LOCUS       NM_003942               3128 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribosomal protein S6 kinase A4 (RPS6KA4), transcript
            variant 1, mRNA.
ACCESSION   NM_003942
VERSION     NM_003942.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3128)
  AUTHORS   Wu,S., Jin,J., Huang,J., Chen,G. and Chen,Y.
  TITLE     Comprehensive analysis of the RSK gene family in acute myeloid
            leukemia determines a prognostic signature for the prediction of
            clinical prognosis and treatment responses
  JOURNAL   Hematology 28 (1), 2235833 (2023)
   PUBMED   37462338
  REMARK    GeneRIF: Comprehensive analysis of the RSK gene family in acute
            myeloid leukemia determines a prognostic signature for the
            prediction of clinical prognosis and treatment responses.
REFERENCE   2  (bases 1 to 3128)
  AUTHORS   Qiu,M., Lin,Q., Liu,Y., Chen,P., Zhou,Y., Jiang,Y., Zhou,Z.,
            Wen,Q., Zhou,X., Liang,X., Gan,H. and Yu,H.
  TITLE     Potentially functional genetic variants in RPS6KA4 and MAP2K5 in
            the MAPK signaling pathway predict HBV-related hepatocellular
            carcinoma survival
  JOURNAL   Mol Carcinog 62 (9), 1378-1387 (2023)
   PUBMED   37278562
  REMARK    GeneRIF: Potentially functional genetic variants in RPS6KA4 and
            MAP2K5 in the MAPK signaling pathway predict HBV-related
            hepatocellular carcinoma survival.
REFERENCE   3  (bases 1 to 3128)
  AUTHORS   Sattarifard,H., Safaei,A., Khazeeva,E., Rastegar,M. and Davie,J.R.
  TITLE     Mitogen- and stress-activated protein kinase (MSK1/2) regulated
            gene expression in normal and disease states
  JOURNAL   Biochem Cell Biol 101 (3), 204-219 (2023)
   PUBMED   36812480
  REMARK    GeneRIF: Mitogen- and stress-activated protein kinase (MSK1/2)
            regulated gene expression in normal and disease states.
            Review article
REFERENCE   4  (bases 1 to 3128)
  AUTHORS   Akbar,N., Forteath,C., Hussain,M.S., Reyskens,K., Belch,J.J.F.,
            Lang,C.C., Mordi,I.R., Bhalraam,U., Arthur,J.S.C. and Khan,F.
  TITLE     Mitogen and Stress-Activated Kinases 1 and 2 Mediate Endothelial
            Dysfunction
  JOURNAL   Int J Mol Sci 22 (16), 8655 (2021)
   PUBMED   34445361
  REMARK    GeneRIF: Mitogen and Stress-Activated Kinases 1 and 2 Mediate
            Endothelial Dysfunction.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3128)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3128)
  AUTHORS   Du,K. and Montminy,M.
  TITLE     CREB is a regulatory target for the protein kinase Akt/PKB
  JOURNAL   J Biol Chem 273 (49), 32377-32379 (1998)
   PUBMED   9829964
REFERENCE   7  (bases 1 to 3128)
  AUTHORS   Zhu,S. and Gerhard,D.S.
  TITLE     A transcript map of an 800-kb region on human chromosome 11q13,
            part of the candidate region for SCA5 and BBS1
  JOURNAL   Hum Genet 103 (6), 674-680 (1998)
   PUBMED   9921902
REFERENCE   8  (bases 1 to 3128)
  AUTHORS   Pierrat,B., Correia,J.S., Mary,J.L., Tomas-Zuber,M. and
            Lesslauer,W.
  TITLE     RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase
            under dominant control of p38alpha mitogen-activated protein kinase
            (p38alphaMAPK)
  JOURNAL   J Biol Chem 273 (45), 29661-29671 (1998)
   PUBMED   9792677
REFERENCE   9  (bases 1 to 3128)
  AUTHORS   Deak,M., Clifton,A.D., Lucocq,L.M. and Alessi,D.R.
  TITLE     Mitogen- and stress-activated protein kinase-1 (MSK1) is directly
            activated by MAPK and SAPK2/p38, and may mediate activation of CREB
  JOURNAL   EMBO J 17 (15), 4426-4441 (1998)
   PUBMED   9687510
REFERENCE   10 (bases 1 to 3128)
  AUTHORS   Xing,J., Ginty,D.D. and Greenberg,M.E.
