LOCUS       NM_014496               8465 bp    mRNA    linear   PRI 28-JUN-2024
DEFINITION  Homo sapiens ribosomal protein S6 kinase A6 (RPS6KA6), transcript
            variant 2, mRNA.
ACCESSION   NM_014496
VERSION     NM_014496.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8465)
  AUTHORS   Qin,Z., Yang,J., Zhang,K., Gao,X., Ran,Q., Xu,Y., Wang,Z., Lou,D.,
            Huang,C., Zellmer,L., Meng,G., Chen,N., Ma,H., Wang,Z. and
            Liao,D.J.
  TITLE     Updating mRNA variants of the human RSK4 gene and their expression
            in different stressed situations
  JOURNAL   Heliyon 10 (7), e27475 (2024)
   PUBMED   38560189
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8465)
  AUTHORS   He,S., Lu,M., Zhang,L. and Wang,Z.
  TITLE     RSK4 promotes the macrophage recruitment and M2 polarization in
            esophageal squamous cell carcinoma
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (3), 166996 (2024)
   PUBMED   38142759
  REMARK    GeneRIF: RSK4 promotes the macrophage recruitment and M2
            polarization in esophageal squamous cell carcinoma.
REFERENCE   3  (bases 1 to 8465)
  AUTHORS   Arechavaleta-Velasco,F., Dominguez-Lopez,P., Acosta-Jimenez,E. and
            Diaz-Cueto,L.
  TITLE     Ribosomal S6 kinase 4 (RSK4) tumor suppressor gene promoter
            methylation status in ovarian cancer
  JOURNAL   Mol Biol Rep 50 (8), 6863-6870 (2023)
   PUBMED   37402066
  REMARK    GeneRIF: Ribosomal S6 kinase 4 (RSK4) tumor suppressor gene
            promoter methylation status in ovarian cancer.
REFERENCE   4  (bases 1 to 8465)
  AUTHORS   Ma,J., Wang,K., Chai,J., Xu,T., Wei,J., Liu,Y., Wang,Y., Xu,J.,
            Li,M. and Fan,L.
  TITLE     High RSK4 expression constitutes a predictor of poor prognosis for
            patients with clear cell renal carcinoma
  JOURNAL   Pathol Res Pract 227, 153642 (2021)
   PUBMED   34649054
  REMARK    GeneRIF: High RSK4 expression constitutes a predictor of poor
            prognosis for patients with clear cell renal carcinoma.
REFERENCE   5  (bases 1 to 8465)
  AUTHORS   Chen,L., Xu,T., Jia,Q., Wang,X., Li,M. and Liang,G.
  TITLE     RSK4: a new prognostic factor in glioma
  JOURNAL   Pathol Res Pract 216 (8), 153020 (2020)
   PUBMED   32703488
  REMARK    GeneRIF: RSK4: a new prognostic factor in glioma.
REFERENCE   6  (bases 1 to 8465)
  AUTHORS   Dummler,B.A., Hauge,C., Silber,J., Yntema,H.G., Kruse,L.S.,
            Kofoed,B., Hemmings,B.A., Alessi,D.R. and Frodin,M.
  TITLE     Functional characterization of human RSK4, a new 90-kDa ribosomal
            S6 kinase, reveals constitutive activation in most cell types
  JOURNAL   J Biol Chem 280 (14), 13304-13314 (2005)
   PUBMED   15632195
  REMARK    GeneRIF: The unusual regulation and growth factor-independent
            activity of ribosomal S6 kinase 4 (RSK4) indicate that it is
            functionally distinct from other RSKs and may explain why RSK4 can
            participate in non-growth factor signaling.
REFERENCE   7  (bases 1 to 8465)
  AUTHORS   Berns,K., Hijmans,E.M., Mullenders,J., Brummelkamp,T.R., Velds,A.,
            Heimerikx,M., Kerkhoven,R.M., Madiredjo,M., Nijkamp,W., Weigelt,B.,
            Agami,R., Ge,W., Cavet,G., Linsley,P.S., Beijersbergen,R.L. and
            Bernards,R.
