LOCUS       NM_004755              26829 bp    mRNA    linear   PRI 15-MAR-2025
DEFINITION  Homo sapiens ribosomal protein S6 kinase A5 (RPS6KA5), transcript
            variant 1, mRNA.
ACCESSION   NM_004755
VERSION     NM_004755.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 26829)
  AUTHORS   Xu,P., Tao,Y., Zhang,H., Jin,M., Xu,H., Zou,S., Deng,F., Huang,L.,
            Zhang,H., Wang,X., Tang,X., Wang,Y., Yin,L. and Sun,X.
  TITLE     Associations of MSK1 Methylation and Executive Function With
            Suicidal Ideation in Adolescents With Major Depressive Disorder: A
            Prospective Cohort Study
  JOURNAL   J Clin Psychiatry 85 (1) (2024)
   PUBMED   38385994
  REMARK    GeneRIF: Associations of MSK1 Methylation and Executive Function
            With Suicidal Ideation in Adolescents With Major Depressive
            Disorder: A Prospective Cohort Study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 26829)
  AUTHORS   Sattarifard,H., Safaei,A., Khazeeva,E., Rastegar,M. and Davie,J.R.
  TITLE     Mitogen- and stress-activated protein kinase (MSK1/2) regulated
            gene expression in normal and disease states
  JOURNAL   Biochem Cell Biol 101 (3), 204-219 (2023)
   PUBMED   36812480
  REMARK    GeneRIF: Mitogen- and stress-activated protein kinase (MSK1/2)
            regulated gene expression in normal and disease states.
            Review article
REFERENCE   3  (bases 1 to 26829)
  AUTHORS   Akbar,N., Forteath,C., Hussain,M.S., Reyskens,K., Belch,J.J.F.,
            Lang,C.C., Mordi,I.R., Bhalraam,U., Arthur,J.S.C. and Khan,F.
  TITLE     Mitogen and Stress-Activated Kinases 1 and 2 Mediate Endothelial
            Dysfunction
  JOURNAL   Int J Mol Sci 22 (16), 8655 (2021)
   PUBMED   34445361
  REMARK    GeneRIF: Mitogen and Stress-Activated Kinases 1 and 2 Mediate
            Endothelial Dysfunction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 26829)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 26829)
  AUTHORS   Eno,C.C., Graakjaer,J., Svaneby,D., Nizon,M., Kianmahd,J.,
            Signer,R., Martinez-Agosto,J.A. and Quintero-Rivera,F.
  TITLE     14q32.11 microdeletion including CALM1, TTC7B, PSMC1, and RPS6KA5:
            A new potential cause of developmental and language delay in three
            unrelated patients
  JOURNAL   Am J Med Genet A 185 (5), 1519-1524 (2021)
   PUBMED   33634591
  REMARK    GeneRIF: 14q32.11 microdeletion including CALM1, TTC7B, PSMC1, and
            RPS6KA5: A new potential cause of developmental and language delay
            in three unrelated patients.
REFERENCE   6  (bases 1 to 26829)
  AUTHORS   Thomson,S., Clayton,A.L., Hazzalin,C.A., Rose,S., Barratt,M.J. and
            Mahadevan,L.C.
  TITLE     The nucleosomal response associated with immediate-early gene
            induction is mediated via alternative MAP kinase cascades: MSK1 as
            a potential histone H3/HMG-14 kinase
  JOURNAL   EMBO J 18 (17), 4779-4793 (1999)
   PUBMED   10469656
REFERENCE   7  (bases 1 to 26829)
  AUTHORS   New,L., Zhao,M., Li,Y., Bassett,W.W., Feng,Y., Ludwig,S.,
            Padova,F.D., Gram,H. and Han,J.
  TITLE     Cloning and characterization of RLPK, a novel RSK-related protein
            kinase
  JOURNAL   J Biol Chem 274 (2), 1026-1032 (1999)
   PUBMED   9873047
REFERENCE   8  (bases 1 to 26829)
  AUTHORS   Jain,N., Zhang,T., Fong,S.L., Lim,C.P. and Cao,X.
  TITLE     Repression of Stat3 activity by activation of mitogen-activated
            protein kinase (MAPK)
  JOURNAL   Oncogene 17 (24), 3157-3167 (1998)
   PUBMED   9872331
REFERENCE   9  (bases 1 to 26829)
  AUTHORS   Deak,M., Clifton,A.D., Lucocq,L.M. and Alessi,D.R.
  TITLE     Mitogen- and stress-activated protein kinase-1 (MSK1) is directly
            activated by MAPK and SAPK2/p38, and may mediate activation of CREB
  JOURNAL   EMBO J 17 (15), 4426-4441 (1998)
   PUBMED   9687510
REFERENCE   10 (bases 1 to 26829)
  AUTHORS   Chung,J., Uchida,E., Grammer,T.C. and Blenis,J.
  TITLE     STAT3 serine phosphorylation by ERK-dependent and -independent
            pathways negatively modulates its tyrosine phosphorylation
  JOURNAL   Mol Cell Biol 17 (11), 6508-6516 (1997)
   PUBMED   9343414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121784.5, AL133454.6 and AL159191.4.
            
            On Nov 25, 2018 this sequence version replaced NM_004755.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.8221.1,
                                           SRR1660807.30363.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000614987.5/ ENSP00000479667.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               AL121784.5         166169-166478
            311-382             AL133454.6         107984-108055       c
            383-601             AL133454.6         85202-85420         c
            602-717             AL133454.6         54331-54446         c
            718-825             AL133454.6         49974-50081         c
            826-909             AL133454.6         30009-30092         c
            910-1013            AL133454.6         27102-27205         c
            1014-1164           AL133454.6         13045-13195         c
            1165-1326           AL133454.6         9704-9865           c
            1327-1452           AL133454.6         7507-7632           c
            1453-1586           AL133454.6         7004-7137           c
            1587-1680           AL133454.6         6225-6318           c
