LOCUS       NM_001369671            5188 bp    mRNA    linear   PRI 22-MAR-2025
DEFINITION  Homo sapiens ribosomal protein S6 kinase B1 (RPS6KB1), transcript
            variant 7, mRNA.
ACCESSION   NM_001369671
VERSION     NM_001369671.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5188)
  AUTHORS   Huang,Y., Yue,S., Yan,Z., Liu,Y., Qiao,J., Zhang,M., Dong,Y. and
            Zheng,J.
  TITLE     Lactate-upregulated ARG2 expression induces cellular senescence in
            fibroblast-like synoviocytes of osteoarthritis via activating the
            mTOR/S6K1 signaling pathway
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113071 (2024)
   PUBMED   39236462
  REMARK    GeneRIF: Lactate-upregulated ARG2 expression induces cellular
            senescence in fibroblast-like synoviocytes of osteoarthritis via
            activating the mTOR/S6K1 signaling pathway.
REFERENCE   2  (bases 1 to 5188)
  AUTHORS   Ru,J., Lu,J., Ge,J., Ding,B., Su,R., Jiang,Y., Sun,Y., Ma,J.,
            Li,Y., Sun,J., Xu,G., Tong,R., Zheng,S., Yang,B. and Wu,J.
  TITLE     IRGM is a novel regulator of PD-L1 via promoting S6K1-mediated
            phosphorylation of YBX1 in hepatocellular carcinoma
  JOURNAL   Cancer Lett 581, 216495 (2024)
   PUBMED   37993085
  REMARK    GeneRIF: IRGM is a novel regulator of PD-L1 via promoting
            S6K1-mediated phosphorylation of YBX1 in hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 5188)
  AUTHORS   Ben-Hur,V., Denichenko,P., Siegfried,Z., Maimon,A., Krainer,A.,
            Davidson,B. and Karni,R.
  TITLE     S6K1 alternative splicing modulates its oncogenic activity and
            regulates mTORC1
  JOURNAL   Cell Rep 3 (1), 103-115 (2013)
   PUBMED   23273915
  REMARK    GeneRIF: alternative splicing of S6K1 acts as a molecular switch in
            breast cancer cells, elevating oncogenic isoforms that activate
            mTORC1.
REFERENCE   4  (bases 1 to 5188)
  AUTHORS   Rosner,M. and Hengstschlager,M.
  TITLE     Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms
            p85 and p31, is regulated by TSC2/mTOR
  JOURNAL   Oncogene 30 (44), 4509-4522 (2011)
   PUBMED   21602892
REFERENCE   5  (bases 1 to 5188)
  AUTHORS   Fenton,T.R. and Gout,I.T.
  TITLE     Functions and regulation of the 70kDa ribosomal S6 kinases
  JOURNAL   Int J Biochem Cell Biol 43 (1), 47-59 (2011)
   PUBMED   20932932
  REMARK    GeneRIF: Dysregulation of S6 kinases contributes to the
            pathogenesis of human diseases.
            Review article
REFERENCE   6  (bases 1 to 5188)
  AUTHORS   Karni,R., de Stanchina,E., Lowe,S.W., Sinha,R., Mu,D. and
            Krainer,A.R.
  TITLE     The gene encoding the splicing factor SF2/ASF is a proto-oncogene
  JOURNAL   Nat Struct Mol Biol 14 (3), 185-193 (2007)
   PUBMED   17310252
REFERENCE   7  (bases 1 to 5188)
  AUTHORS   Couch,F.J., Wang,X.Y., Wu,G.J., Qian,J., Jenkins,R.B. and
            James,C.D.
  TITLE     Localization of PS6K to chromosomal region 17q23 and determination
            of its amplification in breast cancer
  JOURNAL   Cancer Res 59 (7), 1408-1411 (1999)
   PUBMED   10197603
REFERENCE   8  (bases 1 to 5188)
  AUTHORS   Moser,B.A., Dennis,P.B., Pullen,N., Pearson,R.B., Williamson,N.A.,
            Wettenhall,R.E., Kozma,S.C. and Thomas,G.
  TITLE     Dual requirement for a newly identified phosphorylation site in
            p70s6k
  JOURNAL   Mol Cell Biol 17 (9), 5648-5655 (1997)
   PUBMED   9271440
REFERENCE   9  (bases 1 to 5188)
  AUTHORS   Proud,C.G.
