LOCUS       NM_015920               6110 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ribosomal protein S27 like (RPS27L), mRNA.
ACCESSION   NM_015920
VERSION     NM_015920.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6110)
  AUTHORS   Sun,S., He,H., Ma,Y., Xu,J., Chen,G., Sun,Y. and Xiong,X.
  TITLE     Inactivation of ribosomal protein S27-like impairs DNA interstrand
            cross-link repair by destabilization of FANCD2 and FANCI
  JOURNAL   Cell Death Dis 11 (10), 852 (2020)
   PUBMED   33051438
  REMARK    GeneRIF: Inactivation of ribosomal protein S27-like impairs DNA
            interstrand cross-link repair by destabilization of FANCD2 and
            FANCI.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6110)
  AUTHORS   Xiong,X., Cui,D., Bi,Y., Sun,Y. and Zhao,Y.
  TITLE     Neddylation modification of ribosomal protein RPS27L or RPS27 by
            MDM2 or NEDP1 regulates cancer cell survival
  JOURNAL   FASEB J 34 (10), 13419-13429 (2020)
   PUBMED   32779270
  REMARK    GeneRIF: Neddylation modification of ribosomal protein RPS27L or
            RPS27 by MDM2 or NEDP1 regulates cancer cell survival.
REFERENCE   3  (bases 1 to 6110)
  AUTHORS   Xiong,X., Liu,X., Li,H., He,H., Sun,Y. and Zhao,Y.
  TITLE     Ribosomal protein S27-like regulates autophagy via the
            beta-TrCP-DEPTOR-mTORC1 axis
  JOURNAL   Cell Death Dis 9 (11), 1131 (2018)
   PUBMED   30425236
  REMARK    GeneRIF: The study suggests that RPS27L reduction might play a
            promoting role during breast tumorigenesis by autophagy induction
            via the beta-TrCP-DEPTOR-mTORC1 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6110)
  AUTHORS   Huang,C.J., Yang,S.H., Lee,C.L., Cheng,Y.C., Tai,S.Y. and
            Chien,C.C.
  TITLE     Ribosomal protein S27-like in colorectal cancer: a candidate for
            predicting prognoses
  JOURNAL   PLoS One 8 (6), e67043 (2013)
   PUBMED   23826192
  REMARK    GeneRIF: Elevated RPS27L may improve the prognoses of certain
            colorectal cancer patients by enhancing the DNA repair capacity of
            their colonic cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6110)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 6110)
  AUTHORS   Xiong,X., Zhao,Y., He,H. and Sun,Y.
  TITLE     Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as
            a target, a substrate and a regulator
  JOURNAL   Oncogene 30 (15), 1798-1811 (2011)
   PUBMED   21170087
REFERENCE   7  (bases 1 to 6110)
  AUTHORS   Li,J., Tan,J., Zhuang,L., Banerjee,B., Yang,X., Chau,J.F.,
            Lee,P.L., Hande,M.P., Li,B. and Yu,Q.
  TITLE     Ribosomal protein S27-like, a p53-inducible modulator of cell fate
            in response to genotoxic stress
  JOURNAL   Cancer Res 67 (23), 11317-11326 (2007)
   PUBMED   18056458
  REMARK    Erratum:[Cancer Res. 2008 Feb 1;68(3):956]
REFERENCE   8  (bases 1 to 6110)
  AUTHORS   He,H. and Sun,Y.
  TITLE     Ribosomal protein S27L is a direct p53 target that regulates
            apoptosis
  JOURNAL   Oncogene 26 (19), 2707-2716 (2007)
   PUBMED   17057733
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW013916.1, AF070668.1,
            BC003667.1 and AC087612.6.
            
            On Nov 22, 2018 this sequence version replaced NM_015920.3.