  TITLE     A large-scale RNAi screen in human cells identifies new components
            of the p53 pathway
  JOURNAL   Nature 428 (6981), 431-437 (2004)
   PUBMED   15042092
REFERENCE   8  (bases 1 to 8465)
  AUTHORS   Roux,P.P., Richards,S.A. and Blenis,J.
  TITLE     Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates
            extracellular signal-regulated kinase docking and RSK activity
  JOURNAL   Mol Cell Biol 23 (14), 4796-4804 (2003)
   PUBMED   12832467
REFERENCE   9  (bases 1 to 8465)
  AUTHORS   Harum,K.H., Alemi,L. and Johnston,M.V.
  TITLE     Cognitive impairment in Coffin-Lowry syndrome correlates with
            reduced RSK2 activation
  JOURNAL   Neurology 56 (2), 207-214 (2001)
   PUBMED   11160957
REFERENCE   10 (bases 1 to 8465)
  AUTHORS   Yntema,H.G., van den Helm,B., Kissing,J., van Duijnhoven,G.,
            Poppelaars,F., Chelly,J., Moraine,C., Fryns,J.P., Hamel,B.C.,
            Heilbronner,H., Pander,H.J., Brunner,H.G., Ropers,H.H.,
            Cremers,F.P. and van Bokhoven,H.
  TITLE     A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in
            patients with complex X-linked mental retardation
  JOURNAL   Genomics 62 (3), 332-343 (1999)
   PUBMED   10644430
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL389887.7, AK313240.1,
            AF184965.1, AL354653.26 and BQ448025.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_014496.4.
            
            Summary: This gene encodes a member of ribosomal S6 kinase family,
            serine-threonine protein kinases which are regulated by growth
            factors. The encoded protein may be distinct from other members of
            this family, however, as studies suggest it is not growth factor
            dependent and may not participate in the same signaling pathways.
            [provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region, compared to variant 1. The encoded isoform (2) is
            the same length as isoform 1, but has a distinct N-terminus.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.84669.1, AF184965.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262752.5/ ENSP00000262752.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               AL389887.7         98430-98724         c
            296-2538            AK313240.1         11-2253
            2539-2839           AF184965.1         2319-2619
            2840-7874           AL354653.26        146915-151949       c
            7875-8465           BQ448025.1         23-613              c
FEATURES             Location/Qualifiers
     source          1..8465
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.1"
     gene            1..8465
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /note="ribosomal protein S6 kinase A6"
                     /db_xref="GeneID:27330"
                     /db_xref="HGNC:HGNC:10435"
                     /db_xref="MIM:300303"
     exon            1..381
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..2538
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ribosomal S6 kinase 4; S6K-alpha 6; ribosomal protein S6
                     kinase alpha-6; ribosomal protein S6 kinase, 90kDa,
                     polypeptide 6; p90-RSK 6; 90 kDa ribosomal protein S6
                     kinase 6"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase alpha-6 isoform 2"
                     /protein_id="NP_055311.1"
                     /db_xref="CCDS:CCDS14451.1"
