LOCUS       NM_001029               1140 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens ribosomal protein S26 (RPS26), mRNA.
ACCESSION   NM_001029
VERSION     NM_001029.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1140)
  AUTHORS   Song,R., Xie,L., Ding,J., Chen,Y., Zou,H., Pang,H., Peng,Y.,
            Xia,Y., Xie,Z., Li,X., Xiao,Y., Zhou,Z. and Hu,J.
  TITLE     Association of RPS26 gene polymorphism with different types of
            diabetes in Chinese individuals
  JOURNAL   J Diabetes Investig 15 (1), 34-43 (2024)
   PUBMED   38041572
  REMARK    GeneRIF: Association of RPS26 gene polymorphism with different
            types of diabetes in Chinese individuals.
REFERENCE   2  (bases 1 to 1140)
  AUTHORS   Li,J., Su,Y., Chen,L., Lin,Y. and Ru,K.
  TITLE     Identification of novel mutations in patients with Diamond-Blackfan
            anemia and literature review of RPS10 and RPS26 mutations
  JOURNAL   Int J Lab Hematol 45 (5), 766-773 (2023)
   PUBMED   37376976
  REMARK    GeneRIF: Identification of novel mutations in patients with
            Diamond-Blackfan anemia and literature review of RPS10 and RPS26
            mutations.
            Review article
REFERENCE   3  (bases 1 to 1140)
  AUTHORS   Bulygin,K.N., Malygin,A.A., Graifer,D.M. and Karpova,G.G.
  TITLE     The functional role of the eukaryote-specific motif YxxPKxYxK of
            the human ribosomal protein eS26 in translation
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1865 (6), 194842 (2022)
   PUBMED   35817369
  REMARK    GeneRIF: The functional role of the eukaryote-specific motif
            YxxPKxYxK of the human ribosomal protein eS26 in translation.
REFERENCE   4  (bases 1 to 1140)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 1140)
  AUTHORS   Sun,Q., Gao,Y., Yang,J., Lu,J., Feng,W. and Yang,W.
  TITLE     Mendelian Randomization Analysis Identified Potential Genes
            Pleiotropically Associated with Polycystic Ovary Syndrome
  JOURNAL   Reprod Sci 29 (3), 1028-1037 (2022)
   PUBMED   34704236
  REMARK    GeneRIF: Mendelian Randomization Analysis Identified Potential
            Genes Pleiotropically Associated with Polycystic Ovary Syndrome.
REFERENCE   6  (bases 1 to 1140)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   7  (bases 1 to 1140)
  AUTHORS   Filipenko,M.L., Mishin,V.P., Suturina,Iu.A., Muravlev,A.I.,
            Kopantsev,E.A., Karpova,G.G. and Mertvetsov,N.P.
  TITLE     [Mapping of the genes for ribosomal proteins S26, L19, and L32 on
            human chromosomes]
  JOURNAL   Bioorg Khim 21 (11), 838-844 (1995)
   PUBMED   8670309
REFERENCE   8  (bases 1 to 1140)
  AUTHORS   Filipenko,M.L., Vladimirov,S.N., Muravlev,A.I., Karpova,G.G. and
            Mertvetsov,N.P.
  TITLE     [Cloning cDNA of human S26 ribosomal protein and determination of
            its primary structure]
  JOURNAL   Bioorg Khim 20 (6), 644-649 (1994)
   PUBMED   7945460
REFERENCE   9  (bases 1 to 1140)
  AUTHORS   Vincent,S., Marty,L. and Fort,P.
  TITLE     S26 ribosomal protein RNA: an invariant control for gene regulation
            experiments in eucaryotic cells and tissues
  JOURNAL   Nucleic Acids Res 21 (6), 1498 (1993)
   PUBMED   8464749
REFERENCE   10 (bases 1 to 1140)
  AUTHORS   Sieff,C.
  TITLE     Diamond-Blackfan Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AV681946.1, BC002604.1, CF129685.1 and AC034102.32.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2018 this sequence version replaced NM_001029.4.
