LOCUS       NM_002953               3192 bp    mRNA    linear   PRI 15-MAR-2025
DEFINITION  Homo sapiens ribosomal protein S6 kinase A1 (RPS6KA1), transcript
            variant 1, mRNA.
ACCESSION   NM_002953
VERSION     NM_002953.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3192)
  AUTHORS   Zhou,N., Guo,C., Du,J., Xu,Q., Li,J., Huang,D., Zheng,X. and Tu,L.
  TITLE     PPP1R14B-mediated phosphorylation enhances protein stability of
            RPS6KA1 to promote hepatocellular carcinoma tumorigenesis
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119840 (2024)
   PUBMED   39216602
  REMARK    GeneRIF: PPP1R14B-mediated phosphorylation enhances protein
            stability of RPS6KA1 to promote hepatocellular carcinoma
            tumorigenesis.
REFERENCE   2  (bases 1 to 3192)
  AUTHORS   Guo,X., Huang,G., Qiu,D., He,H., Niu,X., Guo,Z. and Ye,Y.
  TITLE     RPS6KA1 is a histone acetylation-related oncoprotein in acute
            myeloid leukemia which is targeted by afzelin
  JOURNAL   BMC Cancer 24 (1), 1189 (2024)
   PUBMED   39333927
  REMARK    GeneRIF: RPS6KA1 is a histone acetylation-related oncoprotein in
            acute myeloid leukemia which is targeted by afzelin.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3192)
  AUTHORS   Wu,S., Jin,J., Huang,J., Chen,G. and Chen,Y.
  TITLE     Comprehensive analysis of the RSK gene family in acute myeloid
            leukemia determines a prognostic signature for the prediction of
            clinical prognosis and treatment responses
  JOURNAL   Hematology 28 (1), 2235833 (2023)
   PUBMED   37462338
  REMARK    GeneRIF: Comprehensive analysis of the RSK gene family in acute
            myeloid leukemia determines a prognostic signature for the
            prediction of clinical prognosis and treatment responses.
REFERENCE   4  (bases 1 to 3192)
  AUTHORS   Weidenauer,K., Schmidt,C., Rohde,C., Pauli,C., Blank,M.F., Heid,D.,
            Waclawiczek,A., Corbacioglu,A., Gollner,S., Lotze,M., Vierbaum,L.,
            Renders,S., Krijgsveld,J., Raffel,S., Sauer,T., Trumpp,A.,
            Pabst,C., Muller-Tidow,C. and Janssen,M.
  TITLE     The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces
            resistance to venetoclax/azacitidine in acute myeloid leukemia
  JOURNAL   Leukemia 37 (8), 1611-1625 (2023)
   PUBMED   37414921
  REMARK    GeneRIF: The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces
            resistance to venetoclax/azacitidine in acute myeloid leukemia.
REFERENCE   5  (bases 1 to 3192)
  AUTHORS   Ali,E.S., Liponska,A., O'Hara,B.P., Amici,D.R., Torno,M.D., Gao,P.,
            Asara,J.M., Yap,M.F., Mendillo,M.L. and Ben-Sahra,I.
  TITLE     The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de
            novo nucleotide synthesis
  JOURNAL   Mol Cell 82 (17), 3284-3298 (2022)
   PUBMED   35772404
REFERENCE   6  (bases 1 to 3192)
  AUTHORS   Moller,D.E., Xia,C.H., Tang,W., Zhu,A.X. and Jakubowski,M.
  TITLE     Human rsk isoforms: cloning and characterization of tissue-specific
            expression
  JOURNAL   Am J Physiol 266 (2 Pt 1), C351-C359 (1994)
   PUBMED   8141249
REFERENCE   7  (bases 1 to 3192)
  AUTHORS   Chen,R.H., Abate,C. and Blenis,J.