                     /db_xref="GeneID:27330"
                     /db_xref="HGNC:HGNC:10435"
                     /db_xref="MIM:300303"
                     /translation="MLPFAPQDEPWDREMEVFSGGGASSGEVNGLKMVDEPMEEGEAD
                     SCHDEGVVKEIPITHHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLY
                     AMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDV
                     FTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFG
                     LSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGK
                     DRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFFANID
                     WDKLYKREVQPPFKPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFVA
                     TSIAEEYKITPITSANVLPIVQINGNAAQFGEVYELKEDIGVGSYSVCKRCIHATTNM
                     EFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDR
                     ILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDF
                     GFAKQLRGENGLLLTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFAN
                     GPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSW
                     ITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQPVLEPVAASSLAQRRSMKKR
                     TSTGL"
     exon            382..441
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            442..558
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            559..640
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            641..721
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            722..801
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            802..908
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            909..946
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1089
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1160
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1249
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1308
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1411
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1542
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1665
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1755
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1914
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2076
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2153
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2271
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2412
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..8465
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5407..5412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /note="hexamer: AATAAA"
     polyA_site      5427
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /note="major polyA site"
     regulatory      8440..8445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /note="hexamer: AATAAA"
     polyA_site      8465
                     /gene="RPS6KA6"
                     /gene_synonym="p90RSK6; PP90RSK4; RSK-4; RSK4;
                     S6K-alpha-6"
                     /note="major polyA site"
ORIGIN      
        1 agtcaccacc gagcggctgt cgttgtggtg gcagtggtga gcgcgagccg agcggcagct
       61 cttggagagg cagcacagag ttgtcttctc tatgggaatc accgggcggc ggcggcggcg
      121 acccccagct cccagcctct gagagacccg gcggcgaggg cagcgctcgc tgaaggcggg
      181 gctgggggtc gcggcggcgg cggcggcggc ggcggcggcg gcgggccagt tcaatagaca
