LOCUS       NM_001023                519 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ribosomal protein S20 (RPS20), transcript variant 2,
            mRNA.
ACCESSION   NM_001023
VERSION     NM_001023.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 519)
  AUTHORS   Tian,Y., Babaylova,E.S., Gopanenko,A.V., Tupikin,A.E., Kabilov,M.R.
            and Malygin,A.A.
  TITLE     Deficiency of the ribosomal protein uS10 (RPS20) reorganizes human
            cells translatome according to the abundance, CDS length and GC
            content of mRNAs
  JOURNAL   Open Biol 14 (1), 230366 (2024)
   PUBMED   38290548
  REMARK    GeneRIF: Deficiency of the ribosomal protein uS10 (RPS20)
            reorganizes human cells translatome according to the abundance, CDS
            length and GC content of mRNAs.
REFERENCE   2  (bases 1 to 519)
  AUTHORS   Anees,F.F., Preethi,K.A., Selvakumar,S.C., Murthykumar,K.,
            Ganapathy,D. and Sekar,D.
  TITLE     Prospective study: expression levels of microRNA-7-3p and its
            target STAT3 in head and neck cancer
  JOURNAL   Minerva Dent Oral Sci 72 (6), 326-331 (2023)
   PUBMED   37326506
  REMARK    GeneRIF: Prospective study: expression levels of microRNA-7-3p and
            its target STAT3 in head and neck cancer.
REFERENCE   3  (bases 1 to 519)
  AUTHORS   Shen,C., Chen,Z., Zhang,Y., Xu,W., Peng,R., Jiang,J., Zuo,W.,
            Fan,Y. and Zheng,B.
  TITLE     Biochemical and clinical effects of RPS20 expression in renal clear
            cell carcinoma
  JOURNAL   Oncol Rep 49 (1) (2023)
   PUBMED   36484407
  REMARK    GeneRIF: Biochemical and clinical effects of RPS20 expression in
            renal clear cell carcinoma.
REFERENCE   4  (bases 1 to 519)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 519)
  AUTHORS   Bhar,S., Zhou,F., Reineke,L.C., Morris,D.K., Khincha,P.P., Giri,N.,
            Mirabello,L., Bergstrom,K., Lemon,L.D., Williams,C.L., Toh,Y.,
            Elghetany,M.T., Lloyd,R.E., Alter,B.P., Savage,S.A. and
            Bertuch,A.A.
  TITLE     Expansion of germline RPS20 mutation phenotype to include
            Diamond-Blackfan anemia
  JOURNAL   Hum Mutat 41 (11), 1918-1930 (2020)
   PUBMED   32790018
  REMARK    GeneRIF: Expansion of germline RPS20 mutation phenotype to include
            Diamond-Blackfan anemia.
REFERENCE   6  (bases 1 to 519)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   7  (bases 1 to 519)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   8  (bases 1 to 519)
  AUTHORS   Kiss-Laszlo,Z., Henry,Y., Bachellerie,J.P., Caizergues-Ferrer,M.
            and Kiss,T.
  TITLE     Site-specific ribose methylation of preribosomal RNA: a novel
            function for small nucleolar RNAs
  JOURNAL   Cell 85 (7), 1077-1088 (1996)
   PUBMED   8674114
REFERENCE   9  (bases 1 to 519)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   10 (bases 1 to 519)
  AUTHORS   Chu,W., Presky,D.H., Swerlick,R.A. and Burns,D.K.
  TITLE     Human ribosomal protein S20 cDNA sequence
  JOURNAL   Nucleic Acids Res 21 (7), 1672 (1993)
   PUBMED   8479924
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from CB138358.1 and BC007507.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_001023.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S10P family of ribosomal proteins. It is located in the
            cytoplasm. This gene is co-transcribed with the small nucleolar RNA
            gene U54, which is located in its second intron. As is typical for
            genes encoding ribosomal proteins, there are multiple processed
            pseudogenes of this gene dispersed through the genome. Two
            transcript variants encoding different isoforms have been
            identified for this gene. [provided by RefSeq, Apr 2009].
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR, compared to variant 1. The resulting isoform (2)
            has a distinct C-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK130961.1, BG028867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000009589.8/ ENSP00000009589.3
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                CB138358.1         76-91
            17-519              BC007507.2         1-503
FEATURES             Location/Qualifiers
     source          1..519
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q12.1"
     gene            1..519
                     /gene="RPS20"
                     /gene_synonym="S20; uS10"
                     /note="ribosomal protein S20"
                     /db_xref="GeneID:6224"
                     /db_xref="HGNC:HGNC:10405"
                     /db_xref="MIM:603682"
     exon            1..126
                     /gene="RPS20"
                     /gene_synonym="S20; uS10"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..483
                     /gene="RPS20"
                     /gene_synonym="S20; uS10"
                     /note="isoform 2 is encoded by transcript variant 2; 40S
                     ribosomal protein S20; small ribosomal subunit protein
                     uS10"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS10 isoform 2"
                     /protein_id="NP_001014.1"
                     /db_xref="CCDS:CCDS6163.1"
                     /db_xref="GeneID:6224"
                     /db_xref="HGNC:HGNC:10405"
                     /db_xref="MIM:603682"
                     /translation="MAFKDTGKTPVEPEVAIHRIRITLTSRNVKSLEKVCADLIRGAK
                     EKNLKVKGPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQIT
                     SISIEPGVEVEVTIADA"
     exon            127..226
                     /gene="RPS20"
                     /gene_synonym="S20; uS10"
                     /inference="alignment:Splign:2.1.0"
     exon            227..300
                     /gene="RPS20"
                     /gene_synonym="S20; uS10"
                     /inference="alignment:Splign:2.1.0"
     exon            301..519
                     /gene="RPS20"
                     /gene_synonym="S20; uS10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      496..501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS20"
                     /gene_synonym="S20; uS10"
                     /note="hexamer: AATAAA"
     polyA_site      519
                     /gene="RPS20"
                     /gene_synonym="S20; uS10"
                     /note="major polyA site"
ORIGIN      
        1 ctttttgagg aagacgcggt cgtaagggct gaggattttt ggtccgcacg ctcctgctcc
       61 tgactcaccg ctgttcgctc tcgccgagga acaagtcggt caggaagccc gcgcgcaaca
      121 gccatggctt ttaaggatac cggaaaaaca cccgtggagc cggaggtggc aattcaccga
      181 attcgaatca ccctaacaag ccgcaacgta aaatccttgg aaaaggtgtg tgctgacttg
      241 ataagaggcg caaaagaaaa gaatctcaaa gtgaaaggac cagttcgaat gcctaccaag
      301 actttgagaa tcactacaag aaaaactcct tgtggtgaag gttctaagac gtgggatcgt
      361 ttccagatga gaattcacaa gcgactcatt gacttgcaca gtccttctga gattgttaag
      421 cagattactt ccatcagtat tgagccagga gttgaggtgg aagtcaccat tgcagatgct
      481 taagtcaact attttaataa attgatgacc agttgttaa
//
