSLLYELLTGMALSQSHPSGIQAHTQLQLPEWLSRPAA
                     SLLTELLQFEPTRRLGMGEGGVSKLKSHPFFSTIQWSKLVG"
     exon            875..999
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1092
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1140
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1273
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1879
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1969
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2052
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2148
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..5322
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3610..3615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /note="hexamer: AATAAA"
     polyA_site      3630
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /note="major polyA site"
     regulatory      4206..4211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /note="hexamer: ATTAAA"
     polyA_site      4226
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
     regulatory      5297..5302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
                     /note="hexamer: AATAAA"
     polyA_site      5322
                     /gene="RPS6KL1"
                     /gene_synonym="RSKL2"
ORIGIN      
        1 ggcccgcggc gcgctctggc gtgaagggcc ggtacgtgag ggggaggcct ggcccgcgga
       61 cccggctccc agctcgggca gttcttacag cccagctctg tgctctgctc tctgctggct
      121 ccaggagggg tcctcactcg ctgaccacac tgacctcagg accaagggaa caaaacacag
      181 caggggcaat ccatccggtc cacggagaag tgctaaaccc caaagggtaa atgagattcc
      241 cacaggagga gcagggagga gacaacaggc agggtggagg gaacagcatg aggaacagca
      301 tttgagccca gcgtgtgtgg cctccatgtg ctgaatgcgt actggatacc aagcttgctc
      361 tacggaggcc ctgtgaaggt ggctgtggat cacagatatc ctcagctctc tccagagctc
      421 aacacagtac cagatgctcc agaaatgttt gctgaactga atttgactgg aaaggaaaac
      481 agagccccag gcctgcgcgg tggctcacgt ctataatccc agcactgtgg gaggccgagg
      541 cagacggatc acttgaggtc aggagttcaa gaccagcctg gccaacatgg tcccagctgc
      601 agggcagcca tgagcctggt ggcctgtgag tgcctgccca gccccggcct ggagcctgag
      661 ccttgctcac gagcacggtc ccaagctcac gtgtacctgg agcagattcg caacagggtg
      721 gctctgggag tgcctgacat gacaaaacgt gactatctgg tggatgcggc cacgcagatc
      781 cggctggccc tggagcgcga tgttagtgag gactatgagg cggccttcaa ccactatcag
      841 aatggcgtgg acgtgctgct ccgtggcata cacgttgacc ccaacaagga gcgacgtgag
      901 gctgtgaagc tgaaaattac caaatacctg cggcgggcag aggagatctt caactgccac
      961 ctgcagcggc cgctgagcag tggagccagc cccagcgcgg gtttcagcag cctgaggctc
     1021 cggcccattc gcacgctgag ctctgccgtg gagcagctga ggggctgcag ggtggtcggg
     1081 gtcatcgaga aggtgcagct ggtccaggac ccggcaaccg gagggacctt tgtggtgaag
     1141 agcctaccca ggtgccacat ggtgagcagg gagcggctga ccatcatccc acacggagtc
     1201 ccctacatga cgaagctgct caggtacttt gtgagcgagg actccatctt cctgcacctg
     1261 gagcatgtgc aaggaggcac tctctggtcc cacctgctct cccaggcgca ctcccgacat
     1321 tctgggctca gctctggctc tacccaggag aggatgaagg ctcagctcaa cccccacctc
     1381 aacctcctga ccccagcgag gcttccctca ggccatgccc ctggccagga cagaatcgcc
     1441 ctggagcctc ctaggacttc tccgaacctt ctcctagctg gggaggcccc atccaccaga
     1501 ccccagaggg aggctgaagg tgaacccaca gccaggacca gcacctctgg ctcctcggac
     1561 cttccaaagg ccccaggtgg ccacctgcac cttcaagcta ggagggctgg ccagaactca
     1621 gacgctgggc cccctcgggg gctcacttgg gttcctgagg gggccggccc ggtgctaggg
     1681 ggctgtggcc gaggcatgga tcagagctgc ctgtcagcag atggggccgg ccggggctgt
     1741 ggcagggcca cctggagtgt gagagaggag caggtgaagc agtgggcggc agagatgctg
     1801 gtagcgctgg aggcgctgca cgagcagggg gtgctgtgcc gggacctcca ccccgggaac
     1861 ctgctcctgg accaggcagg tcacatccgg ctcacatatt ttggccagtg gtcagaggtg
     1921 gagccccagt gctgcgggga ggccgtggac aatctctaca gcgccccaga ggtgggtggg
     1981 atttccgagc tgacggaagc ctgtgactgg tggagctttg ggtctctact gtatgaactg
     2041 ctgacgggaa tggcactgtc ccagagccac ccttcaggaa tccaggccca cacccagctc
     2101 cagctgcccg agtggctcag tcgcccagcg gcctctctgc tgactgagct gctgcagttc
