LOCUS       NM_001008               1189 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens ribosomal protein S4 Y-linked 1 (RPS4Y1), mRNA.
ACCESSION   NM_001008
VERSION     NM_001008.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1189)
  AUTHORS   Spena,S., Cordiglieri,C., Garagiola,I. and Peyvandi,F.
  TITLE     Development of a Specific Monoclonal Antibody to Detect Male Cells
            Expressing the RPS4Y1 Protein
  JOURNAL   Int J Mol Sci 22 (4), 2001 (2021)
   PUBMED   33670450
  REMARK    GeneRIF: Development of a Specific Monoclonal Antibody to Detect
            Male Cells Expressing the RPS4Y1 Protein.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1189)
  AUTHORS   Fan,Z., Zhao,W., Fan,S., Li,C., Qiao,J. and Xu,Y.
  TITLE     Identification of Potential Biomarkers for Intervertebral Disc
            Degeneration Using the Genome-Wide Expression Analysis
  JOURNAL   J Comput Biol 27 (9), 1341-1349 (2020)
   PUBMED   31904996
  REMARK    GeneRIF: Identification of Potential Biomarkers for Intervertebral
            Disc Degeneration Using the Genome-Wide Expression Analysis.
REFERENCE   3  (bases 1 to 1189)
  AUTHORS   Chang,R., Chen,L., Su,G., Du,L., Qin,Y., Xu,J., Tan,H., Zhou,C.,
            Cao,Q., Yuan,G., Kijlstra,A. and Yang,P.
  TITLE     Identification of Ribosomal Protein S4, Y-Linked 1 as a cyclosporin
            A plus corticosteroid resistance gene
  JOURNAL   J Autoimmun 112, 102465 (2020)
   PUBMED   32331925
  REMARK    GeneRIF: Identification of Ribosomal Protein S4, Y-Linked 1 as a
            cyclosporin A plus corticosteroid resistance gene.
REFERENCE   4  (bases 1 to 1189)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1189)
  AUTHORS   Sun,A.G., Wang,J., Shan,Y.Z., Yu,W.J., Li,X., Cong,C.H. and Wang,X.
  TITLE     Identifying distinct candidate genes for early Parkinson's disease
            by analysis of gene expression in whole blood
  JOURNAL   Neuro Endocrinol Lett 35 (5), 398-404 (2014)
   PUBMED   25275262
  REMARK    GeneRIF: DLG1, XIST, DDX3Y and RPS4Y1 genes can classify samples
            into different group clearly, and they are regarded as high
            confidence distinct gene biomarkers of Parkinson disease.
REFERENCE   6  (bases 1 to 1189)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   7  (bases 1 to 1189)
  AUTHORS   Weller,P.A., Critcher,R., Goodfellow,P.N., German,J. and Ellis,N.A.
  TITLE     The human Y chromosome homologue of XG: transcription of a
            naturally truncated gene
  JOURNAL   Hum Mol Genet 4 (5), 859-868 (1995)
   PUBMED   7633446
REFERENCE   8  (bases 1 to 1189)
  AUTHORS   Zinn,A.R., Alagappan,R.K., Brown,L.G., Wool,I. and Page,D.C.
  TITLE     Structure and function of ribosomal protein S4 genes on the human
            and mouse sex chromosomes
  JOURNAL   Mol Cell Biol 14 (4), 2485-2492 (1994)
   PUBMED   8139551
REFERENCE   9  (bases 1 to 1189)
  AUTHORS   Watanabe,M., Zinn,A.R., Page,D.C. and Nishimoto,T.
  TITLE     Functional equivalence of human X- and Y-encoded isoforms of
            ribosomal protein S4 consistent with a role in Turner syndrome
  JOURNAL   Nat Genet 4 (3), 268-271 (1993)
   PUBMED   8358435
REFERENCE   10 (bases 1 to 1189)
  AUTHORS   Fisher,E.M., Beer-Romero,P., Brown,L.G., Ridley,A., McNeil,J.A.,
            Lawrence,J.B., Willard,H.F., Bieber,F.R. and Page,D.C.
  TITLE     Homologous ribosomal protein genes on the human X and Y
            chromosomes: escape from X inactivation and possible implications
            for Turner syndrome
  JOURNAL   Cell 63 (6), 1205-1218 (1990)
   PUBMED   2124517
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BF242790.1, BC010286.1, AI167386.1 and AC006040.3.
            
            On Nov 23, 2018 this sequence version replaced NM_001008.3.
            
            Summary: Cytoplasmic ribosomes, organelles that catalyze protein
            synthesis, consist of a small 40S subunit and a large 60S subunit.