  TITLE     Phosphorylation of the c-Fos transrepression domain by
            mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 10952-10956 (1993)
   PUBMED   8248197
REFERENCE   8  (bases 1 to 3192)
  AUTHORS   Rivera,V.M., Miranti,C.K., Misra,R.P., Ginty,D.D., Chen,R.H.,
            Blenis,J. and Greenberg,M.E.
  TITLE     A growth factor-induced kinase phosphorylates the serum response
            factor at a site that regulates its DNA-binding activity
  JOURNAL   Mol Cell Biol 13 (10), 6260-6273 (1993)
   PUBMED   8413226
REFERENCE   9  (bases 1 to 3192)
  AUTHORS   Tratner,I., Ofir,R. and Verma,I.M.
  TITLE     Alteration of a cyclic AMP-dependent protein kinase phosphorylation
            site in the c-Fos protein augments its transforming potential
  JOURNAL   Mol Cell Biol 12 (3), 998-1006 (1992)
   PUBMED   1545828
REFERENCE   10 (bases 1 to 3192)
  AUTHORS   Chen,R.H., Sarnecki,C. and Blenis,J.
  TITLE     Nuclear localization and regulation of erk- and rsk-encoded protein
            kinases
  JOURNAL   Mol Cell Biol 12 (3), 915-927 (1992)
   PUBMED   1545823
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL627313.16.
            
            On Nov 23, 2018 this sequence version replaced NM_002953.3.
            
            Summary: This gene encodes a member of the RSK (ribosomal S6
            kinase) family of serine/threonine kinases. This kinase contains 2
            nonidentical kinase catalytic domains and phosphorylates various
            substrates, including members of the mitogen-activated kinase
            (MAPK) signalling pathway. The activity of this protein has been
            implicated in controlling cell growth and differentiation.
            Alternate transcriptional splice variants, encoding different
            isoforms, have been characterized. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014966.1, SRR1803615.117813.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374168.7/ ENSP00000363283.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-223               AL627313.16        110677-110899       c
            224-268             AL627313.16        103691-103735       c
            269-385             AL627313.16        93677-93793         c
            386-467             AL627313.16        93390-93471         c
            468-548             AL627313.16        89183-89263         c
            549-628             AL627313.16        88937-89016         c
            629-735             AL627313.16        87163-87269         c
            736-773             AL627313.16        86409-86446         c
            774-916             AL627313.16        85922-86064         c
            917-987             AL627313.16        85439-85509         c
            988-1076            AL627313.16        85035-85123         c
            1077-1141           AL627313.16        83942-84006         c
            1142-1244           AL627313.16        83560-83662         c
            1245-1375           AL627313.16        81723-81853         c
            1376-1501           AL627313.16        79809-79934         c
            1502-1591           AL627313.16        79526-79615         c
            1592-1750           AL627313.16        78997-79155         c
            1751-1912           AL627313.16        69050-69211         c
            1913-1989           AL627313.16        68735-68811         c
            1990-2107           AL627313.16        68367-68484         c
            2108-2245           AL627313.16        67299-67436         c
            2246-3192           AL627313.16        65635-66581         c
FEATURES             Location/Qualifiers
     source          1..3192
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..3192
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /note="ribosomal protein S6 kinase A1"
                     /db_xref="GeneID:6195"
