LOCUS       NP_001021                 84 aa            linear   PRI 06-OCT-2024
DEFINITION  small ribosomal subunit protein eS27 isoform 1 [Homo sapiens].
ACCESSION   NP_001021
VERSION     NP_001021.1
DBSOURCE    REFSEQ: accession NM_001030.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 84)
  AUTHORS   Wan,J., Lv,J., Wang,C. and Zhang,L.
  TITLE     RPS27 selectively regulates the expression and alternative splicing
            of inflammatory and immune response genes in thyroid cancer cells
  JOURNAL   Adv Clin Exp Med 31 (8), 889-901 (2022)
   PUBMED   35546566
  REMARK    GeneRIF: RPS27 selectively regulates the expression and alternative
            splicing of inflammatory and immune response genes in thyroid
            cancer cells.
REFERENCE   2  (residues 1 to 84)
  AUTHORS   Woodford,M.R., Backe,S.J., Wengert,L.A., Dunn,D.M., Bourboulia,D.
            and Mollapour,M.
  TITLE     Hsp90 chaperone code and the tumor suppressor VHL cooperatively
            regulate the mitotic checkpoint
  JOURNAL   Cell Stress Chaperones 26 (6), 965-971 (2021)
   PUBMED   34586601
  REMARK    GeneRIF: Hsp90 chaperone code and the tumor suppressor VHL
            cooperatively regulate the mitotic checkpoint.
REFERENCE   3  (residues 1 to 84)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   4  (residues 1 to 84)
  AUTHORS   Xiong,X., Cui,D., Bi,Y., Sun,Y. and Zhao,Y.
  TITLE     Neddylation modification of ribosomal protein RPS27L or RPS27 by
            MDM2 or NEDP1 regulates cancer cell survival
  JOURNAL   FASEB J 34 (10), 13419-13429 (2020)
   PUBMED   32779270
  REMARK    GeneRIF: Neddylation modification of ribosomal protein RPS27L or
            RPS27 by MDM2 or NEDP1 regulates cancer cell survival.
REFERENCE   5  (residues 1 to 84)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (residues 1 to 84)
  AUTHORS   Fernandez-Pol,J.A.
  TITLE     Metallopanstimulin as a novel tumor marker in sera of patients with
            various types of common cancers: implications for prevention and
            therapy
  JOURNAL   Anticancer Res 16 (4B), 2177-2185 (1996)
   PUBMED   8694540
REFERENCE   7  (residues 1 to 84)
  AUTHORS   Fernandez-Pol,J.A., Klos,D.J. and Hamilton,P.D.
  TITLE     Metallopanstimulin gene product produced in a baculovirus
            expression system is a nuclear phosphoprotein that binds to DNA
  JOURNAL   Cell Growth Differ 5 (8), 811-825 (1994)
   PUBMED   7986747
REFERENCE   8  (residues 1 to 84)
  AUTHORS   Xynos,F.P., Klos,D.J., Hamilton,P.D., Schuette,V., Huygens,P. and
            Fernandez-Pol,J.A.
  TITLE     Expression of metallopanstimulin in condylomata acuminata of the
            female anogenital region induced by papilloma virus
  JOURNAL   Anticancer Res 14 (3A), 773-786 (1994)
   PUBMED   8074479
REFERENCE   9  (residues 1 to 84)
  AUTHORS   Fernandez-Pol,J.A., Klos,D.J. and Hamilton,P.D.
  TITLE     A growth factor-inducible gene encodes a novel nuclear protein with
            zinc finger structure
  JOURNAL   J Biol Chem 268 (28), 21198-21204 (1993)
   PUBMED   8407955
REFERENCE   10 (residues 1 to 84)
  AUTHORS   Sieff,C.
  TITLE     Diamond-Blackfan Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Karyn Megy, Francesco Amaldi. The reference
            sequence was derived from BC070219.1, D28454.1 and AJ572583.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of four RNA species and approximately
            80 structurally distinct proteins. This gene encodes a member of
            the S27e family of ribosomal proteins and component of the 40S
            subunit. The encoded protein contains a C4-type zinc finger domain
            that can bind to zinc and may bind to nucleic acid. Mutations in
            this gene have been identified in numerous melanoma patients and in
            at least one patient with Diamond-Blackfan anemia (DBA). Elevated
            expression of this gene has been observed in various human cancers.
            As is typical for genes encoding ribosomal proteins, there are
            multiple processed pseudogenes of this gene dispersed through the
            genome. [provided by RefSeq, Jul 2018].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU963235.1, CD520794.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651669.1/ ENSP00000499044.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..84
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     Protein         1..84
                     /product="small ribosomal subunit protein eS27 isoform 1"
                     /note="metallopan-stimulin 1; metallopanstimulin 1; small
                     ribosomal subunit protein eS27"
                     /calculated_mol_wt=9330
     Region          1..23
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P42677.3)"
     Region          6..82
                     /region_name="PLN00209"
                     /note="ribosomal protein S27; Provisional"
                     /db_xref="CDD:165774"
     Site            11
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17081983,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (P42677.3)"
     CDS             1..84
                     /gene="RPS27"
                     /gene_synonym="DBA17; eS27; MPS-1; MPS1; S27"
                     /coded_by="NM_001030.6:36..290"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS1059.1"
                     /db_xref="GeneID:6232"
                     /db_xref="HGNC:HGNC:10416"
                     /db_xref="MIM:603702"
ORIGIN      
        1 mplakdllhp speeekrkhk kkrlvqspns yfmdvkcpgc ykittvfsha qtvvlcvgcs
       61 tvlcqptggk arltegcsfr rkqh
//
