LOCUS       NM_001009                741 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens ribosomal protein S5 (RPS5), mRNA.
ACCESSION   NM_001009
VERSION     NM_001009.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 741)
  AUTHORS   Zhou,C., Wu,Q., Zhao,H., Xie,R., He,X. and Gu,H.
  TITLE     Unraveling the Role of RNA-Binding Proteins, with a Focus on RPS5,
            in the Malignant Progression of Hepatocellular Carcinoma
  JOURNAL   Int J Mol Sci 25 (2), 773 (2024)
   PUBMED   38255847
  REMARK    GeneRIF: Unraveling the Role of RNA-Binding Proteins, with a Focus
            on RPS5, in the Malignant Progression of Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 741)
  AUTHORS   Liang,H., Li,Q., Wang,N., Wang,C., Shi,S., Yang,H., Cao,Y., Shi,R.,
            Jin,L. and Zhang,C.
  TITLE     KDM4D enhances osteo/dentinogenic differentiation and migration of
            SCAPs via binding to RPS5
  JOURNAL   Oral Dis 29 (7), 2827-2836 (2023)
   PUBMED   36579641
  REMARK    GeneRIF: KDM4D enhances osteo/dentinogenic differentiation and
            migration of SCAPs via binding to RPS5.
REFERENCE   3  (bases 1 to 741)
  AUTHORS   Qiu,L., Chao,W., Zhong,S. and Ren,A.J.
  TITLE     Eukaryotic Ribosomal Protein S5 of the 40S Subunit: Structure and
            Function
  JOURNAL   Int J Mol Sci 24 (4), 3386 (2023)
   PUBMED   36834797
  REMARK    GeneRIF: Eukaryotic Ribosomal Protein S5 of the 40S Subunit:
            Structure and Function.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 741)
  AUTHORS   Iizumi,Y., Sowa,Y., Goi,W., Aono,Y., Watanabe,M., Kurumida,Y.,
            Kameda,T., Akaji,K., Kitagawa,M. and Sakai,T.
  TITLE     Stabilization of CDK6 by ribosomal protein uS7, a target protein of
            the natural product fucoxanthinol
  JOURNAL   Commun Biol 5 (1), 564 (2022)
   PUBMED   35681048
  REMARK    GeneRIF: Stabilization of CDK6 by ribosomal protein uS7, a target
            protein of the natural product fucoxanthinol.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 741)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   6  (bases 1 to 741)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   7  (bases 1 to 741)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   8  (bases 1 to 741)
  AUTHORS   Frigerio,J.M., Dagorn,J.C. and Iovanna,J.L.
  TITLE     Cloning, sequencing and expression of the L5, L21, L27a, L28, S5,
            S9, S10 and S29 human ribosomal protein mRNAs
  JOURNAL   Biochim Biophys Acta 1262 (1), 64-68 (1995)
   PUBMED   7772601
REFERENCE   9  (bases 1 to 741)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   10 (bases 1 to 741)
  AUTHORS   Mundus,D.A., Bulygin,K.N., Yamkovoy,V.I., Malygin,A.A.,
            Repkova,M.N., Vratskikh,L.V., Venijaminova,A.G., Vladimirov,S.N.
            and Karpova,G.G.
  TITLE     Structural arrangement of the codon-anticodon interaction area in
            human placenta ribosomes. Affinity labelling of the 40S subunits by
            derivatives of oligoribonucleotides containing the AUG codon
  JOURNAL   Biochim Biophys Acta 1173 (3), 273-282 (1993)
   PUBMED   8318536
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BG687415.1 and BC015405.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001009.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S7P family of ribosomal proteins. It is located in the
            cytoplasm. Variable expression of this gene in colorectal cancers
            compared to adjacent normal tissues has been observed, although no
            correlation between the level of expression and the severity of the
            disease has been found. As is typical for genes encoding ribosomal
            proteins, there are multiple processed pseudogenes of this gene
            dispersed through the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.100764.1,
                                           SRR5189658.142489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000196551.8/ ENSP00000196551.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BG687415.1         1-39
            40-741              BC015405.1         28-729
FEATURES             Location/Qualifiers
     source          1..741
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..741
                     /gene="RPS5"
                     /gene_synonym="S5; uS7"
                     /note="ribosomal protein S5"
                     /db_xref="GeneID:6193"
                     /db_xref="HGNC:HGNC:10426"
                     /db_xref="MIM:603630"
     exon            1..71
                     /gene="RPS5"
                     /gene_synonym="S5; uS7"
                     /inference="alignment:Splign:2.1.0"
     exon            72..180
                     /gene="RPS5"
                     /gene_synonym="S5; uS7"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..687
                     /gene="RPS5"
                     /gene_synonym="S5; uS7"
                     /note="40S ribosomal protein S5"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS7"
                     /protein_id="NP_001000.2"
                     /db_xref="CCDS:CCDS12978.1"
                     /db_xref="GeneID:6193"
                     /db_xref="HGNC:HGNC:10426"
                     /db_xref="MIM:603630"
                     /translation="MTEWETAAPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEK
                     YAKYLPHSAGRYAAKRFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHL
                     LTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGARE
                     AAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR"
     exon            181..390
                     /gene="RPS5"
                     /gene_synonym="S5; uS7"
                     /inference="alignment:Splign:2.1.0"
     exon            391..519
                     /gene="RPS5"
                     /gene_synonym="S5; uS7"
                     /inference="alignment:Splign:2.1.0"
     exon            520..618
                     /gene="RPS5"
                     /gene_synonym="S5; uS7"
                     /inference="alignment:Splign:2.1.0"
     exon            619..741
                     /gene="RPS5"
                     /gene_synonym="S5; uS7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      706..711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS5"
                     /gene_synonym="S5; uS7"
                     /note="hexamer: AATAAA"
     polyA_site      741
                     /gene="RPS5"
                     /gene_synonym="S5; uS7"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcctgt ctgtaccagg gcggcgcgtg gtctacgccg agtgacagag acgctcaggc
       61 tgtgttctca ggatgaccga gtgggagaca gcagcaccag cggtggcaga gaccccagac
      121 atcaagctct ttgggaagtg gagcaccgat gatgtgcaga tcaatgacat ttccctgcag
      181 gattacattg cagtgaagga gaagtatgcc aagtacctgc ctcacagtgc agggcggtat
      241 gccgccaaac gcttccgcaa agctcagtgt cccattgtgg agcgcctcac taactccatg
      301 atgatgcacg gccgcaacaa cggcaagaag ctcatgactg tgcgcatcgt caagcatgcc
      361 ttcgagatca tacacctgct cacaggcgag aaccctctgc aggtcctggt gaacgccatc
      421 atcaacagtg gtccccggga ggactccaca cgcattgggc gcgccgggac tgtgagacga
      481 caggctgtgg atgtgtcccc cctgcgccgt gtgaaccagg ccatctggct gctgtgcaca
      541 ggcgctcgtg aggctgcctt ccggaacatt aagaccattg ctgagtgcct ggcagatgag
      601 ctcatcaatg ctgccaaggg ctcctcgaac tcctatgcca ttaagaagaa ggacgagctg
      661 gagcgtgtgg ccaagtccaa ccgctgattt tcccagctgc tgcccaataa acctgtctgc
      721 cctttggggc agtcccagcc a
//
