LOCUS       NM_012424               5505 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribosomal protein S6 kinase C1 (RPS6KC1), transcript
            variant 1, mRNA.
ACCESSION   NM_012424 NM_058253
VERSION     NM_012424.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5505)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5505)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5505)
  AUTHORS   So,J., Pasculescu,A., Dai,A.Y., Williton,K., James,A., Nguyen,V.,
            Creixell,P., Schoof,E.M., Sinclair,J., Barrios-Rodiles,M., Gu,J.,
            Krizus,A., Williams,R., Olhovsky,M., Dennis,J.W., Wrana,J.L.,
            Linding,R., Jorgensen,C., Pawson,T. and Colwill,K.
  TITLE     Integrative analysis of kinase networks in TRAIL-induced apoptosis
            provides a source of potential targets for combination therapy
  JOURNAL   Sci Signal 8 (371), rs3 (2015)
   PUBMED   25852190
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5505)
  AUTHORS   Leparc,G.G. and Mitra,R.D.
  TITLE     Non-EST-based prediction of novel alternatively spliced cassette
            exons with cell signaling function in Caenorhabditis elegans and
            human
  JOURNAL   Nucleic Acids Res 35 (10), 3192-3202 (2007)
   PUBMED   17452356
REFERENCE   5  (bases 1 to 5505)
  AUTHORS   Liu,L., Yang,C., Yuan,J., Chen,X., Xu,J., Wei,Y., Yang,J., Lin,G.
            and Yu,L.
  TITLE     RPK118, a PX domain-containing protein, interacts with
            peroxiredoxin-3 through pseudo-kinase domains
  JOURNAL   Mol Cells 19 (1), 39-45 (2005)
   PUBMED   15750338
  REMARK    GeneRIF: findings indicate that RPK118 is a PRDX3-binding protein
            that may be involved in transporting PRDX3 from the cytoplasm to
            its mitochondrial site of function or to other membrane structures
            via endosome trafficking.
REFERENCE   6  (bases 1 to 5505)
  AUTHORS   Manning,G., Whyte,D.B., Martinez,R., Hunter,T. and Sudarsanam,S.
  TITLE     The protein kinase complement of the human genome
  JOURNAL   Science 298 (5600), 1912-1934 (2002)
   PUBMED   12471243
  REMARK    GeneRIF: Identified as a pseudokinase and named RSKL1
            Review article
REFERENCE   7  (bases 1 to 5505)
  AUTHORS   Hayashi,S., Okada,T., Igarashi,N., Fujita,T., Jahangeer,S. and
            Nakamura,S.
  TITLE     Identification and characterization of RPK118, a novel sphingosine
            kinase-1-binding protein
  JOURNAL   J Biol Chem 277 (36), 33319-33324 (2002)
   PUBMED   12077123
  REMARK    GeneRIF: cloning and characterization of RPK118 as a sphingosine
            kinase-1-binding protein
REFERENCE   8  (bases 1 to 5505)
  AUTHORS   Zhang,H., Yu,L., Mao,N., Fu,Q., Tu,Q., Gao,J. and Zhao,S.
  TITLE     Cloning, characterization, and chromosome mapping of RPS6KC1, a
            novel putative member of the ribosome protein S6 kinase family, to
            chromosome 12q12-q13.1
  JOURNAL   Genomics 61 (3), 314-318 (1999)
   PUBMED   10552933
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC323473.1, AK122989.1,
            AL645860.5, AL512449.6 and AL583826.16.
            
            On Nov 22, 2018 this sequence version replaced NM_012424.5.
            
            Summary: Sphingosine kinase catalyzes the formation of sphingosine
            1 phosphate, a lipid cellular messenger. The protein encoded by
            this gene can bind to sphingosine kinase and to
            phosphatidylinositol 3-phosphate, suggesting a role in sphingosine
            1 phophate signaling. The encoded protein can also bind to
            peroxiredoxin-3 and may help transport it to mitochondria.
