LOCUS       NM_001005               2059 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens ribosomal protein S3 (RPS3), transcript variant 1,
            mRNA.
ACCESSION   NM_001005
VERSION     NM_001005.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2059)
  AUTHORS   Jiang,Z., Yang,G., Wang,G., Wan,J., Zhang,Y., Song,W., Zhang,H.,
            Ni,J., Zhang,H., Luo,M., Wang,K. and Peng,B.
  TITLE     SEC14L3 knockdown inhibited clear cell renal cell carcinoma
            proliferation, metastasis and sunitinib resistance through an
            SEC14L3/RPS3/NFkappaB positive feedback loop
  JOURNAL   J Exp Clin Cancer Res 43 (1), 288 (2024)
   PUBMED   39425205
  REMARK    GeneRIF: SEC14L3 knockdown inhibited clear cell renal cell
            carcinoma proliferation, metastasis and sunitinib resistance
            through an SEC14L3/RPS3/NFkappaB positive feedback loop.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2059)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2059)
  AUTHORS   Havkin-Solomon,T., Itzhaki,E., Joffe,N., Reuven,N., Shaul,Y. and
            Dikstein,R.
  TITLE     Selective translational control of cellular and viral mRNAs by RPS3
            mRNA binding
  JOURNAL   Nucleic Acids Res 51 (9), 4208-4222 (2023)
   PUBMED   37070189
  REMARK    GeneRIF: Selective translational control of cellular and viral
            mRNAs by RPS3 mRNA binding.
REFERENCE   4  (bases 1 to 2059)
  AUTHORS   Ahn,W.S., Kim,H.D., Kim,T.S., Ahn,M.J., Park,Y.J. and Kim,J.
  TITLE     Phosphorylation of rpS3 by Lyn increases translation of Multi-Drug
            Resistance (MDR1) gene
  JOURNAL   BMB Rep 56 (5), 302-307 (2023)
   PUBMED   36724904
  REMARK    GeneRIF: Phosphorylation of rpS3 by Lyn increases translation of
            Multi-Drug Resistance (MDR1) gene.
REFERENCE   5  (bases 1 to 2059)
  AUTHORS   Wang,T., Jin,C., Yang,P., Chen,Z., Ji,J., Sun,Q., Yang,S., Feng,Y.,
            Tang,J. and Sun,Y.
  TITLE     UBE2J1 inhibits colorectal cancer progression by promoting
            ubiquitination and degradation of RPS3
  JOURNAL   Oncogene 42 (9), 651-664 (2023)
   PUBMED   36567344
  REMARK    GeneRIF: UBE2J1 inhibits colorectal cancer progression by promoting
            ubiquitination and degradation of RPS3.
REFERENCE   6  (bases 1 to 2059)
  AUTHORS   Kim,J., Chubatsu,L.S., Admon,A., Stahl,J., Fellous,R. and Linn,S.
  TITLE     Implication of mammalian ribosomal protein S3 in the processing of
            DNA damage
  JOURNAL   J Biol Chem 270 (23), 13620-13629 (1995)
   PUBMED   7775413
REFERENCE   7  (bases 1 to 2059)
  AUTHORS   Polakiewicz,R.D., Munroe,D.J., Sait,S.N., Tycowski,K.T.,
            Nowak,N.J., Shows,T.B., Housman,D.E. and Page,D.C.
  TITLE     Mapping of ribosomal protein S3 and internally nested snoRNA U15A
            gene to human chromosome 11q13.3-q13.5
  JOURNAL   Genomics 25 (2), 577-580 (1995)
   PUBMED   7789996
REFERENCE   8  (bases 1 to 2059)
  AUTHORS   Pogue-Geile,K., Geiser,J.R., Shu,M., Miller,C., Wool,I.G.,
            Meisler,A.I. and Pipas,J.M.
