LOCUS       NM_001018                501 bp    mRNA    linear   PRI 30-APR-2025
DEFINITION  Homo sapiens ribosomal protein S15 (RPS15), transcript variant 2,
            mRNA.
ACCESSION   NM_001018 NM_001080831
VERSION     NM_001018.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 501)
  AUTHORS   Zhao,M., Liu,A., Mo,L., Wan,G. and Lu,F.
  TITLE     The value of RPS15 and MRPS27 in ischemic stroke
  JOURNAL   Medicine (Baltimore) 102 (33), e34706 (2023)
   PUBMED   37603533
  REMARK    GeneRIF: The value of RPS15 and MRPS27 in ischemic stroke.
REFERENCE   2  (bases 1 to 501)
  AUTHORS   Zhao,Y., Li,Y., Zhu,R., Feng,R., Cui,H., Yu,X., Huang,F., Zhang,R.,
            Chen,X., Li,L., Chen,Y., Liu,Y., Wang,J., Du,G. and Liu,Z.
  TITLE     RPS15 interacted with IGF2BP1 to promote esophageal squamous cell
            carcinoma development via recognizing m6A modification
  JOURNAL   Signal Transduct Target Ther 8 (1), 224 (2023)
   PUBMED   37264021
  REMARK    GeneRIF: RPS15 interacted with IGF2BP1 to promote esophageal
            squamous cell carcinoma development via recognizing m[6]A
            modification.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 501)
  AUTHORS   Rossler,I., Weigl,S., Fernandez-Fernandez,J., Martin-Villanueva,S.,
            Strauss,D., Hurt,E., de la Cruz,J. and Pertschy,B.
  TITLE     The C-terminal tail of ribosomal protein Rps15 is engaged in
            cytoplasmic pre-40S maturation
  JOURNAL   RNA Biol 19 (1), 560-574 (2022)
   PUBMED   35438042
  REMARK    GeneRIF: The C-terminal tail of ribosomal protein Rps15 is engaged
            in cytoplasmic pre-40S maturation.
REFERENCE   4  (bases 1 to 501)
  AUTHORS   Ntoufa,S., Gerousi,M., Laidou,S., Psomopoulos,F., Tsiolas,G.,
            Moysiadis,T., Papakonstantinou,N., Mansouri,L., Anagnostopoulos,A.,
            Stavrogianni,N., Pospisilova,S., Plevova,K., Makris,A.M.,
            Rosenquist,R. and Stamatopoulos,K.
  TITLE     RPS15 mutations rewire RNA translation in chronic lymphocytic
            leukemia
  JOURNAL   Blood Adv 5 (13), 2788-2792 (2021)
   PUBMED   34251413
  REMARK    GeneRIF: RPS15 mutations rewire RNA translation in chronic
            lymphocytic leukemia.
REFERENCE   5  (bases 1 to 501)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 501)
  AUTHORS   Roepcke,S., Zhi,D., Vingron,M. and Arndt,P.F.
  TITLE     Identification of highly specific localized sequence motifs in
            human ribosomal protein gene promoters
  JOURNAL   Gene 365, 48-56 (2006)
   PUBMED   16343812
REFERENCE   7  (bases 1 to 501)
  AUTHORS   Kitagawa,M., Takasawa,S., Kikuchi,N., Itoh,T., Teraoka,H.,
            Yamamoto,H. and Okamoto,H.
  TITLE     rig encodes ribosomal protein S15. The primary structure of
            mammalian ribosomal protein S15
  JOURNAL   FEBS Lett 283 (2), 210-214 (1991)
   PUBMED   2044758
REFERENCE   8  (bases 1 to 501)
  AUTHORS   Shiga,K., Yamamoto,H. and Okamoto,H.
  TITLE     Isolation and characterization of the human homologue of rig and
            its pseudogenes: the functional gene has features characteristic of
            housekeeping genes
  JOURNAL   Proc Natl Acad Sci U S A 87 (9), 3594-3598 (1990)
   PUBMED   2159154
REFERENCE   9  (bases 1 to 501)
  AUTHORS   Marion,M.J. and Marion,C.