  TITLE     p70 S6 kinase: an enigma with variations
  JOURNAL   Trends Biochem Sci 21 (5), 181-185 (1996)
   PUBMED   8871403
  REMARK    Review article
REFERENCE   10 (bases 1 to 5188)
  AUTHORS   Grove,J.R., Banerjee,P., Balasubramanyam,A., Coffer,P.J.,
            Price,D.J., Avruch,J. and Woodgett,J.R.
  TITLE     Cloning and expression of two human p70 S6 kinase polypeptides
            differing only at their amino termini
  JOURNAL   Mol Cell Biol 11 (11), 5541-5550 (1991)
   PUBMED   1922062
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004686.2.
            
            Summary: This gene encodes a member of the ribosomal S6 kinase
            family of serine/threonine kinases. The encoded protein responds to
            mTOR (mammalian target of rapamycin) signaling to promote protein
            synthesis, cell growth, and cell proliferation. Activity of this
            gene has been associated with human cancer. Alternatively spliced
            transcript variants have been observed. The use of alternative
            translation start sites results in isoforms with longer or shorter
            N-termini which may differ in their subcellular localizations.
            There are two pseudogenes for this gene on chromosome 17. [provided
            by RefSeq, Jan 2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.251252.1,
                                           SRR14038194.2048722.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146, SAMN03267782
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC004686.2         61945-62149         c
            206-353             AC004686.2         28688-28835         c
            354-411             AC004686.2         25096-25153         c
            412-512             AC004686.2         23548-23648         c
            513-603             AC004686.2         21010-21100         c
            604-694             AC004686.2         20746-20836         c
            695-802             AC004686.2         19970-20077         c
            803-865             AC004686.2         18993-19055         c
            866-943             AC004686.2         18729-18806         c
            944-1051            AC004686.2         14327-14434         c
            1052-1164           AC004686.2         9752-9864           c
            1165-5188           AC004686.2         4696-8719           c
FEATURES             Location/Qualifiers
     source          1..5188
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.1"
     gene            1..5188
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /note="ribosomal protein S6 kinase B1"
                     /db_xref="GeneID:6198"
                     /db_xref="HGNC:HGNC:10436"
                     /db_xref="MIM:608938"
     exon            1..205
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1402
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /EC_number="2.7.11.1"
                     /note="isoform h is encoded by transcript variant 7;
                     serine/threonine kinase 14 alpha; ribosomal protein S6
                     kinase beta-1; ribosomal protein S6 kinase I;
                     serine/threonine-protein kinase 14A; ribosomal protein S6
                     kinase, 70kDa, polypeptide 1"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase beta-1 isoform h"
                     /protein_id="NP_001356600.1"
                     /db_xref="GeneID:6198"
                     /db_xref="HGNC:HGNC:10436"
                     /db_xref="MIM:608938"
                     /translation="MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEDEL
                     EEGAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFM
                     QLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC
                     KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENR
                     KKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHIN
                     WEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYV
                     APSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPV
