LOCUS       NM_001025071            2363 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ribosomal protein S14 (RPS14), transcript variant 1,
            mRNA.
ACCESSION   NM_001025071
VERSION     NM_001025071.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2363)
  AUTHORS   Han,L., Huo,Y., Huang,L., Zheng,Y., Yu,X., Zhang,N. and Yang,M.
  TITLE     Genome-wide functional integration identified MAZ-controlled RPS14
            dysregulation in hepatocellular carcinoma
  JOURNAL   Arch Toxicol 98 (3), 985-997 (2024)
   PUBMED   38189915
  REMARK    GeneRIF: Genome-wide functional integration identified
            MAZ-controlled RPS14 dysregulation in hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 2363)
  AUTHORS   Hu,S., Cai,J., Fang,H., Chen,Z., Zhang,J. and Cai,R.
  TITLE     RPS14 promotes the development and progression of glioma via p53
            signaling pathway
  JOURNAL   Exp Cell Res 423 (1), 113451 (2023)
   PUBMED   36535509
  REMARK    GeneRIF: RPS14 promotes the development and progression of glioma
            via p53 signaling pathway.
REFERENCE   3  (bases 1 to 2363)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   4  (bases 1 to 2363)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2363)
  AUTHORS   Boussaid,I., Le Goff,S., Floquet,C., Gautier,E.F., Raimbault,A.,
            Viailly,P.J., Al Dulaimi,D., Burroni,B., Dusanter-Fourt,I.,
            Hatin,I., Mayeux,P., Cosson,B. and Fontenay,M.
  TITLE     Integrated analyses of translatome and proteome identify the rules
            of translation selectivity in RPS14-deficient cells
  JOURNAL   Haematologica 106 (3), 746-758 (2021)
   PUBMED   32327500
  REMARK    GeneRIF: Integrated analyses of translatome and proteome identify
            the rules of translation selectivity in RPS14-deficient cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2363)
  AUTHORS   Diaz,J.J. and Roufa,D.J.
  TITLE     Fine-structure map of the human ribosomal protein gene RPS14
  JOURNAL   Mol Cell Biol 12 (4), 1680-1686 (1992)
   PUBMED   1549121
REFERENCE   7  (bases 1 to 2363)
  AUTHORS   Rhoads,D.D. and Roufa,D.J.
  TITLE     A cloned human ribosomal protein gene functions in rodent cells
  JOURNAL   Mol Cell Biol 7 (10), 3767-3774 (1987)
   PUBMED   3683397
REFERENCE   8  (bases 1 to 2363)
  AUTHORS   Chen,I.T., Dixit,A., Rhoads,D.D. and Roufa,D.J.
  TITLE     Homologous ribosomal proteins in bacteria, yeast, and humans
  JOURNAL   Proc Natl Acad Sci U S A 83 (18), 6907-6911 (1986)
   PUBMED   3529092
REFERENCE   9  (bases 1 to 2363)
  AUTHORS   Rhoads,D.D., Dixit,A. and Roufa,D.J.
  TITLE     Primary structure of human ribosomal protein S14 and the gene that
            encodes it
  JOURNAL   Mol Cell Biol 6 (8), 2774-2783 (1986)
   PUBMED   3785212
REFERENCE   10 (bases 1 to 2363)
  AUTHORS   Dana,S. and Wasmuth,J.J.
  TITLE     Selective linkage disruption in human-Chinese hamster cell hybrids:
            deletion mapping of the leuS, hexB, emtB, and chr genes on human
            chromosome 5
  JOURNAL   Mol Cell Biol 2 (10), 1220-1228 (1982)
   PUBMED   7177110
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AC011388.7, BM557014.1 and AA467888.1.
            
            On May 31, 2019 this sequence version replaced NM_001025071.1.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S11P family of ribosomal proteins. It is located in the
            cytoplasm. Transcript variants utilizing alternative transcription
            initiation sites have been described in the literature. As is
            typical for genes encoding ribosomal proteins, there are multiple
            processed pseudogenes of this gene dispersed through the genome. In
            Chinese hamster ovary cells, mutations in this gene can lead to
            resistance to emetine, a protein synthesis inhibitor. Multiple
            alternatively spliced transcript variants encoding the same protein
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.29299.1,
                                           SRR1660809.172087.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC011388.7         9554-9616
            64-757              BM557014.1         16-709
            758-769             AA467888.1         325-336
            770-2363            AC011388.7         15065-16658
FEATURES             Location/Qualifiers
     source          1..2363
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.1"
     gene            1..2363
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /note="ribosomal protein S14"
                     /db_xref="GeneID:6208"
                     /db_xref="HGNC:HGNC:10387"
                     /db_xref="MIM:130620"
     exon            1..254
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /inference="alignment:Splign:2.1.0"
     exon            255..405