  TITLE     Ribosomal proteins S2, S6, S10, S14, S15 and S25 are localized on
            the surface of mammalian 40 S subunits and stabilize their
            conformation. A study with immobilized trypsin
  JOURNAL   FEBS Lett 232 (2), 281-285 (1988)
   PUBMED   3378620
REFERENCE   10 (bases 1 to 501)
  AUTHORS   Inoue,C., Shiga,K., Takasawa,S., Kitagawa,M., Yamamoto,H. and
            Okamoto,H.
  TITLE     Evolutionary conservation of the insulinoma gene rig and its
            possible function
  JOURNAL   Proc Natl Acad Sci U S A 84 (19), 6659-6662 (1987)
   PUBMED   2821540
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AC027307.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 5, 2020 this sequence version replaced NM_001018.4.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S19P family of ribosomal proteins. It is located in the
            cytoplasm. This gene has been found to be activated in various
            tumors, such as insulinomas, esophageal cancers, and colon cancers.
            As is typical for genes encoding ribosomal proteins, there are
            multiple processed pseudogenes of this gene dispersed through the
            genome. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (2) uses an alternate 5'-terminal
            exon, which results in a different 5' UTR and use of an alternate
            start codon compared to variant 1. It encodes isoform 2, which is
            shorter than and has a distinct N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG477036.1, BP274730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000592588.7/ ENSP00000467466.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC027307.5         28219-28251
            34-119              AC027307.5         28630-28715
            120-354             AC027307.5         29842-30076
            355-501             AC027307.5         30172-30318
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..501
                     /gene="RPS15"
                     /gene_synonym="RIG; S15; uS19"
                     /note="ribosomal protein S15"
                     /db_xref="GeneID:6209"
                     /db_xref="HGNC:HGNC:10388"
                     /db_xref="MIM:180535"
     exon            1..33
                     /gene="RPS15"
                     /gene_synonym="RIG; S15; uS19"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..468
                     /gene="RPS15"
                     /gene_synonym="RIG; S15; uS19"
                     /note="isoform 2 is encoded by transcript variant 2; 40S
                     ribosomal protein S15; homolog of rat insulinoma;
                     insulinoma protein; small ribosomal subunit protein uS19"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS19 isoform 2"
                     /protein_id="NP_001009.1"
                     /db_xref="CCDS:CCDS12067.1"
                     /db_xref="GeneID:6209"
                     /db_xref="HGNC:HGNC:10388"
                     /db_xref="MIM:180535"
                     /translation="MAEVEQKKKRTFRKFTYRGVDLDQLLDMSYEQLMQLYSARQRRR
                     LNRGLRRKQHSLLKRLRKAKKEAPPMEKPEVVKTHLRDMIILPEMVGSMVGVYNGKTF
                     NQVEIKPEMIGHYLGEFSITYKPVKHGRPGIGATHSSRFIPLK"
     exon            34..119
                     /gene="RPS15"
                     /gene_synonym="RIG; S15; uS19"
                     /inference="alignment:Splign:2.1.0"
     exon            120..354
                     /gene="RPS15"
                     /gene_synonym="RIG; S15; uS19"
                     /inference="alignment:Splign:2.1.0"
     exon            355..501
                     /gene="RPS15"
                     /gene_synonym="RIG; S15; uS19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      479..484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS15"
                     /gene_synonym="RIG; S15; uS19"
                     /note="hexamer: AATAAA"
     polyA_site      501
                     /gene="RPS15"
                     /gene_synonym="RIG; S15; uS19"
                     /note="major polyA site"
ORIGIN      
        1 caaagcgatc tcttctgagg atccggcaag atggcagaag tagagcagaa gaagaagcgg
       61 accttccgca agttcaccta ccgcggcgtg gacctcgacc agctgctgga catgtcctac
      121 gagcagctga tgcagctgta cagtgcgcgc cagcggcggc ggctgaaccg gggcctgcgg
      181 cggaagcagc actccctgct gaagcgcctg cgcaaggcca agaaggaggc gccgcccatg
      241 gagaagccgg aagtggtgaa gacgcacctg cgggacatga tcatcctacc cgagatggtg
      301 ggcagcatgg tgggcgtcta caacggcaag accttcaacc aggtggagat caagcccgag
      361 atgatcggcc actacctggg cgagttctcc atcacctaca agcccgtaaa gcatggccgg
      421 cccggcatcg gggccaccca ctcctcccgc ttcatccctc tcaagtaatg gctcagctaa
      481 taaaggcgca catgactcca g
//
