LOCUS       NM_001010               1369 bp    mRNA    linear   PRI 22-MAR-2025
DEFINITION  Homo sapiens ribosomal protein S6 (RPS6), mRNA.
ACCESSION   NM_001010
VERSION     NM_001010.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1369)
  AUTHORS   Smolen,K.A., Papke,C.M., Swingle,M.R., Musiyenko,A., Li,C.,
            Salter,E.A., Camp,A.D., Honkanen,R.E. and Kettenbach,A.N.
  TITLE     Quantitative proteomics and phosphoproteomics of PP2A-PPP2R5D
            variants reveal deregulation of RPS6 phosphorylation via converging
            signaling cascades
  JOURNAL   J Biol Chem 299 (9), 105154 (2023)
   PUBMED   37572851
  REMARK    GeneRIF: Quantitative proteomics and phosphoproteomics of
            PP2A-PPP2R5D variants reveal deregulation of RPS6 phosphorylation
            via converging signaling cascades.
REFERENCE   2  (bases 1 to 1369)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   3  (bases 1 to 1369)
  AUTHORS   Karg,M.M., John,L., Refaian,N., Buettner,C., Rottmar,T., Sommer,J.,
            Bock,B., Resheq,Y.J., Ksander,B.R., Heindl,L.M., Mackensen,A. and
            Bosch,J.J.
  TITLE     Midkine Promotes Metastasis and Therapeutic Resistance via
            mTOR/RPS6 in Uveal Melanoma
  JOURNAL   Mol Cancer Res 20 (8), 1320-1336 (2022)
   PUBMED   35503453
  REMARK    GeneRIF: Midkine Promotes Metastasis and Therapeutic Resistance via
            mTOR/RPS6 in Uveal Melanoma.
REFERENCE   4  (bases 1 to 1369)
  AUTHORS   Nabeel-Shah,S., Lee,H., Ahmed,N., Burke,G.L., Farhangmehr,S.,
            Ashraf,K., Pu,S., Braunschweig,U., Zhong,G., Wei,H., Tang,H.,
            Yang,J., Marcon,E., Blencowe,B.J., Zhang,Z. and Greenblatt,J.F.
  TITLE     SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates
            stress granules to impair host stress response
  JOURNAL   iScience 25 (1), 103562 (2022)
   PUBMED   34901782
REFERENCE   5  (bases 1 to 1369)
  AUTHORS   Bohlen,J., Roiuk,M. and Teleman,A.A.
  TITLE     Phosphorylation of ribosomal protein S6 differentially affects mRNA
            translation based on ORF length
  JOURNAL   Nucleic Acids Res 49 (22), 13062-13074 (2021)
   PUBMED   34871442
  REMARK    GeneRIF: Phosphorylation of ribosomal protein S6 differentially
            affects mRNA translation based on ORF length.
REFERENCE   6  (bases 1 to 1369)
  AUTHORS   Pata,I., Hoth,S., Kruppa,J. and Metspalu,A.
  TITLE     The human ribosomal protein S6 gene: isolation, primary structure
            and location in chromosome 9
  JOURNAL   Gene 121 (2), 387-392 (1992)
   PUBMED   1446836
  REMARK    Erratum:[Gene. 1993 May 30;127(2):275-6. doi:
            10.1016/0378-1119(93)90735-l. PMID: 8500771]
REFERENCE   7  (bases 1 to 1369)
  AUTHORS   Antoine,M. and Fried,M.
  TITLE     The organization of the intron-containing human S6 ribosomal
            protein (rpS6) gene and determination of its location at chromosome
            9p21
  JOURNAL   Hum Mol Genet 1 (8), 565-570 (1992)
   PUBMED   1301164
REFERENCE   8  (bases 1 to 1369)
  AUTHORS   Penner,C.G., Murphy,L.C., Huzel,N.J. and Yamada,E.W.
  TITLE     Antigenic reactivity of ribosomal protein S6 and the
            calcium-binding ATPase inhibitor protein of mammalian mitochondria
  JOURNAL   Mol Cell Biochem 108 (1), 57-66 (1991)
   PUBMED   1837589
REFERENCE   9  (bases 1 to 1369)
  AUTHORS   Pogue-Geile,K., Geiser,J.R., Shu,M., Miller,C., Wool,I.G.,
            Meisler,A.I. and Pipas,J.M.
  TITLE     Ribosomal protein genes are overexpressed in colorectal cancer:
            isolation of a cDNA clone encoding the human S3 ribosomal protein
  JOURNAL   Mol Cell Biol 11 (8), 3842-3849 (1991)
   PUBMED   1712897
REFERENCE   10 (bases 1 to 1369)
  AUTHORS   Kaerlein,M. and Horak,I.
  TITLE     Identification and characterization of ribosomal proteins
            phosphorylated in vaccinia-virus-infected HeLa cells
  JOURNAL   Eur J Biochem 90 (3), 463-469 (1978)
   PUBMED   710442
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AL391834.8.
            
            On May 17, 2019 this sequence version replaced NM_001010.2.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a cytoplasmic
            ribosomal protein that is a component of the 40S subunit. The
            protein belongs to the S6E family of ribosomal proteins. It is the
            major substrate of protein kinases in the ribosome, with subsets of
            five C-terminal serine residues phosphorylated by different protein
            kinases. Phosphorylation is induced by a wide range of stimuli,
            including growth factors, tumor-promoting agents, and mitogens.