  TITLE     Coupling of the RAS-MAPK pathway to gene activation by RSK2, a
            growth factor-regulated CREB kinase
  JOURNAL   Science 273 (5277), 959-963 (1996)
   PUBMED   8688081
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI523588.1, AJ010119.1 and
            BC028079.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003942.2.
            
            Summary: This gene encodes a member of the RSK (ribosomal S6
            kinase) family of serine/threonine kinases. This kinase contains 2
            non-identical kinase catalytic domains and phosphorylates various
            substrates, including CREB1 and ATF1. The encoded protein can also
            phosphorylate histone H3 to regulate certain inflammatory genes.
            Several transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ010119.1, AK292163.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334205.9/ ENSP00000333896.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BI523588.1         35-43
            10-309              AJ010119.1         1-300
            310-312             BC028079.1         283-285
            313-3128            AJ010119.1         304-3119
FEATURES             Location/Qualifiers
     source          1..3128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..3128
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /note="ribosomal protein S6 kinase A4"
                     /db_xref="GeneID:8986"
                     /db_xref="HGNC:HGNC:10433"
                     /db_xref="MIM:603606"
     exon            1..129
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..2393
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 1;
                     ribosomal protein kinase B; mitogen- and stress-activated
                     protein kinase 2; ribosomal protein S6 kinase, 90kDa,
                     polypeptide 4; ribosomal protein S6 kinase alpha-4; 90 kDa
                     ribosomal protein S6 kinase 4; nuclear mitogen- and
                     stress-activated protein kinase 2"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase alpha-4 isoform a"
                     /protein_id="NP_003933.1"
                     /db_xref="CCDS:CCDS8073.1"
                     /db_xref="GeneID:8986"
                     /db_xref="HGNC:HGNC:10433"
                     /db_xref="MIM:603606"
                     /translation="MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAY
                     GKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLH
                     YAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYR
                     DLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKA
                     VDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRL
                     LCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEE
                     FTRLEPVYSPPGSPPPGDPRIFQGYSFVAPSILFDHNNAVMTDGLEAPGAGDRPGRAA
                     VARSAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEANT
                     QREVAALRLCQSHPNVVNLHEVHHDQLHTYLVLELLRGGELLEHIRKKRHFSESEASQ
                     ILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPGVPM
                     QTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEI
                     MCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSS
                     PPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSATA
                     SRRGSPAPANPGRAPVASKGAPRRANGPLPPS"
     exon            130..201
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /inference="alignment:Splign:2.1.0"
     exon            202..420
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /inference="alignment:Splign:2.1.0"
     exon            421..536
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /inference="alignment:Splign:2.1.0"
     exon            537..644
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /inference="alignment:Splign:2.1.0"
     exon            645..725
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /inference="alignment:Splign:2.1.0"
     exon            726..829
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /inference="alignment:Splign:2.1.0"
     exon            830..980
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1145
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1274
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1408
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1502
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1676