            Together these subunits are composed of 4 RNA species and
            approximately 80 structurally distinct proteins. This gene encodes
            ribosomal protein S4, a component of the 40S subunit. Ribosomal
            protein S4 is the only ribosomal protein known to be encoded by
            more than one gene, namely this gene and ribosomal protein S4,
            X-linked (RPS4X). The 2 isoforms encoded by these genes are not
            identical, but are functionally equivalent. Ribosomal protein S4
            belongs to the S4E family of ribosomal proteins. It has been
            suggested that haploinsufficiency of the ribosomal protein S4 genes
            plays a role in Turner syndrome; however, this hypothesis is
            controversial. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.90032.1,
                                           SRR5189667.397489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250784.13/ ENSP00000250784.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BF242790.1         22-32
            12-872              BC010286.1         1-861
            873-877             AI167386.1         14-18               c
            878-1189            AC006040.3         142749-143060
FEATURES             Location/Qualifiers
     source          1..1189
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yp11.2"
     gene            1..1189
                     /gene="RPS4Y1"
                     /gene_synonym="RPS4Y; S4"
                     /note="ribosomal protein S4 Y-linked 1"
                     /db_xref="GeneID:6192"
                     /db_xref="HGNC:HGNC:10425"
                     /db_xref="MIM:470000"
     exon            1..26
                     /gene="RPS4Y1"
                     /gene_synonym="RPS4Y; S4"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..815
                     /gene="RPS4Y1"
                     /gene_synonym="RPS4Y; S4"
                     /note="ribosomal protein S4Y; 40S ribosomal protein S4, Y;
                     small ribosomal subunit protein eS4; ribosomal protein S4,
                     Y-linked; small ribosomal subunit protein eS4, Y"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS4, Y isoform
                     1"
                     /protein_id="NP_000999.1"
                     /db_xref="CCDS:CCDS14773.1"
                     /db_xref="GeneID:6192"
                     /db_xref="HGNC:HGNC:10425"
                     /db_xref="MIM:470000"
                     /translation="MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPL
                     IVFLRNRLKYALTGDEVKKICMQRFIKIDGKVRVDVTYPAGFMDVISIEKTGEHFRLV
                     YDTKGRFAVHRITVEEAKYKLCKVRKITVGVKGIPHLVTHDARTIRYPDPVIKVNDTV
                     QIDLGTGKIINFIKFDTGNLCMVIGGANLGRVGVITNRERHPGSFDVVHVKDANGNSF
                     ATRLSNIFVIGNGNKPWISLPRGKGIRLTVAEERDKRLATKQSSG"
     exon            27..104
                     /gene="RPS4Y1"
                     /gene_synonym="RPS4Y; S4"
                     /inference="alignment:Splign:2.1.0"
     exon            105..285
                     /gene="RPS4Y1"
                     /gene_synonym="RPS4Y; S4"
                     /inference="alignment:Splign:2.1.0"
     exon            286..383
                     /gene="RPS4Y1"
                     /gene_synonym="RPS4Y; S4"
                     /inference="alignment:Splign:2.1.0"
     exon            384..555
                     /gene="RPS4Y1"
                     /gene_synonym="RPS4Y; S4"
                     /inference="alignment:Splign:2.1.0"
     exon            556..713
                     /gene="RPS4Y1"
                     /gene_synonym="RPS4Y; S4"
                     /inference="alignment:Splign:2.1.0"
     exon            714..1189
                     /gene="RPS4Y1"
                     /gene_synonym="RPS4Y; S4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      851..856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS4Y1"
                     /gene_synonym="RPS4Y; S4"
                     /note="hexamer: AATAAA"
     polyA_site      872
                     /gene="RPS4Y1"
                     /gene_synonym="RPS4Y; S4"
                     /note="major polyA site"
     regulatory      988..993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS4Y1"
                     /gene_synonym="RPS4Y; S4"
                     /note="hexamer: AATAAA"
     polyA_site      1010
                     /gene="RPS4Y1"
                     /gene_synonym="RPS4Y; S4"
     regulatory      1166..1171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS4Y1"
                     /gene_synonym="RPS4Y; S4"
                     /note="hexamer: ATTAAA"
     polyA_site      1189
                     /gene="RPS4Y1"
                     /gene_synonym="RPS4Y; S4"
ORIGIN      
        1 ctcttccgtc gcagagtttc gccatggccc ggggccccaa gaagcactta aagcgtgttg
       61 cagcgccgaa gcattggatg cttgacaaac taacgggtgt atttgcacct cgtccatcga
      121 caggtcccca caagctgagg gaatgtcttc ctctgatcgt cttcctcagg aatagactca
      181 agtatgcgtt gactggagat gaggtaaaga agatatgtat gcaacgtttc atcaaaattg
      241 atggcaaggt tcgagtggat gtcacatacc ctgctggatt catggatgtc atcagcatcg
      301 agaagacagg tgaacatttc cgcctggtct atgacaccaa gggccgtttt gctgttcacc
      361 gcatcacagt ggaagaggca aagtacaagt tgtgcaaagt gaggaagatt actgtgggag
      421 tgaagggaat ccctcacctg gtgactcatg atgctcgaac catccgctac ccagatcctg
      481 tcatcaaggt gaacgatact gtgcagattg atttagggac tggcaagata atcaacttta
      541 tcaaatttga tacaggcaat ttgtgtatgg tgattggtgg agccaacctc ggtcgtgttg
      601 gtgtgatcac caacagggaa agacatcctg gttcttttga tgtggtgcat gtgaaggatg
      661 ccaatggcaa cagctttgcc acgaggcttt ccaacatttt tgtcattggc aatggcaata
      721 aaccttggat ttccctgccc aggggaaagg gcattcgact tactgttgct gaagagagag
      781 ataagaggct ggccaccaaa cagagcagtg gctaaattgc agtagcagca tatctttttt
      841 tctttgcaca aataaacagt gaattctcgt ttcttaatgt gttttttccc ccttgtggat
      901 aatagtaggg tttgaatttg ctcatgattt tggcactgtc ttaagatctc taggaatacc
      961 acctatactt cctctgaccc tccagtaaat aaacctttgc ttccctcata catgttaccc
     1021 acaccatctc tgtgggcaga gtgatggagt agcattccaa aacgaagtac aaaaaacgta
     1081 tgacatttca gaaaggacgg cattcttttg tggaagctat gggagatggt cttagttttc
     1141 ttgcttgttc acattattgg tagaaattaa atcctgtggc tgtaggaaa
//