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..712
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /note="emetine resistance; 40S ribosomal protein S14"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS11"
                     /protein_id="NP_001020242.1"
                     /db_xref="CCDS:CCDS4307.1"
                     /db_xref="GeneID:6208"
                     /db_xref="HGNC:HGNC:10387"
                     /db_xref="MIM:130620"
                     /translation="MAPRKGKEKKEEQVISLGPQVAEGENVFGVCHIFASFNDTFVHV
                     TDLSGKETICRVTGGMKVKADRDESSPYAAMLAAQDVAQRCKELGITALHIKLRATGG
                     NRTKTPGPGAQSALRALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL"
     exon            406..567
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /inference="alignment:Splign:2.1.0"
     exon            568..644
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /inference="alignment:Splign:2.1.0"
     exon            645..2363
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      740..745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /note="hexamer: AATAAA"
     polyA_site      769
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /note="major polyA site"
     regulatory      1200..1205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /note="hexamer: CATAAA"
     polyA_site      1222
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
     regulatory      1562..1567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /note="hexamer: AATAAA"
     polyA_site      1579
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
     regulatory      2343..2348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
                     /note="hexamer: AATAAA"
     polyA_site      2363
                     /gene="RPS14"
                     /gene_synonym="EMTB; S14; uS11"
ORIGIN      
        1 ctctctttcc ggtgtggagt ctggagacga cgtgcaggta ggaggcccgg gcgcgacaat
       61 cggggggcat cctgcggcga ggggaccctg tggggcttgg gacgagagac gggggtcttt
      121 ccgtgggaac cgagctaggt gccgggcaag agacgcgcgg ctggcccacc tggatcctgg
      181 ccaactcggg attgagttcg ttcctggtct cagaaggccc gttttgcttt cagggaggag
      241 cttgtgaagt aaggaaatgg cacctcgaaa ggggaaggaa aagaaggaag aacaggtcat
      301 cagcctcgga cctcaggtgg ctgaaggaga gaatgtattt ggtgtctgcc atatctttgc
      361 atccttcaat gacacttttg tccatgtcac tgatctttct ggcaaggaaa ccatctgccg
      421 tgtgactggt gggatgaagg taaaggcaga ccgagatgaa tcctcaccat atgctgctat
      481 gttggctgcc caggatgtgg cccagaggtg caaggagctg ggtatcaccg ccctacacat
      541 caaactccgg gccacaggag gaaataggac caagacccct ggacctgggg cccagtcggc
      601 cctcagagcc cttgcccgct cgggtatgaa gatcgggcgg attgaggatg tcacccccat
      661 cccctctgac agcactcgca ggaagggggg tcgccgtggt cgccgtctgt gaacaagatt
      721 cctcaaaata ttttctgtta ataaattgcc ttcatgtaaa ctgtttcaac tccagccttc
      781 tctccttcat caggggctac tcaggcattt gatttcttcc tcctatttgg cttcttggga
      841 gaaaggagcc tgaggagagc tgagatcctg gtgctgcatt tggggtcttt tccatgctac
      901 ttgcggcatt aagttgcctt ggtcatctaa agcagaccaa ggcgttggag acctcgtttt
      961 gagtggagat gctggttcta aatatggacc aattcttaaa gagccagagt gggaactgtt
     1021 gatccaagtg tagcctgaag cgaaagagga gccttccaga cccatgccat atataaacac
     1081 acgtgggtgt gcattctccc cccacacctt ctgtgcaaag ctgggagctc actccactgc
     1141 gtcttgcttt ttttcacttg gcagatcttg gagattgttc cacatcagta cataaagtac
     1201 ataaagattg tcaccccaca aatacacacc aagtcctatt ttcatcagcg ataaaaaaga
     1261 aaagttcttg ctttccggaa gcttgcatgc ggctctgagt acccagtgac accagatggt
     1321 actcagcgtt ttgcaaggga ttaccacaag gccccgtgat ggtgcctgcc atggttagga
     1381 caggctggtg gctgggtagg gttagtgaga cccagtggag aggatgctgt gtgtcacagg
     1441 ctggagaggt gagaccattg aggtagtcag ttgtagagga aagaaaccag caagagggga
     1501 aaatctgttg ggatgctgct tttagccttt gatggcgtgt tccaggcaga gggaataagc
     1561 aaataaatgg gtcctgagac aaggggttac tgtgatgagg cggcgttggt tacatgccaa
     1621 accttgctag ggattttaat aacaacattg aatcttaacc tgatgaaata acagtactcc
     1681 tggggaggcg ggagggatag cattaggaga tatacctaat gctaaatgac gagttaatgg
     1741 gtgcagcaca ccaacatggc acatgtatac atatgtaaca aacctgcacg ttgtgcacat
     1801 gtaccctaaa acttaaagta taataaaaaa aaaaagcttg caaaaaaaat ataacagtac
     1861 tccttaaatt gttaaaagtc atgaaagtca aggacaggag attaaggagg cgtgaaaact
     1921 aaatgcccat tgtggtatcc tggattggat tctggaacca gaatagggta ttagtataaa
     1981 aactagtgaa ataggataaa ggcagggcac agtggttcac gcctataatc ccaacacttt
     2041 gggaagccga gacaggagga cggattgagc ccaggagttt gagaccagcc tgggcaacac
     2101 agggagaccc cgtctctaca aaaaataaaa aattagctgg gcatggtggc acacgtctgt
     2161 actgccagct acttgggagg ctgaggtggg agaattgcct gagcctggga agtggaggcc
     2221 gcagtgagct gtgattgcat cactacattc agcctgggtc acagagcaag atcctatctc
     2281 aaaaactaaa taagtaaata ataaattaaa aaatatgaat aaagtctgga gttaaagtct
     2341 ggaataaagc tagtagtaat gta
//