            
            Summary: This gene encodes a protein sharing 96% amino acid
            similarity with ribosomal protein S27, which suggests the encoded
            protein may be a component of the 40S ribosomal subunit. [provided
            by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG612857.1, SRR1660805.26233.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330964.10/ ENSP00000331019.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AW013916.1         120-132             c
            14-352              AF070668.1         1-339
            353-502             BC003667.1         350-499
            503-1019            AC087612.6         31752-32268
            1020-6110           AC087612.6         32269-37359
FEATURES             Location/Qualifiers
     source          1..6110
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.2"
     gene            1..6110
                     /gene="RPS27L"
                     /note="ribosomal protein S27 like"
                     /db_xref="GeneID:51065"
                     /db_xref="HGNC:HGNC:18476"
                     /db_xref="MIM:612055"
     exon            1..78
                     /gene="RPS27L"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..327
                     /gene="RPS27L"
                     /note="40S ribosomal protein S27-like; small ribosomal
                     subunit protein eS27-like"
                     /codon_start=1
                     /product="ribosomal protein eS27-like"
                     /protein_id="NP_057004.1"
                     /db_xref="CCDS:CCDS42048.1"
                     /db_xref="GeneID:51065"
                     /db_xref="HGNC:HGNC:18476"
                     /db_xref="MIM:612055"
                     /translation="MPLARDLLHPSLEEEKKKHKKKRLVQSPNSYFMDVKCPGCYKIT
                     TVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH"
     exon            79..187
                     /gene="RPS27L"
                     /inference="alignment:Splign:2.1.0"
     exon            188..298
                     /gene="RPS27L"
                     /inference="alignment:Splign:2.1.0"
     exon            299..6110
                     /gene="RPS27L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      483..488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS27L"
                     /note="hexamer: AATAAA"
     polyA_site      506
                     /gene="RPS27L"
                     /note="major polyA site"
     regulatory      991..996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS27L"
                     /note="hexamer: ATTAAA"
     polyA_site      1017
                     /gene="RPS27L"
     regulatory      6084..6089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS27L"
                     /note="hexamer: AATAAA"
     polyA_site      6110
                     /gene="RPS27L"
ORIGIN      
        1 gcagatcgct tgcagcttgc tagctgtgtg ggctgggagg tctggtaggg ctgagcttgc
       61 aagaggatca acatgccttt ggctagagat ttactacatc cgtccttgga agaggaaaag
      121 aaaaaacata aaaagaaacg cctagtacaa agtccaaatt cttactttat ggatgtaaaa
      181 tgtccaggtt gctacaagat caccacggtt ttcagccatg ctcagacagt ggttctttgt
      241 gtaggttgtt caacagtgtt gtgccagcct acaggaggaa aggccagact cacagaaggg
      301 tgttcattta gaagaaagca acactaatga ttcaaacagc ttcctgaatt ttaattttgt
      361 gttgtctcac agaaagcctt atcataaatt ccataattct aattaattta ccaagataat
      421 gtaattacat ttggttttgt aaggtataca gcagtaatct cctattttgg tgtcagtttt
      481 tcaataaagt tttgattatg ggcaaatccc ctctttttct ttttttaaaa tatatttgag