            [provided by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122989.1, AF477978.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366960.8/ ENSP00000355927.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DC323473.1         9-13
            6-136               AK122989.1         1-131
            137-137             AL645860.5         11037-11037
            138-529             AK122989.1         133-524
            530-530             AL512449.6         39970-39970
            531-3984            AK122989.1         526-3979
            3985-5505           AL583826.16        33978-35498
FEATURES             Location/Qualifiers
     source          1..5505
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3"
     gene            1..5505
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /note="ribosomal protein S6 kinase C1"
                     /db_xref="GeneID:26750"
                     /db_xref="HGNC:HGNC:10439"
                     /db_xref="MIM:617517"
     exon            1..269
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..3365
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 1;
                     ribosomal protein S6 kinase delta-1; SPHK1-binding
                     protein; 52 kDa ribosomal protein S6 kinase; ribosomal S6
                     kinase-like protein with two PSK domains 118 kDa protein;
                     ribosomal protein S6 kinase, 52kDa, polypeptide 1"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase delta-1 isoform a"
                     /protein_id="NP_036556.2"
                     /db_xref="CCDS:CCDS1513.1"
                     /db_xref="GeneID:26750"
                     /db_xref="HGNC:HGNC:10439"
                     /db_xref="MIM:617517"
                     /translation="MTSYRERSADLARFYTVTEPQRHPRGYTVYKVTARVVSRRNPED
                     VQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGRFDETVIEERRQCA
                     EDLLQFSANIPALYNSKQLEDFFKGGIINDSSELIGPAEAHSDSLIDTFPECSTEGFS
                     SDSDLVSLTVDVDSLAELDDGMASNQNSPIRTFGLNLSSDSSALGAVASDSEQSKTEE
                     ERESRSLFPGSLKPKLGKRDYLEKAGELIKLALKKEEEDDYEAASDFYRKGVDLLLEG
                     VQGESSPTRREAVKRRTAEYLMRAESISSLYGKPQLDDVSQPPGSLSSRPLWNLRSPA
                     EELKAFRVLGVIDKVLLVMDTRTEQTFILKGLRKSSEYSRNRKTIIPRCVPNMVCLHK
                     YIISEESVFLVLQHAEGGKLWSYISKFLNRSPEESFDIKEVKKPTLAKVHLQQPTSSP
                     QDSSSFESRGSDGGSMLKALPLKSSLTPSSQDDSNQEDDGQDSSPKWPDSGSSSEEEC
                     TTSYLTLCNEYGQEKIEPGSLNEEPFMKTEGNGVDTKAIKSFPAHLAADSDSPSTQLR
                     AHELKFFPNDDPEAVSSPRTSDSLSRSKNSPMEFFRIDSKDSASELLGLDFGEKLYSL
                     KSEPLKPFFTLPDGDSASRSFNTSESKVEFKAQDTISRGSDDSVPVISFKDAAFDDVS
                     GTDEGRPDLLVNLPGELESTREAAAMGPTKFTQTNIGIIENKLLEAPDVLCLRLSTEQ
                     CQAHEEKGIEELSDPSGPKSYSITEKHYAQEDPRMLFVAAVDHSSSGDMSLLPSSDPK
                     FQGLGVVESAVTANNTEESLFRICSPLSGANEYIASTDTLKTEEVLLFTDQTDDLAKE
                     EPTSLFQRDSETKGESGLVLEGDKEIHQIFEDLDKKLALASRFYIPEGCIQRWAAEMV
                     VALDALHREGIVCRDLNPNNILLNDRGHIQLTYFSRWSEVEDSCDSDAIERMYCAPEV
                     GAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMPECVSEEARSLIQQ
                     LLQFNPLERLGAGVAGVEDIKSHPFFTPVDWAELMR"
     exon            270..305
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..426
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..542
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..636
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..999
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1115
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1208
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1256
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1389
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..2985
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3075
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3158
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3254