                     EYPMETSGIEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL"
     exon            206..353
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:2.1.0"
     exon            354..411
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:2.1.0"
     exon            412..512
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:2.1.0"
     exon            513..603
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:2.1.0"
     exon            604..694
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:2.1.0"
     exon            695..802
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:2.1.0"
     exon            803..865
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:2.1.0"
     exon            866..943
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1051
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1164
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..5188
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1511..1516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /note="hexamer: ATTACA"
     polyA_site      1541
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /note="major polyA site"
     regulatory      5013..5018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /note="hexamer: ATTAAA"
     polyA_site      5034
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /note="major polyA site"
     regulatory      5157..5162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
                     /note="hexamer: AATAAA"
     polyA_site      5188
                     /gene="RPS6KB1"
                     /gene_synonym="p70 S6KA; p70(S6K)-alpha; p70-alpha;
                     p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A"
ORIGIN      
        1 gcactgagcc taagcagccg gtgatggcgg cagcggctgt ggtggctgcg gcgggtccgg
       61 gcccatgagg cgacgaagga ggcgggacgg cttttaccca gccccggact tccgagacag
      121 ggaagctgag gacatggcag gagtgtttga catagacctg gaccagccag aggacgcggg
      181 ctctgaggat gagctggagg agggggcaat gatagtaaga aatgctaaag atacagctca
      241 tacaaaagca gaacggaata ttctggagga agtaaagcat cccttcatcg tggatttaat
      301 ttatgccttt cagactggtg gaaaactcta cctcatcctt gagtatctca gtggaggaga
      361 actatttatg cagttagaaa gagagggaat atttatggaa gacactgcct gcttttactt
      421 ggcagaaatc tccatggctt tggggcattt acatcaaaag gggatcatct acagagacct
      481 gaagccggag aatatcatgc ttaatcacca aggtcatgtg aaactaacag actttggact
      541 atgcaaagaa tctattcatg atggaacagt cacacacaca ttttgtggaa caatagaata
      601 catggcccct gaaatcttga tgagaagtgg ccacaatcgt gctgtggatt ggtggagttt
      661 gggagcatta atgtatgaca tgctgactgg agcaccccca ttcactgggg agaatagaaa
      721 gaaaacaatt gacaaaatcc tcaaatgtaa actcaatttg cctccctacc tcacacaaga
      781 agccagagat ctgcttaaaa agctgctgaa aagaaatgct gcttctcgtc tgggagctgg
      841 tcctggggac gctggagaag ttcaagctca tccattcttt agacacatta actgggaaga
      901 acttctggct cgaaaggtgg agcccccctt taaacctctg ttgcaatctg aagaggatgt
      961 aagtcagttt gattccaagt ttacacgtca gacacctgtc gacagcccag atgactcaac
     1021 tctcagtgaa agtgccaatc aggtctttct gggttttaca tatgtggctc catctgtact
     1081 tgaaagtgtg aaagaaaagt tttcctttga accaaaaatc cgatcacctc gaagatttat
     1141 tggcagccca cgaacacctg tcagcccagt caaattttct cctggggatt tctggggaag
     1201 aggtgcttcg gccagcacag caaatcctca gacacctgtg gaatacccaa tggaaacaag
     1261 tggcatagag cagatggatg tgacaatgag tggggaagca tcggcaccac ttccaatacg
     1321 acagccgaac tctgggccat acaaaaaaca agcttttccc atgatctcca aacggccaga
     1381 gcacctgcgt atgaatctat gacagagcaa tgcttttaat gaatttaagg caaaaaaggt
     1441 ggagagggag atgtgtgagc atcctgcaag gtgaaacgac tcaaaatgac agtttcagag
     1501 agtcaatgtc attacataga acacttcaga cacaggaaaa ataaacgtgg attttaaaaa
     1561 atcaatcaat ggtgcaaaaa aaaacttaaa gcaaaatagt attgctgaac tcttaggcac
     1621 atcaattaat tgattcctcg cgacatcttc tcaaccttat caaggatttt catgttgatg
     1681 actcgaaact gacagtatta agggtaggat gttgcttctg aatcactgtt gagttctgat
     1741 tgtgttgaag aagggttatc ctttcattag gcaaagtaca aaattgccta taatacttgc
     1801 aactaaggac aaattagcat gcaagcttgg tcaaactttt tccagcaaaa tggaagcaaa
     1861 gacaaaagaa acttaccaat tgatgtttta cgtgcaaaca acctgaatct tttttttata
