LOCUS       NM_001024                358 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens ribosomal protein S21 (RPS21), mRNA.
ACCESSION   NM_001024
VERSION     NM_001024.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 358)
  AUTHORS   Xia,R., Hu,C., Ye,Y., Zhang,X., Li,T., He,R., Zheng,S., Wen,X. and
            Chen,R.
  TITLE     HNF1A regulates oxaliplatin resistance in pancreatic cancer by
            targeting 53BP1
  JOURNAL   Int J Oncol 62 (4) (2023)
   PUBMED   36825600
  REMARK    GeneRIF: HNF1A regulates oxaliplatin resistance in pancreatic
            cancer by targeting 53BP1.
REFERENCE   2  (bases 1 to 358)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 358)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 358)
  AUTHORS   Sherstnev,V.V., Gruden,M.A., Karlina,V.P., Ryzhov,V.M.,
            Kuznetsova,A.V. and Senko,O.V.
  TITLE     Serum Level of HLDF24 Peptide as an Objective Marker of
            Prehypertension
  JOURNAL   Bull Exp Biol Med 168 (3), 305-308 (2020)
   PUBMED   31938910
  REMARK    GeneRIF: Serum Level of HLDF24 Peptide as an Objective Marker of
            Prehypertension.
REFERENCE   5  (bases 1 to 358)
  AUTHORS   Arthurs,C., Murtaza,B.N., Thomson,C., Dickens,K., Henrique,R.,
            Patel,H.R.H., Beltran,M., Millar,M., Thrasivoulou,C. and Ahmed,A.
  TITLE     Expression of ribosomal proteins in normal and cancerous human
            prostate tissue
  JOURNAL   PLoS One 12 (10), e0186047 (2017)
   PUBMED   29016636
  REMARK    GeneRIF: The results show that RPS19, RPS21 or RPS24 are
            upregulated in malignant tissue and may serve as putative
            biomarkers for prostate cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 358)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   7  (bases 1 to 358)
  AUTHORS   Kostanian,I.A., Astapova,M.V., Starovoitova,E.V., Dranitsyna,S.M.
            and Lipkin,V.M.
  TITLE     [A new differentiation factor from culture media of the HL-60 cell
            line treated with retinoic acid. Isolation and primary structure
            determination]
  JOURNAL   Bioorg Khim 21 (4), 243-248 (1995)
   PUBMED   7786314
REFERENCE   8  (bases 1 to 358)
  AUTHORS   Kostanyan,I.A., Astapova,M.V., Starovoytova,E.V., Dranitsina,S.M.
            and Lipkin,V.M.
  TITLE     A new human leukemia cell 8.2 kDa differentiation factor: isolation
            and primary structure
  JOURNAL   FEBS Lett 356 (2-3), 327-329 (1994)
   PUBMED   7805865
REFERENCE   9  (bases 1 to 358)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   10 (bases 1 to 358)
  AUTHORS   Bhat,K.S. and Morrison,S.G.
  TITLE     Primary structure of human ribosomal protein S21
  JOURNAL   Nucleic Acids Res 21 (12), 2939 (1993)
   PUBMED   8332502
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BM840443.1, L04483.1 and CF124568.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001024.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S21E family of ribosomal proteins. It is located in the
            cytoplasm. Alternative splice variants that encode different
            protein isoforms have been described, but their existence has not
            been verified. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM794524.1, BP317659.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343986.9/ ENSP00000345957.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BM840443.1         39-51
            14-39               L04483.1           1-26
            40-358              CF124568.1         119-437
FEATURES             Location/Qualifiers
     source          1..358
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..358
                     /gene="RPS21"
                     /gene_synonym="eS21; HLDF; S21"
                     /note="ribosomal protein S21"
                     /db_xref="GeneID:6227"
                     /db_xref="HGNC:HGNC:10409"
                     /db_xref="MIM:180477"
     exon            1..34
                     /gene="RPS21"
                     /gene_synonym="eS21; HLDF; S21"
                     /inference="alignment:Splign:2.1.0"
     exon            35..102
                     /gene="RPS21"
                     /gene_synonym="eS21; HLDF; S21"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..304
                     /gene="RPS21"
                     /gene_synonym="eS21; HLDF; S21"
                     /note="40S ribosomal protein S21; 8.2 kDa differentiation
                     factor; human leukemia differentiation factor"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS21"
                     /protein_id="NP_001015.1"
                     /db_xref="CCDS:CCDS13497.1"
                     /db_xref="GeneID:6227"
                     /db_xref="HGNC:HGNC:10409"
                     /db_xref="MIM:180477"
                     /translation="MQNDAGEFVDLYVPRKCSASNRIIGAKDHASIQMNVAEVDKVTG
                     RFNGQFKTYAICGAIRRMGESDDSILRLAKADGIVSKNF"
     exon            103..166
                     /gene="RPS21"
                     /gene_synonym="eS21; HLDF; S21"
                     /inference="alignment:Splign:2.1.0"
     exon            167..238
                     /gene="RPS21"
                     /gene_synonym="eS21; HLDF; S21"
                     /inference="alignment:Splign:2.1.0"
     exon            239..294
                     /gene="RPS21"
                     /gene_synonym="eS21; HLDF; S21"
                     /inference="alignment:Splign:2.1.0"
     exon            295..358
                     /gene="RPS21"
                     /gene_synonym="eS21; HLDF; S21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      340..345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS21"
                     /gene_synonym="eS21; HLDF; S21"
                     /note="hexamer: AATAAA"
     polyA_site      358
                     /gene="RPS21"
                     /gene_synonym="eS21; HLDF; S21"
                     /note="major polyA site"
ORIGIN      
        1 cctttctctc tcgcgcgcgg tgtggtggca gcaggcgcag cccagcctcg aaatgcagaa
       61 cgacgccggc gagttcgtgg acctgtacgt gccgcggaaa tgctccgcta gcaatcgcat
      121 catcggtgcc aaggaccacg catccatcca gatgaacgtg gccgaggttg acaaggtcac
      181 aggcaggttt aatggccagt ttaaaactta tgctatctgc ggggccattc gtaggatggg
      241 tgagtcagat gattccattc tccgattggc caaggccgat ggcatcgtct caaagaactt
      301 ttgactggag agaatcacag atgtggaata tttgtcataa ataaataatg aaaaccta
//
