LOCUS       NM_001030001            7062 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens ribosomal protein S29 (RPS29), transcript variant 2,
            mRNA.
ACCESSION   NM_001030001
VERSION     NM_001030001.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7062)
  AUTHORS   Behrmann,E., Loerke,J., Budkevich,T.V., Yamamoto,K., Schmidt,A.,
            Penczek,P.A., Vos,M.R., Burger,J., Mielke,T., Scheerer,P. and
            Spahn,C.M.
  TITLE     Structural snapshots of actively translating human ribosomes
  JOURNAL   Cell 161 (4), 845-857 (2015)
   PUBMED   25957688
REFERENCE   2  (bases 1 to 7062)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   3  (bases 1 to 7062)
  AUTHORS   Mirabello,L., Macari,E.R., Jessop,L., Ellis,S.R., Myers,T.,
            Giri,N., Taylor,A.M., McGrath,K.E., Humphries,J.M., Ballew,B.J.,
            Yeager,M., Boland,J.F., He,J., Hicks,B.D., Burdett,L., Alter,B.P.,
            Zon,L. and Savage,S.A.
  TITLE     Whole-exome sequencing and functional studies identify RPS29 as a
            novel gene mutated in multicase Diamond-Blackfan anemia families
  JOURNAL   Blood 124 (1), 24-32 (2014)
   PUBMED   24829207
  REMARK    GeneRIF: We uncovered a novel Diamond-Blackfan anemia causative
            gene, RPS29
REFERENCE   4  (bases 1 to 7062)
  AUTHORS   Xie,P., Kranzler,H.R., Yang,C., Zhao,H., Farrer,L.A. and
            Gelernter,J.
  TITLE     Genome-wide association study identifies new susceptibility loci
            for posttraumatic stress disorder
  JOURNAL   Biol Psychiatry 74 (9), 656-663 (2013)
   PUBMED   23726511
REFERENCE   5  (bases 1 to 7062)
  AUTHORS   Anger,A.M., Armache,J.P., Berninghausen,O., Habeck,M., Subklewe,M.,
            Wilson,D.N. and Beckmann,R.
  TITLE     Structures of the human and Drosophila 80S ribosome
  JOURNAL   Nature 497 (7447), 80-85 (2013)
   PUBMED   23636399
REFERENCE   6  (bases 1 to 7062)
  AUTHORS   Kondoh,N., Noda,M., Fisher,R.J., Schweinfest,C.W., Papas,T.S.,
            Kondoh,A., Samuel,K.P. and Oikawa,T.
  TITLE     The S29 ribosomal protein increases tumor suppressor activity of K
            rev-1 gene on v-K ras-transformed NIH3T3 cells
  JOURNAL   Biochim Biophys Acta 1313 (1), 41-46 (1996)
   PUBMED   8781548
REFERENCE   7  (bases 1 to 7062)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   8  (bases 1 to 7062)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   9  (bases 1 to 7062)
  AUTHORS   Frigerio,J.M., Dagorn,J.C. and Iovanna,J.L.
  TITLE     Cloning, sequencing and expression of the L5, L21, L27a, L28, S5,
            S9, S10 and S29 human ribosomal protein mRNAs
  JOURNAL   Biochim Biophys Acta 1262 (1), 64-68 (1995)
   PUBMED   7772601
REFERENCE   10 (bases 1 to 7062)
  AUTHORS   Sieff,C.
  TITLE     Diamond-Blackfan Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU942244.1, BC015974.1 and
            AL139099.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001030001.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit and a member of the
            S14P family of ribosomal proteins. The protein, which contains a
            C2-C2 zinc finger-like domain that can bind to zinc, can enhance
            the tumor suppressor activity of Ras-related protein 1A (KREV1). It
            is located in the cytoplasm. Variable expression of this gene in
            colorectal cancers compared to adjacent normal tissues has been
            observed, although no correlation between the level of expression
            and the severity of the disease has been found. As is typical for
            genes encoding ribosomal proteins, there are multiple processed
            pseudogenes of this gene dispersed through the genome.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Mar
            2013].
