LOCUS       NM_001006                869 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens ribosomal protein S3A (RPS3A), transcript variant 1,
            mRNA.
ACCESSION   NM_001006 NM_182777 XM_001129705
VERSION     NM_001006.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 869)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   2  (bases 1 to 869)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 869)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   4  (bases 1 to 869)
  AUTHORS   Li,Y.H., Wang,J., Liu,Y., Qiu,L., Li,J.Z., Hu,H.G., Hu,Z.L.,
            Zhang,W., Lu,B. and Zhang,J.P.
  TITLE     Esculentoside A specifically binds to ribosomal protein S3a and
            impairs LPS-induced signaling in macrophages
  JOURNAL   Int Immunopharmacol 54, 254-260 (2018)
   PUBMED   29169044
  REMARK    GeneRIF: RPS3a as an essential component for LPS-mediated
            pro-inflammatory signaling
REFERENCE   5  (bases 1 to 869)
  AUTHORS   Gopanenko,A.V., Malygin,A.A., Tupikin,A.E., Laktionov,P.P.,
            Kabilov,M.R. and Karpova,G.G.
  TITLE     Human ribosomal protein eS1 is engaged in cellular events related
            to processing and functioning of U11 snRNA
  JOURNAL   Nucleic Acids Res 45 (15), 9121-9137 (2017)
   PUBMED   28666385
  REMARK    GeneRIF: Ribosomal protein eS1 is engaged in cellular events
            related to processing and functioning of U11 snRNA.
REFERENCE   6  (bases 1 to 869)
  AUTHORS   Kho,C.J., Wang,Y. and Zarbl,H.
  TITLE     Effect of decreased fte-1 gene expression on protein synthesis,
            cell growth, and transformation
  JOURNAL   Cell Growth Differ 7 (9), 1157-1166 (1996)
   PUBMED   8877097
REFERENCE   7  (bases 1 to 869)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   8  (bases 1 to 869)
  AUTHORS   Nolte,D., Taimor,G., Kalff-Suske,M. and Seifart,K.H.
  TITLE     The human S3a ribosomal protein: sequence, location and cell-free
            transcription of the functional gene
  JOURNAL   Gene 169 (2), 179-185 (1996)
   PUBMED   8647443
REFERENCE   9  (bases 1 to 869)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   10 (bases 1 to 869)
  AUTHORS   Metspalu,A., Rebane,A., Hoth,S., Pooga,M., Stahl,J. and Kruppa,J.
  TITLE     Human ribosomal protein S3a: cloning of the cDNA and primary
            structure of the protein
  JOURNAL   Gene 119 (2), 313-316 (1992)
   PUBMED   1398113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BC001708.1 and CA441711.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001006.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S3AE family of ribosomal proteins. It is located in the
            cytoplasm. Disruption of the gene encoding rat ribosomal protein
            S3a, also named v-fos transformation effector protein, in
            v-fos-transformed rat cells results in reversion of the transformed
            phenotype. This gene is co-transcribed with the U73A and U73B small
            nucleolar RNA genes, which are located in its fourth and third
            introns, respectively. As is typical for genes encoding ribosomal
            proteins, there are multiple processed pseudogenes of this gene
            dispersed through the genome. Alternatively spliced transcript
            variants have been found for this gene. [provided by RefSeq, May
            2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.459102.1,
                                           SRR1163655.638439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274065.9/ ENSP00000346050.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-862               BC001708.1         18-879
            863-869             CA441711.1         27-33               c
FEATURES             Location/Qualifiers
     source          1..869
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.3"
     gene            1..869
