LOCUS       NP_001011                146 aa            linear   PRI 28-APR-2025
DEFINITION  small ribosomal subunit protein uS9 isoform 1 [Homo sapiens].
ACCESSION   NP_001011
VERSION     NP_001011.1
DBSOURCE    REFSEQ: accession NM_001020.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 146)
  AUTHORS   Wu,W., Wang,C., Xia,C., Liu,S. and Mei,Q.
  TITLE     MicroRNA let-7 Suppresses Influenza A Virus Infection by Targeting
            RPS16 and Enhancing Type I Interferon Response
  JOURNAL   Front Cell Infect Microbiol 12, 904775 (2022)
   PUBMED   35873150
  REMARK    GeneRIF: MicroRNA let-7 Suppresses Influenza A Virus Infection by
            Targeting RPS16 and Enhancing Type I Interferon Response.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 146)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (residues 1 to 146)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   4  (residues 1 to 146)
  AUTHORS   Liao,Y., Shao,Z., Liu,Y., Xia,X., Deng,Y., Yu,C., Sun,W., Kong,W.,
            He,X., Liu,F., Guo,Z., Chen,G., Tang,D., Gan,H., Liu,J. and
            Huang,H.
  TITLE     USP1-dependent RPS16 protein stability drives growth and metastasis
            of human hepatocellular carcinoma cells
  JOURNAL   J Exp Clin Cancer Res 40 (1), 201 (2021)
   PUBMED   34154657
  REMARK    GeneRIF: USP1-dependent RPS16 protein stability drives growth and
            metastasis of human hepatocellular carcinoma cells.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 146)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (residues 1 to 146)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   7  (residues 1 to 146)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   8  (residues 1 to 146)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   9  (residues 1 to 146)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   10 (residues 1 to 146)
  AUTHORS   Batra,S.K., Metzgar,R.S. and Hollingsworth,M.A.
  TITLE     Molecular cloning and sequence analysis of the human ribosomal
            protein S16
  JOURNAL   J Biol Chem 266 (11), 6830-6833 (1991)
   PUBMED   2016298
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AC011500.7, AK315498.1 and AA890305.1.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S9P family of ribosomal proteins. It is located in the
            cytoplasm. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.380039.1, CD176907.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251453.8/ ENSP00000251453.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..146
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     Protein         1..146
                     /product="small ribosomal subunit protein uS9 isoform 1"
                     /note="40S ribosomal protein S16; small ribosomal subunit
                     protein uS9"
                     /calculated_mol_wt=16314
     Site            3
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P62249.2)"
     Region          6..146
                     /region_name="PLN00210"
                     /note="40S ribosomal protein S16; Provisional"
                     /db_xref="CDD:177799"
     Site            60
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P62249.2)"
     CDS             1..146
                     /gene="RPS16"
                     /gene_synonym="S16; uS9"
                     /coded_by="NM_001020.6:55..495"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS12535.1"
                     /db_xref="GeneID:6217"
                     /db_xref="HGNC:HGNC:10396"
                     /db_xref="MIM:603675"
ORIGIN      
        1 mpskgplqsv qvfgrkktat avahckrgng likvngrple mieprtlqyk llepvlllgk
       61 erfagvdirv rvkggghvaq iyairqsisk alvayyqkyv deaskkeikd iliqydrtll
      121 vadprrcesk kfggpgarar yqksyr
//
