LOCUS       NM_001007               1474 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens ribosomal protein S4 X-linked (RPS4X), mRNA.
ACCESSION   NM_001007
VERSION     NM_001007.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1474)
  AUTHORS   Ryu,S., Nakashima,H., Tanaka,Y., Mukai,R., Ishihara,Y., Tominaga,T.
            and Ohshima,T.
  TITLE     Ribosomal Protein S4 X-Linked as a Novel Modulator of MDM2
            Stability by Suppressing MDM2 Auto-Ubiquitination and SCF
            Complex-Mediated Ubiquitination
  JOURNAL   Biomolecules 14 (8), 885 (2024)
   PUBMED   39199272
  REMARK    GeneRIF: Ribosomal Protein S4 X-Linked as a Novel Modulator of MDM2
            Stability by Suppressing MDM2 Auto-Ubiquitination and SCF
            Complex-Mediated Ubiquitination.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1474)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 1474)
  AUTHORS   Li,Y., Zhang,J., Sun,H., Chen,Y., Li,W., Yu,X., Zhao,X., Zhang,L.,
            Yang,J., Xin,W., Jiang,Y., Wang,G., Shi,W. and Zhu,D.
  TITLE     lnc-Rps4l-encoded peptide RPS4XL regulates RPS6 phosphorylation and
            inhibits the proliferation of PASMCs caused by hypoxia
  JOURNAL   Mol Ther 29 (4), 1411-1424 (2021)
   PUBMED   33429084
  REMARK    GeneRIF: lnc-Rps4l-encoded peptide RPS4XL regulates RPS6
            phosphorylation and inhibits the proliferation of PASMCs caused by
            hypoxia.
            Erratum:[Mol Ther. 2024 Aug 7;32(8):2799. doi:
            10.1016/j.ymthe.2024.06.032. PMID: 38959895]
REFERENCE   4  (bases 1 to 1474)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1474)
  AUTHORS   Paquet,E.R., Hovington,H., Brisson,H., Lacombe,C., Larue,H.,
            Tetu,B., Lacombe,L., Fradet,Y. and Lebel,M.
  TITLE     Low level of the X-linked ribosomal protein S4 in human urothelial
            carcinomas is associated with a poor prognosis
  JOURNAL   Biomark Med 9 (3), 187-197 (2015)
   PUBMED   25731206
  REMARK    GeneRIF: Low RPS4X expression is associated with poor
            disease-specific and recurrence-free survival in bladder cancer
REFERENCE   6  (bases 1 to 1474)
  AUTHORS   Matoba,R., Okubo,K., Hori,N., Fukushima,A. and Matsubara,K.
  TITLE     The addition of 5'-coding information to a 3'-directed cDNA library
            improves analysis of gene expression
  JOURNAL   Gene 146 (2), 199-207 (1994)
   PUBMED   8076819
REFERENCE   7  (bases 1 to 1474)
  AUTHORS   Zinn,A.R., Alagappan,R.K., Brown,L.G., Wool,I. and Page,D.C.
  TITLE     Structure and function of ribosomal protein S4 genes on the human
            and mouse sex chromosomes
  JOURNAL   Mol Cell Biol 14 (4), 2485-2492 (1994)
   PUBMED   8139551
REFERENCE   8  (bases 1 to 1474)
  AUTHORS   Watanabe,M., Furuno,N., Goebl,M., Go,M., Miyauchi,K., Sekiguchi,T.,
            Basilico,C. and Nishimito,T.
  TITLE     Molecular cloning of the human gene, CCG2, that complements the
            BHK-derived temperature-sensitive cell cycle mutant tsBN63:
            identity of CCG2 with the human X chromosomal SCAR/RPS4X gene
  JOURNAL   J Cell Sci 100 (Pt 1), 35-43 (1991)
   PUBMED   1795030
REFERENCE   9  (bases 1 to 1474)
  AUTHORS   Fisher,E.M., Beer-Romero,P., Brown,L.G., Ridley,A., McNeil,J.A.,
            Lawrence,J.B., Willard,H.F., Bieber,F.R. and Page,D.C.
  TITLE     Homologous ribosomal protein genes on the human X and Y
            chromosomes: escape from X inactivation and possible implications
            for Turner syndrome
  JOURNAL   Cell 63 (6), 1205-1218 (1990)
   PUBMED   2124517
REFERENCE   10 (bases 1 to 1474)
  AUTHORS   Wiles,M.V., Alexander,C.M. and Goodfellow,P.N.