            1681-1851           AL133454.6         1309-1479           c
            1852-2043           AL159191.4         103267-103458       c
            2044-2203           AL159191.4         87981-88140         c
            2204-2367           AL159191.4         86412-86575         c
            2368-26829          AL159191.4         60641-85102         c
FEATURES             Location/Qualifiers
     source          1..26829
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.11"
     gene            1..26829
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="ribosomal protein S6 kinase A5"
                     /db_xref="GeneID:9252"
                     /db_xref="HGNC:HGNC:10434"
                     /db_xref="MIM:603607"
     exon            1..310
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..2616
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 1;
                     RSK-like protein kinase; nuclear mitogen- and
                     stress-activated protein kinase 1; ribosomal protein S6
                     kinase alpha-5; RSKL; S6K-alpha-5; 90 kDa ribosomal
                     protein S6 kinase 5; ribosomal protein S6 kinase, 90kDa,
                     polypeptide 5"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase alpha-5 isoform a"
                     /protein_id="NP_004746.2"
                     /db_xref="CCDS:CCDS9893.1"
                     /db_xref="GeneID:9252"
                     /db_xref="HGNC:HGNC:10434"
                     /db_xref="MIM:603607"
                     /translation="MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKV
                     GIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTER
                     QVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGE
                     IVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIE
                     YMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEP
                     PYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAAKKVPAP
                     FKPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSEKLFQGYSFVAPSILFKRNAAVID
                     PLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQ
                     AFAVKIISKRMEANTQKEITALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFE
                     RIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDF
                     GFARLKPPDNQPLKTPCFTLHYAAPELLNQNGYDESCDLWSLGVILYTMLSGQVPFQS
                     HDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLR
                     YNEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPL
                     AKRRKMKKTSTSTETRSSSSESSHSSSSHSHGKTTPTKTLQPSNPADSNNPETLFQFS
                     DSVA"
     exon            311..382
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:2.1.0"
     exon            383..601
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:2.1.0"
     exon            602..717
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:2.1.0"
     exon            718..825
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:2.1.0"
     exon            826..909
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1013
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1164
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1326
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1452
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1586
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1680
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1851
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2043
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2203
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2367
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..26829
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7824..7829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="hexamer: AATAAA"
     polyA_site      7843
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
     regulatory      17332..17337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="hexamer: ATTAAA"
     polyA_site      17357
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
     regulatory      26801..26806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="hexamer: AATAAA"
     polyA_site      26829
                     /gene="RPS6KA5"
                     /gene_synonym="MSK1; MSPK1; RLPK"
                     /note="major polyA site"
ORIGIN      
        1 gcggtactag cggtgcccgc cgaaggggga ggaggcgagg agcgagccgt gcggccagag
       61 cgggaaagag actcgtcttt gcgtccgagt tctggagccg ccgcaccccg actcctgggg
      121 ccgcggcagc ggctgcgagg ggacgggcgt ccgctgtctc ctgggttccc ctcgtagcga
      181 cccgcgggat cggaaaaaaa ggagaagatg gaggaggagg gtggcagcag cggcggcgcc
      241 gcggggacca gcgcggacgg cggcgacgga ggagagcagc tcctcactgt caagcacgag
      301 ctgcggactg ctaatttgac aggacatgct gagaaggtgg gaatagaaaa ttttgagctc
      361 ctgaaggtcc taggaactgg agcttatgga aaagtatttc tagttcgtaa aataagtggc
      421 catgatactg gaaagctgta tgccatgaaa gttttgaaaa aggcaacaat cgttcaaaag
      481 gccaaaacca cagagcatac aaggacagaa cgacaagtcc tggaacacat taggcagtcg
      541 ccatttttgg taacattaca ttatgctttc cagacagaaa ccaaacttca tctcatttta
      601 gattatataa atggtggtga actttttact catctttctc aaagagagcg tttcacagag
      661 catgaggtgc agatttatgt tggagagatt gtgcttgccc tcgaacatct ccacaagttg
      721 gggattatat atcgtgatat taagcttgag aatattctac ttgattctaa tggccatgtg
      781 gtgctgacag attttggtct gagtaaggag tttgtggctg atgaaactga aagagcatat