      541 tatgccatac atttatatat atggtgtata tgaatttggt ttaaacattt taaaatttat
      601 tctgattagt ttgtgtcttt tttttttttt ttgagagaga gagtcctgct ctgtcactca
      661 agctggagtg cagtggtgcg atctcggctc actgcaacct ccgcctccca ggtccaagca
      721 attctcttgc cttgtcctcc caagtagctg ggattatagg cacacaccac catgcctggc
      781 taatttgtgt ctcattttca agagtagaaa ccctaaatat tttattttca ttccttttcc
      841 aaattgctat gaatgggatt aaaggattac agatgtaaag tctattattt gtgaattcta
      901 aatgtagttc tgctgttgta cctgtggaaa catcttaaag aagtacatat tttgcacgtc
      961 ctgcacgtgt accccagaac ttaaactata attaaaaaga atagtttcaa aaaaatacat
     1021 attgatcaca gtgtaatgcc ttggatttat gtggccttgc tatactacta tataatttag
     1081 gacagtaact gctagctggg gtgtgagtta tttattggaa gctccttttt agggtagaaa
     1141 atttgaggag aaatctgaag tggcatgatt tacccgcaga agtcctggtt ggggatagta
     1201 gatggtgttg aattctctgg cccagatagg tgagcactcc tgactacaga tgtgtgttga
     1261 gtggttctgg tgcctgcctc attgtcattt tcatagttta tgaagtaatc ctggggagct
     1321 gagacgggga gtgtatccac tcactataca actcctcatt ggactaggaa gatagtccag
     1381 tttctactct gcttctattt gatttgttac cttgtggcag gtatttaaaa caggcatttc
     1441 ctatcaacag gtaggcctct aatgtgagca actgatcctc ttacatactg cttaaatcag
     1501 agaactgttg cacaagaact aaagaatgat ggcaagtttg gggtgtatat agttgtataa
     1561 ggaaggctgg gcgcagtggc tcacacctgt aatcccagca ctttgggagc ctgaggcagg
     1621 tggatcacct gaggtcggga gttcaagacc agcctgacca acatggaaaa accccgtctc
     1681 tactaaaaat gcaaaattag ctgggcgtgg tggtgcatgc ctgtaatctc agctaactcg
     1741 ggaggctgag gcaggagaat tcgcttgaac ctgggaggtg gaggttgtgg tgagccaaga
     1801 tcgtgccatt gcactctagc ctgggcaaca agcacgaaac tccgtctcaa aaaaaaaaag
     1861 aaaaaaaaaa tatatatata tacatatata tgtagatgac ccagagattc tcagactttt
     1921 agtttctgac atcattagaa tctcagtaat ttttttcagg ccattccttg gccaaaagaa
     1981 atacctaaca gttacattta ttaacttatg ttctaacaac tctagtagcc atttgaaaaa
     2041 aactatacac acacaagagc aaaagtgatg tgatgatttt tttaaaaata gagacagtgt
     2101 cttggctcta ttgcccaggt tggagggtca tagctcattg tgacctcaaa ctcctgggct
     2161 caagcaagcc tcccacctct gcctcctgag tagcggagac ttcaggcacg tgccaccacg
     2221 cccgcctaat ttttttgtag agatggggct ctggctgtgt tgcccaggct gtaaggaact
     2281 cctggcctca ggtgatctgc cttggcctac caaagtgctg ggattacagg tgtgagccac
     2341 tgtgcccagc ctgatgtgat aatttttatc tcatccttaa atcatcacag ttactaatgg
     2401 aatgtgtgtg ccttttgggc tccatacagt ttctcaaaat tgaaatcaga ttggacacca
     2461 ttgtccttat ttcttccaca ttgatttttg catggtgctt tttgtcatag cagtggctcc
     2521 aaacccagct tcacaaggat aggatgccat caaagggaat gtagtgccat atcatattga
     2581 aactgaactt cctggaacta gtagtttata caaaagatgc gtcagtgtca agtgtttttc
     2641 ctgaggtact ccaaggcact tcagcttgca cagtttagga tacttggcta taaggagaga
     2701 cagtgggatg acagcttttg atgagaagga atcaaaccta tgatgaggac taatctaaca
     2761 aaccctgaaa attcccttgg aagtattttt taaaaaagga ttatacttta aagaccacat
     2821 ctaagggctg ggcgcggtgg ctcacaccta taatcccagc agtttgggag gctgaggcag
     2881 gcagatcact tgcagtcagg agttcgagac cagcctggcc aacacagtga aaccccgtct
     2941 ctactaaaca tacaaaaatt agctgggcgt ggtggtgtac acctgtagtc ccagctactt
     3001 gggaggctga ggcacaagaa ttgcttgaaa ccaggaggca gaggttgcag tgagccaaaa
     3061 tcgcaccact gcacttcagc ctgggtgaca gcgtgaagct gtgtctcaaa gaaagaacac
     3121 atctaaggat ttacatggca ttgggaaacg aatggtgtat taagttttac tttattatta
     3181 atctagatgg tattactggt tttgaaaagt gctgaatagg acaccaggac tttcccaaac
     3241 ttcagggtca gccacataca ttattatata ctgaatgttt taaatattat ttatattgac