            
            Transcript Variant: This variant (2) utilizes an alternate
            3'-terminal exon, compared to variant 1, resulting in a longer
            isoform (2) with a unique C-terminus.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK307833.1, SRR14038197.414287.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BU942244.1         40-43
            5-375               BC015974.1         5-375
            376-7062            AL139099.3         84959-91645
FEATURES             Location/Qualifiers
     source          1..7062
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.3"
     gene            1..7062
                     /gene="RPS29"
                     /gene_synonym="DBA13; S29; uS14"
                     /note="ribosomal protein S29"
                     /db_xref="GeneID:6235"
                     /db_xref="HGNC:HGNC:10419"
                     /db_xref="MIM:603633"
     exon            1..96
                     /gene="RPS29"
                     /gene_synonym="DBA13; S29; uS14"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..238
                     /gene="RPS29"
                     /gene_synonym="DBA13; S29; uS14"
                     /note="isoform 2 is encoded by transcript variant 2; 40S
                     ribosomal protein S29; small ribosomal subunit protein
                     uS14"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS14 isoform 2"
                     /protein_id="NP_001025172.1"
                     /db_xref="CCDS:CCDS32072.1"
                     /db_xref="GeneID:6235"
                     /db_xref="HGNC:HGNC:10419"
                     /db_xref="MIM:603633"
                     /translation="MGHQQLYWSHPRKFGQGSRSCRVCSNRHGLIRKYGLNMCRQCFR
                     QYAKDIGFIKKDLSCLPWHCLWR"
     exon            97..196
                     /gene="RPS29"
                     /gene_synonym="DBA13; S29; uS14"
                     /inference="alignment:Splign:2.1.0"
     exon            197..7062
                     /gene="RPS29"
                     /gene_synonym="DBA13; S29; uS14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      699..704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS29"
                     /gene_synonym="DBA13; S29; uS14"
                     /note="hexamer: AATAAA"
     regulatory      713..718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS29"
                     /gene_synonym="DBA13; S29; uS14"
                     /note="hexamer: AACAAA"
     polyA_site      720
                     /gene="RPS29"
                     /gene_synonym="DBA13; S29; uS14"
                     /note="major polyA site"
     polyA_site      729
                     /gene="RPS29"
                     /gene_synonym="DBA13; S29; uS14"
                     /note="major polyA site"
     regulatory      3702..3707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS29"
                     /gene_synonym="DBA13; S29; uS14"
                     /note="hexamer: AATAAA"
     polyA_site      3728
                     /gene="RPS29"
                     /gene_synonym="DBA13; S29; uS14"
