LOCUS       NM_194326                820 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ribosomal protein S19 binding protein 1 (RPS19BP1),
            transcript variant 1, mRNA.
ACCESSION   NM_194326 XM_039373
VERSION     NM_194326.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 820)
  AUTHORS   Weiss,S., Adolph,R.S., Schweimer,K., DiFonzo,A., Meleshin,M.,
            Schutkowski,M. and Steegborn,C.
  TITLE     Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein
  JOURNAL   Int J Mol Sci 23 (21), 12764 (2022)
   PUBMED   36361557
  REMARK    GeneRIF: Molecular Mechanism of Sirtuin 1 Modulation by the AROS
            Protein.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 820)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 820)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 820)
  AUTHORS   Schuhmacher,M.K., Rolando,M., Brohm,A., Weirich,S., Kudithipudi,S.,
            Buchrieser,C. and Jeltsch,A.
  TITLE     The Legionella pneumophila Methyltransferase RomA Methylates Also
            Non-histone Proteins during Infection
  JOURNAL   J Mol Biol 430 (13), 1912-1925 (2018)
   PUBMED   29733858
  REMARK    GeneRIF: Results provide evidence that RomA methylates AROS, a
            nonhistone target, during infection of human cells.
REFERENCE   5  (bases 1 to 820)
  AUTHORS   Kwon,J.H., Ahn,K.S., Moon,Y.H., Park,J.Y., Wang,H.J., Choi,K.Y.,
            Kim,G., Joh,J.W., Lee,K.G. and Kang,K.J.
  TITLE     AROS Is a Significant Biomarker for Tumor Aggressiveness in
            Non-cirrhotic Hepatocellular Carcinoma
  JOURNAL   J Korean Med Sci 30 (9), 1253-1259 (2015)
   PUBMED   26339164
  REMARK    GeneRIF: AROS is a significant biomarker for tumor aggressiveness
            in non-cirrhotic hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 820)
  AUTHORS   Kim,E.J., Kho,J.H., Kang,M.R. and Um,S.J.
  TITLE     Active regulator of SIRT1 cooperates with SIRT1 and facilitates
            suppression of p53 activity
  JOURNAL   Mol Cell 28 (2), 277-290 (2007)
   PUBMED   17964266
  REMARK    GeneRIF: Active regulator of SIRT1 (AROS) is the first direct SIRT1
            regulator to be identified that modulates p53-mediated growth
            regulation.
            Erratum:[Mol Cell. 2007 Nov 9;28(3):513]
REFERENCE   7  (bases 1 to 820)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 820)
  AUTHORS   Maeda,N., Toku,S., Kenmochi,N. and Tanaka,T.
  TITLE     A novel nucleolar protein interacts with ribosomal protein S19
  JOURNAL   Biochem Biophys Res Commun 339 (1), 41-46 (2006)
   PUBMED   16289379
REFERENCE   9  (bases 1 to 820)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   10 (bases 1 to 820)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC037573.1.
            
            On Nov 22, 2018 this sequence version replaced NM_194326.3.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037573.1, BU175572.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968832,
                                           SAMEA2142680 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334678.8/ ENSP00000333948.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-820               BC037573.1         118-937
FEATURES             Location/Qualifiers
     source          1..820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..820
                     /gene="RPS19BP1"
                     /gene_synonym="AROS; S19BP"
                     /note="ribosomal protein S19 binding protein 1"
                     /db_xref="GeneID:91582"
                     /db_xref="HGNC:HGNC:28749"
                     /db_xref="MIM:610225"
     exon            1..62
                     /gene="RPS19BP1"
                     /gene_synonym="AROS; S19BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..421
                     /gene="RPS19BP1"
                     /gene_synonym="AROS; S19BP"
                     /note="homolog of mouse S19 binding protein; RPS19-binding
                     protein 1; 40S ribosomal protein S19-binding protein 1"
                     /codon_start=1
                     /product="active regulator of SIRT1"
                     /protein_id="NP_919307.1"
                     /db_xref="CCDS:CCDS13997.1"
                     /db_xref="GeneID:91582"
                     /db_xref="HGNC:HGNC:28749"
                     /db_xref="MIM:610225"
                     /translation="MSAALLRRGLELLAASEAPRDPPGQAKPRGAPVKRPRKTKAIQA
                     QKLRNSAKGKVPKSALDEYRKRECRDHLRVNLKFLTRTRSTVAESVSQQILRQNRGRK
                     ACDRPVAKTKKKKAEGTVFTEEDFQKFQQEYFGS"
     exon            63..191
                     /gene="RPS19BP1"
                     /gene_synonym="AROS; S19BP"
                     /inference="alignment:Splign:2.1.0"
     exon            192..289
                     /gene="RPS19BP1"
                     /gene_synonym="AROS; S19BP"
                     /inference="alignment:Splign:2.1.0"
     exon            290..820
                     /gene="RPS19BP1"
                     /gene_synonym="AROS; S19BP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      802..807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS19BP1"
                     /gene_synonym="AROS; S19BP"
                     /note="hexamer: AATAAA"
     polyA_site      820
                     /gene="RPS19BP1"
                     /gene_synonym="AROS; S19BP"
                     /note="major polyA site"
ORIGIN      
        1 aagcgccgcc atgtccgccg ccctgctgcg gcggggcctg gagctgctgg cggcgtccga
       61 ggccccccgg gaccctccag gtcaggccaa gccgagaggg gctccggtga aacggccccg
      121 gaagacgaag gcaattcagg cccagaaact gcggaactcg gccaagggaa aggtgcccaa
      181 gtcggcactg gacgagtacc ggaagcgaga gtgtcgagac cacctcagag taaacctgaa
      241 gtttctgacc aggacgagaa gcaccgtggc tgagtctgtg agccagcaga ttttgcgcca
      301 gaaccggggc cgcaaggcct gtgaccggcc tgtggccaag accaagaaga agaaggctga
      361 gggcaccgtg ttcaccgagg aagacttcca gaagttccag caggaatact tcggcagcta
      421 ggctccctgg agggcacggt gaagaggcct tcaagccctg cagcctccga ctcctgctgg
      481 ctccaggaac cggccgtgcc gcgcggccag cagatggcga tgcaggacca gcctggctcg
      541 aggaagccgc ggagctgagc cgagtggagg ctggaatgga gctggtgggc cggaagtcct
      601 ggggaggatt tacacacaga ccggagctgg cttccgcagg cctgggcaga gcatctgcac
      661 ctgccggaaa ggaacgtatc tgttttgttt gcttttgccc aggtggggcc tctgggctgt
      721 ttgctgtgga gcaaggctaa ttcctgagcc cttggggacg acagctccag gagtaggaag
      781 aagggtgggc ttccaagtta caataaatgt gaacccaaga
//
