LOCUS       NM_001021                488 bp    mRNA    linear   PRI 06-OCT-2024
DEFINITION  Homo sapiens ribosomal protein S17 (RPS17), transcript variant 1,
            mRNA.
ACCESSION   NM_001021
VERSION     NM_001021.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 488)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   2  (bases 1 to 488)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   3  (bases 1 to 488)
  AUTHORS   Kenney,S.P. and Meng,X.J.
  TITLE     Identification and fine mapping of nuclear and nucleolar
            localization signals within the human ribosomal protein S17
  JOURNAL   PLoS One 10 (4), e0124396 (2015)
   PUBMED   25853866
  REMARK    GeneRIF: Nuclear and nucleolar localization signals within the
            human ribosomal protein S17 have been mapped.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 488)
  AUTHORS   Chae,H., Park,J., Lee,S., Kim,M., Kim,Y., Lee,J.W., Chung,N.G.,
            Cho,B., Jeong,D.C., Kim,J., Kim,J.R. and Park,G.
  TITLE     Ribosomal protein mutations in Korean patients with
            Diamond-Blackfan anemia
  JOURNAL   Exp Mol Med 46 (3), e88 (2014)
   PUBMED   24675553
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 488)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   6  (bases 1 to 488)
  AUTHORS   Mundus,D.A., Bulygin,K.N., Yamkovoy,V.I., Malygin,A.A.,
            Repkova,M.N., Vratskikh,L.V., Venijaminova,A.G., Vladimirov,S.N.
            and Karpova,G.G.
  TITLE     Structural arrangement of the codon-anticodon interaction area in
            human placenta ribosomes. Affinity labelling of the 40S subunits by
            derivatives of oligoribonucleotides containing the AUG codon
  JOURNAL   Biochim Biophys Acta 1173 (3), 273-282 (1993)
   PUBMED   8318536
REFERENCE   7  (bases 1 to 488)
  AUTHORS   Sieff,C.
  TITLE     Diamond-Blackfan Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301769
REFERENCE   8  (bases 1 to 488)
  AUTHORS   Feo,S., Davies,B. and Fried,M.
  TITLE     The mapping of seven intron-containing ribosomal protein genes
            shows they are unlinked in the human genome
  JOURNAL   Genomics 13 (1), 201-207 (1992)
   PUBMED   1577483
REFERENCE   9  (bases 1 to 488)
  AUTHORS   Chen,I.T. and Roufa,D.J.
  TITLE     The transcriptionally active human ribosomal protein S17 gene
  JOURNAL   Gene 70 (1), 107-116 (1988)
   PUBMED   3240863
REFERENCE   10 (bases 1 to 488)
  AUTHORS   Chen,I.T., Dixit,A., Rhoads,D.D. and Roufa,D.J.
  TITLE     Homologous ribosomal proteins in bacteria, yeast, and humans
  JOURNAL   Proc Natl Acad Sci U S A 83 (18), 6907-6911 (1986)
   PUBMED   3529092
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BC062715.1 and BE905890.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 8, 2018 this sequence version replaced NM_001021.5.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of four RNA species and approximately
            80 structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S17E family of ribosomal proteins and is located in the
            cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia 4.
            Alternative splicing of this gene results in multiple transcript
            variants. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (1) encodes the supported protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD246863.1, BE902183.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000647841.1/ ENSP00000498019.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-483               BC062715.1         86-568
            484-488             BE905890.1         447-451
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.2"
     gene            1..488
                     /gene="RPS17"
                     /gene_synonym="DBA4; eS17; RPS17L; RPS17L1; RPS17L2; S17"
                     /note="ribosomal protein S17"
                     /db_xref="GeneID:6218"
                     /db_xref="HGNC:HGNC:10397"
                     /db_xref="MIM:180472"
     exon            1..32
                     /gene="RPS17"
                     /gene_synonym="DBA4; eS17; RPS17L; RPS17L1; RPS17L2; S17"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..437
                     /gene="RPS17"
                     /gene_synonym="DBA4; eS17; RPS17L; RPS17L1; RPS17L2; S17"
                     /note="40S ribosomal protein S17"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS17"
                     /protein_id="NP_001012.1"
                     /db_xref="CCDS:CCDS10320.1"
                     /db_xref="GeneID:6218"
                     /db_xref="HGNC:HGNC:10397"
                     /db_xref="MIM:180472"
                     /translation="MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSK
                     KLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPDT
                     KEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGPV"
     exon            33..184
                     /gene="RPS17"
                     /gene_synonym="DBA4; eS17; RPS17L; RPS17L1; RPS17L2; S17"
                     /inference="alignment:Splign:2.1.0"
     exon            185..290
                     /gene="RPS17"
                     /gene_synonym="DBA4; eS17; RPS17L; RPS17L1; RPS17L2; S17"
                     /inference="alignment:Splign:2.1.0"
     exon            291..356
                     /gene="RPS17"
                     /gene_synonym="DBA4; eS17; RPS17L; RPS17L1; RPS17L2; S17"
                     /inference="alignment:Splign:2.1.0"
     exon            357..488
                     /gene="RPS17"
                     /gene_synonym="DBA4; eS17; RPS17L; RPS17L1; RPS17L2; S17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      466..471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS17"
                     /gene_synonym="DBA4; eS17; RPS17L; RPS17L1; RPS17L2; S17"
                     /note="hexamer: AATAAA"
     polyA_site      486
                     /gene="RPS17"
                     /gene_synonym="DBA4; eS17; RPS17L; RPS17L1; RPS17L2; S17"
                     /note="major polyA site"
ORIGIN      
        1 gtttcctctt ttaccaagga cccgccaaca tgggccgcgt tcgcaccaaa accgtgaaga
       61 aggcggcccg ggtcatcata gaaaagtact acacgcgcct gggcaacgac ttccacacga
      121 acaagcgcgt gtgcgaggag atcgccatta tccccagcaa aaagctccgc aacaagatag
      181 caggttatgt cacgcatctg atgaagcgaa ttcagagagg cccagtaaga ggtatctcca
      241 tcaagctgca ggaggaggag agagaaagga gagacaatta tgttcctgag gtctcagcct
      301 tggatcagga gattattgaa gtagatcctg acactaagga aatgctgaag cttttggact
      361 tcggcagtct gtccaacctt caggtcactc agcctacagt tgggatgaat ttcaaaacgc
      421 ctcggggacc tgtttgaatt ttttctgtag tgctgtatta ttttcaataa atctgggaca
      481 acagcctt
//
