LOCUS       NM_022551                549 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribosomal protein S18 (RPS18), mRNA.
ACCESSION   NM_022551
VERSION     NM_022551.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 549)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 549)
  AUTHORS   Lee,J.H., Han,J.H., Kim,H., Park,S.M., Joe,E.H. and Jou,I.
  TITLE     Parkinson's disease-associated LRRK2-G2019S mutant acts through
            regulation of SERCA activity to control ER stress in astrocytes
  JOURNAL   Acta Neuropathol Commun 7 (1), 68 (2019)
   PUBMED   31046837
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 549)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   4  (bases 1 to 549)
  AUTHORS   Martin,I., Kim,J.W., Lee,B.D., Kang,H.C., Xu,J.C., Jia,H.,
            Stankowski,J., Kim,M.S., Zhong,J., Kumar,M., Andrabi,S.A.,
            Xiong,Y., Dickson,D.W., Wszolek,Z.K., Pandey,A., Dawson,T.M. and
            Dawson,V.L.
  TITLE     Ribosomal protein s15 phosphorylation mediates LRRK2
            neurodegeneration in Parkinson's disease
  JOURNAL   Cell 157 (2), 472-485 (2014)
   PUBMED   24725412
REFERENCE   5  (bases 1 to 549)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   6  (bases 1 to 549)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   7  (bases 1 to 549)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   8  (bases 1 to 549)
  AUTHORS   Chassin,D., Benifla,J.L., Delattre,C., Fernandez,H., Ginisty,D.,
            Janneau,J.L., Prade,M., Contesso,G., Caillou,B., Tournaire,M. et
            al.
  TITLE     Identification of genes overexpressed in tumors through
            preferential expression screening in trophoblasts
  JOURNAL   Cancer Res 54 (19), 5217-5223 (1994)
   PUBMED   7923143
REFERENCE   9  (bases 1 to 549)
  AUTHORS   Chassin,D., Bellet,D. and Koman,A.
  TITLE     The human homolog of ribosomal protein S18
  JOURNAL   Nucleic Acids Res 21 (3), 745 (1993)
   PUBMED   8441687
REFERENCE   10 (bases 1 to 549)
  AUTHORS   Chan,Y.L., Paz,V. and Wool,I.G.
  TITLE     The primary structure of rat ribosomal protein S18
  JOURNAL   Biochem Biophys Res Commun 178 (3), 1212-1218 (1991)
   PUBMED   1872840
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AL645940.4 and AL662820.6.
            
            On Nov 25, 2018 this sequence version replaced NM_022551.2.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S13P family of ribosomal proteins. It is located in the
            cytoplasm. The gene product of the E. coli ortholog (ribosomal
            protein S13) is involved in the binding of fMet-tRNA, and thus, in
            the initiation of translation. This gene is an ortholog of mouse
            Ke3. As is typical for genes encoding ribosomal proteins, there are
            multiple processed pseudogenes of this gene dispersed through the
            genome. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.4343.1, CD173693.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000439602.7/ ENSP00000393241.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AL645940.4         157112-157159
            49-147              AL645940.4         157665-157763
            148-234             AL662820.6         4801-4887
            235-336             AL662820.6         4969-5070
            337-428             AL662820.6         5180-5271
            429-549             AL662820.6         5395-5515
FEATURES             Location/Qualifiers
     source          1..549
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..549
                     /gene="RPS18"
                     /gene_synonym="D6S218E; HKE3; KE-3; KE3; S18; uS13"
                     /note="ribosomal protein S18"
                     /db_xref="GeneID:6222"
                     /db_xref="HGNC:HGNC:10401"
                     /db_xref="MIM:180473"
     exon            1..48
                     /gene="RPS18"
                     /gene_synonym="D6S218E; HKE3; KE-3; KE3; S18; uS13"
                     /inference="alignment:Splign:2.1.0"
     exon            49..147
                     /gene="RPS18"
                     /gene_synonym="D6S218E; HKE3; KE-3; KE3; S18; uS13"
                     /inference="alignment:Splign:2.1.0"
     exon            148..234
                     /gene="RPS18"
                     /gene_synonym="D6S218E; HKE3; KE-3; KE3; S18; uS13"
                     /inference="alignment:Splign:2.1.0"
     exon            235..336
                     /gene="RPS18"
                     /gene_synonym="D6S218E; HKE3; KE-3; KE3; S18; uS13"
                     /inference="alignment:Splign:2.1.0"
     exon            337..428
                     /gene="RPS18"
                     /gene_synonym="D6S218E; HKE3; KE-3; KE3; S18; uS13"
                     /inference="alignment:Splign:2.1.0"
     exon            429..549
                     /gene="RPS18"
                     /gene_synonym="D6S218E; HKE3; KE-3; KE3; S18; uS13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      525..530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS18"
                     /gene_synonym="D6S218E; HKE3; KE-3; KE3; S18; uS13"
                     /note="hexamer: AATAAA"
     polyA_site      549
                     /gene="RPS18"
                     /gene_synonym="D6S218E; HKE3; KE-3; KE3; S18; uS13"
                     /note="major polyA site"
ORIGIN      
        1 ctctcttcca caggaggcct acacgccgcc gcttgtgctg cagccatgtc tctagtgatc
       61 cctgaaaagt tccagcatat tttgcgagta ctcaacacca acatcgatgg gcggcggaaa
      121 atagcctttg ccatcactgc cattaagggt gtgggccgaa gatatgctca tgtggtgttg
      181 aggaaagcag acattgacct caccaagagg gcgggagaac tcactgagga tgaggtggaa
      241 cgtgtgatca ccattatgca gaatccacgc cagtacaaga tcccagactg gttcttgaac
      301 agacagaagg atgtaaagga tggaaaatac agccaggtcc tagccaatgg tctggacaac
      361 aagctccgtg aagacctgga gcgactgaag aagattcggg cccatagagg gctgcgtcac
      421 ttctggggcc ttcgtgtccg aggccagcac accaagacca ctggccgccg tggccgcacc
      481 gtgggtgtgt ccaagaagaa ataagtctgt aggccttgtc tgttaataaa tagtttatat
      541 acctatggc
//