  TITLE     Isolation of an abundantly expressed sequence from the human X
            chromosome by differential screening
  JOURNAL   Somat Cell Mol Genet 14 (1), 31-39 (1988)
   PUBMED   2829364
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AL135749.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001007.4.
            
            Summary: Cytoplasmic ribosomes, organelles that catalyze protein
            synthesis, consist of a small 40S subunit and a large 60S subunit.
            Together these subunits are composed of 4 RNA species and
            approximately 80 structurally distinct proteins. This gene encodes
            ribosomal protein S4, a component of the 40S subunit. Ribosomal
            protein S4 is the only ribosomal protein known to be encoded by
            more than one gene, namely this gene and ribosomal protein S4,
            Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not
            identical, but are functionally equivalent. Ribosomal protein S4
            belongs to the S4E family of ribosomal proteins. This gene is not
            subject to X-inactivation. It has been suggested that
            haploinsufficiency of the ribosomal protein S4 genes plays a role
            in Turner syndrome; however, this hypothesis is controversial. As
            is typical for genes encoding ribosomal proteins, there are
            multiple processed pseudogenes of this gene dispersed through the
            genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.43996.1,
                                           SRR5189658.132986.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2151358
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316084.10/ ENSP00000362744.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AL135749.3         91082-91137         c
            57-134              AL135749.3         90046-90123         c
            135-315             AL135749.3         89433-89613         c
            316-413             AL135749.3         88942-89039         c
            414-585             AL135749.3         87690-87861         c
            586-743             AL135749.3         87121-87278         c
            744-1474            AL135749.3         85931-86661         c
FEATURES             Location/Qualifiers
     source          1..1474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..1474
                     /gene="RPS4X"
                     /gene_synonym="CCG2; DXS306; eS4; RPS4; S4; SCAR; SCR10"
                     /note="ribosomal protein S4 X-linked"
                     /db_xref="GeneID:6191"
                     /db_xref="HGNC:HGNC:10424"
                     /db_xref="MIM:312760"
     exon            1..56
                     /gene="RPS4X"
                     /gene_synonym="CCG2; DXS306; eS4; RPS4; S4; SCAR; SCR10"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..845
                     /gene="RPS4X"
                     /gene_synonym="CCG2; DXS306; eS4; RPS4; S4; SCAR; SCR10"
                     /note="single-copy abundant mRNA; cell cycle gene 2;
                     single copy abundant mRNA protein; small ribosomal subunit
                     protein eS4; 40S ribosomal protein S4"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS4, X isoform"
                     /protein_id="NP_000998.1"
                     /db_xref="CCDS:CCDS14418.1"
                     /db_xref="GeneID:6191"
                     /db_xref="HGNC:HGNC:10424"
                     /db_xref="MIM:312760"
                     /translation="MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPL
                     IIFLRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLI
                     YDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTI
                     QIDLETGKITDFIKFDTGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSF
                     ATRLSNIFVIGKGNKPWISLPRGKGIRLTIAEERDKRLAAKQSSG"
     exon            57..134
                     /gene="RPS4X"
                     /gene_synonym="CCG2; DXS306; eS4; RPS4; S4; SCAR; SCR10"
                     /inference="alignment:Splign:2.1.0"
     exon            135..315
                     /gene="RPS4X"
