LOCUS       NM_005617               2146 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribosomal protein S14 (RPS14), transcript variant 3,
            mRNA.
ACCESSION   NM_005617
VERSION     NM_005617.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2146)
  AUTHORS   Han,L., Huo,Y., Huang,L., Zheng,Y., Yu,X., Zhang,N. and Yang,M.
  TITLE     Genome-wide functional integration identified MAZ-controlled RPS14
            dysregulation in hepatocellular carcinoma
  JOURNAL   Arch Toxicol 98 (3), 985-997 (2024)
   PUBMED   38189915
  REMARK    GeneRIF: Genome-wide functional integration identified
            MAZ-controlled RPS14 dysregulation in hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 2146)
  AUTHORS   Hu,S., Cai,J., Fang,H., Chen,Z., Zhang,J. and Cai,R.
  TITLE     RPS14 promotes the development and progression of glioma via p53
            signaling pathway
  JOURNAL   Exp Cell Res 423 (1), 113451 (2023)
   PUBMED   36535509
  REMARK    GeneRIF: RPS14 promotes the development and progression of glioma
            via p53 signaling pathway.
REFERENCE   3  (bases 1 to 2146)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   4  (bases 1 to 2146)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2146)
  AUTHORS   Boussaid,I., Le Goff,S., Floquet,C., Gautier,E.F., Raimbault,A.,
            Viailly,P.J., Al Dulaimi,D., Burroni,B., Dusanter-Fourt,I.,
            Hatin,I., Mayeux,P., Cosson,B. and Fontenay,M.
  TITLE     Integrated analyses of translatome and proteome identify the rules
            of translation selectivity in RPS14-deficient cells
  JOURNAL   Haematologica 106 (3), 746-758 (2021)
   PUBMED   32327500
  REMARK    GeneRIF: Integrated analyses of translatome and proteome identify
            the rules of translation selectivity in RPS14-deficient cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2146)
  AUTHORS   Diaz,J.J. and Roufa,D.J.
  TITLE     Fine-structure map of the human ribosomal protein gene RPS14
  JOURNAL   Mol Cell Biol 12 (4), 1680-1686 (1992)
   PUBMED   1549121
REFERENCE   7  (bases 1 to 2146)
  AUTHORS   Rhoads,D.D. and Roufa,D.J.
  TITLE     A cloned human ribosomal protein gene functions in rodent cells
  JOURNAL   Mol Cell Biol 7 (10), 3767-3774 (1987)
   PUBMED   3683397
REFERENCE   8  (bases 1 to 2146)
  AUTHORS   Chen,I.T., Dixit,A., Rhoads,D.D. and Roufa,D.J.
  TITLE     Homologous ribosomal proteins in bacteria, yeast, and humans
  JOURNAL   Proc Natl Acad Sci U S A 83 (18), 6907-6911 (1986)
   PUBMED   3529092
REFERENCE   9  (bases 1 to 2146)
  AUTHORS   Rhoads,D.D., Dixit,A. and Roufa,D.J.
  TITLE     Primary structure of human ribosomal protein S14 and the gene that
            encodes it
  JOURNAL   Mol Cell Biol 6 (8), 2774-2783 (1986)
   PUBMED   3785212
REFERENCE   10 (bases 1 to 2146)
  AUTHORS   Dana,S. and Wasmuth,J.J.
  TITLE     Selective linkage disruption in human-Chinese hamster cell hybrids:
            deletion mapping of the leuS, hexB, emtB, and chr genes on human
            chromosome 5
  JOURNAL   Mol Cell Biol 2 (10), 1220-1228 (1982)
   PUBMED   7177110
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AC011388.7, BC006784.1 and AA467888.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005617.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S11P family of ribosomal proteins. It is located in the
            cytoplasm. Transcript variants utilizing alternative transcription
            initiation sites have been described in the literature. As is
            typical for genes encoding ribosomal proteins, there are multiple
            processed pseudogenes of this gene dispersed through the genome. In
            Chinese hamster ovary cells, mutations in this gene can lead to
            resistance to emetine, a protein synthesis inhibitor. Multiple
            alternatively spliced transcript variants encoding the same protein
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) lacks a big segment in the 5'
            UTR, as compared to variant 1. Variants 1-3 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.119410.1,
                                           SRR1803613.205922.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407193.7/ ENSP00000385425.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC011388.7         9554-9568
            16-543              BC006784.1         1-528
            544-552             AA467888.1         328-336
            553-2146            AC011388.7         15065-16658
FEATURES             Location/Qualifiers
     source          1..2146
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.1"
     gene            1..2146
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /note="ribosomal protein S14"
                     /db_xref="GeneID:6208"