     regulatory      7033..7038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS29"
                     /gene_synonym="DBA13; S29; uS14"
                     /note="hexamer: AATAAA"
     polyA_site      7062
                     /gene="RPS29"
                     /gene_synonym="DBA13; S29; uS14"
ORIGIN      
        1 cttcctttta cctcgttgca ctgctgagag caagatgggt caccagcagc tgtactggag
       61 ccacccgcga aaattcggcc agggttctcg ctcttgtcgt gtctgttcaa accggcacgg
      121 tctgatccgg aaatatggcc tcaatatgtg ccgccagtgt ttccgtcagt acgcgaagga
      181 tatcggtttc attaagaaag acctgagctg tcttccttgg cactgcctat ggaggtgaca
      241 cccatctcct ccatcatggc catcctgaga ccgctcgcga agcccaagat catcaaaaag
      301 agcaccaagt tcactgggaa ccagtcagac tgatatgtca aaattaaggg taactggtgg
      361 aaacacagag gtattaacaa cagggttcat agaaggtttg agggccagat ctatgcccaa
      421 cattggttat gggagaaaca aaaagacaaa gcacatactg cccagtggct tctggaagtt
      481 cctggtccac aacgttaagg agctggaagt actgctggtg agcaacaaat cttactgtgt
      541 tgagatcact catgatgttt cttccaagaa ctgcaaagcc atcttggaaa gagcagccca
      601 ggtggtcatc agagtcacca atgccaatgc cagcctgcac agtgcagaaa gtgaatagac
      661 agtgaatgtg tttgttttat tggggtttaa ataaaaccaa taaaactgta aaaacaaaaa
      721 caacaaaaac cagagaccct ggcttttgga cagttgttcg tgtggctaat gcccccaaca
      781 gttttatttt ttaaaatttt atttatgtat tgtttttgag atgaagtctt cctctgactg
      841 gagtgcagtg atgcaagctc agctctctgc aacttccacc tcccaggttc aagtgattct
      901 tctgtctcag cctcccaagt ggctgggatt acaggtgccc actaccacac ctgactaatt
      961 tttgtatttt tgtagagatg gggtttcatc ctcttggcca ggctggtttc gaactcctga
     1021 cctcaaggga tcctcccacc tcagcttccc aaagtgctgg gatcacaggc ttgtattagt
     1081 tcattttcac actgctgata aagacatacc taagactggg aagaaaaata ggtttattgg
     1141 actcacagtt ccatgtggct ggggatgcct cacaattatg gtagaaggca aaaggcactt
     1201 cttagatggc agcggcaagc aggaaatgag gaagacatga aagcagatat cccttataaa
     1261 accatcagtt ctcgtgatac ttactcacta ccatgagaaa gtatggggga aaccgctccc
     1321 atgattcagt tatctcccac cgggtccctc tcacaacatg tggggattat gcgagtacaa
     1381 ttcaagatga gatttgggtg gggacacagc ccacaaacca taatcaaggc atgagccact
     1441 gtgcctggcc ttcaacagtt ttaaagcagc ctgcttgcat aacctctgct aggacatcgt
     1501 tcttaaaaac tatctttaat ggtaattggt gtattaggga tttgggtttt taggtaggca
     1561 gagaaaaaac acttctagtg gtatgattaa gaagggtata ataaagtgtt ttaatttcct
     1621 caatattgac aaaaattgaa aaaaagaggc caggcaaagt ggctcatgcc tgtaatccta
     1681 gccttttggg aggctgaggc aggaggatgg tttgatgcca ggagttccag accagcctgg
     1741 gcaacatcag gagatcccct atctaccaaa attaaacaaa caaaaaaacc caaaaacaat
     1801 tagccaggcg tggtggtgca tgtctgtagt cccagtttct caggaggctg agatgagagg
     1861 ataacttgag cccaagaggt ccaggtttca atgagtcatg tttgtatcac ttaaaaaaaa
     1921 aaaaaaggct gcactattag ctgtttctca ggaaggttaa tgtagaacat aaaaggctca
     1981 gtttgtagat agactgagta tatgtgtgtg taggaatcaa ggctatacag ggtccaaaaa
     2041 ttagcctaga ttatgtgtgc tagttccagg tatcttctat cttttagaat tttaaaagaa
     2101 tagaggcaga aagtcacaag cttaatctag atgaggtaat tatcatttaa tgtcttgaac