                     /gene_synonym="CCG2; DXS306; eS4; RPS4; S4; SCAR; SCR10"
                     /inference="alignment:Splign:2.1.0"
     exon            316..413
                     /gene="RPS4X"
                     /gene_synonym="CCG2; DXS306; eS4; RPS4; S4; SCAR; SCR10"
                     /inference="alignment:Splign:2.1.0"
     exon            414..585
                     /gene="RPS4X"
                     /gene_synonym="CCG2; DXS306; eS4; RPS4; S4; SCAR; SCR10"
                     /inference="alignment:Splign:2.1.0"
     exon            586..743
                     /gene="RPS4X"
                     /gene_synonym="CCG2; DXS306; eS4; RPS4; S4; SCAR; SCR10"
                     /inference="alignment:Splign:2.1.0"
     exon            744..1474
                     /gene="RPS4X"
                     /gene_synonym="CCG2; DXS306; eS4; RPS4; S4; SCAR; SCR10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      884..889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS4X"
                     /gene_synonym="CCG2; DXS306; eS4; RPS4; S4; SCAR; SCR10"
                     /note="hexamer: ATTAAA"
     polyA_site      913
                     /gene="RPS4X"
                     /gene_synonym="CCG2; DXS306; eS4; RPS4; S4; SCAR; SCR10"
                     /note="major polyA site"
     regulatory      1323..1328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS4X"
                     /gene_synonym="CCG2; DXS306; eS4; RPS4; S4; SCAR; SCR10"
                     /note="hexamer: ATTAAA"
     regulatory      1335..1340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS4X"
                     /gene_synonym="CCG2; DXS306; eS4; RPS4; S4; SCAR; SCR10"
                     /note="hexamer: CATAAA"
     polyA_site      1345
                     /gene="RPS4X"
                     /gene_synonym="CCG2; DXS306; eS4; RPS4; S4; SCAR; SCR10"
     polyA_site      1363
                     /gene="RPS4X"
                     /gene_synonym="CCG2; DXS306; eS4; RPS4; S4; SCAR; SCR10"
     regulatory      1449..1454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS4X"
                     /gene_synonym="CCG2; DXS306; eS4; RPS4; S4; SCAR; SCR10"
                     /note="hexamer: CATAAA"
     polyA_site      1474
                     /gene="RPS4X"
                     /gene_synonym="CCG2; DXS306; eS4; RPS4; S4; SCAR; SCR10"
ORIGIN      
        1 aatttctacg cgcaccggaa gacggaggtc ctctttcctt gcctaacgca gccatggctc
       61 gtggtcccaa gaagcatctg aagcgggtgg cagctccaaa gcattggatg ctggataaat
      121 tgaccggtgt gtttgctcct cgtccatcca ccggtcccca caagttgaga gagtgtctcc
      181 ccctcatcat tttcctgagg aacagactta agtatgccct gacaggagat gaagtaaaga
      241 agatttgcat gcagcggttc attaaaatcg atggcaaggt ccgaactgat ataacctacc
      301 ctgctggatt catggatgtc atcagcattg acaagacggg agagaatttc cgtctgatct
      361 atgacaccaa gggtcgcttt gctgtacatc gtattacacc tgaggaggcc aagtacaagt
      421 tgtgcaaagt gagaaagatc tttgtgggca caaaaggaat ccctcatctg gtgactcatg
      481 atgcccgcac catccgctac cccgatcccc tcatcaaggt gaatgatacc attcagattg
      541 atttggagac tggcaagatt actgatttca tcaagttcga cactggtaac ctgtgtatgg
      601 tgactggagg tgctaaccta ggaagaattg gtgtgatcac caacagagag aggcaccctg
      661 gatcttttga cgtggttcac gtgaaagatg ccaatggcaa cagctttgcc actcgacttt
      721 ccaacatttt tgttattggc aagggcaaca aaccatggat ttctcttccc cgaggaaagg
      781 gtatccgcct caccattgct gaagagagag acaaaagact ggcggccaaa cagagcagtg
      841 ggtgaaatgg gtccctgggt gacatgtcag atctttgtac gtaattaaaa atattgtggc
      901 aggattaata gcattttggt tttgtgggtt gttttttttt ttaattcagt ttcctgctat
      961 tttactgtat aacatgaaca gtgattaagt tctcaggcag gcttaggcag tctgttattg
     1021 gctgggctta gttagtggtg ggaagtagaa gataccagac ttgggaaagg aacagcaact
     1081 aaccaaggag tagaaagagc caagaaatcc cggagtattt atctcccccg ccttgacttg
     1141 gccaagaact tctctacaca gtggacccct ctgccctgtt aagttccctt ggctttctaa
     1201 aaatctgccc tcattttctt ctccagtctg tattgcacta gcccatccac aagcctggct
     1261 catctgtttt tcccactcct gtgcccatct tgccaaacgc aggatgaaaa tctccagttg
     1321 ccattaaagg tggtcataaa tgggctgttg atgttgcaaa gcattgcagt tccttggact
     1381 tagtgccctt attctccagc tgccgctgca gtcctcaact ctgtttttca gaggacagag
     1441 atgtagaaca taaacttgtt cttgcttgtc caaa
//