                     /gene="RPS3A"
                     /gene_synonym="eS1; FTE1; MFTL; S3A"
                     /note="ribosomal protein S3A"
                     /db_xref="GeneID:6189"
                     /db_xref="HGNC:HGNC:10421"
                     /db_xref="MIM:180478"
     exon            1..87
                     /gene="RPS3A"
                     /gene_synonym="eS1; FTE1; MFTL; S3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..820
                     /gene="RPS3A"
                     /gene_synonym="eS1; FTE1; MFTL; S3A"
                     /EC_number="3.6.5.3"
                     /note="isoform 1 is encoded by transcript variant 1; 40S
                     ribosomal protein S3a; v-fos transformation effector
                     protein 1; fte-1; small ribosomal subunit protein eS1"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS1 isoform 1"
                     /protein_id="NP_000997.1"
                     /db_xref="CCDS:CCDS3775.1"
                     /db_xref="GeneID:6189"
                     /db_xref="HGNC:HGNC:10421"
                     /db_xref="MIM:180478"
                     /translation="MAVGKNKRLTKGGKKGAKKKVVDPFSKKDWYDVKAPAMFNIRNI
                     GKTLVTRTQGTKIASDGLKGRVFEVSLADLQNDEVAFRKFKLITEDVQGKNCLTNFHG
                     MDLTRDKMCSMVKKWQTMIEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQ
                     VRQIRKKMMEIMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKML
                     KKPKFELGKLMELHGEGSSSGKATGDETGAKVERADGYEPPVQESV"
     exon            88..191
                     /gene="RPS3A"
                     /gene_synonym="eS1; FTE1; MFTL; S3A"
                     /inference="alignment:Splign:2.1.0"
     exon            192..379
                     /gene="RPS3A"
                     /gene_synonym="eS1; FTE1; MFTL; S3A"
                     /inference="alignment:Splign:2.1.0"
     exon            380..588
                     /gene="RPS3A"
                     /gene_synonym="eS1; FTE1; MFTL; S3A"
                     /inference="alignment:Splign:2.1.0"
     exon            589..698
                     /gene="RPS3A"
                     /gene_synonym="eS1; FTE1; MFTL; S3A"
                     /inference="alignment:Splign:2.1.0"
     exon            699..869
                     /gene="RPS3A"
                     /gene_synonym="eS1; FTE1; MFTL; S3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      844..849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS3A"
                     /gene_synonym="eS1; FTE1; MFTL; S3A"
                     /note="hexamer: AATAAA"
     polyA_site      869
                     /gene="RPS3A"
                     /gene_synonym="eS1; FTE1; MFTL; S3A"
                     /note="major polyA site"
ORIGIN      
        1 cccttttggc tctctgacca gcaccatggc ggttggcaag aacaagcgcc ttacgaaagg
       61 cggcaaaaag ggagccaaga agaaagtggt tgatccattt tctaagaaag attggtatga
      121 tgtgaaagca cctgctatgt tcaatataag aaatattgga aagacgctcg tcaccaggac
      181 ccaaggaacc aaaattgcat ctgatggtct caagggtcgt gtgtttgaag tgagtcttgc
      241 tgatttgcag aatgatgaag ttgcatttag aaaattcaag ctgattactg aagatgttca
      301 gggtaaaaac tgcctgacta acttccatgg catggatctt acccgtgaca aaatgtgttc
      361 catggtcaaa aaatggcaga caatgattga agctcacgtt gatgtcaaga ctaccgatgg
      421 ttacttgctt cgtctgttct gtgttggttt tactaaaaaa cgcaacaatc agatacggaa
      481 gacctcttat gctcagcacc aacaggtccg ccaaatccgg aagaagatga tggaaatcat
      541 gacccgagag gtgcagacaa atgacttgaa agaagtggtc aataaattga ttccagacag
      601 cattggaaaa gacatagaaa aggcttgcca atctatttat cctctccatg atgtcttcgt
      661 tagaaaagta aaaatgctga agaagcccaa gtttgaattg ggaaagctca tggagcttca
      721 tggtgaaggc agtagttctg gaaaagccac tggggacgag acaggtgcta aagttgaacg
      781 agctgatgga tatgaaccac cagtccaaga atctgtttaa agttcagact tcaaatagtg
      841 gcaaataaaa agtgctattt gtgatggtt
//