     1921 taaatatata tttttcaaat agatttttga ttcagctcat tatgaaaaac atcccaaact
     1981 ttaaaatgcg aaattattgg ttggtgtgaa gaaagccaga caacttctgt ttcttctctt
     2041 ggtgaaataa taaaatgcaa atgaatcatt gttaaccaca gctgtggctc gtttgaggga
     2101 ttggggtgga cctggggttt attttcagta acccagctgc aatacctgtc tgtaatatga
     2161 gaaaaaaaaa atgaatctat ttaatcattt ctacttgcag tactgctatg tgctaagctt
     2221 aactggaagc cttggaatgg gcataagttg tatgtcctac atttcatcat tgtcccgggc
     2281 ctgcattgca ctggaaaaaa aaatcgccac ctgttcttac accagtattt ggttcaagac
     2341 accaaatgtc ttcagcccat ggctgaagaa caacagaaga gagtcaggat aaaaaataca
     2401 tactgtggtc ggcaaggtga gggagatagg gatatccagg ggaagagggt gttgctgtgg
     2461 cccactctct gtctaatctc tttacagcaa attggtaaga ttttcagttt tacttctttc
     2521 tactgtttct gctgtctacc ttccttatat ttttttcctc aacagtttta aaaagaaaaa
     2581 aaggtctatt tttttttctc ctatacttgg gctacatttt ttgattgtaa aaatatttga
     2641 tggccttttg atgaatgtct tccacagtaa agaaaactta gtggcttaat ttaggaaaca
     2701 tgttaacagg acactatgtt tttgaaattg taacaaaatc tacataaatg atttacaggt
     2761 taaaagaata aaaataaagg taactttacc tttcttaaat atttcctgcc ttaaagagag
     2821 catttccatg actttagctg gtgaaagggt ttaatatctg cagagcttta taaaaatata
     2881 tttcagtgca tactggtata atagatgatc atgcagttgc agttgagttg tatcaccttt
     2941 tttgtttgtc ttttataatg tcttcagtct gagtgtgcaa agtcaatttg taatattttg
     3001 caaccctagg atttttttaa atagatgctg cttgctatgt tttcaaacct ttttgagcca
     3061 taggatccaa gccataaaat tctttatgca tgttgaattc agtcagaaaa gagcaaggct
     3121 ttgctttttg aaattgcaac tcaaatgaga tgggatgaaa tcctatgaca gtaagcaaaa
     3181 acagaaccat gaaaaatgat tggacataca ccttttcaat tgtggcaata attgaaagaa
     3241 tcgataaaag ttcatctttg gacagaaagc ctttaaaaaa aaaatcactc cctcttcccc
     3301 ctcctccctt attgcagcag cctactgaga actttgactg ttgctggtaa attagaagct
     3361 acaataataa ttaagggcag aaattatact taaaaagtgc agatccttgt tctttgacaa
     3421 tttgtgatgt ctgaaaaaac agaacccgaa aagctatggt gatatgtaca ggcattattt
     3481 cagactgtaa atggcttgtg atactcttga tacttgtttt caaatatgtt tactaactgt
     3541 agtgttgact gcctgaccaa attccagtga aacttataca ccaaaatatt cttcctaggt
     3601 cctatttgct agtaacatga gcactgtgat tggctggcta taaccacccc agttaaacca
     3661 ttttcataat tagtagtgcc agcaatagtg gcaaacactg caacttttct gcataaaaag
     3721 cattaattgc acagctacca tccacacaaa tacatagttt ttctgacttc acatttatta
     3781 agtgaaattt atttcccatg ctgtggaaag tttattgaga acttgtttca taaatggata
     3841 tccctactat gactgtgaaa acatgtcaag tgtcacatta gtgtcacaga cagaaagcac
     3901 acacctatgc aatatggctt atctatattt atttgtaaaa atccaagcat agtttaaaat
     3961 atgatgtcga tattactagt cttgagtttc taagagggtt ctttatgtta taccaggtaa
     4021 gtgtataaaa gagattaagt gctttttttt catcacttga ttattttctt taaaatcagc
     4081 tattacagga tattttttta ttttatacat gctgtttttt aattaaaata taatcactga
     4141 agtttactaa tttgatttta taaggtttgt agcattacag aataactaaa ctgggattta
     4201 taaaccagct gtgattaaca atgtaaagta ttaattattg aactttgaac cagattttta
     4261 ggaaaattat gttctttttc cccctttatg gtcttaacta atttgaatcc ttcaagaagg
     4321 atttttccat actatttttt aagatagaag ataatttgtg ggcaggggtg gaggatgcat
     4381 gtatgatact ccataaattc aacattcttt actataggta atgaatgatt ataaacaaga
     4441 tgcatcttag atagtattaa tatactgagc cttggattat atatttaata taggacctat
     4501 tttgaatatt cagttaatca tatggttcct agcttacaag ggctagatct aagattattc
     4561 ccatgagaaa tgttgaattt atgaagaata gattttaagg ctttgaaaat ggttaatttc
     4621 tcaaaaacat caatgtccaa acatctacct tttttcatag gagtagacac tagcaagctg
     4681 gacaaactat cacaaaagta tttgtcacac ataacctgtg gtctgttgct gattaataca
     4741 gtactttttc ttgtgtgatt cttaacatta tagcacaagt attatctcag tggattatcc
     4801 ggaataacat ctgaaagatg ggttcatcta tgtttgtgtt tgctctttaa actattgttt
     4861 ctcctatccc aagttcgctt tgcatctatc agtaaataaa attcttcagc tgccttatta
     4921 ggagtgctat gagggtaaca cctgttctgc ttttcatctt gtatttagtt gactgtatta
     4981 tttgatttcg gattgaatga atgtaaatag aaattaaatg caaatttgaa tgaacataaa
     5041 tagaagtgat ttattttttt attatcttaa agataggaag gaattagtat acgtatcagg
     5101 tgtataaatg gtttaaattt attttaacat gtcagatgtg ttcaagttgt catataaata
     5161 aactatgtat gtaaggaatg ggttaaaa
//
