LOCUS       NM_001019               2203 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ribosomal protein S15a (RPS15A), transcript variant 2,
            mRNA.
ACCESSION   NM_001019
VERSION     NM_001019.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2203)
  AUTHORS   Ding,L., Sun,M., Sun,Y., Li,J., Zhang,Z., Dang,S., Zhang,J.,
            Yang,B., Dai,Y., Zhou,Q., Zhou,D., Li,E., Peng,S. and Li,G.
  TITLE     MCM8 promotes gastric cancer progression through RPS15A and
            predicts poor prognosis
  JOURNAL   Cancer Med 13 (13), e7424 (2024)
   PUBMED   38988047
  REMARK    GeneRIF: MCM8 promotes gastric cancer progression through RPS15A
            and predicts poor prognosis.
REFERENCE   2  (bases 1 to 2203)
  AUTHORS   Natani,S., Ramakrishna,M., Nallavolu,T. and Ummanni,R.
  TITLE     MicroRNA-147b induces neuroendocrine differentiation of prostate
            cancer cells by targeting ribosomal protein RPS15A
  JOURNAL   Prostate 83 (10), 936-949 (2023)
   PUBMED   37069746
  REMARK    GeneRIF: MicroRNA-147b induces neuroendocrine differentiation of
            prostate cancer cells by targeting ribosomal protein RPS15A.
REFERENCE   3  (bases 1 to 2203)
  AUTHORS   Yang,H., Li,M. and Qi,Y.
  TITLE     FOXN3 inhibits the progression of ovarian cancer through negatively
            regulating the expression of RPS15A
  JOURNAL   Hum Cell 36 (3), 1120-1134 (2023)
   PUBMED   37016167
  REMARK    GeneRIF: FOXN3 inhibits the progression of ovarian cancer through
            negatively regulating the expression of RPS15A.
REFERENCE   4  (bases 1 to 2203)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   5  (bases 1 to 2203)
  AUTHORS   Wan,B.S., Wang,X.Y., Tiang,J., Zhou,C., Lin,J. and Wang,Z.
  TITLE     Ribosomal protein RPS15A augments proliferation of colorectal
            cancer RKO cells via regulation of BIRC3, p38 MAPK and Chk1
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (11), 3967-3980 (2021)
   PUBMED   34156695
  REMARK    GeneRIF: Ribosomal protein RPS15A augments proliferation of
            colorectal cancer RKO cells via regulation of BIRC3, p38 MAPK and
            Chk1.
REFERENCE   6  (bases 1 to 2203)
  AUTHORS   Kenmochi,N., Kawaguchi,T., Rozen,S., Davis,E., Goodman,N.,
            Hudson,T.J., Tanaka,T. and Page,D.C.
  TITLE     A map of 75 human ribosomal protein genes
  JOURNAL   Genome Res 8 (5), 509-523 (1998)
   PUBMED   9582194
REFERENCE   7  (bases 1 to 2203)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   8  (bases 1 to 2203)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   9  (bases 1 to 2203)
  AUTHORS   Chan,Y.L., Olvera,J., Paz,V. and Wool,I.G.
  TITLE     The primary structure of rat ribosomal protein S15a
  JOURNAL   Biochem Biophys Res Commun 200 (3), 1498-1504 (1994)
   PUBMED   8185605
REFERENCE   10 (bases 1 to 2203)
  AUTHORS   Sieff,C.
  TITLE     Diamond-Blackfan Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301769
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BF678907.1, BC001697.2 and AC138811.3.
            
            On Nov 22, 2018 this sequence version replaced NM_001019.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S8P family of ribosomal proteins. It is located in the
            cytoplasm. As is typical for genes encoding ribosomal proteins,
            there are multiple processed pseudogenes of this gene dispersed
            through the genome. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) is the longest transcript and
            utilizes an alternate splice site on the 5'-terminal exon, compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291988.1, SRR3476690.797572.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322989.8/ ENSP00000318646.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-332               BF678907.1         2-333
            333-528             BC001697.2         302-497
            529-543             BF678907.1         531-545
            544-2203            AC138811.3         157203-158862       c
FEATURES             Location/Qualifiers
     source          1..2203
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.3"
     gene            1..2203
                     /gene="RPS15A"
                     /gene_synonym="DBA20; S15a; uS8"
                     /note="ribosomal protein S15a"
                     /db_xref="GeneID:6210"
                     /db_xref="HGNC:HGNC:10389"
                     /db_xref="MIM:603674"
     exon            1..91
                     /gene="RPS15A"
                     /gene_synonym="DBA20; S15a; uS8"
                     /inference="alignment:Splign:2.1.0"
     exon            92..229
                     /gene="RPS15A"
                     /gene_synonym="DBA20; S15a; uS8"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..489