     2161 ataaagtaat ttgctaaatt agaatttatt ttaatttttt tggacatggc cttgctctat
     2221 cacccagact ggcattcagt ggcacaaaca tggcttattg caacctcaac ctcctgggct
     2281 caagtaatcc tcctacctca gactccaagt agctaggacc ataagtgtgc accacaatgc
     2341 ccagctaatt tttataaaat ttttcgtaga gatggaagtc tcaccatgtt gctcaggctg
     2401 gtctggaact cctgggctca tgcaatcctc ccttcctagt ctcccaaagt gttgggatca
     2461 caggggtgag ccactgtgtt cagccagaaa ataatttaga gaagccagaa ctggcttcct
     2521 ttggtgaaaa ttctttgagc agattccaga ctggaccttc tgactgttat aaataaatgg
     2581 tggattccca ttatttgttt gtgggacaga aatattgaag gcctgtagaa ccataatgcc
     2641 ttccccttcc ttctgtcact cacccacttc atttctccta ttaggcccct tagaaagaga
     2701 tccctgatgc caggcacagt ggcttacgcc tgtaatccta gcagtttggg aggctgaggc
     2761 gggtggatca cctgaggtca ggagttaaag accagcctgg ccaatgcagt gaaaccccat
     2821 ctttactaaa aatacaaaaa aattagccag gcatggtggc gagtgcctgt aatctcagct
     2881 actcaggagg ctgaggcagg agaatggcgt gaacccggga ggcggagctt gcagtgagcg
     2941 gagatcaggc cgctgcactc cagcctgggc gacagagcga gactccgtct caaaaaaaaa
     3001 gataaagaaa gagatccctg actgcctgta tagtttgaga accactgatc ctggggcaag
     3061 gactcaaagt ctctggctct agaagtggct ggtgtggacc tcaaatggac cctgttctaa
     3121 gagtccaaag gacacatttc aggaagctgt gctctaagcc taaatgacca accttgcctt
     3181 cactttggac atataccatc tgatcatctt cctcgatttc tgttctttgc tcaggccttc
     3241 caatttcttc gtgggtgacc cctccttacc agtgctttgc tctgagtcag ctcaccagac
     3301 ccagcaggct gccactaaag gtttattgta aaaccttgat taattcagat aaccttgaaa
     3361 tacttacata acatcactga caaataggaa agggagtgca tttccattga tagagactat
     3421 ggctagagtt actaaggtct ggaaaaaagg caggagagtg aagtatctgg agacgtaggg
     3481 agagaaagag actggtgtta agagaaaaat cacgcctttt tcctgcttgt atcttacagt
     3541 ggttctgcca ccagtaatgc aggatcccac tgatctctct gaacacattt taggacaggt
     3601 ccatattcgg gagctgactt tgtaacttct tactgtatat agtttaggtt cgaatgggat
     3661 caccataggt gtgcttatga ccttaactgt aacagcgatg aaataaaaaa aatggtttag
     3721 tttaataata atgttgtaag agtgtaagta ccagtagctt catgtacatt ctacaaccca
     3781 ataataatta tgctgaccgt gtaaacagct ccctcgtgta gactgagact ccattgccaa
     3841 acatcaagca ttaacagcaa gtgctagaaa aatcaataag cctttaccca gggaaccaaa
     3901 gatatgtggg ttactaaaac ccctaacagt tgcccataaa gagtaatatc tcattatttt
     3961 aatgccaaag gaggtttttg tttcatttcc taaataataa caagatcgca tattaaagga
     4021 cgagttgatg gagtgataaa cattcctggc agcacagaca aatcaacaag agactaaaat
     4081 aaaaagaaat gaaacttgcc tcttggcaat ctgtttagtt gaatttcata gactgagtct
     4141 ggttcaccct ggattttctt ttcacacacc cacacgtccc atttcatgat gacacttgtg
     4201 catctattct tcctttgatg gtaattaact cttattaaca ttcatgaaga ctaagtgtga
     4261 gcctctagca cagatgacat attcagacaa ccacaaaaag atagggttta taaaaactaa
     4321 tgcatatttg gaactgaggc caaaagataa agatggtcca ctccaacagt gctgacatgc
     4381 ttgagaaatc caaggggtgt tgacctaatg taaaaaggat ataggagaca aattttacca
     4441 ttgtgtaatt ttgtcttagg ccagttctgt caaatatagc ttctgaaatt ctgaatagtc
     4501 ctctgcccag tgtggtttaa ttgttggtgt tgtcaggact cttggggaga agtcaccttt
     4561 ctcttttttt tttttttttt tttgattcta actctgttgt ccaggctgga gtgcagtggt