     2161 gagcctaccc ggcgcctggg catgggagaa ggtggtgtca gcaaactcaa gtcccatccc
     2221 tttttcagta ccatccaatg gagcaagctg gtggggtaag agggcagagc gggtgacgga
     2281 agcagctggc ctggtctgga tcgcctctcc tccttgcctg acacccaacc cagggctggc
     2341 cctctatcag cgggctttgg gcgaggaatg gagggcactg tctgtcctgc tgggctccca
     2401 ctggggcctc agaattatgg ccaccaccca ggaagggcca gctcctggaa aagctggagg
     2461 tgggggcagt caaggcttgc cctgctaagc agcttgaacc atctacccat cagtcaacag
     2521 acccgttgag catgtggact caccatgtta aaggttgcct tctgtggcac tggcgctgag
     2581 ctgttgacca cctgctgcac cctactgtga ggttctgtga ctcactcact gccatgttgt
     2641 gccccactca ggacatctct ggagactcat ctcaggacac tgatccactg gctcagtgga
     2701 cccaaaccag actgtcctgg ctagtcctct tagtcacaca gcgagtaggc ctcttccacc
     2761 agaagctgtt cgtgcagctg gggaggccca gaagcaggga tgccatctgt tgtgcaggga
     2821 gggatgaggt aggggacagg atgaccccca cccccacccc cccacccccg attcctgacc
     2881 atgcccccta tcttgtgatt tcagacttgg gagagcaaaa gggaggggaa gaaaataaga
     2941 gtaatggggg gaggaaggaa tgcatgggtc tgccccttag agcaagtctg aaaccagaat
     3001 caagagtcct cctccccagt gggcctgtgt gggggaagag gggcagcctg ccccaggggt
     3061 gcaagaggac agcaattcag cttccaggcc aaagcagttt agacaaggtg tgcccatcag
     3121 gactccctct caggccctgg ctgtttacca tgtcactgcc tactgtgact tcatgccctt
     3181 ttgggataag aaaccacaaa acgcatggaa caactatcca tggctcttag ccagaaatgt
     3241 cttgcctctg gtctctgaaa agctggggtg agtggttacc tcaaagacaa ttgcctccag
     3301 tttgggggct cctctcaggg ttcaccctgt caccggggcg tgggaccgac ctgggaaatt
     3361 tccactagag ttttgccctc agctcctccc tgccagcatc ccagtcacca ccaggtggcg
     3421 cttctgacac ggtccacgtg cctggctctg aaggcccaac tgtcagacca gacccctcac
     3481 tcatggtggg gagacttgac ttcctcgggc tcttcaggag actgagacag agaagacaag
     3541 tgaaagcgca gcctgtacat gactctctgt ggtccacgtc ctgcctctcc ctggggttta
     3601 cacggcccca ataaagcctg ctctggccta cggtgttctc gcttcttcca tgcaatgacc
     3661 acggctcatt ggggcaggtt ggaaggctcc cctgtagaag ctccagagtg aagtcaagag
     3721 cgagcttggg gctgccagga agtaggacgc agggctggtg gtgagcagca tgccatgtgg
     3781 gcctcagggg aaggggtggg gtcggggagg accaggttct gtggggaaga ggatgaagaa
     3841 gccttggaag aggctcatgg tgcctggggg aataccagtt tcatcctcac agtgacccct
     3901 tgcaacagac ggtagctcct gagaaaactg aagctcaaaa aggttaagga cacaacctag
     3961 ccagagttgc aagttagtgt tccttctgct actctcccta agtcaggctg gaccacttcc
     4021 aaccaccgct tcatgaagca caagtccctt ctggaacttc tgtgcttcat ccacccaaag
     4081 ctacacatct gacactttgt tgggccctga gtttagaata ctgtgggtcc cagctcttac
     4141 agtcgacctc ctttcgataa aatggggtaa ataatgccta ttttgcaggt ttaccagata
     4201 gataaattaa agcttctaac accaaatcct gttcttcctt tcattcaacc taatttgttt
     4261 ttctatctac tagagctcta gttctactct ctgggaccca cttccctcct gtgacagacc
     4321 ttcacagagg gatggcctca ctgcaagagc tcagcagaca gggactctgg aaaagacaag
     4381 gctgtgttta agcctggact ccatcacacc tgccacctgc agtctaggtt agctacccac
     4441 cctgtacact cacgctcact gaccactgct cctaggtcat caaccctcac ctgttcatgt
     4501 gtattgacct tgagcatctt ggtccacaag gctatcaaat ccaaatgaaa tgagatgccc
     4561 ccactcctcc caaatccatc actgaaataa tgtaagccca cacaaaaaat gcaagtctac
     4621 tggtgttttg aaagggcttc acaaagatgg tgaccccaaa ttctctattc tagagtatgg
     4681 cttgacaggc tcaaggaagg tggggcacta agagactatg atgctttatg gaaacaaaac
     4741 aaaaaacatc ctaagccccc caaccatctg tatggacccc tcgtctcagt caagggtatt
     4801 ccaaagttaa cctgaaacgc tagttcgggc catggtggga agagggagcc agccattcct
     4861 cattatactc ccctcccttt tggaattact gttaaaacag gctccttaag tctgatgaga
     4921 agcatttaca atctattttc tctgaagcct gctggctgga ggcttcatct gcataaaacc
     4981 ttggtctcca caacccctta ctgtaaccca gacattcctt tctattgatt ccaggtcttt
     5041 agataataac tctttcaacc aattgccaat cagaaaatct ttgattctgc ctatgacaac
     5101 atccccaggt cttgagctgt cctgcctctc cagaccaaac cactgtacat cttacatgta
     5161 ctgactggta tcttatgtct ccctaaaatg tattaaatgt ataaaactaa gttgtagcca
     5221 gacgaccctg gacacatgtt ctcaggatct cctaagagtt gtatcacagg ccatcagtca
     5281 ctcacacttg gctcagaata aatctcttca aatattttta ca
//