            Dephosphorylation occurs at growth arrest. The protein may
            contribute to the control of cell growth and proliferation through
            the selective translation of particular classes of mRNA. As is
            typical for genes encoding ribosomal proteins, there are multiple
            processed pseudogenes of this gene dispersed through the genome.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.41015.1, AK291517.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380394.9/ ENSP00000369757.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AL391834.8         59683-59729         c
            48-179              AL391834.8         58980-59111         c
            180-390             AL391834.8         58201-58411         c
            391-537             AL391834.8         57861-58007         c
            538-695             AL391834.8         55987-56144         c
            696-1369            AL391834.8         55208-55881         c
FEATURES             Location/Qualifiers
     source          1..1369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p22.1"
     gene            1..1369
                     /gene="RPS6"
                     /gene_synonym="eS6; S6"
                     /note="ribosomal protein S6"
                     /db_xref="GeneID:6194"
                     /db_xref="HGNC:HGNC:10429"
                     /db_xref="MIM:180460"
     exon            1..47
                     /gene="RPS6"
                     /gene_synonym="eS6; S6"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..791
                     /gene="RPS6"
                     /gene_synonym="eS6; S6"
                     /note="40S ribosomal protein S6; phosphoprotein NP33"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS6"
                     /protein_id="NP_001001.2"
                     /db_xref="CCDS:CCDS6492.1"
                     /db_xref="GeneID:6194"
                     /db_xref="HGNC:HGNC:10429"
                     /db_xref="MIM:180460"
                     /translation="MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEE
                     WKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIV
                     DANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRK
                     PLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMK
                     EAKEKRQEQIAKRRRLSSLRASTSKSESSQK"
     exon            48..179
                     /gene="RPS6"
                     /gene_synonym="eS6; S6"
                     /inference="alignment:Splign:2.1.0"
     exon            180..390
                     /gene="RPS6"
                     /gene_synonym="eS6; S6"
                     /inference="alignment:Splign:2.1.0"
     exon            391..537
                     /gene="RPS6"
                     /gene_synonym="eS6; S6"
                     /inference="alignment:Splign:2.1.0"
     exon            538..695
                     /gene="RPS6"
                     /gene_synonym="eS6; S6"
                     /inference="alignment:Splign:2.1.0"
     exon            696..1369
                     /gene="RPS6"
                     /gene_synonym="eS6; S6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      808..813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6"
                     /gene_synonym="eS6; S6"
                     /note="hexamer: AATAAA"
     polyA_site      829
                     /gene="RPS6"
                     /gene_synonym="eS6; S6"
                     /note="major polyA site"
     regulatory      1147..1152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS6"
                     /gene_synonym="eS6; S6"
                     /note="hexamer: AATACA"
     polyA_site      1171
                     /gene="RPS6"
                     /gene_synonym="eS6; S6"
ORIGIN      
        1 ctcttttccg tggcgcctcg gaggcgttca gctgcttcaa gatgaagctg aacatctcct
       61 tcccagccac tggctgccag aaactcattg aagtggacga tgaacgcaaa cttcgtactt
      121 tctatgagaa gcgtatggcc acagaagttg ctgctgacgc tctgggtgaa gaatggaagg
      181 gttatgtggt ccgaatcagt ggtgggaacg acaaacaagg tttccccatg aagcagggtg
      241 tcttgaccca tggccgtgtc cgcctgctac tgagtaaggg gcattcctgt tacagaccaa
      301 ggagaactgg agaaagaaag agaaaatcag ttcgtggttg cattgtggat gcaaatctga
      361 gcgttctcaa cttggttatt gtaaaaaaag gagagaagga tattcctgga ctgactgata
      421 ctacagtgcc tcgccgcctg ggccccaaaa gagctagcag aatccgcaaa cttttcaatc
      481 tctctaaaga agatgatgtc cgccagtatg ttgtaagaaa gcccttaaat aaagaaggta
      541 agaaacctag gaccaaagca cccaagattc agcgtcttgt tactccacgt gtcctgcagc
      601 acaaacggcg gcgtattgct ctgaagaagc agcgtaccaa gaaaaataaa gaagaggctg
      661 cagaatatgc taaacttttg gccaagagaa tgaaggaggc taaggagaag cgccaggaac
      721 aaattgcgaa gagacgcaga ctttcctctc tgcgagcttc tacttctaag tctgaatcca
      781 gtcagaaata agattttttg agtaacaaat aaataagatc agactctgat ctctgttgac
      841 ttttcattgc tgatagaaaa ctacataaat gaagagaggg aaagttaggt catagaaaat
      901 ggggatatgt atatatggta ttccaatggt ggataaagtc agacctattg tgtgtggtag
      961 tggaagacaa ggtcagtgta caggggttcc tttcagggga tgggtggcac aggaagggat
     1021 tctgagcata agacacctgc ctcttcagaa tggcatggaa cttaggggaa atgatgagga
     1081 ctattaatct tttttatata gtttattttt gaggaatata gctctttaaa gcactataca
     1141 caatttaata catgaaaatt gaccttgtga agatgaacat gtctttttta aaaggtaact
     1201 tttaaggcat agttttagtg gatacctagt tttagtggat accatccact aaatggtttt
     1261 taagccattt caaatttgtt ttaacaaagc ttttcaactc cagtgaattg ttaggctgtt
     1321 cacacactga aaaggaaatg actaaaaaca ttcttggatc agtgaaaaa
//
