LOCUS       NM_003952               1733 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ribosomal protein S6 kinase B2 (RPS6KB2), mRNA.
ACCESSION   NM_003952
VERSION     NM_003952.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1733)
  AUTHORS   Ma,Q., Yang,Y., Chen,S., Cheng,H., Gong,P. and Hao,J.
  TITLE     Ribosomal protein S6 kinase 2 (RPS6KB2) is a potential
            immunotherapeutic target for cancer that upregulates
            proinflammatory cytokines
  JOURNAL   Mol Biol Rep 51 (1), 229 (2024)
   PUBMED   38281249
  REMARK    GeneRIF: Ribosomal protein S6 kinase 2 (RPS6KB2) is a potential
            immunotherapeutic target for cancer that upregulates
            proinflammatory cytokines.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1733)
  AUTHORS   Awah,C.U., Winter,J., Mazdoom,C.M. and Ogunwobi,O.O.
  TITLE     NSUN6, an RNA methyltransferase of 5-mC controls glioblastoma
            response to temozolomide (TMZ) via NELFB and RPS6KB2 interaction
  JOURNAL   Cancer Biol Ther 22 (10-12), 587-597 (2021)
   PUBMED   34705606
  REMARK    GeneRIF: NSUN6, an RNA methyltransferase of 5-mC controls
            glioblastoma response to temozolomide (TMZ) via NELFB and RPS6KB2
            interaction.
REFERENCE   3  (bases 1 to 1733)
  AUTHORS   Sahni,A., Narra,H.P. and Sahni,S.K.
  TITLE     Activation of Mechanistic Target of Rapamycin (mTOR) in Human
            Endothelial Cells Infected with Pathogenic Spotted Fever Group
            Rickettsiae
  JOURNAL   Int J Mol Sci 21 (19), 7179 (2020)
   PUBMED   33003310
  REMARK    GeneRIF: Activation of Mechanistic Target of Rapamycin (mTOR) in
            Human Endothelial Cells Infected with Pathogenic Spotted Fever
            Group Rickettsiae.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1733)
  AUTHORS   Chen,J., Zhou,X., Yang,J., Sun,Q., Liu,Y., Li,N., Zhang,Z. and
            Xu,H.
  TITLE     Circ-GLI1 promotes metastasis in melanoma through interacting with
            p70S6K2 to activate Hedgehog/GLI1 and Wnt/beta-catenin pathways and
            upregulate Cyr61
  JOURNAL   Cell Death Dis 11 (7), 596 (2020)
   PUBMED   32732916
  REMARK    GeneRIF: Circ-GLI1 promotes metastasis in melanoma through
            interacting with p70S6K2 to activate Hedgehog/GLI1 and
            Wnt/beta-catenin pathways and upregulate Cyr61.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1733)
  AUTHORS   Sridharan,S. and Basu,A.
  TITLE     Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer
  JOURNAL   Int J Mol Sci 21 (4), 1199 (2020)
   PUBMED   32054043
  REMARK    GeneRIF: Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast
            Cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1733)
  AUTHORS   Martin,K.A., Schalm,S.S., Richardson,C., Romanelli,A., Keon,K.L.
            and Blenis,J.
  TITLE     Regulation of ribosomal S6 kinase 2 by effectors of the
            phosphoinositide 3-kinase pathway
  JOURNAL   J Biol Chem 276 (11), 7884-7891 (2001)
   PUBMED   11108711
REFERENCE   7  (bases 1 to 1733)
  AUTHORS   Koh,H., Jee,K., Lee,B., Kim,J., Kim,D., Yun,Y.H., Kim,J.W.,
            Choi,H.S. and Chung,J.
  TITLE     Cloning and characterization of a nuclear S6 kinase, S6
            kinase-related kinase (SRK); a novel nuclear target of Akt
  JOURNAL   Oncogene 18 (36), 5115-5119 (1999)
   PUBMED   10490848
REFERENCE   8  (bases 1 to 1733)
  AUTHORS   Lee-Fruman,K.K., Kuo,C.J., Lippincott,J., Terada,N. and Blenis,J.