      841 tccttttgtg gaactattga atacatggca ccagatattg tcagaggggg agattcagga
      901 catgacaagg cagttgactg gtggagtttg ggtgttctaa tgtatgaatt actaactgga
      961 gcatctcctt tcactgttga tggagaaaaa aattcccaag ctgagatatc taggagaata
     1021 ttaaaaagtg agcctccata tccccaagaa atgagtgctt tagcgaaaga cctaattcag
     1081 cgtcttttga tgaaagatcc caagaagaga ttgggatgtg gtccacgtga tgcagatgaa
     1141 atcaaagaac atctcttctt tcagaaaata aattgggatg atttagccgc caaaaaagtg
     1201 cctgcaccat ttaagccagt cattcgagat gaattagatg tgagtaactt tgcagaagag
     1261 ttcacagaaa tggatcccac ttattctccc gcagccctgc cccagagttc tgagaagctg
     1321 tttcagggct attcctttgt tgctccttcc atcctattca agcgtaatgc agctgtcata
     1381 gaccctcttc agtttcacat gggagttgaa cgtcctggag tgacaaatgt tgccaggagt
     1441 gcaatgatga aggactctcc attctatcaa cactatgacc tagatttgaa ggacaaaccc
     1501 ctgggagaag gtagtttttc aatttgtcga aagtgtgtgc ataaaaaaag taaccaagct
     1561 tttgcagtca aaataatcag caaaaggatg gaagccaata ctcaaaagga aataacagct
     1621 ctgaaactct gtgaaggaca ccccaatatt gtgaagttgc atgaagtttt tcatgatcag
     1681 cttcacacgt ttctagtgat ggaacttctg aatggaggag aactgtttga gcgcattaag
     1741 aaaaagaagc acttcagtga gacggaagcc agctacatca tgaggaagct tgtttcagct
     1801 gtaagccaca tgcatgatgt tggagtggtg cacagggatc tgaaacctga gaatttattg
     1861 ttcaccgatg aaaatgacaa tttggaaatt aaaataattg attttggatt tgcacggcta
     1921 aagccaccgg ataatcagcc cctgaagact ccatgcttca cccttcatta tgccgcccca
     1981 gagctcttga atcagaacgg ctacgatgag tcctgtgacc tgtggagctt gggcgtcatt
     2041 ttgtacacaa tgttgtcagg acaggttccc ttccaatctc atgaccgaag tttgacgtgt
     2101 accagcgcgg tggaaatcat gaagaaaatt aaaaagggag atttctcctt tgaaggagaa
     2161 gcctggaaga atgtatccca agaggctaaa gatttgatcc aaggacttct cacagtagat
     2221 ccaaacaaaa ggcttaaaat gtctggcttg aggtacaatg aatggctaca agatggaagt
     2281 cagctgtcct ccaatcctct gatgactccg gatattctag gatcttccgg agctgccgtg
     2341 catacctgtg tgaaagcaac cttccacgcc tttaacaaat acaagagaga ggggttttgc
     2401 cttcagaatg ttgataaggc ccctttggct aagagaagaa aaatgaaaaa gactagcacc
     2461 agtaccgaga cgcgcagcag ttccagtgag agttcccatt cttcttcctc tcattctcac
     2521 ggtaaaacta cacccaccaa gacactgcag cccagcaatc ctgccgacag caataacccg
     2581 gagaccctct tccagttctc ggactcagta gcttaggcat ggtaggagtg tatcagtgat
     2641 ccattgcacc tttattccct cagcatatgc ctgaggcgat cttttatgct tttaaaaatg
     2701 tttcccgttg gtctcattgg aatctgcctc ctaatgattt ttttcaggaa aacctgtttg
     2761 gttatcctca ttcaaaagca ctggacagag aatgttactg tgaatagagc acatattact
     2821 ctttttagca acctagcatg atgccaacaa gactattctt gaaagagcaa aggttcctgt
     2881 aaatttaatt agggctagat ttgagctgct tgtaagtcac aggttttcca gatgtctgcc
     2941 aacaagaaat gactcatact gtgatgatac cttttgcttt gccttgtgga caatgtgggt
     3001 ttttgaaatt tgcacccttc aaacaatgat ttatcagaga aaggggtctg ttttcaaaaa
     3061 agattctgta atgaatttta tgtgtggcat atacttattt cttgagagaa gattttaact
     3121 tattgttttt attttatggt tacatatgat gataacctgc tattattaaa ctttttctaa
     3181 aaagtgaaaa aaaaaaaaaa agatataaga actcaaggtc ccatactctg tattcgggat
     3241 ccatctgaga tgcatgctaa gctatgtgta tgtttttaat tttgcactgc tctttcctgg
     3301 caatttgttt taatggttat tgcagaatat taaggtacat gtctctctgt tttaagtaat
     3361 attgcacttt ataaaaaagt atgaataaag caaactattt tataaagtgc actgtttaaa
     3421 gcatttgcac tgtatttttg ccatttattt tcattttcta ctttaaattt gtcctcacat
     3481 tcctcttcta ctttgtatgc aacaagtaga atggggcatg ttgtgtcatg tagtcagcca
     3541 cttatgcacc aatgtgagga aaacctaaag ggaaattaaa ctaaacactg tgcttcatat
     3601 ttgtacactg tgttgtacta cagtgaggaa tttcctcctg tagtcatata ttatgtacat
     3661 aatattttag aatcatacct atgacttgtt tggaaatttt tctgttaaat tttaaatcca
     3721 gaaagcatat tttataaact tatgcagagc acttttattg ctcaaaagtt ctgaattcat
     3781 acagaaaaca agtactatgt gatgaaaaca tttcattaaa agattgctgc atttaaaaat
     3841 acaattaatt cgttccctat gcaaaaaaaa aaaaaaaaaa aaaagaagtg atagggtttg
     3901 tgtgttatat tttcttttaa agccatcatg tgaaatgtca ggactgagaa aagtgatttt
     3961 tttgctttgt ttacaggaat catgcttaaa gagataatgc ccaacatgtt tattttatag
     4021 tttttgttaa tgataacctt ttgagcatta gtttggaatt tggacatgat atttatttat
     4081 tcctttcttg aggttatagc agcattaatt tcaaccagtt atgaatacta aaaatattgc
     4141 actctatgta atagtagtat atttattact aaatcaatgt atatattaat agcacaggca
     4201 aaaaatggca aatattaaaa tattttcaaa atattatatt atcctgttca cattttgtcc
     4261 acagtggtta ttgggaataa tattttacac tttttgctgg cccaaatggc tacataatat
     4321 tgagttaatg aaagttttct actcccagct ttcagttatt cctagtaatt atgggaaatt
     4381 ttgtgtgaat tattaccaaa ctattgctaa ttcacaaaat gtgattccat caggcacaga
     4441 tctctagtaa tcaagaaaat gaccatattt ataattatat tggacatatt gggaacatat
     4501 ttggctcttc aagccatttt ttaaactgtg catcctggta gaaaatacta gttataaagt
     4561 acaaactaaa gggactatgt tgctaataga aaatgatcca gaaaaatggt cagacagtat
     4621 acagattgat gatgtgattg atttcattgt gaatattgga aattaatggg tttcattttc
     4681 atttatttcc cttgcctctt cttgaggagg attcgacagg cgatgaaatg ggtaaaaagg
     4741 cagtcagact aacaggaaga aggaaagata ggctagctgt caactgatga gcctgcctga
     4801 ataatctcaa atgggctttt gaaaagacct taacaaacac tgttgcactc ttgtcaaata
     4861 tctttatcta caccctactt ataagtacca aaaagacagc atttgatgcc aagtttgaag
     4921 cagttaggtc ctatgcaggc tgtgtattaa catacagtga attgcacttt aaaattcaga
     4981 aagctttcat ttggtcacat caaaaataaa cactacaaaa tatataaaaa gttaaatgat
     5041 aggactcttt ttttggtatt aagagtaaaa tagaagaaga tctaagaaat acaaatactt
     5101 acattatttc tccttatgac attaactttg ggactagagc cacaccaccc cctcccttct
