LOCUS       NM_001017                527 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens ribosomal protein S13 (RPS13), mRNA.
ACCESSION   NM_001017
VERSION     NM_001017.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 527)
  AUTHORS   Rashid,M., Shah,S.G., Natu,A., Verma,T., Rauniyar,S., Gera,P.B. and
            Gupta,S.
  TITLE     RPS13, a potential universal reference gene for normalisation of
            gene expression in multiple human normal and cancer tissue samples
  JOURNAL   Mol Biol Rep 48 (12), 7967-7974 (2021)
   PUBMED   34657252
  REMARK    GeneRIF: RPS13, a potential universal reference gene for
            normalisation of gene expression in multiple human normal and
            cancer tissue samples.
REFERENCE   2  (bases 1 to 527)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 527)
  AUTHORS   Kennedy,S.A., Jarboui,M.A., Srihari,S., Raso,C., Bryan,K.,
            Dernayka,L., Charitou,T., Bernal-Llinares,M., Herrera-Montavez,C.,
            Krstic,A., Matallanas,D., Kotlyar,M., Jurisica,I., Curak,J.,
            Wong,V., Stagljar,I., LeBihan,T., Imrie,L., Pillai,P., Lynn,M.A.,
            Fasterius,E., Al-Khalili Szigyarto,C., Breen,J., Kiel,C.,
            Serrano,L., Rauch,N., Rukhlenko,O., Kholodenko,B.N.,
            Iglesias-Martinez,L.F., Ryan,C.J., Pilkington,R., Cammareri,P.,
            Sansom,O., Shave,S., Auer,M., Horn,N., Klose,F., Ueffing,M.,
            Boldt,K., Lynn,D.J. and Kolch,W.
  TITLE     Extensive rewiring of the EGFR network in colorectal cancer cells
            expressing transforming levels of KRASG13D
  JOURNAL   Nat Commun 11 (1), 499 (2020)
   PUBMED   31980649
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 527)
  AUTHORS   Lee,J.H., Han,J.H., Kim,H., Park,S.M., Joe,E.H. and Jou,I.
  TITLE     Parkinson's disease-associated LRRK2-G2019S mutant acts through
            regulation of SERCA activity to control ER stress in astrocytes
  JOURNAL   Acta Neuropathol Commun 7 (1), 68 (2019)
   PUBMED   31046837
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 527)
  AUTHORS   Khatter,H., Myasnikov,A.G., Natchiar,S.K. and Klaholz,B.P.
  TITLE     Structure of the human 80S ribosome
  JOURNAL   Nature 520 (7549), 640-645 (2015)
   PUBMED   25901680
REFERENCE   6  (bases 1 to 527)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   7  (bases 1 to 527)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   8  (bases 1 to 527)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   9  (bases 1 to 527)
  AUTHORS   Chadeneau,C., LeMoullac,B. and Denis,M.G.
  TITLE     Cloning and analysis of the human S13 ribosomal protein cDNA
  JOURNAL   Nucleic Acids Res 21 (12), 2945 (1993)
   PUBMED   8332508
REFERENCE   10 (bases 1 to 527)
  AUTHORS   Suzuki,K., Olvera,J. and Wool,I.G.
  TITLE     The primary structure of rat ribosomal protein S13
  JOURNAL   Biochem Biophys Res Commun 171 (2), 519-524 (1990)
   PUBMED   2403345
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from AC116533.11.
            
            On Nov 26, 2018 this sequence version replaced NM_001017.2.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S15P family of ribosomal proteins. It is located in the
            cytoplasm. The protein has been shown to bind to the 5.8S rRNA in
            rat. The gene product of the E. coli ortholog (ribosomal protein
            S15) functions at early steps in ribosome assembly. This gene is
            co-transcribed with two U14 small nucleolar RNA genes, which are
            located in its third and fifth introns. As is typical for genes
            encoding ribosomal proteins, there are multiple processed
            pseudogenes of this gene dispersed through the genome. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP318859.1, SRR1163655.395667.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000525634.6/ ENSP00000435777.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                AC116533.11        78331-78379
            50-98               AC116533.11        78521-78569
            99-177              AC116533.11        78752-78830
            178-347             AC116533.11        80375-80544
            348-448             AC116533.11        80801-80901
            449-527             AC116533.11        81532-81610
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..527
                     /gene="RPS13"
                     /gene_synonym="S13; uS15"
                     /note="ribosomal protein S13"
                     /db_xref="GeneID:6207"
                     /db_xref="HGNC:HGNC:10386"
                     /db_xref="MIM:180476"
     exon            1..49
                     /gene="RPS13"
                     /gene_synonym="S13; uS15"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..482
                     /gene="RPS13"
                     /gene_synonym="S13; uS15"
                     /EC_number="3.6.5.3"
                     /note="40S ribosomal protein S13"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS15"
                     /protein_id="NP_001008.1"
                     /db_xref="CCDS:CCDS7823.1"
                     /db_xref="GeneID:6207"
                     /db_xref="HGNC:HGNC:10386"
                     /db_xref="MIM:180476"
                     /translation="MGRMHAPGKGLSQSALPYRRSVPTWLKLTSDDVKEQIYKLAKKG
                     LTPSQIGVILRDSHGVAQVRFVTGNKILRILKSKGLAPDLPEDLYHLIKKAVAVRKHL
                     ERNRKDKDAKFRLILIESRIHRLARYYKTKRVLPPNWKYESSTASALVA"
     exon            50..98
                     /gene="RPS13"
                     /gene_synonym="S13; uS15"
                     /inference="alignment:Splign:2.1.0"
     exon            99..177
                     /gene="RPS13"
                     /gene_synonym="S13; uS15"
                     /inference="alignment:Splign:2.1.0"
     exon            178..347
                     /gene="RPS13"
                     /gene_synonym="S13; uS15"
                     /inference="alignment:Splign:2.1.0"
     exon            348..448
                     /gene="RPS13"
                     /gene_synonym="S13; uS15"
                     /inference="alignment:Splign:2.1.0"
     exon            449..527
                     /gene="RPS13"
                     /gene_synonym="S13; uS15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      503..508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS13"
                     /gene_synonym="S13; uS15"
                     /note="hexamer: AATAAA"
     polyA_site      527
                     /gene="RPS13"
                     /gene_synonym="S13; uS15"
                     /note="major polyA site"
ORIGIN      
        1 cctttcgttg cctgatcgcc gccatcatgg gtcgcatgca tgctcccggg aagggcctgt
       61 cccagtcggc tttaccctat cgacgcagcg tccccacttg gttgaagttg acatctgacg
      121 acgtgaagga gcagatttac aaactggcca agaagggcct tactccttca cagatcggtg
      181 taatcctgag agattcacat ggtgttgcac aagtacgttt tgtgacaggc aataaaattt
      241 taagaattct taagtctaag ggacttgctc ctgatcttcc tgaagatctc taccatttaa
      301 ttaagaaagc agttgctgtt cgaaagcatc ttgagaggaa cagaaaggat aaggatgcta
      361 aattccgtct gattctaata gagagccgga ttcaccgttt ggctcgatat tataagacca
      421 agcgagtcct ccctcccaat tggaaatatg aatcatctac agcctctgcc ctggtcgcat
      481 aaatttgtct gtgtactcaa gcaataaaat gattgtttaa ctaaaag
//
