LOCUS       NP_001000                204 aa            linear   PRI 28-APR-2025
DEFINITION  small ribosomal subunit protein uS7 [Homo sapiens].
ACCESSION   NP_001000
VERSION     NP_001000.2
DBSOURCE    REFSEQ: accession NM_001009.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 204)
  AUTHORS   Zhou,C., Wu,Q., Zhao,H., Xie,R., He,X. and Gu,H.
  TITLE     Unraveling the Role of RNA-Binding Proteins, with a Focus on RPS5,
            in the Malignant Progression of Hepatocellular Carcinoma
  JOURNAL   Int J Mol Sci 25 (2), 773 (2024)
   PUBMED   38255847
  REMARK    GeneRIF: Unraveling the Role of RNA-Binding Proteins, with a Focus
            on RPS5, in the Malignant Progression of Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 204)
  AUTHORS   Liang,H., Li,Q., Wang,N., Wang,C., Shi,S., Yang,H., Cao,Y., Shi,R.,
            Jin,L. and Zhang,C.
  TITLE     KDM4D enhances osteo/dentinogenic differentiation and migration of
            SCAPs via binding to RPS5
  JOURNAL   Oral Dis 29 (7), 2827-2836 (2023)
   PUBMED   36579641
  REMARK    GeneRIF: KDM4D enhances osteo/dentinogenic differentiation and
            migration of SCAPs via binding to RPS5.
REFERENCE   3  (residues 1 to 204)
  AUTHORS   Qiu,L., Chao,W., Zhong,S. and Ren,A.J.
  TITLE     Eukaryotic Ribosomal Protein S5 of the 40S Subunit: Structure and
            Function
  JOURNAL   Int J Mol Sci 24 (4), 3386 (2023)
   PUBMED   36834797
  REMARK    GeneRIF: Eukaryotic Ribosomal Protein S5 of the 40S Subunit:
            Structure and Function.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 204)
  AUTHORS   Iizumi,Y., Sowa,Y., Goi,W., Aono,Y., Watanabe,M., Kurumida,Y.,
            Kameda,T., Akaji,K., Kitagawa,M. and Sakai,T.
  TITLE     Stabilization of CDK6 by ribosomal protein uS7, a target protein of
            the natural product fucoxanthinol
  JOURNAL   Commun Biol 5 (1), 564 (2022)
   PUBMED   35681048
  REMARK    GeneRIF: Stabilization of CDK6 by ribosomal protein uS7, a target
            protein of the natural product fucoxanthinol.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 204)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   6  (residues 1 to 204)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   7  (residues 1 to 204)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   8  (residues 1 to 204)
  AUTHORS   Frigerio,J.M., Dagorn,J.C. and Iovanna,J.L.
  TITLE     Cloning, sequencing and expression of the L5, L21, L27a, L28, S5,
            S9, S10 and S29 human ribosomal protein mRNAs
  JOURNAL   Biochim Biophys Acta 1262 (1), 64-68 (1995)
   PUBMED   7772601
REFERENCE   9  (residues 1 to 204)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   10 (residues 1 to 204)
  AUTHORS   Mundus,D.A., Bulygin,K.N., Yamkovoy,V.I., Malygin,A.A.,
            Repkova,M.N., Vratskikh,L.V., Venijaminova,A.G., Vladimirov,S.N.
            and Karpova,G.G.
  TITLE     Structural arrangement of the codon-anticodon interaction area in
            human placenta ribosomes. Affinity labelling of the 40S subunits by
            derivatives of oligoribonucleotides containing the AUG codon
  JOURNAL   Biochim Biophys Acta 1173 (3), 273-282 (1993)
   PUBMED   8318536
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BG687415.1 and BC015405.1.
            
            On May 1, 2001 this sequence version replaced NP_001000.1.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S7P family of ribosomal proteins. It is located in the
            cytoplasm. Variable expression of this gene in colorectal cancers
            compared to adjacent normal tissues has been observed, although no
            correlation between the level of expression and the severity of the
            disease has been found. As is typical for genes encoding ribosomal
            proteins, there are multiple processed pseudogenes of this gene
            dispersed through the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.100764.1,
                                           SRR5189658.142489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000196551.8/ ENSP00000196551.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..204
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     Protein         1..204
                     /product="small ribosomal subunit protein uS7"
                     /note="40S ribosomal protein S5"
                     /calculated_mol_wt=22745
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine, in 40S ribosomal protein S5,
                     alternate. /evidence=ECO:0000269|Ref.7,
                     ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895,
                     ECO:0007744|PubMed:25944712; propagated from
                     UniProtKB/Swiss-Prot (P46782.4)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylthreonine, in 40S ribosomal protein S5,
                     N-terminally processed. /evidence=ECO:0000269|Ref.6,
                     ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330,
                     ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:25944712;
                     propagated from UniProtKB/Swiss-Prot (P46782.4)"
     Site            14
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (P46782.4)"
     Region          18..204
                     /region_name="uS7_Eukaryote"
                     /note="Eukaryota homolog of Ribosomal Protein S7; cd14867"
                     /db_xref="CDD:271246"
     Site            order(18,47..49,51..54,87,91)
                     /site_type="other"
                     /note="S9 interface [polypeptide binding]"
                     /db_xref="CDD:271246"
     Site            47
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P46782.4)"
     Site            order(51,53,57..60,63,71,74,76..80,84..88,91,131..133,135,
                     145,152,159,162,168..169)
                     /site_type="other"
                     /note="rRNA binding site [nucleotide binding]"
                     /db_xref="CDD:271246"
     Site            order(95,98..99,102,168,170..171)
                     /site_type="other"
                     /note="S25 interface [polypeptide binding]"
                     /db_xref="CDD:271246"
     Site            order(130,133,135,204)
                     /site_type="other"
                     /note="S11 interface [polypeptide binding]"
                     /db_xref="CDD:271246"
     Site            142
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P46782.4)"
     CDS             1..204
                     /gene="RPS5"
                     /gene_synonym="S5; uS7"
                     /coded_by="NM_001009.4:73..687"
                     /db_xref="CCDS:CCDS12978.1"
                     /db_xref="GeneID:6193"
                     /db_xref="HGNC:HGNC:10426"
                     /db_xref="MIM:603630"
ORIGIN      
        1 mtewetaapa vaetpdiklf gkwstddvqi ndislqdyia vkekyakylp hsagryaakr
       61 frkaqcpive rltnsmmmhg rnngkklmtv rivkhafeii hlltgenplq vlvnaiinsg
      121 predstrigr agtvrrqavd vsplrrvnqa iwllctgare aafrniktia ecladelina
      181 akgssnsyai kkkdelerva ksnr
//