  TITLE     Ribosomal protein genes are overexpressed in colorectal cancer:
            isolation of a cDNA clone encoding the human S3 ribosomal protein
  JOURNAL   Mol Cell Biol 11 (8), 3842-3849 (1991)
   PUBMED   1712897
REFERENCE   9  (bases 1 to 2059)
  AUTHORS   Bommer,U.A., Lutsch,G., Stahl,J. and Bielka,H.
  TITLE     Eukaryotic initiation factors eIF-2 and eIF-3: interactions,
            structure and localization in ribosomal initiation complexes
  JOURNAL   Biochimie 73 (7-8), 1007-1019 (1991)
   PUBMED   1742346
  REMARK    Review article
REFERENCE   10 (bases 1 to 2059)
  AUTHORS   Zhang,X.T., Tan,Y.M. and Tan,Y.H.
  TITLE     Isolation of a cDNA encoding human 40S ribosomal protein s3
  JOURNAL   Nucleic Acids Res 18 (22), 6689 (1990)
   PUBMED   2129557
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BC034149.1, AP000744.4 and CB241053.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001005.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit, where it forms part
            of the domain where translation is initiated. The protein belongs
            to the S3P family of ribosomal proteins. Studies of the mouse and
            rat proteins have demonstrated that the protein has an
            extraribosomal role as an endonuclease involved in the repair of
            UV-induced DNA damage. The protein appears to be located in both
            the cytoplasm and nucleus but not in the nucleolus. Higher levels
            of expression of this gene in colon adenocarcinomas and adenomatous
            polyps compared to adjacent normal colonic mucosa have been
            observed. This gene is co-transcribed with the small nucleolar RNA
            genes U15A and U15B, which are located in its first and fifth
            introns, respectively. As is typical for genes encoding ribosomal
            proteins, there are multiple processed pseudogenes of this gene
            dispersed through the genome. Multiple alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, May 2012].
            
            Transcript Variant: This variant (1) and variant 2 both encode the
            same protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034149.1, SRR1660803.48040.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000531188.6/ ENSP00000434643.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-840               BC034149.1         1-840
            841-2051            AP000744.4         96298-97508
            2052-2059           CB241053.1         23-30               c
FEATURES             Location/Qualifiers
     source          1..2059
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..2059
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
                     /note="ribosomal protein S3"
                     /db_xref="GeneID:6188"
                     /db_xref="HGNC:HGNC:10420"
                     /db_xref="MIM:600454"
     exon            1..60
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..762
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
                     /EC_number="4.2.99.18"
                     /note="isoform 1 is encoded by transcript variant 1;
                     IMR-90 ribosomal protein S3; 40S ribosomal protein S3;
                     small ribosomal subunit protein uS3"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS3 isoform 1"
                     /protein_id="NP_000996.2"
                     /db_xref="CCDS:CCDS8236.1"
                     /db_xref="GeneID:6188"
                     /db_xref="HGNC:HGNC:10420"
                     /db_xref="MIM:600454"
                     /translation="MAVQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPT
                     RTEIIILATRTQNVLGEKGRRIRELTAVVQKRFGFPEGSVELYAEKVATRGLCAIAQA
                     ESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHS
                     GDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPTGKIGPKKPLPDHVSIVEPKDEIL
                     PTTPISEQKGGKPEPPAMPQPVPTA"
     exon            61..191
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
                     /inference="alignment:Splign:2.1.0"
     exon            192..285
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
                     /inference="alignment:Splign:2.1.0"
