LOCUS       NM_001016                503 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ribosomal protein S12 (RPS12), mRNA.
ACCESSION   NM_001016
VERSION     NM_001016.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 503)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   2  (bases 1 to 503)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 503)
  AUTHORS   Katanaev,V.L., Kryuchkov,M., Averkov,V., Savitsky,M., Nikolaeva,K.,
            Klimova,N., Khaustov,S. and Solis,G.P.
  TITLE     HumanaFly: high-throughput transgenesis and expression of breast
            cancer transcripts in Drosophila eye discovers the RPS12-Wingless
            signaling axis
  JOURNAL   Sci Rep 10 (1), 21013 (2020)
   PUBMED   33273532
  REMARK    GeneRIF: HumanaFly: high-throughput transgenesis and expression of
            breast cancer transcripts in Drosophila eye discovers the
            RPS12-Wingless signaling axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 503)
  AUTHORS   Shrestha,D., Maharjan,B., Thida Oo,N.A., Isoda,N., Nakajima,C. and
            Suzuki,Y.
  TITLE     Molecular analysis of streptomycin-resistance associating genes in
            Mycobacterium tuberculosis isolates from Nepal
  JOURNAL   Tuberculosis (Edinb) 125, 101985 (2020)
   PUBMED   32829153
  REMARK    GeneRIF: Molecular analysis of streptomycin-resistance associating
            genes in Mycobacterium tuberculosis isolates from Nepal.
REFERENCE   5  (bases 1 to 503)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 503)
  AUTHORS   Vladimirov,S.N., Ivanov,A.V., Karpova,G.G., Musolyamov,A.K.,
            Egorov,T.A., Thiede,B., Wittmann-Liebold,B. and Otto,A.
  TITLE     Characterization of the human small-ribosomal-subunit proteins by
            N-terminal and internal sequencing, and mass spectrometry
  JOURNAL   Eur J Biochem 239 (1), 144-149 (1996)
   PUBMED   8706699
REFERENCE   7  (bases 1 to 503)
  AUTHORS   Wool,I.G., Chan,Y.L. and Gluck,A.
  TITLE     Structure and evolution of mammalian ribosomal proteins
  JOURNAL   Biochem Cell Biol 73 (11-12), 933-947 (1995)
   PUBMED   8722009
  REMARK    Review article
REFERENCE   8  (bases 1 to 503)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   9  (bases 1 to 503)
  AUTHORS   Pogue-Geile,K., Geiser,J.R., Shu,M., Miller,C., Wool,I.G.,
            Meisler,A.I. and Pipas,J.M.
  TITLE     Ribosomal protein genes are overexpressed in colorectal cancer:
            isolation of a cDNA clone encoding the human S3 ribosomal protein
  JOURNAL   Mol Cell Biol 11 (8), 3842-3849 (1991)
   PUBMED   1712897
REFERENCE   10 (bases 1 to 503)
  AUTHORS   Herault,Y., Michel,D., Chatelain,G. and Brun,G.
  TITLE     cDNA and predicted amino acid sequences of the human ribosomal
            protein genes rpS12 and rpL17
  JOURNAL   Nucleic Acids Res 19 (14), 4001 (1991)
   PUBMED   1861993
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BQ276878.1 and BC095424.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001016.3.
            
            Summary: Ribosomes, the organelles that catalyze protein synthesis,
            consist of a small 40S subunit and a large 60S subunit. Together
            these subunits are composed of 4 RNA species and approximately 80
            structurally distinct proteins. This gene encodes a ribosomal
            protein that is a component of the 40S subunit. The protein belongs
            to the S12E family of ribosomal proteins. It is located in the
            cytoplasm. Increased expression of this gene in colorectal cancers
            compared to matched normal colonic mucosa has been observed. As is
            typical for genes encoding ribosomal proteins, there are multiple
            processed pseudogenes of this gene dispersed through the genome.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BJ990964.1, BM742041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000230050.4/ ENSP00000230050.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BQ276878.1         4-13
            11-503              BC095424.1         1-493
FEATURES             Location/Qualifiers
     source          1..503
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.2"
     gene            1..503
                     /gene="RPS12"
                     /gene_synonym="eS12; S12"
                     /note="ribosomal protein S12"
                     /db_xref="GeneID:6206"
                     /db_xref="HGNC:HGNC:10385"
                     /db_xref="MIM:603660"
     exon            1..45
                     /gene="RPS12"
                     /gene_synonym="eS12; S12"
                     /inference="alignment:Splign:2.1.0"
     exon            46..96
                     /gene="RPS12"
                     /gene_synonym="eS12; S12"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..481
                     /gene="RPS12"
                     /gene_synonym="eS12; S12"
                     /note="40S ribosomal protein S12"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS12"
                     /protein_id="NP_001007.2"
                     /db_xref="CCDS:CCDS5164.1"
                     /db_xref="GeneID:6206"
                     /db_xref="HGNC:HGNC:10385"
                     /db_xref="MIM:603660"
                     /translation="MAEEGIAAGGVMDVNTALQEVLKTALIHDGLARGIREAAKALDK
                     RQAHLCVLASNCDEPMYVKLVEALCAEHQINLIKVDDNKKLGEWVGLCKIDREGKPRK
                     VVGCSCVVVKDYGKESQAKDVIEEYFKCKK"
     exon            97..213
                     /gene="RPS12"
                     /gene_synonym="eS12; S12"
                     /inference="alignment:Splign:2.1.0"
     exon            214..316
                     /gene="RPS12"
                     /gene_synonym="eS12; S12"
                     /inference="alignment:Splign:2.1.0"
     exon            317..418
                     /gene="RPS12"
                     /gene_synonym="eS12; S12"
                     /inference="alignment:Splign:2.1.0"
     exon            419..503
                     /gene="RPS12"
                     /gene_synonym="eS12; S12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      485..490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RPS12"
                     /gene_synonym="eS12; S12"
                     /note="hexamer: AATAAA"
     polyA_site      503
                     /gene="RPS12"
                     /gene_synonym="eS12; S12"
                     /note="major polyA site"
ORIGIN      
        1 ctctttccct gccgccgccg agtcgcgcgg aggcggaggc ttgggtgcgt tcaagattca
       61 acttcacccg taacccaccg ccatggccga ggaaggcatt gctgctggag gtgtaatgga
      121 cgttaatact gctttacaag aggttctgaa gactgccctc atccacgatg gcctagcacg
      181 tggaattcgc gaagctgcca aagccttaga caagcgccaa gcccatcttt gtgtgcttgc
      241 atccaactgt gatgagccta tgtatgtcaa gttggtggag gccctttgtg ctgaacacca
      301 aatcaaccta attaaggttg atgacaacaa gaaactagga gaatgggtag gcctttgtaa
      361 aattgacaga gaggggaaac cccgtaaagt ggttggttgc agttgtgtag tagttaagga
      421 ctatggcaag gagtctcagg ccaaggatgt cattgaagag tatttcaaat gcaagaaatg
      481 aagaaataaa tctttggctc aca
//