     3301 ttcatatttt aatgtaaata tatttgtaaa ggaaaccttc cataaactta atataaattt
     3361 atttttaggg gaaggcttcc taaatggaaa aaccagttac ataaagatag ctaaaaatag
     3421 gccgggcgca gtggctcacg cctataatcc cagcactttg ggaggccgag gcgggtggat
     3481 cacgaggtca ggagatcgag accaccctgg ctaacacggt gtaaccccgt ctctactaaa
     3541 aatacaaaaa attagccggg catggtggtg ggcgcctgta gtcccagcta cttgggaggc
     3601 tgaggcagga gaatggcgtg aacctgggag gcggagcttg cagtgagcca agatcacgcc
     3661 tctgcactcc agcctgggtg acagagcaag actccagctc aagaaaaaaa taaataagct
     3721 aaaaataaaa tgaaattctt ggcttctggc ctgatgagat gacaaatggt tttgtgtctg
     3781 gtcgttcctg taagtcatct gataaagctc taattccttt ctgttttatt tttctggaga
     3841 tatgattcag atactataaa atccaaactt ctgtgatgta aaagtcagta gtttttacta
     3901 tatttacaag gttgtgcaac cattactact gtctaatccc agaccatttt catcacctta
     3961 gaaagaaact tcatacctat cagcattcac tccctattct tccctcctct cagccattgg
     4021 cagccactaa gctacttttg tctccatgga tttgcttctt ctcaatattt catataatgc
     4081 tatttcgtat aaatggaatc acatggtatg tagcttctgt atgtttcact tagcataatg
     4141 ttttcaaggg ctgtccatgc tgttgcatgt atcaatattt cattcctttt tttgacaata
     4201 ttctgtgtaa taatatacaa tgtttatcca ttcatcagtt gatagatact tagagtgttt
     4261 tcacttttta tttatttatt tttgagatgg agtcttgctc tgttccctag gtggagtgca
     4321 gtggcgtgat ctcagctcac tgcaacctcc tccacctccc aggcttgagt gaccctctgg
     4381 cctcagcctc ccgagtagct ggaactacag gcacgtgcca ccacaccccg ctaatttttt
     4441 gtattttttg tagagatggg gtttcgccat gttgcccagg ctggtcttga actccttgcc
     4501 tcaggccatc cgcccacctc agcctcccaa agtgctggca ttacaggtgt gagccactgc
     4561 atccggccaa ataaagtatt cttaatgaca tctgcaaaat ccattttgct atgtaaggta
     4621 acatattcgt aggttctggg gattagggtg tgggaatctt tagagggcca ttattctgct
     4681 accacagaat ataaagttgt aaaattctac cccatatttg gaaactgaga ttcttaaatt
     4741 atgtctttgt aattctcttt tttctttttc tttctttttt tttttttttt ttgagacgga
     4801 gtcttgctcc gtcgcccagg ctgaagtgca gtggcgcaat ctcagttcac cgcaagctcc
     4861 tcctcctggg ttcacgccat tctcctgcct cagcctccag agtacctgag actacaggcg
     4921 tgtgccacca cgccgggcta atttttttaa agtattttta gtagagatgg ggtttcaccg
     4981 tgttagccag gatggtctcg atctgctgac ctcgtgatcc gcctgcctcg gcctctcatg
     5041 tcttcgtaat tttccatgga aaaaaactta aatctttgga aggaatagag tacattattg
     5101 cattttacaa agaaaaggat aacttttata gaataatgac cttgtattct tttaggattt
     5161 tacagctact ttttcacaac tataggcata gaaaatgaca tcaggggccg ggcgcggtgg
     5221 ctcacgcctg taatcccaac actttgggag gcccaggcgg cggatcacga ggtcgagatt
     5281 gagaccatcc tggccaacat gatgaaaccg cgtctctgct aaaaatacaa aaattagctg
     5341 ggcgtggtgt cgggcgcctg tagtcccagc tactcgggag gctgaggcag gagaattgct
     5401 tgaacctggg aggcggagct tgcagtgagc ccagatcgta ccactgcact ccagcctggg
     5461 cgacagagca agactgtctc agaaaaaaaa aaaaaaaaaa aaaaaagaaa tgacatcagg
     5521 tcatggtgtt tgctattgat cgacacttaa atagcctttg aattttgttt caaaggagat
     5581 gccagaattg caaattttct ctgctgattt gtgtcctact gattctggct cgctttcccc
     5641 ctacactact agggctactc tcactttcac acctagcaaa acttcacctt tcaaagaatt
     5701 taggcagaat agtcctaatt tagttaataa gctttcattt taaatcttag ggaagcagtg
     5761 ttagtttcag ttattctata ggaacagaaa ttggagctgc cacagccttt tgaaccagag
     5821 cccggcagac cctcagcttc agccctgctc agtgttttgt gtctatgaaa gtctttttaa
     5881 ttttctcatt acacatttta tatatcatgc tatgtattta gaacagaggg gttgtgtaag
     5941 attatgactc tatgttcttt atcttgtctt tgtattaatt tgaagttgtg ttttttcttt
     6001 atttgtagcc aactaattaa aataccaaca tatttatttt tattcatttt tatgtgacaa
     6061 acttttaaac tgaagactgc atcaataaaa ttgcatgcca ttaaatatga
//