      241 ggatgcgcgg ccgcgccagc ggtaggcggc agctcctgtt tgagtgctcc tgaaggggag
      301 atgctaccat tcgctcctca ggacgagccc tgggaccgag aaatggaagt gttcagcggc
      361 ggcggcgcga gcagcggcga ggtaaatggt cttaaaatgg ttgatgagcc aatggaagag
      421 ggagaagcag attcttgtca tgatgaagga gttgttaaag aaatccctat tactcatcat
      481 gttaaggaag gctatgagaa agcagatcct gcacagtttg agttgctcaa ggttcttggt
      541 caggggtcat ttggaaaggt ttttcttgtt agaaagaaga ccggtcctga tgctgggcag
      601 ctctatgcaa tgaaggtgtt aaaaaaagcc tctttaaaag ttcgagacag agttcggaca
      661 aagatggaga gggatatact ggtggaagta aatcatccat ttattgtcaa attgcactat
      721 gcctttcaga ctgaagggaa actgtactta atactggatt ttctcagggg aggagatgtt
      781 ttcacaagat tatccaaaga ggttctgttt acagaggaag atgtgaaatt ctacctcgca
      841 gaactggccc ttgctttgga tcatctgcac caattaggaa ttgtttatag agacctgaag
      901 ccagaaaaca ttttgcttga tgaaatagga catatcaaat taacagattt tggactcagc
      961 aaggagtcag tagatcaaga aaagaaggct tactcatttt gtggtacagt agagtatatg
     1021 gctcctgaag tagtaaatag gagaggccat tcccagagtg ctgattggtg gtcatatggt
     1081 gttcttatgt ttgaaatgct tactggtact ctgccatttc aaggtaaaga cagaaatgag
     1141 accatgaata tgatattaaa agcaaaactt ggaatgcctc aatttcttag tgctgaagca
     1201 caaagtcttc taaggatgtt attcaaaagg aatccagcaa atagattggg atcagaagga
     1261 gttgaagaaa tcaaaagaca tctgtttttt gcaaatattg actgggataa attatataaa
     1321 agagaagttc aacctccttt caaacctgct tctggaaaac cagatgatac tttttgtttt
     1381 gatcctgaat ttactgcaaa aacacctaaa gattctcccg gtttgccagc cagtgcaaat
     1441 gctcatcagc tcttcaaagg attcagcttt gttgcaactt ctattgcaga agaatataaa
     1501 atcactccta tcacaagtgc aaatgtatta ccaattgttc agataaatgg aaatgctgca
     1561 caatttggtg aagtatatga attgaaggag gatattggtg ttggctccta ctctgtttgc
     1621 aagcgatgca tacatgcaac taccaacatg gaatttgcag tgaagatcat tgacaaaagt
     1681 aagcgagacc cttcagaaga gattgaaata ttgatgcgct atggacaaca tcccaacatt
     1741 attactttga aggatgtctt tgatgatggt agatatgttt accttgttac ggatttaatg
     1801 aaaggaggag agttacttga ccgtattctc aaacaaaaat gtttctcgga acgggaggct
     1861 agtgatatac tatatgtaat aagtaagaca gttgactatc ttcattgtca aggagttgtt
     1921 catcgtgatc ttaaacctag taatatttta tacatggatg aatcagccag tgcagattca
     1981 atcaggatat gtgattttgg gtttgcaaaa caacttcgag gagaaaatgg acttctctta
     2041 actccatgct acactgcaaa ctttgttgca cctgaggttc ttatgcaaca gggatatgat
     2101 gctgcttgtg atatctggag tttaggagtc cttttttaca caatgttggc tggctacact
     2161 ccatttgcta atggccccaa tgatactcct gaagagatac tgctgcgtat aggcaatgga
     2221 aaattctctt tgagtggtgg aaactgggac aatatttcag acggagcaaa ggatttgctt
     2281 tcccatatgc ttcatatgga cccacatcag cggtatactg ctgaacaaat attaaagcac
     2341 tcatggataa ctcacagaga ccagttgcca aatgatcagc caaagagaaa tgatgtgtca
     2401 catgttgtta agggagcaat ggttgcaaca tactctgccc tgactcacaa gacctttcaa
     2461 ccagtcctag agcctgtagc tgcttcaagc ttagcccagc gacggagcat gaaaaagcga
     2521 acatcaactg gcctgtaaga tttgtggtgt tcctaggcca aactggatga agatgaaatt
     2581 aaatgtgtgg cttttttcct attcttatca aaggcatcgt tgtctgctaa attacttgaa
     2641 tattaagtaa tattaaatcc ccatttttag gggaagtgag atttaaaaaa ccattcacag
     2701 gtccacaata ttcatactat gtgtttgcag tagtgttcaa gtgtttattt aagcatataa
     2761 ttggtgtcca ccaggtcctc acaacttctc tgcacacaag cttctaaaat tcctttcaaa
     2821 taaagttact ttaatatttt ttttcttgtt tcatacaatt atggtttggg gagtcattac
     2881 caacaatcag tatacatata taatagtata atgacaagca atgttagtat ttttaaacat
     2941 cagatcctga aggataggct ttttctaatg aaagaaaaac aacaaaaact tattataaaa
