LOCUS       NM_001039567             848 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ribosomal protein S4 Y-linked 2 (RPS4Y2), mRNA.
ACCESSION   NM_001039567
VERSION     NM_001039567.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 848)
  AUTHORS   Yang,H., Li,Q., Zhang,L., Zhu,M., Niu,J., Xue,F., Yang,L., Qu,Q.,
            Lao,Y., Ding,Z., Xiao,C. and Wang,K.
  TITLE     LncPRYP4-3 serves as a novel diagnostic biomarker for dissecting
            subtypes of metabolic associated fatty liver disease by targeting
            RPS4Y2
  JOURNAL   Clin Exp Med 20 (4), 587-600 (2020)
   PUBMED   32494880
  REMARK    GeneRIF: LncPRYP4-3 serves as a novel diagnostic biomarker for
            dissecting subtypes of metabolic associated fatty liver disease by
            targeting RPS4Y2.
REFERENCE   2  (bases 1 to 848)
  AUTHORS   Ye,J., Coulouris,G., Zaretskaya,I., Cutcutache,I., Rozen,S. and
            Madden,T.L.
  TITLE     Primer-BLAST: a tool to design target-specific primers for
            polymerase chain reaction
  JOURNAL   BMC Bioinformatics 13, 134 (2012)
   PUBMED   22708584
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 848)
  AUTHORS   Lopes,A.M., Miguel,R.N., Sargent,C.A., Ellis,P.J., Amorim,A. and
            Affara,N.A.
  TITLE     The human RPS4 paralogue on Yq11.223 encodes a structurally
            conserved ribosomal protein and is preferentially expressed during
            spermatogenesis
  JOURNAL   BMC Mol Biol 11, 33 (2010)
   PUBMED   20459660
  REMARK    GeneRIF: One of the Y-linked copies of the ribosomal protein S4 is
            expressed during spermatogenesis and germ cell development and the
            C-terminus of the protein has some degree of functional
            specialisation of this protein in spermatogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 848)
  AUTHORS   Skaletsky,H., Kuroda-Kawaguchi,T., Minx,P.J., Cordum,H.S.,
            Hillier,L., Brown,L.G., Repping,S., Pyntikova,T., Ali,J., Bieri,T.,
            Chinwalla,A., Delehaunty,A., Delehaunty,K., Du,H., Fewell,G.,
            Fulton,L., Fulton,R., Graves,T., Hou,S.F., Latrielle,P.,
            Leonard,S., Mardis,E., Maupin,R., McPherson,J., Miner,T., Nash,W.,
            Nguyen,C., Ozersky,P., Pepin,K., Rock,S., Rohlfing,T., Scott,K.,
            Schultz,B., Strong,C., Tin-Wollam,A., Yang,S.P., Waterston,R.H.,
            Wilson,R.K., Rozen,S. and Page,D.C.
  TITLE     The male-specific region of the human Y chromosome is a mosaic of
            discrete sequence classes
  JOURNAL   Nature 423 (6942), 825-837 (2003)
   PUBMED   12815422
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF497481.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001039567.2.
            
            Summary: The protein encoded by this gene is a ribosomal protein
            that is highly similar to RPS4Y1. This gene is located in the
            male-specific region of the Y chromosome. [provided by RefSeq, Aug
            2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF497481.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000629237.2/ ENSP00000486252.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-848               AF497481.2         41-888
FEATURES             Location/Qualifiers
     source          1..848
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yq11.223"
     gene            1..848
                     /gene="RPS4Y2"
                     /gene_synonym="RPS4Y2P"
                     /note="ribosomal protein S4 Y-linked 2"
                     /db_xref="GeneID:140032"
                     /db_xref="HGNC:HGNC:18501"
                     /db_xref="MIM:400030"
     exon            1..59
                     /gene="RPS4Y2"
                     /gene_synonym="RPS4Y2P"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..848
                     /gene="RPS4Y2"
                     /gene_synonym="RPS4Y2P"
                     /note="ribosomal protein S4, Y-linked 2 pseudogene; 40S
                     ribosomal protein S4, Y; small ribosomal subunit protein
                     eS4; small ribosomal subunit protein eS4, Y"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS4, Y isoform
                     2"
                     /protein_id="NP_001034656.1"
                     /db_xref="CCDS:CCDS44028.1"
                     /db_xref="GeneID:140032"
                     /db_xref="HGNC:HGNC:18501"
                     /db_xref="MIM:400030"
                     /translation="MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPL
                     IVFLRNRLKYALTGDEVKKICMQHFLKIDGKVRVDITYPAGFIDVISIEKTGEHFRLV
                     YNTKGCFAVHRITVEEAKYKLCKVRKITVGTKGIPHLVTHDARTIRYPDPLIKVNDTV
                     QIDLGTGKITSFIKFDTGNVCMVIAGANLGRVGVITNRERHPGSCDVVHVKDANGNSF
                     ATRISNIFVIGNGNKPWISLPRGKGIRLTIAEERDKRLAAKQSSG"
     exon            60..137
                     /gene="RPS4Y2"
                     /gene_synonym="RPS4Y2P"
                     /inference="alignment:Splign:2.1.0"
     exon            138..318
                     /gene="RPS4Y2"
                     /gene_synonym="RPS4Y2P"
                     /inference="alignment:Splign:2.1.0"
     exon            319..416
                     /gene="RPS4Y2"
                     /gene_synonym="RPS4Y2P"
                     /inference="alignment:Splign:2.1.0"
     exon            417..588
                     /gene="RPS4Y2"
                     /gene_synonym="RPS4Y2P"
                     /inference="alignment:Splign:2.1.0"
     exon            589..746
                     /gene="RPS4Y2"
                     /gene_synonym="RPS4Y2P"
                     /inference="alignment:Splign:2.1.0"
     exon            747..848
                     /gene="RPS4Y2"
                     /gene_synonym="RPS4Y2P"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagattacg gttgcaccgt aaaaggagag gttctgttcc gtcgcgggat ttcgccatgg
       61 cccggggccc caagaagcac ttgaagcgtg ttgcagcgcc gaagcattgg atgctggata
      121 aactaactgg tgtatttgca cctcgtccat cgacaggtcc tcacaagctg agggaatgtc
      181 ttcccctgat agtcttcctc aggaatagac tcaagtatgc attgactgga gatgaggtaa
      241 agaagatatg tatgcaacac ttcctcaaaa ttgatggcaa ggttcgagtg gacatcacat
      301 accctgctgg attcatagat gtcatcagca ttgagaaaac aggtgagcat ttccgcctgg
      361 tctataatac caagggctgt tttgctgttc atcgtatcac agtggaagag gcaaagtaca
      421 agttgtgcaa agtgaggaag attactgtgg ggacaaaggg aattccacac ctggtgactc
      481 atgatgctcg aaccattcgc tacccagatc ctctcatcaa ggtgaacgat actgtgcaga
      541 ttgatttagg gactgggaag ataaccagct ttatcaaatt tgacacaggc aatgtatgta
      601 tggtgattgc tggagctaac ctcggtcgtg ttggtgtgat cacaaacagg gaaagacatc
      661 ctggttcttg cgatgtggta catgtgaagg atgccaacgg caacagcttt gccacaagga
      721 tttccaacat ttttgtcatt ggcaatggta ataaaccttg gatttccctg cccaggggaa
      781 agggcatccg acttactatt gctgaagaga gagacaagag gctggctgcc aaacagagca
      841 gtggctaa
//