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1871
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..2031
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2195
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..3128
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3098..3103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /note="hexamer: AATAAA"
     polyA_site      3128
                     /gene="RPS6KA4"
                     /gene_synonym="MSK2; RSK-B; S6K-alpha-4"
                     /note="major polyA site"
ORIGIN      
        1 gccccggccg gagccgccat gtaaccggcg ccgcccggag cccgagccgc gcgggcccca
       61 gcgacccgcc cgccatgggg gacgaggacg acgatgagag ctgcgccgtg gagctgcgga
      121 tcacagaagc caacctgacc gggcacgagg agaaggtgag cgtggagaac ttcgagctgc
      181 tcaaggtgct gggcacggga gcctacggca aggtgttcct ggtgcggaag gcgggcgggc
      241 acgacgcggg gaagctgtac gccatgaagg tgctgcgcaa ggcggcgctg gtgcagcgcg
      301 ccaagacgca agagcacacg cgcaccgagc gctcggtgct ggagctggtg cgccaggcgc
      361 ccttcctggt cacgctgcac tacgctttcc agacggatgc caagctgcac ctcatcctgg
      421 actatgtgag cggcggggag atgttcaccc acctctacca gcgccagtac ttcaaggagg
      481 ctgaggtgcg cgtgtatggg ggtgagatcg tgctggccct ggaacacctg cacaagctcg
      541 gcatcattta ccgagacctg aaactggaga atgtgctgct ggactccgag ggccacattg
      601 tcctcacgga cttcgggctg agcaaggagt tcctgacgga ggagaaagag cggaccttct
      661 ccttctgtgg caccatcgag tacatggccc ccgaaatcat ccgtagcaag acggggcatg
      721 gcaaggctgt ggactggtgg agcctgggca tcttgctctt cgagctgctg acgggggcct
      781 cgcccttcac cctggagggc gagaggaaca cgcaggctga ggtgtctcga cggatcctga
      841 agtgctcccc tcccttcccc cctcggatcg ggcccgtggc gcaggacctg ctgcagcggc
      901 tgctttgtaa ggatcctaag aagcgattgg gcgcggggcc ccagggggca caagaagtcc
      961 ggaaccatcc cttcttccag ggcctcgatt gggtggctct ggctgccagg aagattccag
     1021 ccccattccg gccccaaatc cgctcagagc tggatgtggg caactttgcg gaggaattca
     1081 ctcggctgga gcctgtctac tcaccccctg gcagcccccc acctggggac ccccgaatct
     1141 ttcagggata ctcctttgtg gcaccctcca ttctctttga ccacaacaac gcggtgatga
     1201 ccgatgggct ggaagcgcct ggtgctggag accggccagg tcgggcagcg gtggccagga
     1261 gcgctatgat gcaggactcg cccttcttcc agcagtacga gctggacctg cgggagcctg
     1321 cgctgggcca gggcagcttt tctgtgtgtc gccgctgccg ccagcgccag agcggccagg
     1381 agttcgcagt caagatcctc agtcgcaggc tggaggcgaa cacgcagcgc gaagtggctg
     1441 ccctgcgcct gtgccagtca caccccaacg tggtgaatct gcacgaggtg catcacgacc
     1501 agctgcacac gtacctggtc ctggagctgc tgcggggcgg ggagctgctg gagcacatcc
     1561 gcaagaagcg gcacttcagc gagtcggaag caagccagat cctgcgcagc ctcgtgtcgg
     1621 ccgtgagctt catgcacgag gaggcgggcg tggtgcaccg cgacctcaag ccggagaaca
     1681 tcctgtacgc cgacgacacg cccggggccc cggtgaaaat catcgacttc gggttcgcgc
     1741 ggttgcggcc gcagagtccc ggggtgccca tgcagacgcc ctgcttcacg ctgcagtacg
     1801 ctgcccccga gctgctggcg cagcagggct acgacgagtc ctgcgacctc tggagcctgg
     1861 gcgtcattct gtacatgatg ctgtcggggc aggtcccctt ccagggggcc tctggccagg
     1921 gcgggcagag ccaggcggcc gagatcatgt gcaaaatccg cgaggggcgc ttctcccttg
     1981 acggggaggc ctggcagggt gtatccgagg aagccaagga gctggtccga gggctcctga
     2041 ccgtggaccc cgccaagcgg ctgaagctcg agggactgcg gggcagctcg tggctgcagg
     2101 acggcagcgc gcgctcctcg cccccgctcc ggacgcccga cgtgctcgag tcctctgggc
     2161 ccgcagtgcg ctcgggtctc aacgccacct tcatggcatt caaccggggc aagcgggagg
     2221 gcttcttcct gaagagcgtg gagaatgcac ccctggccaa gcggcggaag cagaagctgc
     2281 ggagcgccac cgcctcccgc cggggctccc ctgcaccagc caacccgggc cgagcccccg
     2341 tcgcctccaa aggggccccc cgccgagcca acggccccct gcccccctcc taatccccac
     2401 cactgtgacc cccttccctc ataggggctg tgacctggga gcccggctca ctcccggagg
     2461 cctctgcctg cggctgacct gatccccaag ggactgtcct ttcctctcct accccacccc
     2521 actcccagac agagcagaag tatttttata agcagagaat tttttatgtc ttaccagata
     2581 gagttgcagg gaaggggggg cctgctgggg agtggggttt ggggggccct ctcccaggac
     2641 actgcctctt ctgggcagaa ggcccctcca gggggactgc tccaacagga aagagcccct
     2701 cccccacttc taagcactga gttaggagtg ctaactccta aactgggacc ccctaccctg
     2761 ttctcccctg aggccccgtt cctgggaggg gcacccctca actgtcactt tatggactgt
     2821 ctgtgcaatt acgtccacca aagacccgtg ttgggggtac tgaaggagag gccctggggg
     2881 accctctgaa gcatttctgc ctcactttat gtcatctgct tctcccctgt tggggctaag
     2941 gaaggagata ggtggctcct aaaagaggag gccatcttct cacccacccc ttcctctttg
     3001 gcacagctac tcctggctgg gggtggggcc ttgggggtct gggctgggca tccatggtca
     3061 ctgcctcagc ccagccaggc tgtgcctttg actttaaaat aaaagtccac ccagtgctgt
     3121 gtgtggca
//