     3001 gcttgttatt ccgtaaaacc aaaggactcc attcatttga ctcactgtag ttactaaaat
     3061 gtaaacatag tggtttggtg ccagagcaaa atacatttgt gctaatatat gaattcttga
     3121 tatagttggt gccaaagttt ttatagaaga attatatctc agataatgtg tgcaggcaga
     3181 tctgtatatt atccataata agtggcctca tttagaaata aaggttttta taaggcttct
     3241 gtaaatttta catcatggaa atttagtaca agtgaaactt tttttttttc caaaggcttt
     3301 atactgttgg tgtaatctta taaataggtc atagttaagc ctttgaaaat gaagtatgtg
     3361 gtgttgacac tatcctggtg ttatataaac tgactttcaa gttaaccaat tggattgtaa
     3421 tcatcatcta tcccctttat aaatgaacta cactgttgtt tttctgactt cgatgtgctt
     3481 tgaagtacag tgtagcatat cattctacct tgaatcctat gataatacag ttgacatctt
     3541 gctgtagtgg acttgtgcat atagcacaca tgatatagta tattgtatta cagtaaactt
     3601 tagacaatgc tacttaatca ttttacttca tgaagataaa ctaacatttt aaatatgaat
     3661 aatattaatg gtctacaaaa aatttgagca cattttaaaa tcatatttat aaaaaactgg
     3721 ccaaattggt cttatttaat gtataattca gaaccactgt gtagtatgta ttcttttctc
     3781 taaatgatga aatgctaaag aatcatttca cgttgttgaa gaaaataccg ttgctacaac
     3841 aacagcagca gctactactg ctactactac tactactact actactacta ctactactga
     3901 cagaaagaat tcatgaatgt aaactggagg atatcacagt tttctttagt gaatataagt
     3961 gaactacttg tgcgtgttag gtgtactatt tgctatgtat tttattttgc tttattcaga
     4021 gagaaagttg attactgagt gctgaattat acaatttagg ctaggaaact cgtaactttg
     4081 gtatttaata aaagaaacta tacatattct gtttgtaatg taaataatct ataccccatg
     4141 cacaaatatc tgtttcctgg gtgtgatata ttaaagtatg tattcttatt ttgaggtatc
     4201 ttttggaaat aattgaaaga gattaaataa caatttatgc cacatgaaaa ataattactt
     4261 agaagtagtt aggtatcatg tcttatggct ttttatgttc cattttggct ttttttctca
     4321 tttgctttat tactatatgt acttgcatgt aacagtttgt aagcatatat tctgacttat
     4381 tttccttctg tcattatcta gtgctgttat gccttcctat cagaatcgat aagtcaaact
     4441 cagaggtgtg attttggtgt tgaagttttc aggacagaga tactatttcc atggatgcat
     4501 tttaagtaat aaaattaggg gaagtgaaat cagaaaatga aaaatgatta caaaataact
     4561 ttcaggtttt ctataatcaa tggctttaaa aagtagacag tcttaattaa ttttaaatta
     4621 gcttgctcag aaaggtcatg ccatacagtc ctatcataaa aggaacacta taagaattaa
     4681 gcaatgaaca gcatgatttc tgatcaccca gtgaggactg acagtgtata aaagatacag
     4741 gtatgctact ggatgtaccc gataattgtt tgagagtttt ctagtgaaaa actcaaatat
     4801 gctagcttaa ccacagtagt agggggcaac cttattatat gggagagctt caaaacatac
     4861 tgtcattttg tagaaggagc ccaggtaagg atgcctaatc ctgtccagtt tggctagaac
     4921 tccatagcca aaaatgcaga tttggattga acattttttt gatgggactt ctatcaatgc
     4981 ttaactagta aaaacacatc ttttctataa gactttagaa tactgtggtt tctaatgggt
     5041 tcttgaataa tgattttgca ttgtgttttt ctagttaatg gtttttggta gtatttaatg
     5101 atagcacagt ttggggtttt attgttcttg aagggggagg atattgaatt tgtttttctt
     5161 agagaaaaca tcaggtttgc tcaaatagac taacaacctg ttgtccttaa gcacatacta
     5221 ccatgaataa actcaggaaa caattttcaa gaaaattcga atgcagtgct ggtgatgggg
     5281 atttttgtgg gaaaaaacaa tggtttcaag tcctttcaca aagatcaaac ttcagcctat
     5341 tttgttagac tcagcaatgt ctaaaacagt gttttttgta atttattgtc attggtaatt
     5401 caatataata aaacaatttt gatagcacct ctgtttggct caaagggatt ccatatgttt
     5461 aggcaaccca caaccttaag aacagatgct tggtatttat aatgtctgcc cattggaaca
     5521 acatgttaaa atagtactgc ccagagaaac ttccatacag attgactagt attttctaga
     5581 tagaggtctt tcatatatga agaaggaaaa caaccattta tcttggccct aaggcccaca
     5641 agaaaactta ggctttaaag tgggcaaagc atatttgtgg tattctgtac attctctttc
     5701 tcctggcttt ccagcccctt catgctatct atcttatttg agcacctcac agcaatactc