     5161 tcacttactg attgtattgc atataatttt catgccaaca taaatcctga ttcatatatt
     5221 ttgtaactgt atatgacaaa ttgagaggca agaataagaa aaggaagata atagaggaaa
     5281 gatgttaaga aagaccagtt tcttctaatt actctgccag atcgtgtgtc tgaaagaggt
     5341 taattagcat tttgaaattg attggctgag tgtggtggct caggcctgta atccttgtgc
     5401 tttgggagta taagactgga gaatcacttg aaaccaggag ttagagacca acctgggcaa
     5461 catagtgaga cactgtctct ccaaaaataa aaataaaaat tagctgagca tggtggctca
     5521 tgggaggcca acatgtggag gatcgcttga gcccaggagt tcgaggctgc agtgagctgt
     5581 gatcacacca ctgcactcca gcctgggcaa cagagcgaga ccctgtctta agaaaaaaag
     5641 aaattcatta attcttccaa acctttataa agtaagaaac cactgaatta ctagaataga
     5701 aagtcagtct cctgagttaa tttccacatt gttgtctgtc ttggagtcac aggttcatta
     5761 cccaagaaaa ctgcctttta atttttttag attactgttg atttcttaag tatgtaaatg
     5821 actaactttt aaatataagg taagttattt taaagaaatc tactaagata gaagtcactt
     5881 tttttaaagt aaggaaattc cttttgtatc tcagtttatg ttctcaaata cactacttta
     5941 taaaagtata caattgactg gatacttatt caccttgccc ccatttcaag cgcctgttat
     6001 tgtcatattt attaaaaaca gggtacctca taatggtgaa aatttctaaa ttattgggtc
     6061 tatatgtgcc ttagactgcc tgattacttt ggctgttctc ccagtgactg ataataatag
     6121 catgatttga gtgttcatgt gagaatacat ctaatattcc ttaagatcta agtaaataag
     6181 ttaaattctg atatgccact tatgtcaaaa taattgttat atagatgaat tattactgta
     6241 acatcatgaa gtatcttaaa attatatgac ttttggcctc tcaaatgtct tacatgataa
     6301 taccccaatt tccagtcttt aattgattgt atacctcacg taagtgtctg tcatcacttg
     6361 atacctgtat ctggcactaa aacaaatgta gccggctcta atgaaatttg aagtttggat
     6421 aggagacatt gtaaaactca agaatgggaa aaaaaaattt taacagaagt atgtatgaag
     6481 gaaatatttt aagtataatc tacccaaaga aaataactgc tacagccaac attaaaggtt
     6541 ttattccctg ttttgttaag taacttcact ccaaattgtg acattcttta gagaaaatat
     6601 tttccttaag agtagttatt tacgtgtttt attgggggag catattttca ggggggcaac
     6661 atcttgctaa gaacatttga ttagcctcac ttctgtcctc accttctata ttgcttactt
     6721 ttcaagatat ttcttctgag cccttttctt tgtatgccca gctccctgtt atgtaattaa
     6781 gtagttgatt accattccaa atgcttcccc tacacaaggc tgttgtccac cctgtttcat
     6841 gaatttgtga attaagtagg tgcctaatat tttcctacta ttagggtgaa aaggaataag
     6901 aaactaaagt ggcttccaaa tgtttgtgtc ttggtttctt caccctagtg caaaatagga
     6961 aatgtttatt ggcagtcatt tcttttccat tactcctttt aaccacatta caaaaagcta
     7021 ggattttgtg tctagaagga gacttgtatt aaaagacaag attcttagta gttattcatc
     7081 aggcttaagt ttcctggtgt atttcttgtg ggagaggtag aaggacattt tgtagtagta
     7141 ttctaactat taatataatg ctgcttgggt tatcagaaag tattgaatac ttcagataag
     7201 tcaagttagt atttagtata gcagctgttc ttcagagcac aggaaactgg gatagtatgt
     7261 agtattatgc tgtttccatt attgtttctc attgcataac acttttaatt tatatgttgg
     7321 tatacaattt gcccctttac taaaaaaaaa aatctagttt cattcttgtt ccttgccaca
     7381 ttaagcagtt ttttcattta cgttttaaat tttcttaata ttagaagaaa aagaaaacag
     7441 aacaaaagag aaatgtcatg acttagaaaa ggaaatttta agttttatgg aatactgtag
     7501 ctttattttc tgacatttct gcttatagat agattagaaa atccttgttt cttttgtttg
     7561 ctttgtttta aaatccagta aggttgagga acttgacatt ttaaaactgc agttttattt
     7621 ttaactacat aagaggctgg tcatgtgaaa tgtgcactgc tatgttggaa tggatatgta
     7681 tgtgacaatt aacctcatta aagctctgtt gctgtggtag gcattcagtt attcctaata
     7741 gtttatttta ggtactatac tgctatccta tttgctgaaa ttataaatac tagcaatgta
     7801 caataattct cattctttgg ctgaataaaa acagaaattt aaaggtgctg tgtcacataa
     7861 acagttaatg cctcagtact aaagttttga aaaatattcc taaaaacttc acaggcatga
     7921 atttttgaaa agaagaagaa accacatata cacatagagg aatttttaaa gactggcatt
     7981 ttaaagtata gctggtaaaa atggtatgta tccttatgtg tagaatttaa acttcttgaa
     8041 aataatctaa gctgcaacaa tctatgtaac tgctcttcca cagttttaca taaagataag
     8101 aatttgtctt actaaaaggt aaatggaaga ttaaaaaaga tgaaaaacat tgtttttcct
     8161 ctattctatg tggacaatta aaagtatagc caagcctcag ctcaaatgag ttgcctttgt
     8221 gtgagacagg gtctcactct gtcaccctgg ccggagtgca gtggcgtgat cacagctcac
     8281 tgcaacctcc acctcctggg ctcaagcaat ccttgtacct cagcctccta agcagctgac
     8341 taagtagact acaggcatga gccaccatgc ccagctaatt tttttttaat agctacaagg
     8401 tatcagtatg gtgcccaggc tagtctcaaa ctcctggctt caagcaatcc tcccgcctca
     8461 gcctcccagc tttgcccagc cgtgagttgc tttgtgagtt gtcttcctta actgcatcag
     8521 ttcatcccat actccgtaca tgcacttttt ctcgtatttt tctgcttttc tatggtgtgt
     8581 ccacactcat ttgtgtattt ctacactggt atttcactac ttattaagat atctgcatgt
     8641 ggacctacat ttataaattg taattccgtt cagagaaata agaacttgat tgggacagag
     8701 ctgggaaatg tttgtgatga aaattattag gaataaggaa ataatgatgc tgtgtgagaa
     8761 agcaagtaga cttaaattct gagatagaaa catctgcaat caacatagag aaggctactt
     8821 tacaaaaatg ttatttcagt gcccgtatgg acaaatctct ttaaaaggct ttgtctactg
     8881 tgtacataaa ggaacttata agcttcataa agtgcttatt tttctctagg aagcccatgt
     8941 gatagctctc tcctctgttt tcccactcct tccccagctt ttcctgctgc ccactgctcc
     9001 aaacactgac atccagtggc cagagaccag tccaaatgga gcactaaaac tacatataga
     9061 tagtgatcat attgtttaaa atgttattgc aacatggtgt gtaaagtgca caggtctgaa
     9121 atatacagct caataaatgt ttacatatat atgcgcccat ataaccatca ttcagatcaa
     9181 gatgaggctc ccagtcagtc ctcatacata accaccactc tgacctctgt cactgttgtt
     9241 gacattccta tacatggaat tatccagtct ataggttttt gtgtctggtt taatttgatc
     9301 agcattatgt ctgtgaaatg catctatgtt gttgcatgta gcaataacag tagtttgttc
     9361 tttttcgttg ctctgtagta ttccatcaga taaatacatc acaatttatc cattctccca
     9421 ctgatagaca ttttggttgt ttgtaatttt tagcttttgt gtttaaagca gccataagca
