LOCUS       NM_001031               1330 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ribosomal protein S28 (RPS28), mRNA.
ACCESSION   NM_001031
VERSION     NM_001031.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1330)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   2  (bases 1 to 1330)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1330)
  AUTHORS   Wei,J., Kishton,R.J., Angel,M., Conn,C.S., Dalla-Venezia,N.,
            Marcel,V., Vincent,A., Catez,F., Ferre,S., Ayadi,L., Marchand,V.,
            Dersh,D., Gibbs,J.S., Ivanov,I.P., Fridlyand,N., Coute,Y.,
            Diaz,J.J., Qian,S.B., Staudt,L.M., Restifo,N.P. and Yewdell,J.W.
  TITLE     Ribosomal Proteins Regulate MHC Class I Peptide Generation for
            Immunosurveillance
  JOURNAL   Mol Cell 73 (6), 1162-1173 (2019)
   PUBMED   30712990
  REMARK    GeneRIF: 40S ribosomal protein S28 (RPS28) knockdown increases
            total peptide supply in uninfected cells by increasing DRiP
            synthesis from non-canonical translation of 'untranslated' regions
            and non-AUG start codons and sensitizes tumor cells for T cell
            targeting.
REFERENCE   4  (bases 1 to 1330)
  AUTHORS   Behrmann,E., Loerke,J., Budkevich,T.V., Yamamoto,K., Schmidt,A.,
            Penczek,P.A., Vos,M.R., Burger,J., Mielke,T., Scheerer,P. and
            Spahn,C.M.
  TITLE     Structural snapshots of actively translating human ribosomes
  JOURNAL   Cell 161 (4), 845-857 (2015)
   PUBMED   25957688
REFERENCE   5  (bases 1 to 1330)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   6  (bases 1 to 1330)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   7  (bases 1 to 1330)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   8  (bases 1 to 1330)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   9  (bases 1 to 1330)
  AUTHORS   Hori,N., Murakawa,K., Matoba,R., Fukushima,A., Okubo,K. and
            Matsubara,K.
  TITLE     A cDNA sequence of human ribosomal protein, homologue of yeast S28
  JOURNAL   Nucleic Acids Res 21 (18), 4394 (1993)
   PUBMED   8415000
REFERENCE   10 (bases 1 to 1330)
  AUTHORS   Sieff,C.
  TITLE     Diamond-Blackfan Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AC010323.8, BC070217.1 and BC021239.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001031.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S28E family of ribosomal proteins. It is located in the
            cytoplasm. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.13077.1,
                                           SRR5189652.21846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000600659.3/ ENSP00000472469.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC010323.8         71648-71651
            5-312               BC070217.1         1-308
            313-386             BC021239.2         288-361
            387-1330            AC010323.8         72549-73492
FEATURES             Location/Qualifiers
     source          1..1330
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1330
                     /gene="RPS28"
                     /gene_synonym="DBA15; eS28; S28"
                     /note="ribosomal protein S28"
                     /db_xref="GeneID:6234"
                     /db_xref="HGNC:HGNC:10418"
                     /db_xref="MIM:603685"
     exon            1..74
                     /gene="RPS28"
                     /gene_synonym="DBA15; eS28; S28"
                     /inference="alignment:Splign:2.1.0"
     exon            75..122
                     /gene="RPS28"
                     /gene_synonym="DBA15; eS28; S28"
                     /inference="alignment:Splign:2.1.0"
     exon            123..261
                     /gene="RPS28"
                     /gene_synonym="DBA15; eS28; S28"
                     /inference="alignment:Splign:2.1.0"
     exon            262..1330
                     /gene="RPS28"
                     /gene_synonym="DBA15; eS28; S28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      361..366
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS28"
                     /gene_synonym="DBA15; eS28; S28"
                     /note="hexamer: AATAAA"
     polyA_site      386
                     /gene="RPS28"
                     /gene_synonym="DBA15; eS28; S28"
                     /note="major polyA site"
     polyA_site      412
                     /gene="RPS28"
                     /gene_synonym="DBA15; eS28; S28"
     regulatory      1296..1301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS28"
                     /gene_synonym="DBA15; eS28; S28"
                     /note="hexamer: AATAAA"
     polyA_site      1330
                     /gene="RPS28"
                     /gene_synonym="DBA15; eS28; S28"
ORIGIN      
        1 actcctctcc gccagaccgc cgccgcgccg ccatcatgga caccagccgt gtgcagccta
       61 tcaagctggc cagggtcacc aaggtcctgg gcaggaccgg ttctcaggga cagtgcacgc
      121 aggtgcgcgt ggaattcatg gacgacacga gccgatccat catccgcaat gtaaaaggcc
      181 ccgtgcgcga gggcgacgtg ctcacccttt tggagtcaga gcgagaagcc cggaggttgc
      241 gctgagcttg gctgctcgct gggtcttgga tgtcgggttc gaccacttgg ccgatgggaa
      301 tggtctgtca cagtctgctc cttttttttg tccgccacac gtaactgaga tgctccttta
      361 aataaagcgt ttgtgtttca agttaactca ggttcttgtc tgggttatac gactagggtt
      421 tctccaggtt tcttgagtgg ctcccaggcg gtcaccgatc ctccgcactc tggaaatcct
      481 ggccgtgcgg tcttgccaaa cgaagctttt cctttttgag gcggggggtc gtgtttgtcg
      541 attgcaccct ctaccccaaa caaaacacaa gcgtagtagg aatgttttat tagcaaagaa
      601 gtttcagaga gtgggtggat cagggctcta tcacttggtc cccacctcac cttggtgggg
      661 ccagagtgag ccccttcctg ccacagtcac cccaactgaa attgcctttc tcttcggcca
      721 gtgttagcct ctgagcaggg gaccctggac ccttctgtgc gccaaaggct gaggtgactg
      781 acgaggagat ctccccacag ctaggtgtag tgagccagac gaggcagctt actgaacctg
      841 ggggttctct ccattgtcac cgcattctcc ttcaccaggt gtggctgtct gggagccagg
      901 gggtgactcg ctctggagag aggggaaaag aggggggcct gctgcaatct ccttgaggca
      961 ggaaacgtgg gattcagccc cagcctcact tagtggaggt tcttttacca tggacccagg
     1021 ctgcctggtt tgtatccaac ctctgcccct tctgacctgg aagaggcgct tgaccttcct
     1081 cccacatccc ttccagtggg gtgagtacag gtgttcctca gtttacaatg ggttacattc
     1141 cggtgagtac atcataggtt gaaagtattg caagttgaaa tgtgtttaat acacctaatc
     1201 tcccaaacat cacagcttag catggtccat cttaagcttg ttcagaacgc cttagcctgt
     1261 agttggggaa actcgtctaa cacgaagcct gttttaataa agtattgaat gtcttatgta
     1321 atttattgaa
//
