LOCUS       NM_001025               3252 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribosomal protein S23 (RPS23), mRNA.
ACCESSION   NM_001025
VERSION     NM_001025.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3252)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3252)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 3252)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3252)
  AUTHORS   Dong,Z., Pei,S., Zhao,Y., Guo,S. and Wang,Y.
  TITLE     Identification of Hub Genes in Gastric Cancer with High
            Heterogeneity Based on Weighted Gene Co-Expression Network
  JOURNAL   Crit Rev Eukaryot Gene Expr 30 (2), 101-109 (2020)
   PUBMED   32558489
  REMARK    GeneRIF: Identification of Hub Genes in Gastric Cancer with High
            Heterogeneity Based on Weighted Gene Co-Expression Network.
REFERENCE   5  (bases 1 to 3252)
  AUTHORS   Zhao,D., Meng,J., Zhao,Y., Huo,Y., Liu,Y., Zheng,N., Zhang,M.,
            Gao,Y., Chen,Z., Sun,H., Wang,X., Jing,C., Zhang,T., Zhang,X.,
            Luo,H., Wang,X., Zhang,J., Liu,F.R., Li,Y., Bu,G., Wen,L.,
            Huang,T.Y., Xu,H. and Zhang,Y.W.
  TITLE     RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's
            Disease-Associated Cognitive Deficits
  JOURNAL   Biol Psychiatry 86 (3), 171-184 (2019)
   PUBMED   30292394
  REMARK    GeneRIF: The study results reveal a role for RPS23RG1 in
            maintaining synaptic integrity and function and provide a new
            mechanism for synaptic dysfunction in Alzheimer's disease (AD)
            pathogenesis.
REFERENCE   6  (bases 1 to 3252)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   7  (bases 1 to 3252)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   8  (bases 1 to 3252)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   9  (bases 1 to 3252)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
REFERENCE   10 (bases 1 to 3252)
  AUTHORS   Hori,N., Murakawa,K., Matoba,R., Fukushima,A., Okubo,K. and
            Matsubara,K.
  TITLE     A cDNA sequence of human ribosomal protein, homologue of yeast S28
  JOURNAL   Nucleic Acids Res 21 (18), 4394 (1993)
   PUBMED   8415000
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BU594771.1, D14530.1, AC010598.6 and AI955885.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001025.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S12P family of ribosomal proteins. It is located in the
            cytoplasm. The protein shares significant amino acid similarity
            with S. cerevisiae ribosomal protein S28. As is typical for genes
            encoding ribosomal proteins, there are multiple processed
            pseudogenes of this gene dispersed through the genome. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.192371.1,
                                           SRR1803613.42872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296674.13/ ENSP00000296674.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BU594771.1         63-80
            19-506              D14530.1           1-488
            507-2972            AC010598.6         59861-62326
            2973-3252           AI955885.1         12-291              c
FEATURES             Location/Qualifiers
     source          1..3252
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.2"
     gene            1..3252
                     /gene="RPS23"
                     /gene_synonym="BTDD; MABAS; MCINS; PAMAS; S23; uS12"
                     /note="ribosomal protein S23"
                     /db_xref="GeneID:6228"
                     /db_xref="HGNC:HGNC:10410"
                     /db_xref="MIM:603683"
     exon            1..35
                     /gene="RPS23"
                     /gene_synonym="BTDD; MABAS; MCINS; PAMAS; S23; uS12"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..463
                     /gene="RPS23"
                     /gene_synonym="BTDD; MABAS; MCINS; PAMAS; S23; uS12"
                     /note="40S ribosomal protein S23; homolog of yeast
                     ribosomal protein S28"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS12"
                     /protein_id="NP_001016.1"
                     /db_xref="CCDS:CCDS47241.1"
                     /db_xref="GeneID:6228"
                     /db_xref="HGNC:HGNC:10410"
                     /db_xref="MIM:603683"
                     /translation="MGKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGA
                     SHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLV
                     AGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPRS"
     exon            36..195
                     /gene="RPS23"
                     /gene_synonym="BTDD; MABAS; MCINS; PAMAS; S23; uS12"
                     /inference="alignment:Splign:2.1.0"
     exon            196..316
                     /gene="RPS23"
                     /gene_synonym="BTDD; MABAS; MCINS; PAMAS; S23; uS12"
                     /inference="alignment:Splign:2.1.0"
     exon            317..3252