                     /db_xref="HGNC:HGNC:10430"
                     /db_xref="MIM:601684"
     exon            1..223
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..2368
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /EC_number="2.7.11.1"
                     /note="isoform a is encoded by transcript variant 1;
                     p90-RSK 1; ribosomal protein S6 kinase alpha-1; S6K-alpha
                     1; dJ590P13.1 (ribosomal protein S6 kinase, 90kD,
                     polypeptide 1); RSK-1; p90S6K; p90RSK1; MAPKAPK-1a; MAPKAP
                     kinase 1a; ribosomal S6 kinase 1; ribosomal protein S6
                     kinase, 90kDa, polypeptide 1; MAPK-activated protein
                     kinase 1a; 90 kDa ribosomal protein S6 kinase 1; MAP
                     kinase-activated protein kinase 1a"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase alpha-1 isoform a"
                     /protein_id="NP_002944.2"
                     /db_xref="CCDS:CCDS284.1"
                     /db_xref="GeneID:6195"
                     /db_xref="HGNC:HGNC:10430"
                     /db_xref="MIM:601684"
                     /translation="MPLAQLKEPWPLMELVPLDPENGQTSGEEAGLQPSKDEGVLKEI
                     SITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLK
                     VRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFT
                     EEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKK
                     AYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILK
                     AKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREI
                     KPPFKPAVAQPDDTFYFDTEFTSRTPKDSPGIPPSAGAHQLFRGFSFVATGLMEDDGK
                     PRAPQAPLHSVVQQLHGKNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVID
                     KSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFS
                     EREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRA
                     ENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPEE
                     ILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLP
                     QSQLSHQDLQLVKGAMAATYSALNSSKPTPQLKPIESSILAQRRVRKLPSTTL"
     exon            224..268
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            269..385
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            386..467
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..548
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..628
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..735
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..773
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..916
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            917..987
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1076
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1141
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1244
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1375
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1501
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1591
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1750
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1912
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..1989
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2107
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2245
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..3192
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3174..3179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /note="hexamer: AATAAA"
     polyA_site      3192
                     /gene="RPS6KA1"
                     /gene_synonym="HU-1; MAPKAPK1; MAPKAPK1A; p90Rsk; RSK;
                     RSK1"
                     /note="major polyA site"
ORIGIN      
        1 gaagtgctag tgccgcggcg gcggcggcgg acggcccagc cggagcgcga ggggctcggg
       61 ggggcgcggc ggttcgggtc gcagagccag ggaccccagg acccgggagg cggcgcagcc
