LOCUS       NM_033022                534 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens ribosomal protein S24 (RPS24), transcript variant a,
            mRNA.
ACCESSION   NM_033022
VERSION     NM_033022.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 534)
  AUTHORS   Park,J., Nam,D.H., Kim,D. and Chung,Y.J.
  TITLE     RPS24 alternative splicing is a marker of cancer progression and
            epithelial-mesenchymal transition
  JOURNAL   Sci Rep 14 (1), 13246 (2024)
   PUBMED   38853173
  REMARK    GeneRIF: RPS24 alternative splicing is a marker of cancer
            progression and epithelial-mesenchymal transition.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 534)
  AUTHORS   Kerry,J., Specker,E.J., Mizzoni,M., Brumwell,A., Fell,L.,
            Goodbrand,J., Rosen,M.N. and Uniacke,J.
  TITLE     Autophagy-dependent alternative splicing of ribosomal protein S24
            produces a more stable isoform that aids in hypoxic cell survival
  JOURNAL   FEBS Lett 598 (5), 503-520 (2024)
   PUBMED   38281767
  REMARK    GeneRIF: Autophagy-dependent alternative splicing of ribosomal
            protein S24 produces a more stable isoform that aids in hypoxic
            cell survival.
REFERENCE   3  (bases 1 to 534)
  AUTHORS   Wang,S., Xia,L., Zhang,B., Zhang,H. and Lan,F.
  TITLE     Downregulated long intergenic non-coding RNA 00,174 represses
            malignant biological behaviors of lung cancer cells by regulating
            microRNA-584-3p/ribosomal protein S24 axis
  JOURNAL   Funct Integr Genomics 22 (4), 643-653 (2022)
   PUBMED   35451652
  REMARK    GeneRIF: Downregulated long intergenic non-coding RNA 00,174
            represses malignant biological behaviors of lung cancer cells by
            regulating microRNA-584-3p/ribosomal protein S24 axis.
REFERENCE   4  (bases 1 to 534)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   5  (bases 1 to 534)
  AUTHORS   Wang,Y., Wu,Y., Xiao,K., Zhao,Y., Lv,G., Xu,S. and Wu,F.
  TITLE     RPS24c Isoform Facilitates Tumor Angiogenesis Via Promoting the
            Stability of MVIH in Colorectal Cancer
  JOURNAL   Curr Mol Med 20 (5), 388-395 (2020)
   PUBMED   31797757
  REMARK    GeneRIF: RPS24c Isoform Facilitates Tumor Angiogenesis Via
            Promoting the Stability of MVIH in Colorectal Cancer.
REFERENCE   6  (bases 1 to 534)
  AUTHORS   Xu,W.B. and Roufa,D.J.
  TITLE     The gene encoding human ribosomal protein S24 and tissue-specific
            expression of differentially spliced mRNAs
  JOURNAL   Gene 169 (2), 257-262 (1996)
   PUBMED   8647458
REFERENCE   7  (bases 1 to 534)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   8  (bases 1 to 534)
  AUTHORS   Sieff,C.
  TITLE     Diamond-Blackfan Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301769
REFERENCE   9  (bases 1 to 534)
  AUTHORS   Huang,R.T., Li,D.R., Wei,J., Huang,X.R., Yuan,X.T. and Tian,X.
  TITLE     Isolation and identification of hepatitis E virus in Xinjiang,
            China
  JOURNAL   J Gen Virol 73 (Pt 5), 1143-1148 (1992)
   PUBMED   1588318
REFERENCE   10 (bases 1 to 534)
  AUTHORS   Brown,S.J., Jewell,A., Maki,C.G. and Roufa,D.J.
  TITLE     A cDNA encoding human ribosomal protein S24
  JOURNAL   Gene 91 (2), 293-296 (1990)
   PUBMED   2210388
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BG944046.1 and BC071926.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_033022.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S24E family of ribosomal proteins. It is located in the
            cytoplasm. Multiple transcript variants encoding different isoforms
            have been found for this gene. As is typical for genes encoding
            ribosomal proteins, there are multiple processed pseudogenes of
            this gene dispersed through the genome. Mutations in this gene
            result in Diamond-Blackfan anemia. [provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (a) uses an alternate splice
            pattern in the 3' coding region, compared to variant d. The
            resulting protein (isoform a) has a shorter and distinct
            C-terminus, compared to isoform d.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB121452.1, DB075119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372360.9/ ENSP00000361435.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BG944046.1         105-119
            16-534              BC071926.1         1-519
FEATURES             Location/Qualifiers
     source          1..534
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.3"
     gene            1..534
                     /gene="RPS24"
                     /gene_synonym="DBA3; eS24; S24"
                     /note="ribosomal protein S24"
                     /db_xref="GeneID:6229"
                     /db_xref="HGNC:HGNC:10411"
                     /db_xref="MIM:602412"
     exon            1..42
                     /gene="RPS24"
                     /gene_synonym="DBA3; eS24; S24"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..432
                     /gene="RPS24"
                     /gene_synonym="DBA3; eS24; S24"
                     /note="isoform a is encoded by transcript variant a; 40S
                     ribosomal protein S24; small ribosomal subunit protein
                     eS24"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS24 isoform a"
                     /protein_id="NP_148982.1"
                     /db_xref="CCDS:CCDS7356.1"
                     /db_xref="GeneID:6229"
                     /db_xref="HGNC:HGNC:10411"
                     /db_xref="MIM:602412"
                     /translation="MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKL
                     AKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKT
                     SRKQRKERKNRMKKVRGTAKANVGAGKK"
     exon            43..108
                     /gene="RPS24"
                     /gene_synonym="DBA3; eS24; S24"
                     /inference="alignment:Splign:2.1.0"
     exon            109..318
                     /gene="RPS24"
                     /gene_synonym="DBA3; eS24; S24"
                     /inference="alignment:Splign:2.1.0"
     exon            319..429
                     /gene="RPS24"
                     /gene_synonym="DBA3; eS24; S24"
                     /inference="alignment:Splign:2.1.0"
     exon            430..451
                     /gene="RPS24"
                     /gene_synonym="DBA3; eS24; S24"
                     /inference="alignment:Splign:2.1.0"
     exon            452..534
                     /gene="RPS24"
                     /gene_synonym="DBA3; eS24; S24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      517..522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS24"
                     /gene_synonym="DBA3; eS24; S24"
                     /note="hexamer: AATAAA"
     polyA_site      534
                     /gene="RPS24"
                     /gene_synonym="DBA3; eS24; S24"
                     /note="major polyA site"
ORIGIN      
        1 ctcttttcct ccttggctgt ctgaagatag atcgccatca tgaacgacac cgtaactatc
       61 cgcactagaa agttcatgac caaccgacta cttcagagga aacaaatggt cattgatgtc
      121 cttcaccccg ggaaggcgac agtgcctaag acagaaattc gggaaaaact agccaaaatg
      181 tacaagacca caccggatgt catctttgta tttggattca gaactcattt tggtggtggc
      241 aagacaactg gctttggcat gatttatgat tccctggatt atgcaaagaa aaatgaaccc
      301 aaacatagac ttgcaagaca tggcctgtat gagaagaaaa agacctcaag aaagcaacga
      361 aaggaacgca agaacagaat gaagaaagtc agggggactg caaaggccaa tgttggtgct
      421 ggcaaaaagt gagctggaga ttggatcaca gccgaaggag taaaggtgct gcaatgatgt
      481 tagctgtggc cactgtggat ttttcgcaag aacattaata aactaaaaac ttca
//