     4621 gccatcttgg ctcactgcag cctctgtctc ctgggttcaa gagattctcc tgccttaact
     4681 tagcctctgg agtagctggg attacaggtg cgcaccatta catccagcta atttttatat
     4741 ttttagtgga gatggggttt tgtcatgttg gccagtctgg tctcaaactc ctgacctcaa
     4801 ggatctgtct gctttggtct cccaacgtgc tgggattaca ggcatgagcc accacgccca
     4861 gcctattttt ttattttttg tattttcttt tggtaatctc tttctcttgc tttttctttc
     4921 tttctctttc tttctttctt tctttccttc tttctttctt tctttcttct tttttttctt
     4981 tggagacagg gtctcactgt gtcatgcagg ctggagtgaa gtcgtgtgat cttggcttac
     5041 tgcagcctca acctgctggg ctcaatgcaa tcttcccacc tcagcctccc aagtatctgg
     5101 gaccacaggc gtgcatcacc agcatggcta atttttgtat ttttggtgag acaaactttt
     5161 gccatgttgc ccaggttggc cttaaattcc tgggctcaag agatccacct gccttggcct
     5221 cccaaaatgc taggactgca ggcgtgagcc accatgccag gccagggaaa tctctttaaa
     5281 cacaattttc tttaaagttt tctacatggt caggagactt cattatctga tttctgagta
     5341 ctatagcttc tttattgcca agggagcaaa gcatgatgac aatgaccact tctcatttgt
     5401 gtccttcatt atagattttc taaatacact tgttccttgt taatgacttt aatttgttcc
     5461 agaaaactcc accactgagt taaaagctat taagtgaaaa aattccatta agttttcgga
     5521 aaaaattatt tattctatga cactacaggg tacttgagta attttcacaa aaagaagaat
     5581 atactagtta aactttgaaa aaaagctcat aaaagtaatg tacaataatt tgaaagtatt
     5641 ctgacctcaa ccggtatatt gaaattcaat tcttgcacta attagggtta gagaagaccc
     5701 cacaagttaa agggcatgat cccaaacgag gttgtcctca cttttgatgc cagtcacact
     5761 ttgggagtcc ccagtcaatt ggctacaaat ctaggggttt ggctgggtgc cgtggctcac
     5821 acctgtaatc tgagcacatt gggaggccaa ggcaggtgga tcacctgagg ttaggagttc
     5881 gagagcagcc tggccaacac cgtgaacctc gtatctacta aaaatacaaa aattagccgg
     5941 gcatggtggc agtcacctgt aatcccagct acttgggagg ctgaggcacg agaatcgctt
     6001 gaacctggga ggcagaggtt gcagtgagct gagatggtgc cactgcactt cagcctgggc
     6061 aacagagtga gactgggtct caataaaaaa taaaaataaa ataaaacaat aaaacgtagg
     6121 ggtttctgaa gatttccttc aggtttgccg atttgctaga atgactcaca ttactcagga
     6181 agatgctgta tttacaattg ttttattatg aaggatataa gttaggacca gccaatggag
     6241 agacacataa agtaaggtct aggagggcgc tggatgcgaa gctttcatgt cctgcattgt
     6301 ggaatcgggt gtgtcaccct ctcaacacat tgatatgttc accaaccagg atgcttcacc
     6361 atgcttcggt atctaaagtt tttattgggg tttcattata tatgtataat tgattgaatc
     6421 actggccaag tgattgaact aaatctccac cctacccctt actctgggtg tcaggctgac
     6481 tcaaagcacc agctatgtaa tcacatggtt gttctcgctg gtaactggcc tccatcttgg
     6541 gtcatctcat cttccagccc aaattcaggt gtgatccaag aggctcatga aaaacaaaga
     6601 tatccctgtt acttagggaa ttctaattat tttgagtctg cctcctagga accagagaca
     6661 aaagccagtc aaattcttta ctataaaaca gaaagcatgt gaaaacatac tgtgcacgct
     6721 atgtcacaca acaaacacaa gtctattgaa cttgccaatg gtggagtgtt ggttggtagg
     6781 agaggtctga gggcatcatt ctttgcaaag tgtattcttt ctgtaccatt ttcttgacca
     6841 attttcacct tttctgggga ttattcctgt tttgcactca aactactctt aaaaataaag
     6901 ttacagtgca ggaaaacttc tttagggcac aataaaggct aaactcgtgg aaatggtact
     6961 cattcatctg cacagaatga agtctctcaa gatgtttcct tttattccta ctcagttggt
     7021 gcatgtaccc aaaataaaca ttttgagttc atccaaacac aa
//