      121 ggggccgccg gaggagcgcg ggtgacctgg cggcggcgag atgccgctcg cccagctcaa
      181 ggagccctgg ccgctcatgg agctagtgcc tctggacccg gagaatggac agacctcagg
      241 ggaagaagct ggacttcagc cgtccaagga tgagggcgtc ctcaaggaga tctccatcac
      301 gcaccacgtc aaggctggct ctgagaaggc tgatccatcc catttcgagc tcctcaaggt
      361 tctgggccag ggatcctttg gcaaagtctt cctggtgcgg aaagtcaccc ggcctgacag
      421 tgggcacctg tatgctatga aggtgctgaa gaaggcaacg ctgaaagtac gtgaccgcgt
      481 ccggaccaag atggagagag acatcctggc tgatgtaaat cacccattcg tggtgaagct
      541 gcactatgcc ttccagaccg agggcaagct ctatctcatt ctggacttcc tgcgtggtgg
      601 ggacctcttc acccggctct caaaagaggt gatgttcacg gaggaggatg tgaagtttta
      661 cctggctgag ctggctctgg gcctggatca cctgcacagc ctgggtatca tttacagaga
      721 cctcaagcct gagaacatcc ttctggatga ggagggccac atcaaactca ctgactttgg
      781 cctgagcaaa gaggccattg accacgagaa gaaggcctat tctttctgcg ggacagtgga
      841 gtacatggcc cctgaggtcg tcaaccgcca gggccactcc catagtgcgg actggtggtc
      901 ctatggggtg ttgatgtttg agatgctgac gggctccctg cccttccagg ggaaggaccg
      961 gaaggagacc atgacactga ttctgaaggc gaagctaggc atgccccagt ttctgagcac
     1021 tgaagcccag agcctcttgc gggccctgtt caagcggaat cctgccaacc ggctcggctc
     1081 cggccctgat ggggcagagg aaatcaagcg gcatgtcttc tactccacca ttgactggaa
     1141 taagctatac cgtcgtgaga tcaagccacc cttcaagcca gcagtggctc agcctgatga
     1201 caccttctac tttgacaccg agttcacgtc ccgcacaccc aaggattccc caggcatccc
     1261 ccccagcgct ggggcccatc agctgttccg gggcttcagc ttcgtggcca ccggcctgat
     1321 ggaagacgac ggcaagcctc gtgccccgca ggcacccctg cactcggtgg tacagcaact
     1381 ccatgggaag aacctggttt ttagtgacgg ctacgtggta aaggagacaa ttggtgtggg
     1441 ctcctactct gagtgcaagc gctgtgtcca caaggccacc aacatggagt atgctgtcaa
     1501 ggtcattgat aagagcaagc gggatccttc agaagagatt gagattcttc tgcggtatgg
     1561 ccagcacccc aacatcatca ctctgaaaga tgtgtatgat gatggcaaac acgtgtacct
     1621 ggtgacagag ctgatgcggg gtggggagct gctggacaag atcctgcggc agaagttctt
     1681 ctcagagcgg gaggccagct ttgtcctgca caccattggc aaaactgtgg agtatctgca
     1741 ctcacagggg gttgtgcaca gggacctgaa gcccagcaac atcctgtatg tggacgagtc
     1801 cgggaatccc gagtgcctgc gcatctgtga ctttggtttt gccaaacagc tgcgggctga
     1861 gaatgggctc ctcatgacac cttgctacac agccaacttt gtggcgcctg aggtgctgaa
     1921 gcgccagggc tacgatgaag gctgcgacat ctggagcctg ggcattctgc tgtacaccat
     1981 gctggcagga tatactccat ttgccaacgg tcccagtgac acaccagagg aaatcctaac
     2041 ccggatcggc agtgggaagt ttaccctcag tgggggaaat tggaacacag tttcagagac
     2101 agccaaggac ctggtgtcca agatgctaca cgtggatccc caccagcgcc tcacagctaa
     2161 gcaggttctg cagcatccat gggtcaccca gaaagacaag cttccccaaa gccagctgtc
     2221 ccaccaggac ctacagcttg tgaagggagc catggctgcc acgtactccg cactcaacag
     2281 ctccaagccc accccccagc tgaagcccat cgagtcatcc atcctggccc agcggcgagt
     2341 gaggaagttg ccatccacca ccctgtgagg caccagggca ttcgggccac agggcggtgc
     2401 tagcttgaca cagtcagcat gcttcccaga gggagcaggc cggaaccaca gggccagagg
     2461 gagctggaac ccgaggggcc ggggaagctg ccagcccaga acacccctaa tgagggtgtg
     2521 agaagtgcct tctccttccc caggatggac tcttctcggc tcaggctctg ctggtggaaa
     2581 gcgattcact gtataaactt ttttttatga aaaaaatggc atcaaccacc atggattttt
     2641 acaagatcca tttgcctttc tgggagcaga aacagccatt gcggccccag gaggggaact
     2701 gagtcacgct ggggctctct gagactcttt agagcagctt tgggatccca ccctggggac
     2761 ccccacgatt ggccacctgt agccatctgc acacacctcc gagacagtcc agtgtcacct
     2821 ctctcagagc atctggctgt ttagcagaac tcattctatc cccaatcagc tccttttccg
     2881 ttctgttctg ctgggagttc tagaaccact tcctgctaca ggaggggtct catgtcctgc
     2941 tggcttccag cttcaggcac cagcatccac cttggctctg ccagtggatc ccctgcggtc
     3001 aggctgggca gccccagaga gaggatgtgg aaagcacttt ttggctgact tcatctgggg
     3061 ttggcaacag gacagagttc acaggaggcc agtgggcggg ccatgaggga cagggtcttt
     3121 tttcatttct tcctcagctg gttactcagg gttcatctgt ccatggcctt tctaataaac
     3181 tgttgagttg aa
//