     exon            286..380
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
                     /inference="alignment:Splign:2.1.0"
     exon            381..568
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
                     /inference="alignment:Splign:2.1.0"
     exon            569..765
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
                     /inference="alignment:Splign:2.1.0"
     exon            766..2059
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      820..825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
                     /note="hexamer: AATAAA"
     polyA_site      841
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
                     /note="major polyA site"
     regulatory      1131..1136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
                     /note="hexamer: TATAAA"
     regulatory      1142..1147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
                     /note="hexamer: ATTATA"
     polyA_site      1157
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
     polyA_site      1170
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
     regulatory      1277..1282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
                     /note="hexamer: TATAAA"
     polyA_site      1299
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
     regulatory      2032..2037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
                     /note="hexamer: ATTAAA"
     polyA_site      2059
                     /gene="RPS3"
                     /gene_synonym="S3; uS3"
ORIGIN      
        1 cctttccttt cagcggagcg cggcggcaag atggcagtgc aaatatccaa gaagaggaag
       61 tttgtcgctg atggcatctt caaagctgaa ctgaatgagt ttcttactcg ggagctggct
      121 gaagatggct actctggagt tgaggtgcga gttacaccaa ccaggacaga aatcattatc
      181 ttagccacca gaacacagaa tgttcttggt gagaagggcc ggcggattcg ggaactgact
      241 gctgtagttc agaagaggtt tggctttcca gagggcagtg tagagcttta tgctgaaaag
      301 gtggccacta gaggtctgtg tgccattgcc caggcagagt ctctgcgtta caaactccta
      361 ggagggcttg ctgtgcggag ggcctgctat ggtgtgctgc ggttcatcat ggagagtggg
      421 gccaaaggct gcgaggttgt ggtgtctggg aaactccgag gacagagggc taaatccatg
      481 aagtttgtgg atggcctgat gatccacagc ggagaccctg ttaactacta cgttgacact
      541 gctgtgcgcc acgtgttgct cagacagggt gtgctgggca tcaaggtgaa gatcatgctg
      601 ccctgggacc caactggtaa gattggccct aagaagcccc tgcctgacca cgtgagcatt
      661 gtggaaccca aagatgagat actgcccacc acccccatct cagaacagaa gggtgggaag
      721 ccagagccgc ctgccatgcc ccagccagtc cccacagcat aacagggtct ccttggcagc
      781 tgtattctgg agtctggatg ttgctctcta aagaccttta ataaaatttt gtacaaagac
      841 acaaggtctg actagactgt tcagtattca gactgagggg catgttggcc tctggagcat
      901 tacatatctt cttggtttta accatacttg tggtatttgc aagggccaga acagtaagac
      961 ccaagcagag ccaaccagag aaataatatt tgtgtgatag agaaggctga tagcaagcaa
     1021 ggcagcacct tgattcgttg tcctgtagtt caggattgta ggtttagaag agggatatgt
     1081 ttgagttttt cctatgcata aggcgatcca cgttgcacat agaaagtgaa tataaatggc
     1141 cattatattt tgtgtcatgc tgtgctctaa gtgttcttta catatgtact cgttaatcaa
     1201 cctctctaaa gtgtaaagga aatttgcttg caccactgaa ggcacataag gctcagaagt
     1261 aaatttgcct aagcagtata aagctatcat tagaatccac attcctaagt tgtgttctct
     1321 taggggatca tggaaccagt cattggtact acaggctatt atgttctgga gaactgtgaa
     1381 gaacatttaa attgtctctg attttatcta tcaatgtttt gaagtatttt ctaccagtgt
     1441 ctgtacttca caagaaattc ggcactattt tttcaggcaa aactagtgag ggacaggttg
     1501 gcttgaaaat catgagactg ttgttaaatc agatgctggt tgatcacaga ggggacttcc
     1561 agggaaagct gttatcaggt ggctgcttcc tggtgatgca gcctggctga tgagataacc
     1621 ctggctccac agatggctta gcaggtgctg tgatgatttg gttttcttct caattagact
     1681 gagctgcaca tggtgtttat attgcttggc acatggtaag ggcttaatat ttgaggtaat
     1741 tatgtagggc gtacactgac aagtatctga cccccccttc ctttttgact cataaattgg
     1801 tcatcttaac catttaagtg tacacttcta tagtgacaga gttagccctc tgtccaaggg
     1861 atttgcatct gtggattcaa ccaactttgg gtcaaaaata atcaaaaagg atggttgtgt
     1921 gtgtattgaa catgtagact tatttttctt attttcaaaa tactatattt tcttgtcact
     1981 tattttcttg tacactgcag ttgtaacagc tatgtagcat gtacattagg tattaaaagt
     2041 aatccagtga agattgaaa
//