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..5505
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4176..4181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /note="hexamer: AATAAA"
     polyA_site      4196
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /note="major polyA site"
     regulatory      5319..5324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /note="hexamer: AATAAA"
     regulatory      5330..5335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /note="hexamer: GATAAA"
     polyA_site      5337
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
     polyA_site      5353
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
     regulatory      5486..5491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
                     /note="hexamer: CATAAA"
     polyA_site      5505
                     /gene="RPS6KC1"
                     /gene_synonym="humS6PKh1; RPK118; RSKL1; S6K-delta-1;
                     S6PKh1"
ORIGIN      
        1 gacccggaag cagagctgtg cagctgaggc gccgccgtgg agccgccttg gagccaccgc
       61 cccctcgccg cttcgccgct gcgttgggga acctggaccg cggcggcgcc gggtttccct
      121 catgatcccg ggcgggtggc ggcggcggca gaggcggcgg gaggatgacc tcttaccggg
      181 agcggagtgc cgacctggcc cgtttctaca ctgtcaccga gccccagcga cacccgaggg
      241 gctacacagt atataaggtc accgcccggg ttgtttcacg aagaaatcca gaggatgtcc
      301 aggagataat tgtatggaag agatacagtg attttaagaa actacacaaa gaactatggc
      361 aaattcacaa aaacttattc cgacattcag agttgtttcc tccatttgct aaaggaatag
      421 tgtttgggcg atttgatgaa actgttatcg aagagagaag acaatgtgct gaagacctgc
      481 tacagttctc tgccaatatt cctgctcttt acaatagtaa acagcttgaa gactttttca
      541 agggtggaat aattaatgat agttctgaat taattggtcc tgctgaagct cactcagatt
      601 ccctcattga tacctttcct gagtgtagta cggaaggctt ctccagtgac agtgatctgg
      661 tatctcttac tgttgatgtg gattctcttg ctgagttaga tgatggaatg gcttccaatc
      721 aaaattctcc cattagaact tttggtctca atctttcttc ggattcttca gcactagggg
      781 ctgttgcttc tgacagtgaa cagagcaaaa cagaagaaga acgggaaagt cgtagcctct
      841 ttcctggcag tttaaagccg aagcttggca agagagatta tttggagaaa gcaggagaat
      901 taataaagct ggctttaaaa aaggaagaag aagacgacta tgaagctgct tctgattttt
      961 ataggaaggg agttgattta ctcctagaag gtgttcaagg agagtcaagc cctacccgtc
     1021 gagaagctgt gaagagaaga acagccgagt acctcatgcg ggcagaaagt atctctagtc
     1081 tttatgggaa acctcagctt gatgatgtat ctcagcctcc aggatcacta agttcaaggc
     1141 ccctttggaa cctaaggagc cctgccgagg agctgaaggc cttcagagtc cttggggtga
     1201 ttgacaaggt tttacttgta atggacacaa ggacagaaca gactttcatt ttaaaaggtc
     1261 taaggaaaag cagtgaatac agcaggaaca gaaagaccat catcccccgc tgtgtgccca
     1321 acatggtgtg tctgcataag tacatcatct ctgaggagtc agtatttctt gtgctgcagc
     1381 atgcggaagg tggcaaactg tggtcatata tcagtaaatt tctaaacaga agtcctgaag
     1441 aaagctttga catcaaggaa gtgaaaaaac ctacacttgc aaaagttcac ctgcagcagc
     1501 caacttctag tcctcaggac agcagtagct ttgaatccag aggaagtgat ggtggaagca
     1561 tgcttaaagc tctgcctttg aagagtagtc ttactccaag ttctcaagat gacagcaacc
     1621 aggaagatga tggccaagat agctctccaa agtggccaga ttctggttca agttcagaag
     1681 aagaatgtac tactagttat ttaacattat gcaatgaata tgggcaagaa aagattgaac
     1741 cagggtcttt gaatgaggag cccttcatga agactgaagg gaatggtgtt gatacaaaag
     1801 ctattaaaag cttcccagca caccttgctg ctgacagtga cagccccagc acacagctga
     1861 gagctcacga gctgaagttc ttccccaacg atgacccaga agcagttagt tctccaagaa
     1921 catcagattc cctcagtaga tcaaaaaata gccccatgga attctttagg atagacagta
     1981 aggatagcgc aagtgaactc ctgggacttg actttggaga aaaattgtat agtctaaaat
     2041 cagaaccttt gaaaccattc tttactcttc cagatggaga cagtgcttct aggagtttta
     2101 atactagtga aagcaaggta gagtttaaag ctcaggacac cattagcagg ggctcagatg
     2161 actcagtgcc agttatttca tttaaagatg ctgcttttga tgatgtcagt ggtactgatg
     2221 aaggaagacc tgatcttctt gtaaatttac ctggtgaatt ggagtcaaca agagaagctg
     2281 cagcaatggg acctactaag tttacacaaa ctaatatagg gataatagaa aataaactct