     9481 ttcttgtgca tatattttaa tggacacgta cactcatttc tcttgtgtgt ccacttaaaa
     9541 gtgaaacagc tggctgcagt gagccttgat cgcaccacta cattccatcc tgggcgatag
     9601 agtgagaccc tgtctcaaaa aaacagacaa aaaaaaggag tgaaactact gagtcataag
     9661 atgaatatat atttagctgt agaagatatt accaaatggt tttcaacaat ggttgtacca
     9721 atttacatac ccaccaataa tgtgtaagtg ttctagttct tccacatcct catcagtgct
     9781 tggtaccatc agccctagta gtttagccac tctgacaaat gtgtatattt gattgtggtt
     9841 ttaaccattc tggtgatttt gtatttcact gagattttaa ggtgtatttt cctgataagt
     9901 agtgatgtgt ggaacacctt tttatatttt tattagtcat ttggctatcc tcaattaagt
     9961 gcctgttcaa gtcatttgtt catatttatt gggttgtctt tttttcttac tgacttgcag
    10021 gagtctttta tattttatgg atatgagggt ttttgtctga tattttacca taaatgtctt
    10081 ctctttagtt tgcttttcta ctttctaagt gctttccttt gatgaccaaa aattttatga
    10141 agtccaatat accagtcttt tatttaattg ctaatacttt tgcgtcgtat ttaataaatg
    10201 ttcacaccaa ggttatgaag atattcttat attcttctaa aagctttatt ggccgggtga
    10261 ggtggctcat gcctgtaatc ctagtgcttt gggaggccaa gccaggtgga tcactggagg
    10321 tcaggagttg gagaccagcc tggccaacat ggtgaaaccc catctctact aaaagtataa
    10381 aaattagcca ggcatggtgg tgcatgcctg taatcccagc tacgtgggag gctgaggcag
    10441 gagaatcgct tgaacccagg aggcagaggt tgcagtgagc caaggtcatg ccactacact
    10501 ctagcctagg caacagagcg agactctgtc tcaaaaaata aaactaaaag ctttattgtt
    10561 ttaccatcca cattaggttt acagtccatc tactgctgat atttgtatat gatgtgaaat
    10621 agtagccaaa gtttatgtat ttccatatga gtattaactt gacccagcac aatgtattga
    10681 aaagctgagt tgtaattttt atgaagtctt catatctggt agtgtaagac ctctaacttt
    10741 tatctaatag ttctaatagt tttggctatt cttaatcctt tgcatttcca tatacatttt
    10801 agaatcacct tgttagtttt gggggcagag gatgttaggg tttaattggt attgcattga
    10861 atgtataaat caatttcagg agaaattata tcttaccaat tttgagtttt ccaatgcatg
    10921 gacatggtat atccctctat ttacttaggt atttaatttg tctcaccagt gttttataga
    10981 tttacatgta gaggttagat ttatatctag gtttttgaca gttttacttt attatcaaat
    11041 tgtttttaat tagtttatag aaatatagtt tttttggtat attacccttt cacttagaaa
    11101 ccttgttaaa ttcacttttt aattctaatc tgtatattat tttagatttc tttaagtcta
    11161 cagttatatc gtctgtaaat aatgacagtt tcatttctgc cttttcaatt tttatttttc
    11221 ttgccttatt gagctgatca ggacctccaa taacatgcta aatgaagtaa tgacaatgga
    11281 ctccttaaac ttcttcaact cagaataaga attcaatatt tttctattct atatatatat
    11341 atttttttct tttcttttct tttttttttt tttttttttt tttttttgag acggagtctc
    11401 gctctgccac ccaggctgga gtgcagtggc tcaatctcag ctcactgcaa cctccacctc
    11461 ccaggttcaa gtgattcttc tgcctcagtc tcccgggtgg ctgggaccac aggcatgcac
    11521 caccaccctc agctaatttt tgtattatta gtagagatgg ggtttcacca tattggccag
    11581 actggcctcg aattcctgac ctcgtgatcc acccgcctca gcctcccaaa gtgctgagat
    11641 tacaggcatg agccacctca cccagcccaa tattatgttt tatttaattt ttttatagat
    11701 atcatatagc agattgtttt atttctaatt ttcagagagt ttttactaaa tgctttttct
    11761 gcctctgttg agataatctt gtatttttct tctttattct tcaattttca aatgctgaaa
    11821 atagaataaa ttccattttc atgatgtatt gcccttttca tatatcaatg gatatagttt
    11881 gctaatattt tgcctaagat ttttggatca taaggaggat agacctagac tgggtgtggt
    11941 atctcacacc tgtaatccca acactttggg aggccaagag gaaggattgc tttagcccag
    12001 gagttggaga ccagcctggg caacatagag agacctcatc tctacaaaag attaattagc
    12061 caaggatggt ggtgcacacc tgtagtacca aatacctggg aggctgaggt gggagaatca
    12121 cttgagtcca ggaagcagaa gttgcagtga accaagattg taccactgta ctcccacctg
    12181 ggcaacagag caggagccta gcattaaaaa aagaagaaga agaagaagaa gaaggaggag
    12241 gaggaggagg aggaggaaga agaaggacag acctgtaatt tttctgtctt taatattttt
    12301 gtcaagtttt ggtatcaaga ttattctggc ctcataaaaa aaaagttgga gatgtgttcc
    12361 ctttttttct acactctgga agagtttgca cctgatatta ttcctcctgt ttaaaataat
    12421 tcaccattga agccacttga atgagaagtt ttctttgtgg gaaagttgtc attaattgga
    12481 atatatcttg tctacttaca gttaatgtaa ttattattgg ttttaagtct accatcttac
    12541 aatttctttt acatttttgt cctatatcct cttggttcct gtattgtgtc ttcttttgat
    12601 aaaccaaata ttttcttttg tccattgttt cctcctatgt tagttcgtta gtaattttta
    12661 gaaattcatt tagtacctta aagattacag cttgtatctt tgacttgctg ccttaaattg
    12721 gtacattacc acttcccaac aatgcaggaa ttttatgaca gtttaaatct gttttcccct
    12781 tttttttttt tttttttgag atggagtctt tgtcgccagg ctgcagtgca gtggcacgat
    12841 cttggctcac tgcaacctct gattccctgg ttcaagcgat tctcctgcct cagcctcccg
    12901 agtagctggg attacagaca caagccagca cacccagcta atttttgtat ttttagtaga
    12961 gacggggttt caccatgttg gccaggatgg tctagatctc ctgacctcgt gatctgccca
    13021 cctcagcctc ccaaagtgct gggattacag gtattccccc ttcttccttt tatgttattg
    13081 ttgtcatgta ttttacttct acattctatg tatgttttat ctctatatat gtgttttaga
    13141 cttcataaga cattattttt ttttttttga gacagagtct cgctctgtcg cccaggctgg
    13201 agtgcagtgg cgggatctcg gctcactgca agctccgcct cccgggttca tgccattctc
    13261 ctgcctcagc ctcccaagta gctggggcta caggcgcctg ccactacgcc cggctaattt
    13321 tttgtatttt tagtagagat ggggtttcac cgttttagcc gggatggtct cgatctcctg
    13381 acctcgtgat ccgcccgcct cggcctccca aagtgctggg attacaggcg tgagccaccg
    13441 cgcccggccg acattatttt tattagtagt actactacta tatattttaa agactctggc
    13501 tgggcactgt ggctcacgcc tgtaatccca gcactttgcg aggccaaggc aggtggatca
    13561 cctgaggtca ggagttcgag accagcctgg ctaacatggt gaaaccccgt ttctactaaa
    13621 aatacaaaaa atgagccagg agtggtagtg catgcctgta atcctagcta cttgggaggc
    13681 tgaggcagga gaaacgcttg aacccggaag agggaggttg cagtgagcca aggtcgcacc
    13741 attgcactcc agattgggca acaagagcga aactccatct caaaaaaaaa aaaaaaaaaa