                     /gene="RPS15A"
                     /gene_synonym="DBA20; S15a; uS8"
                     /EC_number="3.6.5.3"
                     /note="40S ribosomal protein S15a; up-regulated by HBV X
                     protein"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS8"
                     /protein_id="NP_001010.2"
                     /db_xref="CCDS:CCDS10571.1"
                     /db_xref="GeneID:6210"
                     /db_xref="HGNC:HGNC:10389"
                     /db_xref="MIM:603674"
                     /translation="MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVRFLTVMMKH
                     GYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFI
                     VLTTSAGIMDHEEARRKHTGGKILGFFF"
     exon            230..309
                     /gene="RPS15A"
                     /gene_synonym="DBA20; S15a; uS8"
                     /inference="alignment:Splign:2.1.0"
     exon            310..395
                     /gene="RPS15A"
                     /gene_synonym="DBA20; S15a; uS8"
                     /inference="alignment:Splign:2.1.0"
     exon            396..2203
                     /gene="RPS15A"
                     /gene_synonym="DBA20; S15a; uS8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      512..517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS15A"
                     /gene_synonym="DBA20; S15a; uS8"
                     /note="hexamer: AATAAA"
     polyA_site      543
                     /gene="RPS15A"
                     /gene_synonym="DBA20; S15a; uS8"
                     /note="major polyA site"
     polyA_site      564
                     /gene="RPS15A"
                     /gene_synonym="DBA20; S15a; uS8"
     regulatory      2181..2186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS15A"
                     /gene_synonym="DBA20; S15a; uS8"
                     /note="hexamer: AATAAA"
     polyA_site      2203
                     /gene="RPS15A"
                     /gene_synonym="DBA20; S15a; uS8"
ORIGIN      
        1 ctctttccgc catctttccg cgccggtgag tagcactctc tgagagctcc aatttcatcc
       61 gtctgccatc ggcgccatcc tgcaatctaa gccacaatgg tgcgcatgaa tgtcctggca
      121 gatgctctca agagtatcaa caatgccgaa aagagaggca aacgccaggt gcttattagg
      181 ccgtgctcca aagtcatcgt ccggtttctc actgtgatga tgaagcatgg ttacattggc
      241 gaatttgaaa tcattgatga ccacagagct gggaaaattg ttgtgaacct cacaggcagg
      301 ctaaacaagt gtggggtgat cagccccaga tttgacgtgc aactcaaaga cctggaaaaa
      361 tggcagaata atctgcttcc atcccgccag tttggtttca ttgtactgac aacctcagct
      421 ggcatcatgg accatgaaga agcaagacga aaacacacag gagggaaaat cctgggattc
      481 tttttctagg gatgtaatac atatatttac aaataaaatg cctcatggac tctggtgctt
      541 ccacttggtc gttttgagcc tttacagcag tgtagccaca gcttctgcgg cagcatgcag
      601 ttgcttcgtt tatcggtgaa tgcgattccc tgaagtgact aatacagcca agggaaaaag
      661 ttcttatgaa accagtatgc ctaagaaaca gtcacccctg ctgtctgcca aaaccaggta
      721 tttgacacta aatattttag ttgtatttca gttttttttt ttttttttct tttttggaga
      781 cagagtctga ctctattgct caggctggag tgcagtggcg cgatcttggc ccactgcaac
      841 ctccacctcc cgggttcaag tgattgtcct gtctcagccg cctgagtaac tgggattaca
      901 agtgtgtgtc gccacatccg gctaattttt atattttagt agagacaggg tttcgccatg
      961 ttgcccaggc tggtcttgag ttctgggcct caagtgatca gcctacctcg gcctcccgaa
     1021 gtgctgggat tacagccacg agccattaca cctggcctat atttcagtat tttctattag
     1081 tttttgatga atttgttttg cctggctagg attattctgt agataggatt ttagatctgg
     1141 cttttgtcac tgactgctgt aataaatact tgctaggaat tttttttttt tttttttttt
     1201 ttttaagaca aagtcgctct gtcacacagg ctggagtgca gtggcatgat cttggctcac
     1261 tgcacctccg cttcccagat tcaagtagtt ctcgtgcctc agcctcctga gtagctggga
     1321 ttacaggtgt gtgccaccat gtctggctga tttttgtatt tttagtagag gtggggtttc
     1381 accatgttgg ccaggctggt ctcgaactcc tgatctcaag tgatctgcct gccttggtct
     1441 cccaaagtgc tgggattaca ggtgtgacca ccacgccctg ccttaagaat tgttccaaga
     1501 gaatctggtg ccacttgcag gtgcccattg aagtgcaatg ggcactgttg atcactgagg
     1561 aggtagtggg tgctgacccg gtgctggggc ctgtccccta gtctctgctt tgcccttggc
     1621 tagctaggtg gtgtgccaag tggggagaga agctacctta ttaaggggca tggatcagct
     1681 tcctgaaagg agggcctgcc tctgtaagat atgggaagtc gctgagaatg ttacagaacg
     1741 gccctagaga tggggcagat aacggccccc atttgtgaga agtgagttgg gaggcatgtt
     1801 tggggcctct gatgtttggg aggctgtggg taattaacat gagttttggg gtccagcagc
     1861 agaattcagg tttcctcttc cactcagtaa cctcagcatc cgtatctgta atgggaatga
     1921 tacaaaacct atccccaagt tgagggaaaa atgagattgt gtaaagcgca cttggcacat
     1981 gacagtcaca agcatgggga cagtgagtcc agaaggattt tcttatgcca gcattgtaag
     2041 ccctaggatc acagggctct ggcttgttta accatcgtgt ctctggtccc tagcctgcaa
     2101 acctggtgtg tagggatgcc tcagtcgctt acatgttgat tgagtgaatc gtcggtttct
     2161 ttctggacac tgacttcaaa aataaaatag gatatgaaaa tgg
//