            
            Summary: This gene encodes a ribosomal protein that is a component
            of the 40S subunit. The protein belongs to the S26E family of
            ribosomal proteins. Mutations in this gene are found in
            Diamond-Blackfan anemia 10. There are multiple processed
            pseudogenes of this gene dispersed through the genome. [provided by
            RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD248987.1, BG500507.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000646449.2/ ENSP00000496643.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               AV681946.1         17-244
            229-666             BC002604.1         209-646
            667-809             CF129685.1         24-166
            810-813             AC034102.32        116929-116932       c
            814-1118            CF129685.1         172-476
            1119-1140           AC034102.32        116602-116623       c
FEATURES             Location/Qualifiers
     source          1..1140
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..1140
                     /gene="RPS26"
                     /gene_synonym="DBA10; eS26; S26"
                     /note="ribosomal protein S26"
                     /db_xref="GeneID:6231"
                     /db_xref="HGNC:HGNC:10414"
                     /db_xref="MIM:603701"
     exon            1..252
                     /gene="RPS26"
                     /gene_synonym="DBA10; eS26; S26"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..597
                     /gene="RPS26"
                     /gene_synonym="DBA10; eS26; S26"
                     /note="40S ribosomal protein S26"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS26"
                     /protein_id="NP_001020.2"
                     /db_xref="CCDS:CCDS31832.1"
                     /db_xref="GeneID:6231"
                     /db_xref="HGNC:HGNC:10414"
                     /db_xref="MIM:603701"
                     /translation="MTKKRRNNGRAKKGRGHVQPIRCTNCARCVPKDKAIKKFVIRNI
                     VEAAAVRDISEASVFDAYVLPKLYVKLHYCVSCAIHSKVVRNRSREARKDRTPPPRFR
                     PAGAAPRPPPKPM"
     exon            253..430
                     /gene="RPS26"
                     /gene_synonym="DBA10; eS26; S26"
                     /inference="alignment:Splign:2.1.0"
     exon            431..561
                     /gene="RPS26"
                     /gene_synonym="DBA10; eS26; S26"
                     /inference="alignment:Splign:2.1.0"
     exon            562..1140
                     /gene="RPS26"
                     /gene_synonym="DBA10; eS26; S26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      644..649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS26"
                     /gene_synonym="DBA10; eS26; S26"
                     /note="hexamer: AATAAA"
     polyA_site      673
                     /gene="RPS26"
                     /gene_synonym="DBA10; eS26; S26"
                     /note="major polyA site"
     regulatory      1097..1102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS26"
                     /gene_synonym="DBA10; eS26; S26"
                     /note="hexamer: ATTAAA"
     polyA_site      1119
                     /gene="RPS26"
                     /gene_synonym="DBA10; eS26; S26"
                     /note="major polyA site"
ORIGIN      
        1 gattttcttc cgccatccgg ctaaatagtc ccatgtgcac tttgttccat ggataaataa
       61 acactaggaa cgcatttcca ccctagattt cagcagaaat gctgaatgta aaggaatatt
      121 tgagtaaagt gagttgccgt tcttgaagcc cgtctcctaa ggattctccc ggtgtccgcg
      181 tagggatctc atgctatata ggagggccct gccaggcacc gtctcctctc tccggtccgt
      241 gcctccaaga tgacaaagaa aagaaggaac aatggtcgtg ccaaaaaggg ccgcggccac
      301 gtgcagccta ttcgctgcac taactgtgcc cgatgcgtgc ccaaggacaa ggccattaag
      361 aaattcgtca ttcgaaacat agtggaggcc gcagcagtca gggacatttc tgaagcgagc
      421 gtcttcgatg cctatgtgct tcccaagctg tatgtgaagc tacattactg tgtgagttgt
      481 gcaattcaca gcaaagtagt caggaatcga tctcgtgaag cccgcaagga ccgaacaccc
      541 ccaccccgat ttagacctgc gggtgctgcc ccacgtcccc caccaaagcc catgtaagga
      601 gctgagttct taaagactga agacaggcta ttctctggag aaaaataaaa tggaaattgt
      661 acttaatatt gcatgttaag tgtatctgtg ccagataagg tggggatttt gtgtgttaga
      721 ccaagtgtga agtgacacac attattttca tggggaagaa agcttattca tgtaatttaa
      781 tttttttctt tttttttttt ttttttttga gacggagtct ttgtcgccca agctgaattg
      841 cagtggcgtg atctcagctc actgcaacct ccgtctcccg ggttcaagtg attctcctgc
      901 ctcagcttct tgagtagctg ggattacagg tgtctgccac catgcctggt taatttttgt
      961 atttttggta gagatggggt ttcactatgt tgtccaggct ggtcttgaac ttctgacctc
     1021 agttaatcca ccagccttgg cctcccaaag tgctgggatt acaggcttga gccacctcgc
     1081 ctagctattt atgtaaatta aactttaatt gtggtcgtat ggttggcctc acaattcgca
//