    13801 tagactctat attgtttgtt tgctcacata tttatgtttt ctggtgtttt tctttccatc
    13861 ctgccttttt tacttccatc tgggattact tttcttcatc tggagaattc tctttagtat
    13921 ttattttagt gccagtcttc tgacaatgaa ttctctcagc ttttgttttt tgaaaccttc
    13981 tttcttttgc ctttattttt ctgtattttt atttttttaa gataaaattc atgtatcatg
    14041 taatataccc atctaatcat tccattcaga tacaattcaa tgttaccttt atttttgaag
    14101 gatatttttg ccttgtatga aatactaggt tcaccatttt attttatttt atttttgaga
    14161 ccaagtctca ctctgtcacc caggctggag tgcagtggca caatcttggc tcactgcaac
    14221 ctccacctcc taggttcaag tgattcttgt gtctcagcct cccaggtagc tgggattaca
    14281 ggcatgcacc accacgcctg gctaattttt gtgtttttag tagagatggg gcttcaccac
    14341 attagcgagg ctggtctcaa actcctgacc tcaagtgatc tgcccacctc ggcctcccaa
    14401 agtgctggga ttacaggtgt gagctactgg cgcccagcct aggttcacca ttttcaagat
    14461 atcattccaa tccttaagtt ctgtggaaaa agccattagt tatatttcct ttgaaggtaa
    14521 tgtgtctttt ttctgtggtc acttttaaga ttttctcttc gtctttgttt ttatttttta
    14581 ttatactttt aagttctggg ttacatgtgc agaacgtgca ggtttgttac ataggtatac
    14641 acgtgccctg gtggtttgct gcacccatca acctgtcacc aaattaggta tttctcctaa
    14701 tgttatccct cccctagccc ccaacccccc gacaggcccc agcgtgtgat gttcccctcc
    14761 ctgtttccat gtgttctcat tgttcaactc ccacttatga gtgagaacat gcggtgttta
    14821 gttttctgat cttttgatag tttgctgaga atgatggttt ccagcttcat ccatcctaag
    14881 attggtaaac ttcctgaatc tgttggttga tgtccttcct tattagaatt cttaaccagt
    14941 cattcttcaa atagtttttt ccaatccgtt ttctctctcc cgttttctag gattgtgtgt
    15001 tatactatgt tccatatgtc tgttatagtc ctttgtttgc catcttaatt tctccctgta
    15061 cttcaatctg tatagttttt actgacctaa ttaacttatc ctgttctgct gagcctaatc
    15121 aattttaaat ttagttgtat atcttatatt ttggattcta aaatatccat gacacttttt
    15181 tgtaggtgcc aagtctctga tcatatcttg tcttttcctc tatattcttg aacacattaa
    15241 tcaaagtaat tttaaaactc ttgtctgaga aatccagtgt ctgattacta ctactagttg
    15301 tttgtttcca ttgtctgttg tcagtcattt ggtgctgttt tttagcatgc cttataagtt
    15361 tggtgaaatg tcatacattg tgtgttaaat actgtagggg ctttgaacga tgttatcttc
    15421 ctctaagatg gttatgtttt cttcttgcag tctgataaaa tacaggcata tcactgtaat
    15481 cctattgaag gttggtttta gactttgttg ggcttgtaca tttcagtttt gctcttactc
    15541 ctagcatatg gcctctttgg gctctcatct gaaaatctag ggtgtttatc agggccactt
    15601 cacctcggtg accttgaatt ccaacctttc cctcctcagt actaagagct gctcagctcg
    15661 ttagcctctc atctgctgct ttttgctgga tttcttgaag tctcaccttg ttgcacagga
    15721 gtctgcaatt ggcagacacc tcaaggagat actgtaccag tatttcaggc tcacttccct
    15781 gaggtttctt cgctctggga ttttgcccct taagtcctag ctactttccc aagctccaac
    15841 ttttgtctct tcaaccaagt gggattactg cttgctgcta ggtatttatt tccctgtgtt
    15901 gtgaatttgc agtgccttga agaagtaatc aaaatgaaca cagagctcac caaagtgtgc
    15961 ttcccttttt tccctccttt cagctatttt attgcagctc gtcaagttct ccctgcattg
    16021 gtttgctccc tgttgcctat aaaagatgtt ctacttaacc cttttcctgt ttgccccaag
    16081 aatacttgcc agcagcactt gctgctgcag tatttacccc aagataactt tgccacgaac
    16141 tctcgctttt attattactt tcgtttagct ctagtatatt gacttcagaa aaaaaggaca
    16201 tcgttctctt tatagcattc tgttcttagt agtggtattt ccatttacaa agtataataa
    16261 ttctcgatcg ctgaaaatgt cgaatcctag aaaatgtagc attcctacac gtgatgttaa
    16321 catcattctc gaacagttct tggacagaga tttatttaat gaattcgatt tttctgaaat
    16381 agatgatttt gatgattcag atgcttctga tactagatct gtttagaaat aacatcaaga
    16441 acagttttta tattttattt tcacattgaa aatcagtcag atttgcttta gcctcaaaga
    16501 atgtgtttac gtaaaattaa atgaatgctg gcagtgagct gtactttttt tttctaaacc
    16561 ggaaaagggt taatatagct ttcatcgttg ttttcagtag gagggctagt ccaatcacaa
    16621 gctactctat tgtggccaaa agcaaaaatc tggtggtaat catttttaat cgccattgtt
    16681 gatttctccg cagtggcttc tggcattgat aacttggttg tcacatggtc atatgtgaag
    16741 gcacccggtt tattcatttg ttcctttgtc cattaaatag tttttgagca cttctttcag
    16801 gccaggtatt actctagaca caagcaatat aacaatattt aagataagat ctgtgtcact
    16861 ttggcacttg cagcctgttt ttatagaaag gctactaaat ggttgccgag tcggacttgt
    16921 ggtaattaaa atagactttt cttgtgtggg ggttgggagt gagaaaaaag agactggaat
    16981 cttttagatg attacatctt ctttatataa atatttttag ccttttgaaa aaactctgta
    17041 gagcttaatg cagttcacag ttcacccaca ctacatcaat atttggccta ccttttgcaa
    17101 gcccaattcc ctaactatga gtttctgtgt tacataaaaa tctcaccggg agcacaatta
    17161 tttgacaatt tgagttgaaa ctccaggaac tgatttatgg agaacaaact tagctctgaa
    17221 attatgtctc tttatgaata tcgacatgaa atctgatgaa gaatcatcct actgtggttt
    17281 cccattttaa cttctgtttt tgaaaaacat ttcagatgca actaagcact tattaaatgc
    17341 ttcgtgatac caaaaaatgg cttggtggtc tttgtcttcc agaatagcat aaatttcagt
    17401 gttaccaaga taaaaatata atctgggcac atgtcactgt taaaatatta tagtcagatc
    17461 aaggattcta ttcctgtctt tgttattctt tcccactttt gaaactttat ccagtggatt
    17521 tttttttatt acaaagacgt attccagaga taacagtttg tacttctgat tatgatccat
    17581 gttcatgtga tcaaaaggca gcaataatag gacactgtca tatatggtag ctccatagaa
    17641 actaggctgc actgggagga cagattcgcc atcttgagca cctgtggctt ggtattctcg
    17701 aaattgtagc ccctttggaa tggctgaaga actaccagtt aaaggtaaag aaaccagaca
    17761 cacaaggcca cgtattgtat gattccactt acatgaaatg tccagaatgg gcaaatccat
    17821 agagacagaa agattagtgt ttttcagggg ctggtgggag ggggaaatag ggagtgacaa
    17881 tgtatacagg tgatggggtt ttggggtgat caaaatgttc tggaattagg tagtggtaat
    17941 ggttgcaaga cattgtaaat gtagtaaaaa acaatgaatg gtacacttaa aatgaatttt
    18001 atcttatatt ttaaaaaatc acacacaggc cgtgcacagt ggctcacgcc tgtgatccca
    18061 gcactttggg aggccgagac gggtggatca cctgaggtca ggagttggag aacagcctga
    18121 ccaaaaggga gaaactccat ctctaataaa atacaaaaat tagccgggcg tggtagcgca