     2341 tggaagcccc tgatgtttta tgcctcaggc ttagtactga acaatgccaa gcacatgagg
     2401 agaaaggcat agaggaactg agtgatccct ctgggcccaa atcctatagt ataacagaga
     2461 aacactatgc acaggaggat cccaggatgt tatttgtagc agctgttgat catagtagtt
     2521 caggagatat gtctttgtta cccagctcag atcctaagtt tcaaggactt ggagtggttg
     2581 agtcagcagt aactgcaaac aacacagaag aaagcttatt ccgtatttgt agtccactct
     2641 caggtgctaa tgaatatatt gcaagcacag acactttaaa aacagaagaa gtattgctgt
     2701 ttacagatca gactgatgat ttggctaaag aggaaccaac ttctttattc cagagagact
     2761 ctgagactaa gggtgaaagt ggtttagtgc tagaaggaga caaggaaata catcagattt
     2821 ttgaggacct tgataaaaaa ttagcactag cctccaggtt ttacatccca gagggctgca
     2881 ttcaaagatg ggcagctgaa atggtggtag cccttgatgc tttacataga gagggaattg
     2941 tgtgccgcga tttgaaccca aacaacatct tattgaatga tagaggacac attcagctaa
     3001 cgtattttag caggtggagt gaggttgaag attcctgtga cagcgatgcc atagagagaa
     3061 tgtactgtgc cccagaggtt ggagcaatca ctgaagaaac tgaagcctgt gattggtgga
     3121 gtttgggtgc tgtcctcttt gaacttctca ctggcaagac tctggttgaa tgccatccag
     3181 caggaataaa tactcacact actttgaaca tgccagaatg tgtctctgaa gaggctcgct
     3241 cactcattca acagctcttg cagttcaatc ctctggaacg acttggtgct ggagttgctg
     3301 gtgttgaaga tatcaaatct catccatttt ttacccctgt ggattgggca gaactgatga
     3361 gatgaacgta atgcagggtt atcttcacac attctgatct tctctgtgac aggcatctcc
     3421 agcactgagg cacctctgac tcacagttac ttatggagca ccaaagcatt tggataaaga
     3481 ccgttatagg aaatgggggg gaaatggcta aaagagaaca attcgtttac aattacaaga
     3541 tattagctaa ttgtgccagg ggctgttata tacatatata cacaaccaag gtgtgatctg
     3601 aatttaatcc acatttggtg ttgcagatga gttgtaaagc caactgaaag agttccttca
     3661 agaagttcct ctgataggaa gctagaagtg tagaatgaag ttttacttga cagaaggacc
     3721 tttacatggc agctaacagt gctttttgct gaccaggatt ggtttatatg attaaattaa
     3781 tatttgctta ataatacact aaaagtatat gaacaatgtc atcaatgaaa cttaaaagcg
     3841 agaaaaaaga atatacacat aatttctgac ggaaaacctg taccctgatg ctgtataatg
     3901 tatgttgaat gtggtcccag attatttctg taagaagaca ctccatgttg tcagctttgt
     3961 actctttgtt gatactgctt atttagagaa gggttcatat aaacactcac tctgtgtctt
     4021 caacagcatc tttctttccc catctttcta ttttctgcac cctctgcttg ttccctcata
     4081 ttctgttctt ccgactcctg ctaacacaca tgcaacaaaa aagggaaggg agtgcttatt
     4141 tccctttgtg taaggactaa gaaatcatga tatcaaataa acatggtgaa acattagatc
     4201 tcttcttcat ttaataaccc tccccccttt ttttccttga agaaatgcgt ctgttccttt
     4261 ccttgtgaaa tattatcagt ttctaccatt gcttctcatg cttgactttg ttttactttt
     4321 tggcttggta tactaagaag caaaggatct catctaaatg gaattgaatg gcagtcctag
     4381 tttgttactt atggtgatga gattttcaga tttgaactaa tctatttgac gtgatttaga
     4441 aagaatgtaa gtattcacac atctccaaac atttgtattt gttacttctt tttgttgcta
     4501 aggtagctcc tgtagttatg cattgttgca aaaatttaca aatgttttaa aagtgttaac
     4561 atctgttttt ttttaaacgt tagccaaaga agaagtcact atttccaagt tagaaaccac
     4621 cagaaataat tgaaattttt gatatgttct aatcttcttt gcatttttga gatctgtgtg
     4681 agagcccaac cccactccag gagcatctgt acagcttcca tctgccatcg accaggtcct
     4741 ctcatcaaat taaatggaac agaaaatgct ctagtgaaac aaaggaaatg tgcaagcatt
     4801 tttccttttt ctattattct atttcccttt ttcctttttg gcccccttat aatccaaacc
     4861 ccagctgaaa ggctgcaaca acaccaggtt ggggagcagg tcaccaggat catagttcag
     4921 tcaaaatgac atcactccct ggaactagat ttcaactcac tagtcccctg gcctcataac
     4981 aggaacttat gcaggtgaga cacaagaatg acttcctgtg taggactagt aggaaatctg
     5041 caagtactta gagctggcca ttacagaact tccttccaga agtgccctgt gacatgaaag
     5101 taggacttca caactaaggt gaagatccct gccctaccac atgatttgag tctcttggat
     5161 tcaaaggaca ttaatgtcaa cagatggttg ccatgtcagt ctgttgacac aattccattg
     5221 cttcagtttc tccccttttc tctctatatg tttggttgga gcttgtgcct aatgtaaata
     5281 catcattcat aattagaatg gacattaatt attttagtaa taaacacagg ataaatagct
     5341 ttggggtgat gaaccagagt ctgtttttat tttatggtgt gtacatattt taagctgtac
     5401 ttctgtgaat ggtactgatt tttgtggttg tttttttttt atattttgtt tgtttaagca
     5461 gaagagtgga atatggggtc aaaatcataa aagaagttgc catga
//
