LOCUS       NM_001028                483 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ribosomal protein S25 (RPS25), mRNA.
ACCESSION   NM_001028
VERSION     NM_001028.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Johnson,A.G., Flynn,R.A., Lapointe,C.P., Ooi,Y.S., Zhao,M.L.,
            Richards,C.M., Qiao,W., Yamada,S.B., Couthouis,J., Gitler,A.D.,
            Carette,J.E. and Puglisi,J.D.
  TITLE     A memory of eS25 loss drives resistance phenotypes
  JOURNAL   Nucleic Acids Res 48 (13), 7279-7297 (2020)
   PUBMED   32463448
  REMARK    GeneRIF: A memory of eS25 loss drives resistance phenotypes.
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 483)
  AUTHORS   Yamada,S.B., Gendron,T.F., Niccoli,T., Genuth,N.R., Grosely,R.,
            Shi,Y., Glaria,I., Kramer,N.J., Nakayama,L., Fang,S.,
            Dinger,T.J.I., Thoeng,A., Rocha,G., Barna,M., Puglisi,J.D.,
            Partridge,L., Ichida,J.K., Isaacs,A.M., Petrucelli,L. and
            Gitler,A.D.
  TITLE     RPS25 is required for efficient RAN translation of C9orf72 and
            other neurodegenerative disease-associated nucleotide repeats
  JOURNAL   Nat Neurosci 22 (9), 1383-1388 (2019)
   PUBMED   31358992
  REMARK    GeneRIF: We performed a genetic screen for regulators of RAN
            translation and identified small ribosomal protein subunit 25
            (RPS25), presenting a potential therapeutic target for
            C9orf72-related amyotrophic lateral sclerosis and frontotemporal
            dementia and other neurodegenerative diseases caused by nucleotide
            repeat expansions.
REFERENCE   4  (bases 1 to 483)
  AUTHORS   Terol,M., Gazon,H., Lemasson,I., Duc-Dodon,M., Barbeau,B.,
            Cesaire,R., Mesnard,J.M. and Peloponese,J.M. Jr.
  TITLE     HBZ-mediated shift of JunD from growth suppressor to tumor promoter
            in leukemic cells by inhibition of ribosomal protein S25 expression
  JOURNAL   Leukemia 31 (10), 2235-2243 (2017)
   PUBMED   28260789
  REMARK    GeneRIF: HBZ induces nuclear retention of RPS25 mRNA in the nucleus
            and loss of RPS25 protein expression. Inhibition of RPS25
            expression stimulates Delta JunD synthesis.
REFERENCE   5  (bases 1 to 483)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   6  (bases 1 to 483)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   7  (bases 1 to 483)
  AUTHORS   Imai,T., Sudo,K. and Miwa,T.
  TITLE     Assignment of the human ribosomal protein S25 gene (RPS25) to
            chromosome 11q23.3 by sequence analysis of the marker D11S456
  JOURNAL   Genomics 20 (1), 142-143 (1994)
   PUBMED   8020948
REFERENCE   8  (bases 1 to 483)
  AUTHORS   Li,M. and Center,M.S.
  TITLE     Regulation of ribosomal protein S25 in HL60 cells isolated for
            resistance to adriamycin
  JOURNAL   FEBS Lett 298 (2-3), 142-144 (1992)
   PUBMED   1544436
REFERENCE   9  (bases 1 to 483)
  AUTHORS   Li,M.L., Latoud,C. and Center,M.S.
  TITLE     Cloning and sequencing a cDNA encoding human ribosomal protein S25
  JOURNAL   Gene 107 (2), 329-333 (1991)
   PUBMED   1748303
REFERENCE   10 (bases 1 to 483)
  AUTHORS   Marion,M.J. and Marion,C.
  TITLE     Ribosomal proteins S2, S6, S10, S14, S15 and S25 are localized on
            the surface of mammalian 40 S subunits and stabilize their
            conformation. A study with immobilized trypsin
  JOURNAL   FEBS Lett 232 (2), 281-285 (1988)
   PUBMED   3378620
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from D28369.1 and BC004986.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001028.2.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S25E family of ribosomal proteins. It is located in the
            cytoplasm. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.124115.1,
                                           SRR1163657.237885.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000527673.2/ ENSP00000435096.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                D28369.1           5-17
            14-483              BC004986.1         1-470
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..483
                     /gene="RPS25"
                     /gene_synonym="eS25; S25"
                     /note="ribosomal protein S25"
                     /db_xref="GeneID:6230"
                     /db_xref="HGNC:HGNC:10413"
                     /db_xref="MIM:180465"
     exon            1..62
                     /gene="RPS25"
                     /gene_synonym="eS25; S25"
                     /inference="alignment:Splign:2.1.0"
     exon            63..158
                     /gene="RPS25"
                     /gene_synonym="eS25; S25"
                     /inference="alignment:Splign:2.1.0"
     exon            159..342
                     /gene="RPS25"
                     /gene_synonym="eS25; S25"
                     /inference="alignment:Splign:2.1.0"
     exon            343..441
                     /gene="RPS25"
                     /gene_synonym="eS25; S25"
                     /inference="alignment:Splign:2.1.0"
     exon            442..483
                     /gene="RPS25"
                     /gene_synonym="eS25; S25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      467..472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS25"
                     /gene_synonym="eS25; S25"
                     /note="hexamer: AATAAA"
     polyA_site      483
                     /gene="RPS25"
                     /gene_synonym="eS25; S25"
                     /note="major polyA site"
ORIGIN      
        1 ctttttgtcc gacatcttga cgaggctgcg gtgtctgctg ctattctccg agcttcgcaa
       61 tgccgcctaa ggacgacaag aagaagaagg acgctggaaa gtcggccaag aaagacaaag
      121 acccagtgaa caaatccggg ggcaaggcca aaaagaagaa gtggtccaaa ggcaaagttc
      181 gggacaagct caataactta gtcttgtttg acaaagctac ctatgataaa ctctgtaagg
      241 aagttcccaa ctataaactt ataaccccag ctgtggtctc tgagagactg aagattcgag
      301 gctccctggc cagggcagcc cttcaggagc tccttagtaa aggacttatc aaactggttt
      361 caaagcacag agctcaagta atttacacca gaaataccaa gggtggagat gctccagctg
      421 ctggtgaaga tgcatgaata ggtccaacca gctgtacatt tggaaaaata aaactttatt
      481 aaa
//