    18181 tgcctgtaat cccagctact tgagaggctg aggcaggaga atcactttaa cccgggaggc
    18241 agaggttgca gtgagcctag atcgcaccat tgcactccag cctgggcaac aagagtgaaa
    18301 ctccgtctca aaaaaaaaaa aaaaaaaaat cacgcatagc tagaaaggct gtagctagtt
    18361 tgaggaagtc agtactaaca cctggctatt cagagaatgc catcctgccc ccctttcttt
    18421 ggcatcaact ctgaagcata gttatgttat ggttggaaaa tcttttctaa ctagagatta
    18481 agctcttggg gacaaagtaa acttgcctct tacaggaaac accaaagttc cagcttaaca
    18541 gagaaaggga acctccttgg gaatcatact tttcccatta ttgggtagtg ctcggacaga
    18601 tgtcaaagtg ctgtatgttt ccatggtgat catatccagc ttatcattac ttgtatcttt
    18661 gccctaaagt ttaatttctt actttgggac tcattataat aatgggagca ccggcctttt
    18721 gggaggccaa ggcgggtgga tcacgtgagg tcaggagttt gagagcagcc tggccaacat
    18781 ggcgaaacgc tgtctctact cacgcctgta atcccagcac tttgggaggc tgaggcgggc
    18841 ggatcacgag gtcaggagat cgagaccatc ctggctaaca cggtgaaacc ccgtctttac
    18901 taaaaataca aaaaattagc cgggcgtggt ggcggatgac tgtagtccca gctgctcggg
    18961 aggctgaggc agaagaatgg cgtgaaccta ggaggcagag cttgcagtga gccgagatcg
    19021 cgccactgca ctccagcctg ggcaacagag caagactctg tctcaaaaaa aaaaaaatac
    19081 aaaaattagc tgggcgtggt ggtgggtgcc tgtgggccca gctacttggg aggctgaggc
    19141 aggatactct cttgaaccca ggaagcagag gttgcagtga gccgagatca cgccattgca
    19201 ctccagccta agcgacagag tgaaactccg tctcaaaaaa ataaaaaata aaaaataatg
    19261 taagtaccag gcctttgttt gagttcagtt tttctttggt gagcactttt ctaaaatctc
    19321 tctcatctta cctatgttaa ctttgtctca gaagcaggct catttgtgca gttagctgaa
    19381 atatttattc agaaagtcat ttatagcagt tgtcttttca tcaaacataa tacctttaaa
    19441 atagcagaaa attaatgcca ttcatgattt tgccatttta ctaagtagtc agaagctatg
    19501 tctcccttag ccccatcata tacatttgaa atatctttat cctagataat ctgtattcat
    19561 ttgaatgcaa aagttttatc aatatgagtg aacttataca tctttttatt cgctgatgga
    19621 gatatcactt gaaactttgt tcctggcaaa gcaaagagat gaaatgtatt gaaaaaaatc
    19681 gattagactt ttaaaacttc aaaatacttt tatagaaaat gtaaataaga ttgtttctaa
    19741 ctgcagagtg ttttacataa aatctttatg tgaagaattt atattgcagt acaataaagt
    19801 cagtgctttt tatatgtttt gaatggtaaa cattttgaag gtattttttg aagtaactag
    19861 gtattgacat tttttaataa tatattttga ataaagcaca cctaaaatgc atgaacttgt
    19921 gtaagtattt ggcatcatta gtctagttgt acatattttt aaaaataaga atgggcttag
    19981 aagataatgt atttgtagta agtatagtat attttttact gagtgagtct gatacgtctt
    20041 ttagatattt gagtaaagtc tactgttaaa gtattccaga tttttaaatt ccagtgtcct
    20101 tgctgtggaa tctagtgttg gctttctgat gtcagaataa tcaaaccctg ctcatataca
    20161 catccagaaa actttttcta atgatgatac atttagcaaa atcgcaagtc tttaaaaatt
    20221 ctagttaaat agacttactt gagacaagtg tacattgtga aatctaaaat aaaaatttgt
    20281 gactatataa tacataatct tcattatgta ggctatttct aaaaacttag tttctgtgct
    20341 gatttcatgt taagtttttc aaacgttagc agattataat ggctacagta agttttgttc
    20401 taaatctggt agccatttat tattaaatga ttaatgatta aacattaatc atttaataat
    20461 tacttaggaa ttataaatta caatgtcaaa tcttcataca tcaggctcct tgcactataa
    20521 ttacttaaaa ttagtttgca tcaatagtct atataaacag atatcttagt ttagaggaaa
    20581 aaatattcta ttttctaggt actttaatag tttggtcttg tgaaaattac ataggtgtgt
    20641 gtttatgtat gtgtatacac acatgtattg ggggcttaca ataccaaatt aataagactg
    20701 cccctcactc cttaaatcga ctatctgccc tgccagtaat cccccacctg tactggtata
    20761 tacagagttt tctctggtac aaatgattaa tcaagaaaaa gggtgtgaaa tatttgtgtt
    20821 cgtttctttt taaatgaata atgggataca cataaactag taacaccaca ttgatttcct
    20881 aaagacctaa tacagcttta agagggaata acattccaga gctccaggat tattttaatt
    20941 tagctttcaa gatggttacg attttgattt aatatagaga cttcatagtg ttaaatttta
    21001 gggttttttt tttttttttt gtatttttag tagagatggg gtttcaccat gttggtcagg
    21061 ctggtctcga actcctgccc tgatgatctg cctgcctcgg cctcccaaag tgctgggatt
    21121 acaggcgtga gccactgtgc ccaacctaaa ttttaggtat ttaaaacatc cattgatgct
    21181 ttgttttgtt tttgggtttt ttttttattg ttgttactta agggatgcat cttatttatt
    21241 tggttgactt ttatctagac atcataaatg tgatgcttac ttttttatta gccacttcat
    21301 tgttgatgtc ttaatgggag atcttagttt gatgaatcta ctctttgaaa ttttagtttg
    21361 attagtcatt tgtttctgct aggttttggc ttttgttttg ttttttgagt gataacctaa
    21421 gaagtttcta cagtggaaaa tatcattatg acatcttcat cccttataaa gttgtttcat
    21481 ttagaggaat ttttcaaagc ctatgttgag aaatgggcaa attaagtaaa gcatcataac
    21541 aatttttttt atagtgaact cattttattt atagaacggc aaacacattc actctttttg
    21601 ctaacatccg gggctttttt cattgtgact gctttgcaca cttaaaaatg tttctcccag
    21661 gccgggcacg gtggttcatg cctgtaatcc cagcactttg ggaggccgag gcgggcggat
    21721 cacaaggtca ggagattgag accatcctgg ctaacatggt gaaaccctgt ctctactaaa
    21781 aatacaacaa aaattagccg ggcgtggtgg caggcgcctg tagtcccagc tactggggag
    21841 gctgagacag gagaatggca tgaacccggg aggcggagct tgtagtgagc cgagatcgcg
    21901 ccactgcact ccagcctggg cgacagagca agactctgtc tcaaaaaaaa aaaaaaaaaa
    21961 aaagtttctc ccagcaaagg ctaactggaa tttatttttg tttaaagaca aatactttta
    22021 atgtggataa aataaaagtt ggaagtatgc ctttcatgtg gcaaactgga aattagtggt
    22081 tagtactcca ttgcagcatt aaataccaat tctttacaat agggtgcaca tatcagatgc
    22141 tgtttttccc ttaacctttg cacttttcat tgaaaatgtt ttcaaatcaa atcttgtttt
    22201 attgggtttc acatgattgg actaatactt acatatatgc ttctttttaa ggtatttaga
    22261 cattgacaat tagttatttc cttatgagcc atagctttga aaaaccattt tagaagaaat
    22321 ttccattttt taaacaaaag tgttgggagg ccgaggcggg cagatcacga ggtcgagacc
    22381 atcctggcta acatggtgaa accccgtctc taataaaaat acaaaaaatt agccaggcat
    22441 ggtggtgggc acctgtagtc ccaggtactt gggaggctga ggcaggagaa tggcgtgaac