     5761 catcaacgaa atttacccta tccccagaag gattctgtgt gatccttact ccttgttcct
     5821 tcctcttcct cttccccaaa tcaggatatc cattctatca gaacagacat ttccagctaa
     5881 aaaggtgaaa ggaaagctat cttattaaat taatttacat ttttctgtca gtggctaata
     5941 gttaattggc attttttaag gaagttgtgc attaatcaag tttttagttg ctggatcttc
     6001 aggcaatcta acaaggtgat aattttaaat tcagttccta tcacggaaaa tattttgggg
     6061 gaaaggaaca gtgtgtccca gggtcagagt atctaataaa ctgtttcttt ttttgcacaa
     6121 tttccttcct acttcctttc tacttctcaa tctacctttt ctcttaaaaa cttttaaact
     6181 ttttaatcac aatgaacttc tatgacaaaa tgatgtggag gtagacagag attggcgatt
     6241 atttctgtat atgttgtttt taaacccata gttttgtatt cttgtttctc acagtacatg
     6301 acctatatag cataagaagt tttattcccc ccacccccca tcccattcct gttataaaga
     6361 aaaaaaaaag cacagagaga ttgaatccaa actactcatg gagtccaaat ttttccagat
     6421 cccttttcca gattttagga cctagaaatc ctttaagtca caatgttatt tcaaaaaaaa
     6481 aaaaaaaaaa atgcaagcca tattaagtat atattggcca actgcaatta aacttcttta
     6541 aaacattttt gttttacatt tcaaagctta ttcaggcatt tttggcatgt acctcaagat
     6601 caatgattgt tgaaattagc agaataaatc aatagtgggc tatttgcctt tttatgtggg
     6661 aatatagtgg cattgatagt gattattcac aacatacatt atactcatgg atgcactgtt
     6721 cctggtttta gtcttacagt gtagtgaatt ccatcatata ctttcaataa aatgttatgc
     6781 ttgatcacct aaaattcagt ttggttgcta atacataaga gaaaagggaa ctatacttga
     6841 atatattaaa ttatagacat aagtttcttt gaaatattta gaaaaacaaa agttttagaa
     6901 tatggaaatc caagcttaca ttatattggc aaattatgta tgtttcaatt attcactaaa
     6961 taaattttag ctaaatgctt ataaataaat atatatatgt aattgccaag ttagggtttg
     7021 ctttgtattc acatttctaa acgctggaca atagagcttc tgtggatgac tgttttgctg
     7081 taattccaac tgtctagtta tgggaactaa taatttattc ttcaaaaggt attaagcatt
     7141 taattttacg tggacaatta tagagaatgt actaactgca ttcgtttatt aaaaaattgt
     7201 caaaatgtga ctgattaggt tacttttatc tttcctatga actaatattg ctcaggtcac
     7261 attttctttc tctttccaaa ttcattctct ctgaaattgc tgcttataac aaatatgtag
     7321 tgttttgttt tttagtatga taaaattatt tttaacagca ggaaagcagt ctatcaagaa
     7381 acagccggcc gggcacagtg gctcatgcct gtaatcccag cactttggga ggccgaggcg
     7441 gtggatcacc tgaggtcagg aattcgagac cagcctgacc aacatggaga aacccgtctc
     7501 tactaaaaat acaaagttag ccaggtgtgg tggcgcatgc ctgtaatccc agctactcag
     7561 gaggctgaga caggagaatc acttgaacct gggaggcaga ggttgcggtg agccgagatt
     7621 gtgccaattt cactccagcc tgggcaacaa gagcgaaact ccgtctcaca aaaaaaaaaa
     7681 aaaaaaaaaa aaaaaaaaaa gaaaagaaac agccatttaa aaagttacac attaaacctt
     7741 aaatatccaa attccagcat ggtttgtaag ttagaattta tcttgcatta aattccatag
     7801 tacaaaaaaa aggagaaggt ggtttttctg tttgataaaa aaaaaaaaaa acaggaagta
     7861 ctgttggtag ttgggagtta cataggcttt atgaagcaac cacagtttgc tatagccaca
     7921 ttttttaaaa aattggtttg ccaacacatc ccaagcactt ttgaattcct aaacttattt
     7981 ctgatattaa atatatatgt atatactgac atttcattgc atttctgaag actgaaatgg
     8041 cattaaataa aagttgtgtg tgaatttgat ttacgtgtac ttaaaaactt caaagctgca
     8101 gttaaacaat ccccagtgtt caaaaactat tttattgttc tgactatatt atgaatttta
     8161 tgttaccatt tattttatta atgttttctt taaaccattg gttttttgac attaaaattt
     8221 tcatttatta tactaagttt tttatcatgt aagaccaaat ccagtagttc attttacaat
     8281 gtttctttct ctcacaatgc tgctaaagaa atggctatca ttttgaattt acaacatgcc
     8341 aaagaagaca tagaagttat atttattttt gttcttgtta aaactctgtg agcaacagtt
     8401 ctcaagatat gttaaattac tggcattctc tgggtaccaa ataaaaaggc tgcaactttc
     8461 taaca
//