                     /gene="RPS23"
                     /gene_synonym="BTDD; MABAS; MCINS; PAMAS; S23; uS12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      489..494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS23"
                     /gene_synonym="BTDD; MABAS; MCINS; PAMAS; S23; uS12"
                     /note="hexamer: AATAAA"
     polyA_site      512
                     /gene="RPS23"
                     /gene_synonym="BTDD; MABAS; MCINS; PAMAS; S23; uS12"
                     /note="major polyA site"
     regulatory      3231..3236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS23"
                     /gene_synonym="BTDD; MABAS; MCINS; PAMAS; S23; uS12"
                     /note="hexamer: AATAAA"
     polyA_site      3252
                     /gene="RPS23"
                     /gene_synonym="BTDD; MABAS; MCINS; PAMAS; S23; uS12"
ORIGIN      
        1 ctctttcgct caggcccgtg gcgccgacag gatgggcaag tgtcgtggac ttcgtactgc
       61 taggaagctc cgtagtcacc gacgagacca gaagtggcat gataaacagt ataagaaagc
      121 tcatttgggc acagccctaa aggccaaccc ttttggaggt gcttctcatg caaaaggaat
      181 cgtgctggaa aaagtaggag ttgaagccaa acagccaaat tctgccatta ggaagtgtgt
      241 aagggtccag ctgatcaaga atggcaagaa aatcacagcc tttgtaccca atgacggttg
      301 cttgaacttt attgaggaaa atgatgaagt tctggttgct ggatttggtc gcaaaggtca
      361 tgctgttggt gatattcctg gagtccgctt taaggttgtc aaagtagcca atgtttctct
      421 tttggcccta tacaaaggca agaaggaaag accaagatca taaatattaa tggtgaaaac
      481 actgtagtaa taaattttca tatgccaaaa aatgtttgta tcttactgtc ccctgttctc
      541 accacgaaga tcatgttcat taccaccacc accccccctt atttttttta tcctaaacca
      601 gcaaacgcag gacctgtacc aattttagga gacaataaga cagggttgtt tcaggattct
      661 ctagagttaa taacatttgt aacctggcac agtttccctc atcctgtgga ataagaaaat
      721 gggatagatc tggaataaat gtgcagtatt gtagtattac tttaagaact ttaagggaac
      781 ttcaaaaact cactgaaatt ctagtgagat actttctttt ttattcttgg tattttccat
      841 atcgggtgca acacttcagt taccaaattt cattgcacat agattatctt aggtaccctt
      901 ggaaatgcac attcttgtat ccatcttaca ggggcccaag atgataaata gtaaactcaa
      961 aattgctccc cactctgttt attatttaaa ggtgtcagga tctgtgttgt aatgtgtcta
     1021 cattaatgtg tttaggagaa tacaggcatt ggatcattta gttgatggaa gtatatgcca
     1081 ggcaagggag ataaggtata cgacaagact gatgttttca gtatcttctc atgaggttgt
     1141 cagagacctt catgtcttca aagactagtc agcaaatgaa gtggtttagt gtagagacaa
     1201 gattggttgt gttttgataa tttaagctag gtattgagta catgtggatt ttgctgtcca
     1261 caaatacttg tttcagagtt ttcatggata cagtggcatg gttgaaatga agctgtgagc
     1321 cttctgcttt aaatctgatg taagaaactc ctgttaacaa atagtaagta tgggttaatt
     1381 agccctttga tcaaagccta gctttacatt gtttaggatc tttggaaaac aattggtttg
     1441 gttgcccact ttccgtagga tcaagagcag aacctttcac atggcacaga agaacccagg
     1501 ttgcgcttca tacctgcata ttccagcctt agcctgccat ttctctcctt ggcactttgt
     1561 gctccagcaa cactggtctc agttggtcat cctcaaactt gggttccata tccagcctca
     1621 ggacctctgt tcctgttact atggttcctt gcatgtcgcc tgctcttact aaagagctcg
     1681 tgtgttttcc agcacacttc ggtttatctc ttgatgatga tgctagtctc tccctccgca
     1741 agggcggaaa ggctgcctgt tggtttgtac cagtgtttcc taacgtgtag ctgcagtcag
     1801 tatttggcta agctgttccc aggggctcaa cagatgcttt cggatgagcc ttaactgacc
     1861 caatcctttg tgatgcggga gagattgcta ggcctcgctc acctggccag aaccagggaa
     1921 agaggccgcg gttgcagcgc gattccaggc cctgggcgtc aggcgcgggg tgggcagctc
     1981 tccccgggcg gtggggccct tgtgaccgcg aggcggggcg caccaggaag ggagtgggac
     2041 agcgcgggcg cccagggatg tggcctggtt acctgccttc tctgatacgt caagacacct
     2101 tcaacaatgg cttgcagctg taccctgttg gctgcaccca ggacgccctt ttcactgcta
     2161 agcagtccta cctgaggccc aggggctgcc agattgaccc ataaataatc tccggcgcct
     2221 cagatccaga agctgctgag cctgatctta gtgccttctc ctttctctgt gtggcccccc
     2281 agcccctttc cccactgcct tgtgtccaag gccctttcct tcatgtatcc atggaggaga
     2341 gacaaaaata cacatcaata aaataagata gggaatccat aaatagacat tcagaagtat
     2401 ggccaacgga tttatcttaa aaccaatgga ggaagaagag tttcaataaa tgttgtggac
     2461 ttccatttgt caaagaccaa aacaaaggaa ccccaacctt acatgtaata caaacttaac
     2521 tcaaaatgga tcatatatct aaatgtaaaa tggaaagcta taaaactgaa aacagactat
     2581 ctttacaacc taggcgtagg tatagttttt agacattaca ccaaaagcac atgccgtaaa
     2641 agaaaaaata gataaattgg tggatttcat taaaattaaa aaactttttc tctctgaaaa
     2701 atcctgttaa gctgggcgct gtggttcatg cctgtaatcc cagcactttg ggaggctgag
     2761 ttgggaagaa attaatagct tgaggccagg agttcaagat catcctgggc agcaaagtca
     2821 tacactcttg agggaagaga gagaccttct catattgttt tatattgttt tatactcagt
     2881 acctgtttta agaaaaaaac aaggaagtga aatcaaagac aggcagcccg gcaccaggcc
     2941 tgaaaccagc cctgggcctg cctggcctaa acctagtagt taaaaatcaa cttacgactt
     3001 agaacctgat gttatccgta gattccaagc attgtataaa aaaattgtga aactccctgt
     3061 tgtgttctgt accagtgcat gaaacccctg tcacatatcc cctagattgc tcaatcaatc
     3121 acgacccttt catgtgaaat ctttagtgtt gtgagccctt aaaagggaca gaaattgtgc
     3181 acttgaggag ctcagatttt aaggctgtag cttgccgatg ctcccagctg aataaagccc
     3241 ttccttctac aa
//