  TITLE     Characterization of S6K2, a novel kinase homologous to S6K1
  JOURNAL   Oncogene 18 (36), 5108-5114 (1999)
   PUBMED   10490847
REFERENCE   9  (bases 1 to 1733)
  AUTHORS   Saitoh,M., ten Dijke,P., Miyazono,K. and Ichijo,H.
  TITLE     Cloning and characterization of p70(S6K beta) defines a novel
            family of p70 S6 kinases
  JOURNAL   Biochem Biophys Res Commun 253 (2), 470-476 (1998)
   PUBMED   9878560
REFERENCE   10 (bases 1 to 1733)
  AUTHORS   Gout,I., Minami,T., Hara,K., Tsujishita,Y., Filonenko,V.,
            Waterfield,M.D. and Yonezawa,K.
  TITLE     Molecular cloning and characterization of a novel p70 S6 kinase,
            p70 S6 kinase beta containing a proline-rich region
  JOURNAL   J Biol Chem 273 (46), 30061-30064 (1998)
   PUBMED   9804755
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX337895.2, AP003419.3,
            AB019245.1 and BX538119.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003952.2.
            
            Summary: This gene encodes a member of the RSK (ribosomal S6
            kinase) family of serine/threonine kinases. This kinase contains a
            kinase catalytic domain and phosphorylates the S6 ribosomal protein
            and eukaryotic translation initiation factor 4B (eIF4B).
            Phosphorylation of S6 leads to an increase in protein synthesis and
            cell proliferation. [provided by RefSeq, Jan 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000094.2, SRR1163658.172480.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312629.10/ ENSP00000308413.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BX337895.2         35-56
            23-130              AP003419.3         108981-109088
            131-171             AP003419.3         109447-109487
            172-292             AP003419.3         109585-109705
            293-361             AP003419.3         109992-110060
            362-509             AP003419.3         111833-111980
            510-567             AP003419.3         113065-113122
            568-668             AP003419.3         113202-113302
            669-759             AP003419.3         113417-113507
            760-850             AP003419.3         113591-113681
            851-857             AP003419.3         113805-113811
            858-860             AB019245.1         855-857
            861-958             AP003419.3         113815-113912
            959-1021            AP003419.3         114460-114522
            1022-1099           AP003419.3         114663-114740
            1100-1207           AP003419.3         114842-114949
            1208-1309           AP003419.3         115047-115148
            1310-1312           AB019245.1         1307-1309
            1313-1320           AP003419.3         115152-115159
            1321-1686           AP003419.3         115454-115819
            1687-1733           BX538119.1         872-918
FEATURES             Location/Qualifiers
     source          1..1733
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..1733
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /note="ribosomal protein S6 kinase B2"
                     /db_xref="GeneID:6199"
                     /db_xref="HGNC:HGNC:10437"
                     /db_xref="MIM:608939"
     exon            1..130
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1501
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /EC_number="2.7.11.1"
                     /note="p70 ribosomal S6 kinase beta; S6 kinase-related
                     kinase; serine/threonine-protein kinase 14 beta; p70 S6KB;
                     p70-S6K 2; S6K-beta-2; p70 S6K-beta; p70 S6 kinase beta;
                     serine/threonine-protein kinase 14B; 70 kDa ribosomal
                     protein S6 kinase 2; P70S6K2; ribosomal protein S6 kinase,
                     70kDa, polypeptide 2"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase beta-2"
                     /protein_id="NP_003943.2"
                     /db_xref="CCDS:CCDS41677.1"
                     /db_xref="GeneID:6199"
                     /db_xref="HGNC:HGNC:10437"
                     /db_xref="MIM:608939"
                     /translation="MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGH
                     YEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLR
                     KAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHL
                     EREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKE
                     SIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKK
                     TMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWD
                     DLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAP
                     SVLDSIKEGFSFQPKLRSPRRLNSSPRAPVSPLKFSPFEGFRPSPSLPEPTELPLPPL
                     LPPPPPSTTAPLPIRPPSGTKKSKRGRGRPGR"
     exon            131..171
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /inference="alignment:Splign:2.1.0"
     exon            172..292
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /inference="alignment:Splign:2.1.0"
     exon            293..361
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /inference="alignment:Splign:2.1.0"
     exon            362..509
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /inference="alignment:Splign:2.1.0"
     exon            510..567
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /inference="alignment:Splign:2.1.0"
     exon            568..668
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /inference="alignment:Splign:2.1.0"
     exon            669..759
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /inference="alignment:Splign:2.1.0"
     exon            760..850
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /inference="alignment:Splign:2.1.0"
     exon            851..958
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1021
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1099
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1207
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1320
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1733
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1715..1720
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /note="hexamer: ATTAAA"
     polyA_site      1733
                     /gene="RPS6KB2"
                     /gene_synonym="KLS; p70(S6K)-beta; P70-beta; P70-beta-1;
                     P70-beta-2; p70S6Kb; S6K-beta2; S6K2; S6KB; S6Kbeta;
                     S6KI(2); SRK; STK14B"
                     /note="major polyA site"
ORIGIN      
        1 agtcagtgcg cggccaggta cgggccgacg ggcccgcggg gccggcgccg ccatggcggc
       61 cgtgtttgat ttggatttgg agacggagga aggcagcgag ggcgagggcg agccagagct
      121 cagccccgcg gacgcatgtc cccttgccga gttgagggca gctggcctag agcctgtggg
      181 acactatgaa gaggtggagc tgactgagac cagcgtgaac gttggcccag agcgcatcgg
      241 gccccactgc tttgagctgc tgcgtgtgct gggcaagggg ggctatggca aggtgttcca
      301 ggtgcgaaag gtgcaaggca ccaacttggg caaaatatat gccatgaaag tcctaaggaa
      361 ggccaaaatt gtgcgcaatg ccaaggacac agcacacaca cgggctgagc ggaacattct
      421 agagtcagtg aagcacccct ttattgtgga actggcctat gccttccaga ctggtggcaa
      481 actctacctc atccttgagt gcctcagtgg tggcgagctc ttcacgcatc tggagcgaga
      541 gggcatcttc ctggaagata cggcctgctt ctacctggct gagatcacgc tggccctggg
      601 ccatctccac tcccagggca tcatctaccg ggacctcaag cccgagaaca tcatgctcag
      661 cagccagggc cacatcaaac tgaccgactt tggactctgc aaggagtcta tccatgaggg
      721 cgccgtcact cacaccttct gcggcaccat tgagtacatg gcccctgaga ttctggtgcg
      781 cagtggccac aaccgggctg tggactggtg gagcctgggg gccctgatgt acgacatgct
      841 cactggatcg ccgcccttca ccgcagagaa ccggaagaaa accatggata agatcatcag
      901 gggcaagctg gcactgcccc cctacctcac cccagatgcc cgggaccttg tcaaaaagtt
      961 tctgaaacgg aatcccagcc agcggattgg gggtggccca ggggatgctg ctgatgtgca
     1021 gagacatccc tttttccggc acatgaattg ggacgacctt ctggcctggc gtgtggaccc
     1081 ccctttcagg ccctgtctgc agtcagagga ggacgtgagc cagtttgata cccgcttcac
     1141 acggcagacg ccggtggaca gtcctgatga cacagccctc agcgagagtg ccaaccaggc
     1201 cttcctgggc ttcacatacg tggcgccgtc tgtcctggac agcatcaagg agggcttctc
     1261 cttccagccc aagctgcgct cacccaggcg cctcaacagt agcccccggg cccccgtcag
     1321 ccccctcaag ttctcccctt ttgaggggtt tcggcccagc cccagcctgc cggagcccac
     1381 ggagctacct ctacctccac tcctgccacc gccgccgccc tcgaccaccg cccctctccc
     1441 catccgtccc ccctcaggga ccaagaagtc caagaggggc cgtgggcgtc cagggcgcta
     1501 ggaagccggg tgggggtgag ggtagccctt gagccctgtc cctgcggctg tgagagcagc
     1561 aggaccctgg gccagttcca gagacctggg ggtgtgtctg ggggtggggt gtgagtgcgt
     1621 atgaaagtgt gtgtctgctg gggcagctgt gcccctgaat catgggcacg gagggccgcc
     1681 cgccacgccc cgcgctcaac tgctcccgtg gaagattaaa gggctgaatc atg
//