                     /db_xref="HGNC:HGNC:10387"
                     /db_xref="MIM:130620"
     exon            1..37
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /inference="alignment:Splign:2.1.0"
     exon            38..188
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..495
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /note="emetine resistance; 40S ribosomal protein S14"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS11"
                     /protein_id="NP_005608.1"
                     /db_xref="CCDS:CCDS4307.1"
                     /db_xref="GeneID:6208"
                     /db_xref="HGNC:HGNC:10387"
                     /db_xref="MIM:130620"
                     /translation="MAPRKGKEKKEEQVISLGPQVAEGENVFGVCHIFASFNDTFVHV
                     TDLSGKETICRVTGGMKVKADRDESSPYAAMLAAQDVAQRCKELGITALHIKLRATGG
                     NRTKTPGPGAQSALRALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL"
     exon            189..350
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /inference="alignment:Splign:2.1.0"
     exon            351..427
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /inference="alignment:Splign:2.1.0"
     exon            428..2146
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      523..528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /note="hexamer: AATAAA"
     polyA_site      552
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /note="major polyA site"
     regulatory      983..988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /note="hexamer: CATAAA"
     polyA_site      1005
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
     regulatory      1345..1350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /note="hexamer: AATAAA"
     polyA_site      1362
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
     regulatory      2126..2131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /note="hexamer: AATAAA"
     polyA_site      2146
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
ORIGIN      
        1 ctctctttcc ggtgtggagt ctggagacga cgtgcagaaa tggcacctcg aaaggggaag
       61 gaaaagaagg aagaacaggt catcagcctc ggacctcagg tggctgaagg agagaatgta
      121 tttggtgtct gccatatctt tgcatccttc aatgacactt ttgtccatgt cactgatctt
      181 tctggcaagg aaaccatctg ccgtgtgact ggtgggatga aggtaaaggc agaccgagat
      241 gaatcctcac catatgctgc tatgttggct gcccaggatg tggcccagag gtgcaaggag
      301 ctgggtatca ccgccctaca catcaaactc cgggccacag gaggaaatag gaccaagacc
      361 cctggacctg gggcccagtc ggccctcaga gcccttgccc gctcgggtat gaagatcggg
      421 cggattgagg atgtcacccc catcccctct gacagcactc gcaggaaggg gggtcgccgt
      481 ggtcgccgtc tgtgaacaag attcctcaaa atattttctg ttaataaatt gccttcatgt
      541 aaactgtttc aactccagcc ttctctcctt catcaggggc tactcaggca tttgatttct
      601 tcctcctatt tggcttcttg ggagaaagga gcctgaggag agctgagatc ctggtgctgc
      661 atttggggtc ttttccatgc tacttgcggc attaagttgc cttggtcatc taaagcagac
      721 caaggcgttg gagacctcgt tttgagtgga gatgctggtt ctaaatatgg accaattctt
      781 aaagagccag agtgggaact gttgatccaa gtgtagcctg aagcgaaaga ggagccttcc
      841 agacccatgc catatataaa cacacgtggg tgtgcattct ccccccacac cttctgtgca
      901 aagctgggag ctcactccac tgcgtcttgc tttttttcac ttggcagatc ttggagattg
      961 ttccacatca gtacataaag tacataaaga ttgtcacccc acaaatacac accaagtcct
     1021 attttcatca gcgataaaaa agaaaagttc ttgctttccg gaagcttgca tgcggctctg
     1081 agtacccagt gacaccagat ggtactcagc gttttgcaag ggattaccac aaggccccgt
     1141 gatggtgcct gccatggtta ggacaggctg gtggctgggt agggttagtg agacccagtg
     1201 gagaggatgc tgtgtgtcac aggctggaga ggtgagacca ttgaggtagt cagttgtaga
     1261 ggaaagaaac cagcaagagg ggaaaatctg ttgggatgct gcttttagcc tttgatggcg
     1321 tgttccaggc agagggaata agcaaataaa tgggtcctga gacaaggggt tactgtgatg
     1381 aggcggcgtt ggttacatgc caaaccttgc tagggatttt aataacaaca ttgaatctta
     1441 acctgatgaa ataacagtac tcctggggag gcgggaggga tagcattagg agatatacct
     1501 aatgctaaat gacgagttaa tgggtgcagc acaccaacat ggcacatgta tacatatgta
     1561 acaaacctgc acgttgtgca catgtaccct aaaacttaaa gtataataaa aaaaaaaagc
     1621 ttgcaaaaaa aatataacag tactccttaa attgttaaaa gtcatgaaag tcaaggacag
     1681 gagattaagg aggcgtgaaa actaaatgcc cattgtggta tcctggattg gattctggaa
     1741 ccagaatagg gtattagtat aaaaactagt gaaataggat aaaggcaggg cacagtggtt
     1801 cacgcctata atcccaacac tttgggaagc cgagacagga ggacggattg agcccaggag
     1861 tttgagacca gcctgggcaa cacagggaga ccccgtctct acaaaaaata aaaaattagc
     1921 tgggcatggt ggcacacgtc tgtactgcca gctacttggg aggctgaggt gggagaattg
     1981 cctgagcctg ggaagtggag gccgcagtga gctgtgattg catcactaca ttcagcctgg
     2041 gtcacagagc aagatcctat ctcaaaaact aaataagtaa ataataaatt aaaaaatatg
     2101 aataaagtct ggagttaaag tctggaataa agctagtagt aatgta
//