    22501 ccgggaagca gaacttgcag tgagccaaga tcgcaccaca ccactgcact ccagcctggg
    22561 cgacagagcg agactccgtc ttaaaaaaaa aaaaaaaaaa aaaaaagtga ttttttaaag
    22621 aaaagatacc gataatttgt ctttgctgta gatgaatgcc acgtttttat atactaggac
    22681 tattactgaa taatactgtt tatttcttta gatcaacgaa tatattaaat tctgtctttt
    22741 ttgttcaaat aaacgctgtg agatgattgg gaaggctgtg tgttgaagtt agatgcaaag
    22801 ttggaccttg tacagtgagc ctcttgtgag aactgagcca tgaaagataa agcctgtcat
    22861 tcatgtctgc cttggcctgt gcccagcttt attagtaaaa accattcagt ttttactaat
    22921 gatatctacc agtatctaaa gagaaatacc ttcatcctct agaagaaaac aaggttaccc
    22981 aaagagctca cttaattcct tcctttttcc ctgaaccctt ggttttaagt gaagagtaaa
    23041 atgtactaga tatgacactc tctctgagta ttactgagga ttttgtggaa aaggcagttt
    23101 ggtactttat ttccagctta gctgcagact tggtgaccct gagcaaatca ctcagcctcc
    23161 ctttgcctcc atttcttcat ctgtaaaatg gggttaacct gtgcctccct gtctcaccag
    23221 catactgagg gatcgattaa agaggattaa aaaaatccat aaggtacact gattccaaag
    23281 atgggtagaa tgatatttaa taatgaagac tttctgttat atagcaattt aattttaaaa
    23341 gtatctttac caggccaggt gcggtggctc actcctgtaa tcccagcact ttgggaggct
    23401 gaggagggtg gatcacgagg tcaggagatc aagaccatcc tggctaacac ggtgaaaccc
    23461 cgtctctact aaaagtacaa aaaaattagc caggcatggt gatgagcgcc tgtagtccca
    23521 gctactcacg aggctgaggc aggagaatgg catgaacccg ggaggcggag cttgcagtga
    23581 gccgagatca cgccactgca ctccagcctg gggggcagag tgagactctg tctcaaaaaa
    23641 aaaataaaat aaaagtatct ttacccactt ctctgtagtg aatattgact agcattttga
    23701 agtaggaact aacaaagtat aaaattaagt agatttttta tatttatggg tattgttcta
    23761 gtacaaattt atggtgtaca ctgtcggtct gagtgtgggt ttaaaatata tcattgtgct
    23821 tggctaattt gtagaatgtc ttatttgaat tgacttcatt tatttcagag gaatgcatag
    23881 atgatcagat caaactgtcg tcatagcagt gttttcagca catacgagaa tcttagagtt
    23941 taggagcctt agagctcacc cagtgcaatt tcctgccgga agcagattcc ttcctggtga
    24001 cctcaccaac aggtgcttgt gcagcctttt cctgaaaact ttttgggaaa gtgggggctg
    24061 ctacctcact actttgatgt gtaccttttg ttcaagaact ttctaaaact tggagctaat
    24121 catgggttat ttcagaagat gtaagcattt taagtttttt attgaattcc atccttattt
    24181 aaaaggcctg gttatgtaat attttctgtt tttttttttt ttttttgtat ggtttcccac
    24241 attgattagg ttgttttctt cattttctta atagattaaa aatactttct tctctttcta
    24301 tttgtgtctt cttccattta gtatttatgg gagggagcaa gaagggaaag gatgtctatt
    24361 tttaaaattg actacaatca tgactgttct tcttgtcatt ctgtagcagc tggatttatt
    24421 accatctctt atttaaaggt ccttcagaac acgttgaagc agttcatttc aggtcaatgg
    24481 ctggtaagca atgtcaggac ctctggggaa ggagaagctg acgggatccc agaggaaaga
    24541 attgaggttg tttgctccct tgtagaaagc ccacagatcc cttcccagac tagaaaaaaa
    24601 gtgccagagt gtcctgaaac tttccttcta aggcacatac ttcaaagaga ctggggattc
    24661 ctttgtttta aatataggtg gggtctcaca gtgttgccca ggctgggctc aagcgatcct
    24721 gccacctggg cctcccaaag tgatgggatt acaggcatga gccaccatgc acggccatgg
    24781 agattctaat gtggtgccag ctgccaggta agaaagctgt gagacaatgt gttgattttc
    24841 ctttactacg tcaggtttga ggacatcatc tagcatcaac gggtaacgtc accctttgtt
    24901 ccatctttgg gaaataatag tagtagcttg ttactgttag ctgaccccta cattagcatc
    24961 aataaagtaa atccctttaa ctttcctttt ggcctttcct ttctctctct ctgcctcccc
    25021 accagccccg actctctcct gtgtgcgtac acatccacac acacctccat ggtattcctt
    25081 ctttctccca cctaagggaa gctgtgcccg atcttgctgc agtccaggtc accgtactga
    25141 gatgagtcag ccacagactc taaacactag cagcgattag ccgtatgtag ccaccaagtg
    25201 cactgtttta gacaggttta cacagctctt tgctgtccac tcatatcagc tgtgtagtag
    25261 cccaaggcag cctgtcaggc agaagaatta ccaaccaaag tggatctatt cataagataa
    25321 aagatccgga gtccgtgccc tcttaaaaaa cttttgtctt cagacatatg ggtgcgtgtt
    25381 catctctggc caaaactttg tttccagttt caaagggctg gttgcgaagg tggccttgta
    25441 acctttctgt tgccggctct gttagttgcc tgataagcag tagctaattc atcctcctca
    25501 gaatttgaga gtggcatcta ttagattcag accaccaagg tgcctgcgcg ggctctcctg
    25561 gttacgactg agtccccttt tctcatctgt ggggtgaacg cttctatttg cagaaatttg
    25621 cttgcatctt tttcctttta tttattatta ctttttagag atgcggcctt gctctgttgc
    25681 ccaggctgga gtgcggtgga ctcttttctt ttgttgatct ttgccatcct ctgcctggct
    25741 taatgaggtt ctttccctgc gtatttatgt cccaggagct caccttcccc ctaggttttt
    25801 aagaaggaag cagaaaatgt tacaaagtat aagggattct atgaagtcca tagataggat
    25861 ttgctttggg agtagatgat ttcttcttat tttggtgtaa acatcaattt ggatggcaat
    25921 tagaatgtct ttagcctctt taaaaagccc ttctggggca aacctttgca agtcactcag
    25981 ctggcatgta atgagatttt tatttgcatg gctttttttt tctaagtctc tctagaagaa
    26041 cataaggaca ttctgaacat gcaaggaata cagttattct cacatcaagg atcaatttta
    26101 ttttgtatct tcattttatg tcattttcct ttattttatt cacattaatc tagcattaat
    26161 tccccccaga gggaatgata tttttggttg ctgccacctg tgttattaag tgacagcttt
    26221 tctttatctg cttttctgaa tttcatattt atatacttta ttgtagtttt ttaaaatcta
    26281 ttctagctgg gctagaatct tccaagtatt aattcataat gaacttccct cttctggaat
    26341 tgtttaggag ggctaatgtt ccatgttccc ttcgttgcta tagatatgaa gttatttcga
    26401 tgttctttga gtgctttatt atagcgataa ctggtactgc ctttgattaa aggtgagcta
    26461 tatggagtta agcattttta tactagtaac tatttattga gaattttcag aattctatag
    26521 ctacttgtct ttaacagtta taagaggcat gtattttttt ttccttcatg gtctggaagt
    26581 tagttttctc tttgtttggg tagatcggaa tgagttgttg agctgtgttg aaaacacaca
    26641 tgaatcaaaa aagcagatgt attgtagaaa tgtgatgttt tcatgtttcg ggaatttgac
    26701 cggaaagctt tatgtatggg ttttattttt aacaaagcag taagggctta ctttttacca
    26761 acttgtgtgt gtgtaaagat gtatttgttc aagctttaag aataaacctg tcaatgtaca
    26821 aatgcctga
//
